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Savita Khanna, PhD

Savita Khanna, PhD
Assistant Professor, Department of Surgery
Phone: (614) 366-3806
Email: savita.khanna@osumc.edu;
 
 
 
 
 
 
 
 
 
 
 
 
Our laboratory focuses on the study of brain injury, neurodegeneration and therapeutics. Our laboratory has unique ability to do in vitro and in vivo studies related to mechanisms of neurodegeneration and interventional rescue. In vitro models includes neuronal cell line and primary neuronal cultures. In vivo work utilizes the rat and murine acute ischemic stroke (AIS) model of intraluminal middle cerebral artery occlusion (MACO).  State of the art technologies such as microinjection, laser capture microdissection (LCM), microarray expression (mRNA and miRNA) profiling as well as high resolution brain MRI/spectroscopy (11.7T and 9.4T) are routinely used. Nutritional aspects constitute a major interest.
Team Members
Dr. Huang Yue, Research Assistant
Natasha R. Sinai Hede, Undergraduate student
Dr. Cameron Rink (Collaborator)
Dr. Sashwati Roy (Collaborator)
Dr. Gayle Gordillo (collaborator)
Dr. Chandan K Sen (collaborator)
Research Interests
Stroke
Neurodegenration
Therapeutics
Selected Publications
Rink C, Gnyawali S, Peterson L, Khanna S. Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke. Antioxidants & Redox Signaling. 2011 May 15;14(10):1777-85.

Rink C, Roy S, Khan M, Ananth P, Kuppusamy P, Sen CK, Khanna S. Oxygen-sensitive outcomes and gene expression in acute ischemic stroke. Journal of Cerebral Blood Flow and Metabolism. 2010 Jul;30(7):1275-87.

Khanna S, Parinandi NL, Kotha SR, Roy S, Rink C, Bibus D, Sen CK. Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A and causes neuroprotection. J Neurochem. 2010 Mar;112(5):1249-60.

Khanna S, Park HA, Sen CK, Golakoti T, Sengupta K, Venkateswarlu S, Roy S. Neuroprotective and anti-inflammatory properties of a novel demethylated curcuminoid. Antioxid Redox Signal. 2009 Mar;11(3):449-68.

Khanna S, Roy S, Park HA, Sen CK. Regulation of c-SRC activity in glutamate-induced neurodegeneration. J Biol Chem. 2007 Aug 10; 282 (32):23482-90.

Khanna S, Roy S, Parinandi NL, Maurer M, Sen CK. Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. J Neurochem. 2006 Sep; 98(5):1474-86.

Khanna S, Roy S, Maurer M, Ratan RR, Sen CK. Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: Prolyl hydroxylases tune the biological normoxic set point. Free Radic Biol Med. 2006 Jun 15;40(12):2147-54.

Khanna S, Patel V, Rink C, Roy S and C.K. Sen. Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. Free Radic Biol Med 39: 1310-9, 2005.

Khanna S, Roy S, Slivka A, Craft T.K. S, Chaki S, Rink C, Notestine MA, DeVries AC, Parinandi NL and Sen CK. Neuroprotective properties of the natural vitamin E a-tocotrienol. Stroke 36: 2258-64, 2005.

Khanna S, Roy S, Ryu H, Bahadduri P, Swaan PW, Ratan RR and Sen CK. Molecular basis of vitamin E action. Tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J Biol Chem. 278(44) 43508-43515, 2003. PMCID: