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Traci A. Wilgus, PhD

Traci A. Wilgus, Ph.D.
Assistant Professor
Phone: (614) 366-8526
Email: traci.wilgus@osumc.edu

Research in our laboratory focuses on the role of inflammation and angiogenesis in regeneration, wound healing, and skin carcinogenesis.  One project examines the role of vascular endothelial growth factor-1 (VEGFR-1) in wound healing and in skin cancer development. Vascular endothelial growth factor (VEGF) is a potent mediator of angiogenesis, which signals through receptors (VEGFR-1 and VEGFR-2) on endothelial cells. However, some non-endothelial cell types can also express VEGFRs, including epidermal keratinocytes. Ongoing experiments are being performed to determine whether VEGF can directly influence keratinocytes through VEGFR-1 in vivo, and whether this interaction stimulates wound reepithelialization and /or skin carcinogenesis.

Our laboratory is also interested in fetal wound healing. Early in development (within the first and second trimesters of development) fetal skin can regenerate and heal wounds without a scar, but later in development fetal skin heals similarly to adult skin, losing the ability to regenerate and instead healing with a scar. Currently, we are using a mouse model of fetal wound healing to to determine mechanisms of skin regeneration and to identify putative anti-scarring molecules.
Team Members
Brian Wulff, PhD,  postdoc
Kelly Nye, IBGP graduate student
Adrienne Dardenne, Vet Biomed graduate students
Monica Lachey, Biomedical Sciences undergraduate student
Research Interests
Regulation of wound inflammation
Contribution of angiogenesis to repair
Mechanisms of regenerative healing in fetal skin
Skin carcinogenesis
Selected Publications
TA Wilgus, Y Vodovotz, E Vittadini, EA Clubbs, and TM Oberyszyn. Reduction of scar formation in full-thickness wounds with topical celecoxib treatment. Wound Repair Regen. 2003: 11(1) 25-34.

TA Wilgus, VK Bergdall, KL Tober, KJ Hill, S Mitra, NA Flavahan, and TM Oberyszyn. The impact of cyclooxygenase-2 mediated inflammation on scarless fetal wound healing. Am J Pathol. 2004: 165(3): 753-761.

TA Wilgus, VK Bergdall, LA DiPietro, and TM Oberyszyn. Hydrogen peroxide disrupts scarless fetal wound repair. Wound Rep Regen. 2005: 13(5): 513-519.

TA Wilgus, AM Matthies, KA Radek, J Dovi, A Burns, R Shankar, and LA DiPietro. Novel function for vascular endothelial growth factor receptor-1 on epidermal keratinocytes. Am J Pathol. 2005: 167(5): 1257-1266.

TA Wilgus. Regenerative healing in fetal skin: A review of the literature. Ostomy Wound Manage. 2007: 53(6): 16-31.

TA Wilgus. Immune cells in the healing skin wound: influential players at each stage of repair. Pharmacol Res. 2008: 58(2): 112-116.

TA Wilgus, AM Ferreira, TM Oberyszyn, VK Bergdall, and LA DiPietro. Modulation of dermal scar formation by vascular endothelial growth factor. Lab Invest. 2008: 88(6): 579-590.

TA Wilgus. Lipid Mediators: Important regulators of cutaneous wound inflammation. In: Advances in Wound Care: Translational Medicine: From Benchtop to Bedside to Community and Back. 2010: Vol 1: 230-235.

BC Wulff, AE Parent, MA Meleski, LA DiPietro, ME Schrementi, and TA Wilgus. Mast cells contribute to scar formation during fetal wound healing. J Invest Derm. 2012: 132(2): 458-465.

TA Wilgus and LA DiPietro. Complex roles for VEGF in dermal wound healing. J Invest Derm. 2012: 132(2): 493-494.