Name: Shahid Nimjee

Email: shahid.nimjee@osumc.edu

Department: Neurological Surgery

Lab Manager/Dept Contact: Debra Wheeler

Lab Manager/Dept Contact Email: debra.wheeler@osumc.edu

Lab Manager/Dept Phone: 614-292-1803

Preferred Method of Contact: Lab Manager/Dept Contact email or phone

Previous Mentoring: Yes (funded)

Category of Research: Translational

Research Description: Our lab focuses on elucidating the thrombo-inflammatory mechanisms of stroke and developing RNA-based therapies called aptamers to improve outcomes in thrombosis in the brain, heart and periphery. Aptamers are single-stranded oligonucleotides that can fold into a 3-dimensional conformation to bind to and inhibit protein function. Using an in vitro selection strategy we have identified an aptamer that binds to von Willebrand factor (VWF) and inhibits its activity. We have designed an antidote oligonucleotide to the aptamer that reverses its activity within 2 minutes. We are evaluating this drug-antidote pair in vivo as both therapeutic agents and to shed light on the mechanism of arterial thrombosis in stroke.

Specific Areas of Research Emphasis: Neuroscience; RNA biology; Vascular Disease