Name: Kamal Pohar
Preferred Method of Contact: Faculty Email
Previous Mentoring: Yes (funded)
Category of research: Basic; translational
Research Description: We are modeling specific genetic changes identified in human bladder tumors in mouse models of bladder cancer. The genetic changes being introduced in the mouse are organ and time specific and driven by a bladder specific promoter. The purpose is to develop a mouse model of bladder cancer that better represents the human disease to better understand the biology and identify novel therapeutic targets. We are also investigating therapies that revert the methylation of genes that appear critical to the bladder cancer phenotype. This work is being conducted in cell lines and animal models and being validated in human tissue.
Specific areas of Research Emphasis: Cancer Biology; Cancer Genetics; Cancer Therapy