Assistant Professor, Microbial Infection and Immunity
592 Biomedical Research Tower (BRT)
460 W 12th Ave, Columbus OH 43210
Gang.Xin@osumc.edu
614-685-5476
Membership: Pelotonia Institute for Immuno-Oncology, OSU Comprehensive Cancer Center - James, Infectious Diseases Institute
Research Interests
Dr. Xin’s laboratory focuses on understanding the mechanisms underlying resistance to cancer immunotherapy. Despite the revolutionary success of immunotherapies such as immune checkpoint-blocking (ICB) antibodies, only a small fraction of patients respond to these therapies owing to dysfunctional T cells and immunosuppressive myeloid cells in the tumor. To improve T cell function, our lab will employ cutting edge single-cell sequencing and bioinformatic analysis to identify a novel transcriptional mechanism of T cells exhaustion. Furthermore, we will also explore how the metabolic crosstalk between cancer cells and tumor-infiltrating myeloid cells shapes their inhibitory function against T cells. Ultimately, our goal is to exploit this knowledge to develop novel therapeutic strategies to broaden and boost the efficacy of cancer immunotherapy.
Laboratory
560A Biomedical Research Tower (BRT)460 W 12th Ave, Columbus OH 43210
614-685-5476
Personnel
Fengxia Gao, Post Doctoral Scholar, fengxia.gao@osumc.eduAlex Jin, Graduate Student, jiacheng.jin@osumc.edu
Jianying Li, Graduate Student, jianying.li@osumc.edu
Min Xiao, Research Associate, min.xiao@osumc.edu