U.S. Patents Issued to College of Medicine Faculty & Staff
FY2012
(listed by date order)
- Androgen receptor-ablative agents, U.S. Patent 7,973,062, issued July 5, 2011
Inventors: Chen, Ching-Shih; Wang, WDasheng, Yang, Jian
Assignee: The Ohio State University Research Foundation
Abstract: Compounds of the thiazolidinedione family are provided and shown to be effective androgen receptor ablative agents that can be used in methods of treating or preventing cancer or precancer, including prostate cancer. Also provided are methods of treating or preventing cancer by administering a therapeutically effective amount of one of the androgen receptor ablative agents to a subject in need of such treatment.
Link to patent: http://tinyurl.com/6r5k9mj
- MicroRNA fingerprints during human megakaryocytopoiesis, U.S. Patent 7,985,584, issued July 26, 2011
Inventors: Croce, Carlo; Garzon, Ramiro; Calin, George
Assignee: The Ohio State University Research Foundation
Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer and myeloproliferative disorders. The invention also provides methods of identifying anti-cancer agents.
Link to patent: http://tinyurl.com/73kqmvv
- Customized transition zone system and method for an ablation pattern, U.S. Patent 7,992,569 issued August 9, 2011
Inventors: Roberts, Cynthia; Mahmoud, Ashraf
Assignee: The Ohio State University
Abstract: The present invention discloses a corneal refractive procedure providing a customized transition zone. The customized transition zone provided according to the methods and systems of the present invention exhibits continuous curvature between an ablated optical zone and a non-ablated zone to address curvature discontinuity at the edge of the optical zone, thereby minimizing the biomechanical response and its postoperative effects on vision.
Link to patent: http://tinyurl.com/7aqslyf
- System and method for screening tissue, U.S. Patent 7,993,271 issued August 9, 2011
Inventors: Liu, Jun; Ferrari, Mauro; Rokhlin, Stanislav I.; Sedmak, Daniel D.
Assignee: The Ohio State University
Abstract: A system and method for screening tissue is provided. The system provides a computer-based system for distinguishing between normal and potentially abnormal tissue. The system includes computer components for generating and receiving ultrasonic waves, for storing a tissue model, and for analyzing received ultrasonic waves in the context of the tissue model.
Link to patent: http://tinyurl.com/7wv7fb5
- MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML) U.S. Patent 8,034,560 issued October 11, 2011
Inventor: Croce, Carlo M.
Assignee: The Ohio State University Research Foundation
Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML). The invention also provides methods of identifying anti-AML agents.
Link to patent: http://tinyurl.com/7pc3mof
- Anti-infective agents against intracellular pathogens, U.S. Patent 8,039,502 issued October 18, 2011
Inventors: Chen, Ching-Shih; Chiu, Hao-Chieh; Wang, Dasheng; Gunn, John S.; Schlesinger, Larry S.
Assignee: The Ohio State University Research Foundation
Abstract: A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors.
Link to patent: http://tinyurl.com/7zu8yeu
- Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing, U.S. Patent 8,053,186, issued November 8, 2011
Inventor: Croce, Carlo M.
Assignee: The Ohio State University Research Foundation
Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.
Link to patent: http://tinyurl.com/7rqqt2n
- Nanoparticulate probe for in vivo monitoring of tissue oxygenation, U.S. Patent 8,066,973 issued November 29, 2011
Inventors: Kuppusamy, Periannan; Kutala, Vijay; Zweier, Jay L.; Kwiatkowski, Pawel
Assignee: The Ohio State University Research Foundation
Abstract: A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.
Link to patent: http://tinyurl.com/7z6yw66
- Vascular endothelial growth factors and methods of their use, U.S. Patent 8,067,368 issued November 29, 2011
Inventors: Robertson, Fredika; Bauer, John
Assignees: The Ohio State University Research Foundation and Nationwide Children's Hospital, Inc. (Columbus, OH)
Abstract: Vascular endothelial growth factor alternative splice variants and methods of their use are provided.
Link to patent: http://tinyurl.com/84je8qt
- Leukemia diagnostic methods, U.S. Patent 8,071,292 issued December 6, 2011
Inventor: Croce, Carlo M.
Assignee: The Ohio State University Research Foundation
Abstract: The present invention provides methods and compositions for the diagnosis, prognosis and treatment of chronic lymphocytic leukemia (CLL). The invention also provides methods of identifying anti-CLL agents.
Link to patent: http://tinyurl.com/7hlp5s5
- Chimeric VEGF peptides, U.S. Patent 8,080,253 issued December 20, 2011
Inventors: Kaumaya, Pravin; Cohn, David
Assignee: The Ohio State University Research Foundation
Abstract: Compositions for and methods of treating patients with malignancies associated with overexpression of VEGF, particularly ovarian cancer are provided herein. The compositions include but are not limited to certain VEGF epitopes, multivalent peptides comprising the epitopes, and chimeric peptides comprising one or more of the epitopes and a T cell epitope.
Link to patent: http://tinyurl.com/83c4rk2
- PDK-1/Akt signaling inhibitors, U.S. Patent 8,080,574 issued December 20, 2011
Inventor: Chen, Ching-Shih
Assignee: The Ohio State University Research Foundation
Abstract: Use of a new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I for inducing apoptosis in unwanted rapidly proliferating cells, for treating, inhibiting, or delaying the onset of cancer, and for preventing restenosis in a subject that has undergone an angioplasty or stent.
Link to patent: http://tinyurl.com/6qo9nkw
- Method of diagnosing poor survival prognosis colon cancer using microRNA-21, U.S. Patent 8,084,199 issued December 27, 2011
Inventors: Croce, Carlo M.; Harris, Curtis C.; Schetter, Aaron J.
Assignees: The Ohio State University Research Foundation and The United States of America as represented by the Department of Health and Human Services, National Institutes of Health, Office of Technology Transfer
Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
Link to patent: http://tinyurl.com/6v2rk4z
- Polypeptides and polynucleotides for enhancing immune reactivity to HER-2 protein, U.S. Patent 8,110,657 issued February 7, 2012
Inventor: Kaumaya; Pravin
Assignee: The Ohio State University
Abstract: Compositions for stimulating the immune system and for treating malignancies associated with overexpression of the HER-2 protein are provided. Such compositions include immunogenic epitopes of the HER-2 proteins and chimeric and multivalent peptides which comprise such epitopes. The present invention also relates to polynucleotides which encode the chimeric peptides. Also provided are pharmaceutical compositions comprising such immunogenic compositions. Methods for stimulating an immune response to HER-2 protein are provided. Methods for treating breast cancer, ovarian cancer, prostate cancer, colon cancer and lung cancer are provided.
Link to patent: http://tinyurl.com/7bqp48r
15. Anti-CD74 immunoconjugates and methods of use, U.S. Patent 8,119,101 issued February 21, 2012
Inventors: Byrd, John C.; Goldenberg, David M.; Hansen, Hans J.
Assignees: The Ohio State University and Immunomedics, Inc.
Abstract: Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells.
16. Method and apparatus for detecting interventricular dyssynchrony, U.S. Patent 8,131,043 issued March 6, 2012
Inventors: Binkley, Philip F.; Raman, Subha V.
Assignee: The Ohio State University
Abstract: Several embodiments of a method and apparatus for detecting interventricular dyssynchrony are provided. In one embodiment, the apparatus includes an image segment processor and an image classifier. The image segment processor may segment left and right ventricles in source images of a subject's heart to form left and right ventricle segments in segmented images. Each source image may include cross sections of the right and left ventricles in common spatial relation along the short axis plane and in common temporal relation in reference to a cardiac cycle. The source images and corresponding segmented images may be temporally-spaced in relation to the cardiac cycle. The image classifier may determine first and second cross-sectional areas associated with the left and right ventricle segments for each segmented image, compare the first and second cross-sectional areas, and classify the subject's heart in an interventricular dyssynchronous class or a non-dyssynchronous class.
17. MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of solid cancers, U.S. Patent 8,148,069 issued April 3, 2012
Inventors: Croce; Carlo M.; Calin; George A.; Volinia; Stefano
Assignee: The Ohio State University
Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The present invention is based, in part, on the identification of specific miRNAs that have altered expression levels in particular solid cancers.
18. Alkyl indole-3-carbinol-derived antitumor agents, U.S. Patent 8,153,680 issued April 10, 2012
Inventors: Chen; Ching-Shih; Weng; Jing-Ru
Assignee: The Ohio State University Research Foundation
Abstract: Compounds and methods for treating cancer or inducing apoptosis in proliferating cells. The compounds are shown in formula I: ##STR00001## wherein X is selected from hydroxyl, thiol, and amino; Y is selected from carboxyl and sulfonyl; R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are selected from hydrogen, lower alkyl, and combinations thereof; R.sub.5, R.sub.6, and R.sub.7 are selected from hydrogen, halo, nitro, amino, methoxy, and combinations thereof; and pharmaceutically acceptable salts thereof.