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Kamal D. Mehta

Professor

Office: 464 Hamilton Hall
Lab: 485 Hamilton Hall

Phone: (614) 688-8451
Lab: (614) 688-5765
mehta.80@osu.edu

Education:

Ph.D. - McMaster University Medical Center
Post Doctoral - University of Texas Southwestern Medical Center, Dallas

My lab is interested in two broad themes related to the regulation of lipid metabolism in mammals: Signaling kinase as nutrient sensors- The focus of our laboratory is towards understanding how PKC signaling pathways are regulated by dietary fats and what the consequences are when these pathways become dysregulated in the pathogenesis of human disease. Specifically, we study a family of protein kinases known as protein kinase C (PKC). We use an integrative employing biochemistry, cell biology and mouse genetics to uncover the function of PKCb in sensing individual components of Western-style high fat/cholesterol diets. By using this strategy we are able to investigate how the diet-sensitive protein kinase Cbeta signaling influence an increase in the size of existing fat cells (adipocytes), as well as, an increase in the number of adipocytes in fat tissue by nutrient excess, and participate in the development, manifestation, and complications of diabetes and obesity. Signaling pathways controlling cholesterol homeostasis- We are interested in studying the signaling mechanisms activated by dietary cholesterol in the liver and how these signaling mechanisms function in physiological and pathophysiological processes. Of particular interest is the Raf-1/MEK/ERK kinase cascade and the underlying mechanisms controlling cholesterol homeostasis. By enhancing our understanding of how diet influences gene expression and the genetic regulation of lipid metabolism, we aim to uncover novel therapeutic targets for the treatment of metabolic diseases such as obesity, diabetes, and atherosclerosis.

Recent Publications:

  • ​Mehta, K.D. (2017) PKCO: expanding role in hepatic adaptation of cholesterol homeostasis to dietary fat/cholesterol. Am. J. Physiol. Gastrointest. Liver Physiol. 312:G266-G273.
  • Huang, W. Mehta, D., Sif, S., Kent, L., Jacob, S. T., Ghoshal, K., Mehta, K.D. (2017) Dietary fat/cholesterol-sensitive PKCO-RB signaling: Potential role in NASH/HCC axis. Oncotarget, In Press.
  • Huang, W., Mehta, K.D. (2015) Modulation of hepatic protein kinase Cbeta expression in metabolic  adaptation to a lithogenic diet. Cell. Mol. Gastroenterol. Hepatol. 1:395-405
  • Mehta, K.D. (2014) Protein kinase CB: an emerging connection betweebn nutrient excess and obesity. Biochem. Biophys. Acta 1841:1491-1497.
  • Wallace, J.A., Pitarresi, J. R., Sharma, N., Palettas, M., Cuitino, M.C., Sizemore, S.T., Yu, L., Sanderlin, A., Rosol, T. J., Mehta, K.D., Sizemore, G.M., Ostrowski, M.C. (2014) Protein kinase CB in the tumor microenvironment promotes mammary tumorigenesis. Front. Oncol. 4:87. doi:10.3389/fonc.2014.00087.eCollection 2014. PMCID: PMCID4006052.
  • Mehta, K.D. (2014) Emerging role of protein kinase CB in energy homeostasis: A brief review. World J. Diabet. 5:385-392.
  • Rao, X., Zhong, J., Xu, X., Jordan, B., Maurya, S., Ying, Z., Wang, T., Huang, W., Agarawal, S., Periasamy, M., Rajagopalan, S., Mehta, K. D.*, Sun Q* (2013) "Exercise protects against diet-induced insulin resistance through downregulation of protein kinase Cbeta in mice." PLoS ONE 8(12):e81364. doi:10.1371/journal.pone.0081364. (* Corresponding authors).
  • Patergnani, S., Marchi, S., Rimessi, A., Bonora, M., Giorgi, C., Mehta, K. D., Pinton, P. (2013) "The protein kinase Cbeta and the mitochondrial axis as key regulators of autophagy." Autophagy 9: 1367-1385.
  • Chen, L., Oleskyn, D., Pulnivo, M., Jenks, S., Tipton, C., Misra, R., Lund, F., Schwartz, G., Goldman, B., Mohan, C., Mehta, K. D., Mehta, M., Leitges, M., Zhao, J., and Sanz, I. (2013) "PKCbeta is required for Lupus development in Sle mice." Arthritis & Rheumat. 65:1022-1031.
  • Huang, W., Bansode, R. R., Bal, N. C., Mehta, M, and Mehta, K. D. (2012) "Protein kinase Cbeta deficiency attenuates obesity syndrome of ob/ob mice by promoting white adipose tissue remodeling". J. Lipid Res. 53;368-378.
  • Huang W, Bansode R, Xie Y, Rowland L, Mehta M, Davidson NO and Mehta KD (2011) "Disruption of the protein kinase Cbeta alters biliary lipid and hepatic cholesterol metabolism" J Biol Chem 286(26):22795-805.
  • Huang W, Bansode R, Mehta M and Mehta KD (2009) "Loss of Protein Kinase Cß Function Protects Mice Against Diet-Induced Obesity and Development of Hepatic Steatosis and Insulin Resistance" Hepatology 49(5):1525-36.
  • Bansode RR, Huang W, Roy SK, Mehta M and Mehta KD (2008) "Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage" J Biol Chem 283(1):231-6.
  • Wang HM, Mehta S, Bansode R, Huang W and Mehta KD (2008) "AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade" Biochem Pharmacol 75(2):457-67.
  • Huang W, Batra S, Korrapati S and Mehta KD (2006) "Selective repression of low density lipoprotein receptor expression by SP600125: coupling of histone H3-Ser10 phosphorylation and Sp1 occupancy" Mol Cell Biol 26(4):1307-17.
  • Huang W, Batra S, Atkins BA, Mishra V and Mehta KD (2005) "Increases in intracellular calcium dephosphorylate histone H3 at serine 10 in human hepatoma cells: potential role of protein phosphatase 2A-protein kinase CßII complex" J Cell Physiol 205(1):37-46.
  • Mishra V and Mehta KD (2004) History and Biochemistry of Statins. In Statins: Understanding Clinical Use. Ed. J. L. Mehta, Saunders, Philadelphia.
  • Huang W, Mishra V, Batara S, Dillon I and Mehta KD (2004) "Phorbol ester promotes histone H3-Ser10 phosphorylation at the LDL receptor promoter in a protein kinase C-dependant manner" J Lipid Res 45(8):1519-27.
  • Kapoor GS, Golden C, Atkins BA and Mehta KD (2003) "pp90RSK- and protein kinase C-dependent pathway regulates p42/44MAPK-induced LDL receptor transcription in HepG2 cells" J Lipid Res 44(3):584-93.
  • Mehta KD, Radominska-Pandya A, Kapoor GS, Dave B and Atkins BA (2002) "Critical role of diacylglycerol- and phospholipid-regulated protein kinase Ce in induction of low density lipoprotein receptor transcription in response to depletion of cholesterol" Mol Cell Biol 22(11):3783-93.