Georgios Kyriazis
Associate Professor
Biological Chemistry and Pharmacology
Academic contact
Academic information
- Department: Biological Chemistry and Pharmacology
Research interests
- Chemosensory Mechanisms
- G Protein-Coupled Receptors (GPCRs)
About
Biography
My lab investigates the dynamics of chemosensory mechanisms involving novel nutrient-sensing G protein-coupled receptors (GPCRs), such as sweet taste receptors (STRs). Beyond the tongue, STRs are expressed in the intestine, pancreas, adipose tissue, and the brain where they likely function as nutrient sensors to coordinate adaptive responses to nutrient availability (ingested or circulating).
Our laboratory has pioneered studies on the role of sweet taste receptors (STRs) on pancreatic beta-cells, while ongoing studies have unveiled novel roles of STRs in other relevant tissues to metabolism, such as the gut and the skeletal muscle. The long-term goal of these projects is to understand and extend mechanistic observations made in mouse models of nutrient-sensing receptor biology to human physiology and metabolic disease.
Credentials
Education
- Postdoctoral Training
- Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States
- PhD
- University of Central Florida, Orlando, FL, United States
Research
Research interests
- Chemosensory Mechanisms
- G Protein-Coupled Receptors (GPCRs)