James Elder, MD
Professor
Neurological Surgery
Academic contact
Academic information
- Department: Neurological Surgery
Research interests
- Convention-Enhanced Delivery of Therapeutic Agents
- Intra-Arterial Drug Delivery
- Translational Research
About
Biography
My research largely involves collaborative efforts with the neuro-oncology research team at Ohio State that includes neuro-oncologists, neuro-pathologists and basic science researchers. My contributions include the development of surgical techniques in animal models that facilitate delivery of therapeutic agents in glioma and brain metastasis models, such as convection-enhanced delivery and intra-arterial drug delivery methods.
Throughout my neurosurgical training, I maintained an interest in neurosurgical oncology. I dedicated a year during residency to work at California Institute of Technology developing artificial extracellular matrix proteins with the goal of characterizing the extracellular matrix cues important for brain tumor stem cell differentiation. After residency, I spent a clinical year at Memorial Sloan-Kettering Cancer Center as a neurosurgical oncology fellow. During this time, I participated in the interdepartmental review process for proposed clinical trials and was involved in the enrollment and evaluation of clinical trial participants.
Credentials
Education
- Fellowship - Neurological Surgery
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Memorial Sloan-Kettering Cancer Center, New York, NY, United States
7/1/2009 - 6/30/2010 - Residency - Neurological Surgery
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Los Angeles General Medical Center, Los Angeles, CA, United States
7/1/2003 - 6/30/2009 - Internship - Surgery (General Surgery)
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Los Angeles General Medical Center, Los Angeles, CA, United States
6/1/2002 - 6/30/2003 - Doctor of Medicine (MD)
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Columbia University College of Physicians & Surgeons, New York, NY, United States
9/2/1997 - 5/22/2002
Certification
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American Board of Neurological Surgery
5/20/2015
Research
Research interests
- Convention-Enhanced Delivery of Therapeutic Agents
- Intra-Arterial Drug Delivery
- Translational Research
I focus on clinical trials and translational research related to collaborative efforts at The Ohio State University Comprehensive Cancer Center – James. I am the PI on multiple clinical trials, including a newly opened clinical trial that aims to determine the maximum tolerated dose of carboplatin delivered by convection-enhanced delivery into the brain of patients with recurrent glioblastoma. I am the PI or co-PI on multiple gene therapy studies and oncolytic (cancer-killing) virus studies in humans that involve application of viral vectors into brain tumors during surgery for resection or biopsy for recurrent glioblastoma.