James Londino
Assistant Professor
Internal Medicine
Academic information
- Department: Internal Medicine
Research interests
- Innate immune signaling in acute lung injury
- Epithelial and macrophage biology
- Ubiquitin proteasome pathway
- Proximity Labeling Mass spectrometry
About
Biography
My lab is interested in innate immune signaling during pneumonia, sepsis, acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). We have two main research themes: 1) Examining how the ubiquitin / proteosome machinery regulates the antiviral and inflammatory response (particularly interferon). 2) Using proteomics to examine protein-protein interactions to find novel targets in acute respiratory distress syndrome (ARDS). Despite years of study, ARDS remains common and has a high rate of mortality. Therapeutics developed to date have largely been ineffective. My overarching goal is to better understand the molecular regulators of ARDS to help develop novel therapies.
Credentials
Education
- Postdoctoral Research
- University of Pittsburgh, Pittsburgh, United States of America
- PhD - Cell, developmental and integrative biology
- University of Alabama at Birmingham, Birmingham, United States of America
Research
Research interests
- Innate immune signaling in acute lung injury
- Epithelial and macrophage biology
- Ubiquitin proteasome pathway
- Proximity Labeling Mass spectrometry