John Christman, MD
Professor
Internal Medicine
Academic information
- Department: Internal Medicine
- Division: Pulmonary, Critical Care and Sleep
Research interests
- ARDS
- Severe Asthma
About
Biography
My research interests include Epigenetic and Transcriptional regulation of the Macrophage inflammatory phenotype in ARDS and severe asthma.
Credentials
Education
- Fellowship - Critical Care Medicine
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University of Pittsburgh Medical Center, Pittsburgh, PA, United States
7/1/1983 - 6/30/1984 - Fellowship - Pulmonary Disease
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University of Vermont Medical Center, Burlington, VT, United States
7/1/1981 - 6/30/1983 - Residency - Internal Medicine
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IU Health University Hospital, Indianapolis, IN, United States
7/1/1979 - 6/30/1981 - Internship - Internal Medicine
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IU Health University Hospital, Indianapolis, IN, United States
7/1/1978 - 6/30/1979 - Doctor of Medicine (MD)
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Indiana University School of Medicine-Indianapolis, Indianapolis, IN, United States
8/1/1974 - 6/30/1978
Certifications
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American Heart Association National Center
10/17/2024 -
American Board of Internal Medicine/Critical Care Medicine
11/10/1987 -
American Board of Internal Medicine/Pulmonary Disease
11/13/1984 -
American Board of Internal Medicine
9/16/1981
Research
Research interests
- ARDS
- Severe Asthma
Current Research
R01HL137224-05A1 (PI: Christman) 01/01/2018 – 03/31/2027
Regulation of the macrophage inflammatory phenotype in ARDS
In this proposed research, we will examine the role of NFAT on EV lipid and protein content and their role in mediating permeability pulmonary edema (ARDS) in the clinically relevant mouse models. Our supportive data show that NFATc3 regulates expression of cytoplasmic phospholipase A-2 (cPLA2) and cyclooxygenase-1 (COX-2) that are associated with changes in the lipid content of EVs and that NFATc3 dependent proteins and lipids disrupt the permeability barrier in culture pulmonary microvascular endothelial cells.
Awards and Honors
- John A. Prior Professorship, the Ohio State University, Columbus OH 2015
- Fellow in the American Thoracic Society 2018