Kenneth Wilson

About

Biography

I am a researcher in the faculty department of Neurology at The Ohio State University College of Medicine. I focus on neurodegeneration and Alzheimer’s disease and how they are affected by genetics and aging. I am committed to advancing our understanding of brain aging and improving outcomes for patients affected by neurodegenerative conditions.

My research goals are to elucidate the cellular mechanisms by which brain aging and age-related diseases occur. Currently, this focuses on understanding the role of the protein Oxidation Resistance 1 (OXR1) in regulating the retromer complex in the endolysosomal network to preserve its function with age, as well as understanding the mechanisms of endolysosome-related cellular senescence. I utilize human fibroblasts, human iPSC-derived neurons, and mouse models to assess the mechanisms affected by retromer dysfunction and how retromer stabilization improves brain aging. As part of this, I aim to understand how stimuli such as Alzheimer's disease influence endolysosomal trafficking and gene expression of endolysosomal components.

I appreciate the commitment to innovation here at Ohio State College of Medicine and the resources that allow me to pursue highly complex research.

Credentials

Research