Kirk McHugh

About

Biography

My research efforts focus on the normal development and pathogenesis of the urogenital system. Urinary tractmalformations, obstructive nephropathy, and renal hypoplasia/dysplasia comprise over 50% of the children with end-stage renal disease worldwide. These defects are extremely important in the terms of pediatric health care costs, with end-stage renal disease costing 1.5 billion dollars annually in the United States. Studies in my lab focus on congenital defects in bladder development and the resulting sequelae associated with obstructive nephropathy including chronic renal failure and kidney disease. We have identified a highly unique mouse model, designated mgb for megabladder. Mgb-/- mice represent the first animal model of congenital obstructive nephropathy and we are currently using a wide range of genetic and molecular approaches to identify the gene responsible for the bladder defect observed in these mice. In addition, the identification of the factors responsible for the pathogenic changes in renal function following the development of obstructive nephropathy in mgb mice provides a platform for the evaluation of pharmacological, surgical, and therapeutic strategies designed to prevent and treat the development of progressive renal failure. During my career.

I have mentored over 35 trainees ranging from undergraduate students to medical fellows and junior faculty. My lab provides high quality, cutting-edge translational research training designed to promote trainee career development and scientific independence.As Director of the Nephrology and Urology Research Affinity Group at Nationwide Children’s Hospital, I have worked diligently to create a research program where physicians and basic scientists actively collaborate in cutting-edge translational research designed to enhance the health of children with diseases of the kidney and urinary tract. The success of this program is evidenced by the fact that it has been ranked in the top-ten nationally in 2012 and 2013 (US World & News Report).

Credentials

Research