Nhat Le, PhD

About

Biography

My research focuses on understanding the brain’s mechanisms, especially in the context of neurological disorders.

I hold a Bachelor of Science degree and a Master of Science degree in biochemistry and genetics from VNUHCM-University of Science in Vietnam, and I earned my PhD at SISSA in Italy, studying protein misfolding in prion diseases and Parkinson’s disease. My postdoctoral work in the United States focuses on ALS and prion disorders, using mouse and stem cell models.

At The Ohio State University Wexner Medical Center, my team investigates how synaptic abnormality contributes to ALS, Parkinson’s, prion diseases and glioblastoma.

My focus is on establishing a leading research program at the intersection of neurodegeneration and cancer neuroscience, with particular emphasis on synaptic dysfunction as a converging mechanism of disease progression. We further expand the use of patient-derived models integrated with protein-engineering and chemical biology tools to investigate how pathogenic proteins and signaling pathways drive synaptic vulnerability. My long-term vision is to translate these mechanistic insights into targeted therapeutic strategies that can restore synaptic integrity and halt disease progression.

I appreciate the commitment to innovation here in The Ohio State University College of Medicine, and the readily available resources that allow me to pursue highly complex research.

Credentials

Research