Sethu Madhavan, MBBS
Assistant Professor
Internal Medicine
Academic information
- Department: Internal Medicine
- Division: Nephrology
Research interests
- Molecular Mechanisms of Chronic Kidney Disease
- APOL1-Mediated Kidney Disease
- Podocyte Biology
About
Biography
I received residency and fellowship training in the Physican Sceintist Training Program (PSTP) in Nephrology at MetroHealth/Case Western Reserve University. After my fellowship training, I joined as a faculty at the MetroHealth System from 2013-2018 and then joined OSU in 2018 in the Division of Nephrology. I am interested in understanding the molecular mechanisms of kidney chronic kidney disease pathogenesis and progression, particularly in the context of glomerular diseases.
My research over the past decade has focused on understanding the mechanisms by which variants in the APOL1 gene mediate the pathogenesis of CKD. Currently, my lab uses cultured immortalized human podocytes, human kidney biopsies, and transgenic mouse models to understand the mechanisms of APOL1 variant-mediated kidney disease. My laboratory is well equipped with state-of-the-art technology, and I have developed a collaborative approach to perform the proposed experiments.
My research is now focused on understanding how APOL1 variant proteins cause podocyte dysfunction by causing peroxisomal stress and developing therapeutic targets to mitigate APOL1 variant-associated CKD.
Credentials
Education
- Fellowship - Nephrology
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MetroHealth Medical Center, Cleveland, OH, United States
7/1/2010 - 6/30/2013 - Residency - Internal Medicine
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MetroHealth Medical Center, Cleveland, OH
7/1/2007 - 6/30/2010 - Internship - Internal Medicine
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Icahn School of Medicine At Mount Sinai, New York, NY, United States
7/1/2006 - 6/30/2007 - Residency - Internal Medicine
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All India Institute of Medical Sciences, New Delhi, India, India
7/1/2005 - 6/30/2006 - Residency - Internal Medicine
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All India Institute of Medical Sciences, New Delhi, India, India
7/1/2002 - 6/30/2005 - Doctor of Medicine (MD)
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Medical College Kozhikode, Kerala, India
10/1/1996 - 6/30/2002
Certifications
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American Board of Internal Medicine/Nephrology
8/4/2015 -
American Board of Internal Medicine
8/25/2010
Research
Research interests
- Molecular Mechanisms of Chronic Kidney Disease
- APOL1-Mediated Kidney Disease
- Podocyte Biology
Active Funding
- K08 Mentored Clinical Scientist Research Career Development Award, NIDDK 05/01/2020 – 04/30/2025
- DK123411, Sethu Madhavan, PI
- Project Title: “Apolipoprotein L1 Interaction with SNARE Proteins in the Pathogenesis of Chronic Kidney Disease”