MuChun Tsai, MD

Academic/Clinical Roles

Assistant Professor, Department of Internal Medicine Division of Pulmonary, Critical Care & Sleep Medicine

473 W. 12th Ave
5th Floor
Columbus, OH 43210

Research Interests

  • Lung Epithelial Cell Biology
  • Innate host defense in context of pulmonary infection and inflammation
  • Ubiquitin proteasome pathway

Current Research

My current research projects are being performed with guidance and support from Dr. Rama Mallampalli’s lab, where I am acquiring additional expertise in cell and molecular biology techniques. I am interested in how lung epithelial cells respond to respiratory viral infections and innate immune response in the lungs.

Education and Training

Pulmonary/Critical Care Fellowship: Ohio State University, Columbus, OH
Internal Medicine Residency: Ohio State University, Columbus, OH
MD: Ohio State University, Columbus, OH
BS: University of Maryland, College Park, MD

Select Publications (list of high impact pubs)

Tsai M, Rayner RE, Chafin L, Farkas D, Adair J, Mishan C, Mallampalli RK, Kim SH, Cormet-Boyaka E, Londino JD. Influenza virus reduces ubiquitin E3 ligase MARCH10 expression to decrease ciliary beat frequency. Am J Physiol Lung Cell Mol Physiol. 2023 May 1;324(5):L666-L676. doi: 10.1152/ajplung.00191.2022. Epub 2023 Feb 28. PubMed PMID: 36852930; PubMed Central PMCID: PMC10151042.

Tsai M, Osman W, Adair J, ElMergawy R, Chafin L, Johns F, Farkas D, Elhance A, Londino J, Mallampalli RK. The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection. J Biol Chem. 2022 Dec;298(12):102698. doi: 10.1016/j.jbc.2022.102698. Epub 2022 Nov 13. PubMed PMID: 36379255; PubMed Central PMCID: PMC9747586.

Mallampalli RK, Adair J, Elhance A, Farkas D, Chafin L, Long ME, De M, Mora AL, Rojas M, Peters V, Bednash JS, Tsai M, Londino JD. Interferon Lambda Signaling in Macrophages Is Necessary for the Antiviral Response to Influenza. Front Immunol. 2021;12:735576. doi: 10.3389/fimmu.2021.735576. eCollection 2021. PubMed PMID: 34899695; PubMed Central PMCID: PMC8655102.

Tsai M, Song MA, McAndrew C, Brasky TM, Freudenheim JL, Mathe E, McElroy J, Reisinger SA, Shields PG, Wewers MD. Electronic vs Combustible Cigarette Effects on Inflammasome Component Release into Human Lung. American Journal of Respiratory and Critical Care Medicine, 2019 April 1, 199(7), pp. 922-925.

Tsai M, Mallampalli RK. E-cigarette or Vaping Product Use-Associated Lung Injury: Opportunities and Challenges. American Journal of Respiratory Cell and Molecular Biology, 2020 March; 62(3):397-398.

Tsai M, Byun MK, Shin J, Crotty Alexander LE. Physiologic Effects of E-cigarettes on the Cardiopulmonary System in Human and Animal Studies. Journal of Physiology, 2020 November; 598(22):5039-5062.

View PubMed