505 Davis Heart & Lung Research Institute Ohio State University473 w 12th Ave. Columbus, OH 43210
richard.nho@osumc.edu
614-366-0051
Research Interests
My main research interest is to find the effective therapeutic target molecules for the treatment of Idiopathic Pulmonary Fibrosis (IPF). IPF is the most common and a deadly form of Interstitial lung disease (ILD). We are utilizing various in vitro and in vivo models to understand IPF pathogenesis. To identify and target pathological fibroblasts that are closely associated with lung fibrosis, we are using antimiRs, a neutralizing antibody and biodegradable nanoparticles.
- Extracellular matrix-cell interaction
- Mechanisms of resistance to apoptosis in fibroblasts from patients with IPF
- Targeting of fibrotic fibroblasts
- Anti-fibrotic drug delivery using nanocarriers
- Intercellular communication in lung fibrosis
Education
Yonsei University, S. Korea, BS
University of Manchester, UK, PhD
Professional Activities
Senate’s research committee member, University of Minnesota 2013-14
American Society for Investigative Pathology ambassador 2020-present
Thesis research travel grant committee member, University of Minnesota 2020
Co-organizer/Co-Chair citywide Conference in the Pulmonary Medicine 2016-2019
Library committee member, University of Minnesota 2016-2019
Facilitator for the discussion of lecture series for honors students, U of M 2017, 2018
Facilitator for the poster presentation & discussion. American Thoracic Society (ATS) 2017, 2018
Judge for the scientific evaluation of research in physiology, pathology and health 2017-2019
Editorial member, Clinical and Experimental Medicine 2019
Managing editor, Frontiers in Bioscience 2014
Editorial member, Clinical Research in Pulmonology, SciMed Central 2013-present
Faculty discussion member-faculty, instructors, internationals of color community 2012
Research panel member for honors research students, University of Minnesota 2015
Recruiter for PhD and Master students in a pharmacology, University of Minnesota 2019
Consultant for the biology program, North Central University 2019
Member of the American Thoracic Society 2010-present
Member of the American Society for Investigating Pathology 2018-present
Selected recent publications
Nho, RS. Pathological effects of nano-sized particles on the respiratory system. 2020. Nanomedicine. 29.102242.
Im J, Nho RS. Fibroblasts from patients with Idiopathic Pulmonary Fibrosis are resistant to cisplatin-induced cell death via enhanced CK2-dependent XRCC1 activity. 2019. Apoptosis. 24:499-510.
Song JM, Im J, Nho RS, Han YH, Kass I. Hyaluronan-CD44/RHAMM interaction-dependent cell proliferation and survival in lung cancer cells. 2019. Mol. Carcinog. 58(3):321-333.
Im J, Lawrence J, Seelig D, Nho RS. FoxM1-dependent RAD51 and BRCA2 signaling protects idiopathic pulmonary fibrosis fibroblasts from radiation-induced cell death. 2018. Cell Death Dis. 9:584.
Lawrence J, Nho RS. The role of the mammalian target of rapamycin (mTOR) in pulmonary fibrosis. Int J Mol Sci. 2018. 19:778-809.
Yhee, JY, Im J, Hergert P, Jeon S, Kim K, Nho RS. The effects of collagen-rich extracellular matrix on the intracellular delivery of glycol chitosan nanoparticles in human lung fibroblasts. Int. J. Nanomedicine. 2017. 12:6089-6105.
Im J, Kim K, Yhee JY, O’Grady S, Nho RS. Desensitization of idiopathic pulmonary fibrosis fibroblasts to Alternaria alternate extract-mediated necrotic cell death. 2016. Physiol Reports. 4(21) e13020.
Im J, Hergert P, Nho RS. Idiopathic pulmonary fibrosis fibroblasts become resistant to Fas ligand-dependent apoptosis via the alteration of decoy receptor 3. J. Pathol. 2016. 240:25-37.
Yhee JY, Im J, Nho RS. Advanced Therapeutic Strategies for Chronic Lung Disease Using Nanoparticle-Based Drug Delivery. J Clin Med. 2016. 5(9).
Park JM, Jung CH, Seo M, Otto NM, Grunwald D, Kim KH, Kim YM, Starker C, Nho RS, Voytas D, Kim DH. The ULK1 complex mediates mTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating Atg14. 2016, Autophagy. 12:547-564.
Im J, Hergert P, Nho RS. Reduced FoxO3a expression causes low autophagy in Idiopathic Pulmonary Fibrosis fibroblasts on collagen matrix. 2015, Am J Physiol Lung Cell Mol Physiol. 309:L552-61.
Nho RS. Alteration of aging-dependent microRNAs in Idiopathic Pulmonary Fibrosis (IPF). 2015, invited review article. Drug Dev Res. 76:343-53.
Nho RS*, Im J, Ho YY, Hergert P. mir-96 inhibits FoxO3a on collagen rich matrix. 2014, Am J Physiol Lung Cell Mol Physiol. 15;307:L632-42. *Corresponding author.
Nho RS*, Hergert P. FoxO3a and disease progression. 2014, World J Biol Chem. 5:346-354. *Corresponding author.
Nho RS*, Hergert P. IPF fibroblasts are desensitized to type I collagen matrix induced cell death by suppressing autophagy via aberrant Akt/mTOR kinases. 2014, PLOS One. 9: e94616. *Corresponding author.
Nho RS. Current concept for the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF). 2013, Clin Res Pulmon. 1:1008:1-3.
Nho RS*, Hergert P, Henke C. FoxO3a deficiency protects IPF fibroblasts from type I polymerized collagen matrix induced apoptosis via cav-1 and Fas. 2013, PLOS One. 8:e61017. *Corresponding author.
Nho RS*, Polunovsky V. Translational control of the fibroblasts and extracellular matrix association: an application to pulmonary fibrosis. 2013, Translation.1:1-7. *Corresponding author.
Xia H, Seeman J, Hong J, Buddi V, Jessurun J, Smith K, Nho RS, Kahm J, Henke CA. Low α(2)β(1) integrin function enhances the proliferation of fibroblasts from patients with idiopathic pulmonary fibrosis by activation of the β-catenin pathway. 2012, Am J Pathol. 181:222-33. *Corresponding author.
Presentations
Research Presentation at the Experimental Biology Conference. Title: E-cigar vapor alters lung fibroblast viability via α7 nicotinic acetylcholine receptor. San Diego. 2020. Cancelled by COVID-19.
Research Presentation at the Experimental Biology Conference. Title: miR-96 expression in non-IPF fibroblasts changes their phenotype. Orlando, Florida, 2019.
CVM Research Seminar. Title: Novel approaches to target Idiopathic Pulmonary Fibrosis fibroblasts. College of Veterinary Medicine. University of Minnesota. Feb. 2018
Mini Seminar for Honors students. Honors Program. Feb. 2018, University of Minnesota
Title: Human disease influenced by environmental factors.
Mini Seminar for Honors students. Honors Program. Feb. 2018. University of Minnesota
Title: Our environment and our health.
Research Seminar for Graduate Program, Department of Pharmacology, University of Minnesota. Oct. 2017. Title: Therapeutic target for IPF.
Research Seminar, College of Veterinary Medicine, University of Missouri. Title: Pathological alteration of FoxO3a in Idiopathic Pulmonary Fibrosis 2014.
Research Conference, Department of Medicine, University of Minnesota. 2012.
Title: FoxO3a in IPF pathogenesis: Collagen matrix and IPF fibroblasts.
Research Conference, Department of Medicine, University of Minnesota. 2011.
Title: IPF fibroblast phenotype on collagen matrix.
Research Seminar, Indiana University, Title: Pathological alteration of PTEN/Akt in IPF fibroblasts on polymerized collagen matrix. 2010.
Outreach Seminar, Korean Methodist Church in Minnesota. Title: Genes and environmental factors that affect our health. 2010.
Research Conference, Department of Medicine, University of Minnesota. 2009. Title: Integrins and IPF fibroblast phenotype on collagen.
Research Presentation at the annual meeting of the British Clinical Mycology, Cardiff, UK. Title: Molecular analysis for the identification of clinically important Candidia species. 1996.
Im J, Nho RS. Mir-96 Expression in non-IPF Fibroblasts Changes their Phenotype from Normal to Fibrotic via FoxO3a inhibition. Experimental Biology Conference, Florida, 2019.
Im J, Nho RS. Alteration of CK2/XRCC1-Dependent DNA Repair Activity in Apoptosis-Resistant Lung Fibroblasts Could Be A Risk Factor For IPF. The annual meeting of the American Thoracic Society, Dallas, Texas, 2019.
Im J, Nho RS. A Therapeutic Approach for Idiopathic Pulmonary Fibrosis (IPF) by Targeting miR-96. The annual meeting of the American Thoracic Society, Dallas, Texas, 2019.
Nho RS, Im J, the pathological effects of decellularized fibrotic extracellular matrix from IPF patients. 2018. 197:A2917. The annual meeting of the American Thoracic Society, San Diego, CA Nho RS, Im, J, Lawrence J. Aberrant resistance of IPF fibroblasts to ionizing radiation induced apoptosis via FoxM1 alteration. 2018. 197:A2218. The annual meeting of the American Thoracic Society, San Diego, CA
Nho RS, Im J, Yhee JY, Kim K, Lawrence J. Abnormal Resistance of Idiopathic Pulmonary Fibrosis Fibroblasts in Response to Radiation-Induced Apoptosis. 2017. The annual meeting of the American Thoracic Society, Washington DC
Im J, Yhee JY, Kim K, Nho RS. Idiopathic Pulmonary Fibrosis Fibroblasts Are Resistant to TRAIL-Mediated Apoptosis by the Alteration of Forkhead Box O3a (FoxO3a) Dependent Death Receptor 4 (DR4). 2017. The annual meeting of the American Thoracic Society, Washington DC
Yhee JY, Im J, Nho RS. Targeted Therapy for Idiopathic Pulmonary Fibrosis by Glycol Chitosan Nanoparticles. 2017. The annual meeting of the American Thoracic Society, Washington DC
Im J, Kim K, Nho RS. Lung fibroblasts derived from patients with idiopathic pulmonary fibrosis are resistant to Alternaria alternata-mediated cell death. 21016. The annual meeting of the American Thoracic Society, San Francisco
Im J, Kim K, Polla H, Nho RS. Idiopathic pulmonary fibrosis fibroblasts utilize decoy receptor 3 to evade the Fas ligand-dependent apoptosis. 2016. The annual meeting of the American Thoracic Society, San Francisco
Kim K, Im J, Nho RS. Enhanced resistance to reactive oxygen species driven cell death in IPF fibroblasts is mediated by AMPK-dependent axis. 2016. The annual meeting of the American Thoracic Society, San Francisco
Nho RS*, Jintaek Im. Low Autophagy by Reduced FoxO3a Expression in Idiopathic Pulmonary Fibrosis Fibroblasts. 2015. The annual meeting of the American Thoracic Society, Denver.
Nho RS*, Jintaek Im, Polla Hergert. Alteration of miR-96 expression promotes IPF fibroblast proliferation by deactivating FoxO3a function. 2014. Poster presented and discussed at the annual meeting of the American Thoracic Society, San Diego.
Nho RS*, Hergert P. Henke C. FoxO3a deficiency protects IPF fibroblasts from type I polymerized collagen matrix induced apoptosis via cav-1 and Fas. 2013. Poster presented and discussed at the annual meeting of the American Thoracic Society, Philadelphia.
Nho RS*, Hergert P. Cav-1 alteration by aberrant FoxO3a activity confers a highly proliferative and an anti-apoptotic IPF fibroblast phenotypes on type I collagen matrix. 2012. Poster presented at the annual meeting of the American Thoracic Society, San Francisco.
Nho RS*, Pathological alteration of FoxO3a confers highly proliferative IPF fibroblast phenotype. 2011. Poster presented and discussed at the annual meeting of the American Thoracic Society, Denver.
Nho RS*, Kahm J. FoxO3a activity is aberrantly low in IPF fibroblasts on polymerized collagen matrix. 2010. Poster presented at the annual meeting of the American Thoracic Society, New Orleans.
Xia H, Nho RS, Jessuran J, Kahm J, Henke CA. Low PP2A activity in IPF fibroblasts is associated with elevated level of inactive GSK-3β and increased nuclear β catenin. 2010. Poster presented at the annual meeting of the American Thoracic Society, New Orleans.
Nho RS*, FoxO3a function in Cardiovascular Diseases in Patients with Idiopathic Pulmonary Fibrosis (IPF) 2009. Poster presented at the annual meeting of the American Heart Association (AHA). Washington D.C.
Nho RS, Xia H, Kahm J, Henke CA. Aberrant FoxO3a function confers fibroblasts from patients with Idiopathic Pulmonary Fibrosis (IPF) with a hyper-proliferative and apoptotic resistant phenotype. 2009. Poster presented at the annual meeting of the American Thoracic Society, San Diego.
Nho RS, Xia H, Kahm J, Kleidon J, Diebold D, Henke CA. Integrin-ECM Interaction Regulates 4EBP-1 and Cap-dependent Translation Via Modulation of PP2A. 2008. Poster presented at the annual meeting of the American Thoracic Society, Toronto, Canada.
Nho RS, Xia H, Kahm J, Kleidon J, Diebold D, Henke CA. Phosphorylation of 4EBP-1 by integrin-Ck2 increases lung fibroblast proliferation. 2007. Poster presented at the annual meeting of the American Thoracic Society, San Diego.
Xia H, Nho, RS, Kahm J, Kleidon J, Diebold D, Henke CA. Regulation of TSC-2 by PP2A. 2007. Poster presented at the annual meeting of the American Thoracic Society, San Diego.
Nho RS, Xia H, Kahm J, Kleidon J, Diebold D, Henke CA. PTEN regulation by collagen-ECM interaction. 2006. Poster presented at the annual meeting of the American Thoracic Society, San Diego.
Xia H, Nho RS, Kahm J, Kleidon J, Henke CA. Aberrant signaling pathway in IPF. 2006. Poster presented at the annual meeting of the American Thoracic Society, San Diego.
Nho RS, Xia H, Kahm J, Kleidon J, Diebold D, Henke CA. Actin disassembly in response to collagen matrices activates PTEN via integrin. 2005. Poster presented at the annual meeting of the American Thoracic Society, San Diego.
Xia H, Nho RS, Kahm J, Kleidon J, Henke CA. Focal adhesion kinase is upstream of PI3K/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a β1 integrin viability signaling pathway. 2004. Poster presented at the annual meeting of the American Thoracic Society, Orlando.
Yhee, JY, Hergert P, Nho RS. Targeting therapy for Idiopathic Pulmonary Fibrosis (IPF) by glycol chitosan nanoparticles. Department of Medicine Robert Hebbel Research day. University of Minnesota. 2018.
Phung, G, Im J, Lawrence J, Nho RS. Ionizing Radiation Increases Extracellular Type I Collagen Matrix Production in Apoptosis-Resistant Idiopathic Pulmonary Fibrosis (IPF) Fibroblasts. Department of Medicine Robert Hebbel Research day. University of Minnesota. 2018.
Im J, Kim K, Yhee, JY, Hergert P, Nho RS. Idiopathic pulmonary fibrosis fibroblasts utilize decoy receptor 3 to evade the Fas ligand-dependent apoptosis. Department of Medicine Robert Hebbel Research day. University of Minnesota. 2016
Kim K, Im J, Nho RS. Enhanced resistance to reactive oxygen species driven cell death in IPF fibroblasts is mediated by AMPK-dependent axis. Department of Medicine Robert Hebbel Research day. University of Minnesota. 2016
Miller S. Im J, Nho, RS. The role of death receptors 4 and 5 in Idiopathic Pulmonary Fibrosis. Undergraduate Research Symposium. University of Minnesota. 2016.
Im J, Kim K, Hergert P, Nho RS. Reduced LC3-B expression as a result of aberrantly low FoxO3a activity in IPF fibroblasts on type I collagen matrix. Department of Medicine Robert Hebbel Research day. University of Minnesota. 2015
Kim K, Im J, Nho RS. AMPK regulates detoxification of reactive oxygen species in Idiopathic Pulmonary Fibrosis. Undergraduate Research Symposium. University of Minnesota. 2015.
Im, J, Hergert, P, Kim, K, Nho RS. FoxO3a suppression by miR-96 in idiopathic pulmonary fibroblasts on collagen matrix. Department of Medicine Robert Hebbel Research day. University of Minnesota. 2014.
Nho, RS, Kahm, J. Henke, C. Cav-1 regulation by FoxO3a in IPF fibroblasts on collagen. Department of Medicine Robert Hebbel Research day. University of Minnesota. 2012.
Nho, RS, Kahm, J. Henke, C. IPF fibroblast phenotype on collagen matrix. Department of Medicine Robert Hebbel Research day. University of Minnesota, 2011.
Nho RS, Sheaff R. p27 regulates Bcl-X by modulation of STAT3. Poster presented at the Cancer Center Research Symposium. 2002. Cancer Center, University of Minnesota.
Nho S, Anderson MJ, Moore CB, Denning DW. Rapid differentiation and identification of Candida species by molecular techniques. 1997. Poster presented at the University of Manchester Research Symposium. University of Manchester. UK.