Ulysses J. Magalang, MD


Academic/Clinical Roles

Professor of Medicine
Director, Sleep Medicine Program

241 West 11th Avenue
Suite 5000
Columbus, OH 43201
614-292-4307/Clinic: 614-293-4925
Ulysses.Magalang@osumc.edu

Biography

I was recruited at The Ohio State University in 2004 as a Pulmonary, Critical Care, and Sleep Medicine physician. I serve as the Director of the Sleep Medicine Program, a large academic sleep medicine program that I helped develop in alignment with the service, teaching, and research missions of our medical center. I maintain both a basic science laboratory examining the effects of hypoxia on adipose tissue biology as well as a clinical research program in sleep disorders where I serve as a mentor to undergraduate and medical students, medical residents, and post-doctoral fellows. Over the past several few years, I have been actively involved in an international consortium of sleep researchers- the Sleep Apnea Global Interdisciplinary Consortium (SAGIC), a collaborative group comprised of international experts in the field of sleep research. Our clinical investigations in SAGIC revealed three symptom subtypes of obstructive sleep apnea (OSA) across a worldwide sleep center population that have now been robustly validated in various community and clinic-based populations. These OSA symptom subtypes have recently been shown to predict OSA subjects who are at risk for developing cardiovascular events, a step towards personalized care for sleep apnea. We have also developed objective definitions of extreme phenotypes of OSA that can be applied in sleep centers throughout the world for future studies on genetic, anatomic and physiological pathways to OSA.

Research Interests

  • Effects of hypoxia on adipose tissue biology
  • Cardiovascular and metabolic consequences of sleep disorders

Education and Training

MD: University of the Philippines
Residency: Internal Medicine, Mercy Hospital, University at Buffalo, Buffalo, NY
Fellowship: Pulmonary & Critical Care Medicine, University at Buffalo, Buffalo, NY
Clinical and Research Fellow: Center for Sleep and Respiratory Neurobiology, University of Pennsylvania Health System, Philadelphia, PA

Honors and Awards

Listed in Best Doctors of America in Pulmonary and Sleep Medicine 2005-2021
Listed in Castle Connolly Top Doctors In Pulmonary Medicine 2014-2021

Select Publications (list of high impact pubs)

Reynor A, McArdle N, Shenoy B, Dhaliwal SS, Rea SC, Walsh J, Eastwood PR, Maddison K, Hillman DR, Ling I, Keenan BT, Maislin G, Magalang UJ, Pack AI, Mazzotti DR, Lee CH, Singh B. Continuous positive airway pressure and adverse cardiovascular events in obstructive sleep apnea: are participants of randomized trials representative of sleep clinic patients?. Sleep. 2022 Apr 11;45(4). doi: 10.1093/sleep/zsab264. PubMed PMID: 34739082.

Keenan BT, Magalang UJ, Mazzotti DR, Gislason T, Singh B, Maislin G, Pack AI. The Role of Obstructive Sleep Apnea Symptom Subtypes in Cardiovascular Risk: Conflicting Evidence to an Important Question. Am J Respir Crit Care Med 2022 Mar 15;205(6):729-730. doi: 10.1164/rccm.202111-2467LE. PMID: 34898394.

Holfinger SJ, Lyons MM, Keenan BT, Mazzotti DR, Mindel J, Maislin G, Cistulli PA, Sutherland K, McArdle N, Singh B, Chen NH, Gislason T, Penzel T, Han F, Li QY, Schwab R, Pack AI, Magalang UJ. Diagnostic Performance of Machine Learning-Derived OSA Prediction Tools in Large Clinical and Community-Based Samples. Chest. 2022 Mar;161(3):807-817. doi: 10.1016/j.chest.2021.10.023. PubMed PMID: 34717928; PubMed Central PMCID: PMC8941600.

Pack AI, Magalang UJ, Singh B, Kuna ST, Keenan BT, Maislin G. Randomized clinical trials of cardiovascular disease in obstructive sleep apnea: understanding and overcoming bias. Sleep. 2021 Feb 12;44(2). doi: 10.1093/sleep/zsaa229. PubMed PMID: 33165616; PubMed Central PMCID: PMC7879410.

Rizzatti FG, Mazzotti DR, Mindel J, Maislin G, Keenan BT, Bittencourt L, Chen NH, Cistulli PA, McArdle N, Pack FM, Singh B, Sutherland K, Benediktsdottir B, Fietze I, Gislason T, Lim DC, Penzel T, Sanner B, Han F, Li QY, Schwab R, Tufik S, Pack AI, Magalang UJ. Defining Extreme Phenotypes of OSA Across International Sleep Centers. Chest. 2020 Sep;158(3):1187-1197. doi: 10.1016/j.chest.2020.03.055. PubMed PMID: 32304773; PubMed Central PMCID: PMC7478234.

Poblete JMS, Ballinger MN, Bao S, Alghothani M, Nevado JB Jr, Eubank TD, Christman JW, Magalang UJ. Macrophage HIF-1α mediates obesity-related adipose tissue dysfunction via interleukin-1 receptor-associated kinase M. Am J Physiol Endocrinol Metab. 2020 May 1;318(5):E689-E700. doi: 10.1152/ajpendo.00174.2019. Epub 2020 Mar 10. PubMed PMID: 32154744; PubMed Central PMCID: PMC7717118.

Borniger JC, Walker II WH, Surbhi, Emmer KM, Zhang N, Zalenski AA, Muscarella SL, Fitzgerald JA, Magalang UJ, Lustberg MB, Nelson1 RJ, DeVries AC. A Role for Hypocretin/Orexin in Metabolic Dysfunction in a Mouse Model of Non-Metastatic Breast Cancer. Cell Metabolism 2018 Jul 3; 28(1):118-129.e5. doi: 10.1016/j.cmet.2018.04.021. PMID: 29805100.

Keenan BT, Kim J, Singh B, Bittencourt L, Chen NH, Cistulli PA, Magalang UJ, McArdle N, Mindel JW, Benediktsdottir B, Arnardottir ES, Prochnow LK, Penzel T, Sanner B, Schwab RJ, Shin C, Sutherland K, Tufik S, Maislin G, Gislason T, Pack AI. Recognizable clinical subtypes of obstructive sleep apnea across international sleep centers: a cluster analysis. Sleep. 2018 Mar 1;41(3). doi: 10.1093/sleep/zsx214. PubMed PMID: 29315434; PubMed Central PMCID: PMC5914381.

 

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