Ronald L. Whisler Endowed Chair
Address, Phone Number and Email Address
Hsin-Jung Joyce Wu
Department of Internal Medicine
Division of Rheumatology-Immunology
Rm S2051, Davis Medical Research Center,
480 Medical Center Drive, Columbus, OH, 43210
Dr. Joyce Wu obtained her Bachelor of Veterinarian Medicine degree from National Taiwan University in Taipei, Taiwan. She then relocated to the US, receiving her PhD degree from the University of Kentucky, where she studied B cell signaling. For her post-doctoral training, she joined the lab of Drs. Diane Mathis and Christophe Benoist at Harvard University, where she investigated the roles of gut microbiota in T cells in the context of autoimmune diseases. She joined the University of Arizona as faculty in the Department of Immunobiology in 2011. Dr. Wu was promoted to Associate Professor with tenure in 2018. Dr. Wu was then recruited as a tenured professor and Ronald L. Whisler Endowed Chair to the Division of Rheumatology and Immunology in the Department of Internal Medicine at the Ohio State University in Oct 2021.
Imbalance of gut microbiota (dysbiosis) leads to many diseases including those located systemically (outside the gut). Dysbiosis-associated systemic autoimmune diseases such as rheumatoid arthritis and lupus have been rising rapidly and are emerging as modern epidemics. Dr. Wu’s lab focuses on a big question: how microbiota that reside in the gut alter the development of non-gut diseases. Her lab addresses this question by examining how commensals modulate host’s mucosal and systemic immune responses. The results of Wu lab’s studies will pave the way for novel therapies for dysbiosis-related autoimmune diseases.
Rheumatoid arthritis (RA) is an important health problem. The low concordance rate of RA in monozygotic twins (15%) compared to other autoimmune diseases such as type I diabetes (~50%) suggests that environmental factors must play a crucial role in the etiopathogenesis of RA. Dr. Wu’s current research addresses two major topics, the gut-joint axis and the gut-lung axis. The gut-joint axis project studies mechanisms underlying the gut microbiota’s influence on arthritis, focusing on T cell plasticity and exhaustion; both topics are poorly understood and their role in autoimmune disease remains largely unknown. Using “fate-mapping” in a murine arthritis model, the lab found that gut microbiota can convert already differentiated T cells into another T cell type, promoting arthritis. Dr. Wu and her team are applying these findings to RA patients by using synovial and peripheral blood cells to study the biomarkers and functions that are tied to the gut-origin of the disease.
Lung complications are common, and a major cause of death in RA patients. RA’s lung pathogenesis has remained poorly understood. Dr. Wu’s lab has established a novel RA lung disease model that displays human RA-like lung lesions and functional defects. Many lung diseases are linked to gut dysbiosis, yet this phenomenon, termed the gut-lung axis, remains poorly studied. The gut-lung axis project in the Wu lab studies the TCR repertoire and T cell metabolism with a focus on hypoxia-inducible factor-1a (HIF-1α), an O2 sensor in hypoxic tissue such as gut. The Wu lab has developed a state-of-the-art photoconverting technique to track single cell migration between gut and systemic tissues to study this topic.
- Hsin-Jung Joyce Wu, BVM, PhD (PI)
- Maddie Cutcliffe, BS (Lab manager)
- Laurie Baert, PhD (postdoctoral fellow)
- Tingting Fan, PhD (postdoctoral fellow)
Alison Brittain, DO, PhD (postdoctoral fellow) Sruthi Sureshkumar, MS (research assistant) Essa Gul (undergraduate) Neha Kazmi (undergraduate) Austin Richey (undergraduate)
Active FundingNIH/NIAID, 2R01AI107117 (Wu) 02/01/2019-01/31/2024
Title: Tfh cells: linking the gut microbiota to a gut-distal autoimmune disease
Direct costs: $312,825/yr.
NIH/NHLBI, 1R01HL148347 (Wu) 08/01/2020-07/31/2024
Title: Microbiota control lung Th17 cell response and plasticity leading to autoimmune lung disease
Role: PIDirect costs: $289,409/yr.
Honors and Awards
- 2021 - Ronald L. Whisler Endowed Chair, Dept of Internal Medicine, OSU
- 2017 - AAI Early Career Faculty travel grant, AAI Immunology 2017
- 2016 - AAI Travel Award, 16th International Congress of Immunology
- 2012 - Dynasty Foundation, Russia
- 2010 - Sontag Foundation Fellow of Arthritis National Research Foundation
Select Publications (list of current project-related pubs from Wu lab)
Hsin-Jung Joyce Wu. Methotrexate works remotely, from the gut. Cell Host & Microbe 2021; 29: 325-326. Preview.
Mario Zaiss, Hsin-Jung Joyce Wu, Daniele Mauro, Georg Schett, and Francesco Ciccia.
The gut-joint axis in rheumatoid arthritis 2021; 17: 224-237. Nature Reviews Rheumatology 2021, https://doi.org/10.1038/s41584-021-00585-3
Krysta M. Felix, Fei Teng, Nicholas A. Bates, Heqing Ma, Ivan A. Jaimez, Kiah C. Sleiman, Nhan L. Tran, and Hsin-Jung Joyce Wu. P2RX7 Deletion in T Cells Promotes Autoimmune Arthritis by Unleashing the Tfh Cell Response. Front Immunol 2019; 10: 411.
C. Pierce Bradley, Fei Teng, Krysta M. Felix, Teruyuki Sano, Debdut Naskar, Katharine E. Block, Haochu Huang, Kenneth S. Knox, Dan Littman, Hsin-Jung Joyce Wu. ¬¬ Segmented filamentous bacteria provoke lung autoimmunity by inducing gut-lung axis Th17 Cells expressing dual TCRs. Cell Host & Microbe 2017; 22: 697-704.¬
Debdut Naskar, Fei Teng, Krysta M. Felix, C. Pierce Bradley, Hsin-Jung Joyce Wu. Synthetic retinoid AM80 ameliorates autoimmune lung and joint pathology by inhibiting both Tfh and Th17 cell responses. Journal of Immunology 2017; 198: 1855-1864.
Monica Viladomiu, Charles Kivolowitz, Ahmed Abdulhamid, Belgin Dogan, Daniel Victorio, Jim G. Castellanos, Viola Woo, Fei Teng#, Nhan L. Tran#, Andrew Sczesnak, Christina Chai, Myunghoo Kim, Gretchen E. Diehl, Nadim Ajami, Joseph Petrosino, Xi K. Zhou, Sergio Schwartzman, Lisa Mandl, Meira Abramowitz, Vinita Jacob, Brian Bosworth, Adam Steinlauf, Ellen J. Scherl, Hsin-Jung Joyce Wu#, Kenneth W. Simpson, Randy S. Longman. IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote Th17-dependent inflammation. Science Translational Medicine 2017; 9: eaaf9655.
Tze Guan Tan, Esen Sefik, Naama Geva-Zatorsky, Lindsay Kua, Debdut Naskar#, Fei Teng#, Lesley Pasman, Adriana Ortiz-Lopez, Ray Jupp, Hsin-Jung Joyce Wu#, Dennis L. Kasper, Christophe Benoist, Diane Mathis. Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice. Proc Natl Acad Sci. 2016; 113: E8141-E8150.
Fei Teng, Christina N. Klinger, Krysta M. Felix, C. Pierce Bradley, Eric Wu, Nhan L. Tran, Yoshinori Umesaki, Hsin-Jung Joyce Wu. Gut microbiota drive autoimmune arthritis by promoting differentiation and migration of Peyer’s patch T follicular helper cells. Immunity 2016; 44: 875-888.