Jan Schwab, MD, PHD

Professor

Neurology

Jan Schwab

Academic contact

395 W 12th Ave
Columbus, OH 43210-1267

Fax: 614-293-6111

Jan.Schwab@osumc.edu

Academic information

  • Department: Neurology

Leadership title

  • William E. Hunt, MD & Charlotte M. Curtis Chair in Neuroscience

Research interests

  • Protection of the Intrinsic Recovery Potential After Spinal Cord Injury
  • Resolution of Inflammation in the Lesioned Central Nervous System (CNS)
  • Control of the CNS on the Immune System
  • Improving the Predictive Value of Animal Models for Clinical Translation

About

Biography

My research aims to better understand and treat the maladaptive immune response after spinal cord injury (SCI). This is composed of the systemic SCI-induced immune deficiency syndrome (SCI-IDS) and the developing post-traumatic autoimmunity. Both maladaptive neuro-immunological syndromes are associated with inferior repair and a target to improve neurological recovery.

Credentials

Education

Residency - Neurology
Charite-Universitatsmedizin Berlin, Berlin, Germany
1/1/2007 - 12/4/2012
Doctor of Philosophy
Eberhard-Karls Universitaet Tubingen, D-72076 Tubingen, Germany
12/1/2000 - 6/10/2003
Fellowship - Neuropathology
Eberhard Karls University Of Tuebingen, Tuebingen
7/1/2000 - 1/31/2004
Residency - Neuropathology
Eberhard Karls University Of Tuebingen, Tuebingen
1/1/1999 - 6/30/2000
Doctor of Medicine (MD)
Eberhard-Karls Universitaet Tubingen, D-72076 Tubingen, Germany
4/1/1991 - 8/30/1998

Research

Research interests

  • Protection of the Intrinsic Recovery Potential After Spinal Cord Injury
  • Resolution of Inflammation in the Lesioned Central Nervous System (CNS)
  • Control of the CNS on the Immune System
  • Improving the Predictive Value of Animal Models for Clinical Translation

Research Techniques

Clinical trials

  • Design and conduction of diagnostic and interventional mono-/and multicentric randomized trials in patients following spinal cord injury

Preclinical trials

  • Statistical analytical approaches to detect inflated effect size and confounding bias (Meta-analysis, Egger Regression, Trim and Fill Imputation)

Experimental models

  • SCI-models (contusion, transection)
  • Pneumonia model (Streptococcus pneumoniae)
  • Peritonitis model

Cell and molecular biology

  • Gene expression analysis (qPCR, Western blot)
  • FACS analysis

Immunohistochemistry

  • Single and double labeling

Funding

I am partially funded by the Chronic Brain Injury program, a part of Ohio State’s Discovery Themes Initiative.

More about my research

News and media

My news coverage