Brigstock_David_460x460Nationwide Children's Hospital
700 Children's Drive
Columbus, OH 43205-2664

Research Interests

  • Biology of connective tissue growth factor

Areas of Interest

We are studying the role of connective tissue growth factor (CTGF) in fibrotic diseases, which is characterized by excessive production and deposition of insoluble collagen matrix, resulting in loss of tissue structure and organ dysfunction. Our main research efforts are currently focused on liver and pancreatic fibrosis but we have collaborative efforts that focus on other organ systems such as the lung, intestine, heart and skin. Using molecular, cellular and biochemical approaches, both in vitro and in vivo, our goals are to understand the mechanisms by which CTGF stimulates collagen production by fibrogenic cells types. In this manner, we will determine the therapeutic value of targeting pathways of CTGF biosynthesis or action to treat a variety of fibrotic disorders.


BS: Brunel University, West London, United Kingdom,1984
PhD: Cambridge University, Cambridge, United Kingdom, 1988
Specialty Training: Harvard University, Cambridge, MA

Clinical profile  Center for Clinical and Translational Research