Dr. Gorr’s research is focused on improving patient outcomes by developing novel therapeutic strategies for right heart disease. He utilizes RNA-sequencing, immunohistochemistry, molecular biology, flow cytometry and cell culture to examine and characterize the biology of the right ventricle compared to the left ventricle.
In his lab, Dr. Gorr is testing novel drug targets on right ventricular fibrosis and function using animal models of pulmonary hypertension. Another project involves using patient-derived primary cell culture of smooth muscle cells and fibroblasts to study the expression of relevant genes in lung diseases including pulmonary hypertension, idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. In addition, his team is studying the impact of e-cigarettes using rodent exposure paradigms, cell culture, and precision-cut lung slices.
Education
- Bachelor of Science: The Ohio State University, Biology
- Master of Science: University of Toledo, Biology
- PhD: The Ohio State University, Molecular, Cellular and Developmental Biology
- Postdoctoral Fellowship: University of California San Diego
Research Interests
- Pulmonary hypertension
- Cardiac remodeling
- Environmental exposures
- Fibrosis
Editorial Boards
- Journal of Molecular and Cellular Cardiology
- American Journal of Physiology – Heart and Circulatory Physiology
- Life Sciences
Current Funding
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NIH R01-HL167963
Right ventricle remodeling in pulmonary hypertension