Department of Surgery
Department of Microbial Infection and Immunity
TMRF 270, 420 W 12th Ave, Columbus, OH 43210
Dr. Deng’s research focuses on the mechanisms underlying immune dysregulation during sepsis and trauma. Major areas of emphasis in her lab include the role of DNA-sensing in innate immunity and the immunoregulatory role of fibroblastic reticular cells.
Dr. Deng’s lab is focused on understanding the molecular mechanisms of how DNA-sensing pathways regulate the pathogenesis of sepsis and trauma in a cell type-specific manner. Dr. Deng’s lab has found that experimental therapies in mice using Tlr9-deficient FRCs have successfully improved the therapeutic efficacy of FRC-based therapy by reducing mortality from an intra-abdominal infection model (Xu et al. JCI 2019). Her team will continue studying how cell-specific DNA-sensing controls the body’s response to overwhelming inflammation. The findings from these studies will identify ways to improve the effectiveness of experimental cell-based therapies, which will help us move closer to finding new treatments for sepsis in humans that will reduce morbidity and mortality.
- MD: University of Duisburg-Essen, Essen, Germany, 2010
- TLR9 DNA-sensing
- cGAS-STING DNA-sensing
- Fibroblastic reticular cell biology
- Cell-based therapies
- Innate Immunity