Researchers discover unprecedented interaction among proteins
Researchers at The Ohio State University College of Medicine have discovered a new interaction among proteins, revealing an unprecedented switch in enzymatic functions.
Alone, the SIR2 protein processes DNA and RNA, but when bound to the HerA protein, as part of a defense system, it switches functions completely to help bacteria self-destruct.
The research, led by Tianmin Fu, PhD, assistant professor of Biological Chemistry and Pharmacology at the Ohio State College of Medicine, is a major discovery in the enzymology field. In the bigger picture, these findings could lead to the development of new strategies for cancer treatment.
The research was published Dec. 13, 2023 in Molecular Cell.
