Contact CRMCBT if you have interest in this RO1. 614-292-5621
NIDDK has expanded the research objectives for PAS-10-046: Stimulating Hematology Investigation: New Endeavors (SHINE) (R01) to include Regulatory Determinants of Hematopoietic Stem Cell (HSC) Self-Renewal versus Lineage Commitment and Terminal Differentiation". R01 applications requesting support for this research topic will now be accepted under PAS-10-046.
This additional research area has been added in response to an NIDDK-sponsored workshop on this topic on February 20, 2012, see: http://www2.niddk.nih.gov/News/Calendar/Hema2012.htm. Applications that focus on leukemia and its pathogenesis will not be accepted. Research areas to be addressed include, but are not limited to:
· Clarification of cell-cycle dependent epigenetic and transcriptional events that determine HSC self-renewal vs. lineage commitment
· Use of novel live cell imaging technologies to understand the molecular basis of symmetric and asymmetric divisions and their role in determining HSC self-renewal vs. lineage commitment
· Identification and characterization of epigenetic and transcriptional regulation changes that stabilize hematopoietic lineage fate decisions and promote terminal differentiation of HSC
Clarification of how the hematopoietic stem cell niche influences the epigenetic and transcriptional regulation of HSC self-renewing potential vs. lineage commitment, including signaling networks that impact the fate of HSC.