Innovations in trauma, critical care and burn surgery at Ohio State
The division participates in a broad range of research activities to support the clinical mission. These topics range from basic science and mechanistic analysis through outcomes research and clinical trials. A broad range of sources including the National Institutes of Health, foundation awards and industry support supports these projects. Utilizing a translation model of care, these projects inform and improve the clinical care that is provided on a daily basis.
Faculty members in the division published over 50 scholarly articles in the previous fiscal year. Division members had several podium presentations at national meetings and numerous other presentations at international and national meetings.
- Nicole Bernal, MD, FACS – Diagnosis and treatment of burns, burn health outcomes
- Julia Coleman, MD MPH - Trauma-induced coagulopathy, resuscitation practices, sex dimorphisms in coagulation
- Anahita Jalilvand, MD PhD – Sepsis, emergency general surgery, obesity, adipose tissue inflammation
- Jennifer Knight Davis, MD – Clinical outcomes in emergency general surgery, robotics in acute care surgery, leadership
- Daniel Eiferman, MD- Healthcare quality, spinal cord injury, opioid inpatient management, abdominal wall reconstruction, lymphedema
- John Loftus, MD – Skin substitutes in the management of burns, utilization of plating (open reduction and internal fixation) of traumatic rib fractures , evaluation and management of frostbite
- Carrie Sims, MD – Novel resuscitative strategies, geriatric trauma, sepsis, NADH biology, domestic and intimate partner violence, gun violence
- Brett Tracy, MD – Neurological outcomes research, gun violence, resident education, biostatistical programs, frailty, multicenter trials
- Carrie Valdez, MD - Reducing opioid use in trauma patients, improving outcomes in rib fractured patients, intimate partner violence in trauma patients
- Wendy Wahl, MD – Complications and outcomes in the ICU, geriatric trauma patients, sepsis, anticoagulation
- Jon Wisler, MD – Sepsis, clinical trials, immune dysregulation, necrotizing soft tissue infections, health outcomes
- Andrew Young, MD – Machine learning, predictive analysis, geriatric falls, blood cerebral vascular injuries, failure to rescue, trauma data systems
If you are interested in collaborating with a faculty member, please reach out to Holly Baselice at Holly.Baselice@osumc.edu.
- Epigenetic Regulation and DNA Methylation in Circulating Microvesicles during Sepsis PI: Wisler
- Role of Toll-like Receptor 9 in Fibroblastic Reticular Cell-based Therapy for Intraabdominal Sepsis PI: Deng
Clinical Trials
Ohio State University TRACK SCI Registry PI: Farhadi/Eiferman
What is the ideal dose of whole blood in massively bleeding trauma patients? PI: Valdez
Evaluation of a Ketogenic Diet for Improvement of Neurological Recovery in Individuals with Acute Spinal Cord Injury PI: Yarar-Fisher
A Phase 3, Prospective, Randomized, Open-label, Adaptive Group Sequential, Multicenter Trial with Blinded Endpoint Assessment to Evaluate the Efficacy and Safety of TAK-330 for the Reversal of Direct Oral Factor Xa Inhibitor-induced Anticoagulation in Patients Requiring Urgent Surgery/Invasive Procedure PI: Wisler
- A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Single Dose of Exebacase in Adult Patients Receiving Standard-of-Care Antibiotics for the Treatment of Staphylococcus aureus Bloodstream Infections (Bacteremia), Including Right-Sided Infective Endocarditis PI: Wisler
The VICToRY Pilot Study – VItamin C in Thermal injuRY PI: Wisler
A Pivotal Study to Assess the Safety and Effectiveness of NovoSorb Biodegradable Temporizing Matrix (BTM) in the Treatment of Severe Burn Skin Injuries PI: Bernal
Registry of Myriad Utilization in Soft Tissue Reconstruction Procedures PI: Loftus
Biomarker Response to Amantadine Improves Neurorecovery: The BRAIN Study PI: Tracy
Brain Oxygen Optimiization in Severe Traumatic Brain Injury - Phase 3): A multicenter, randomized, blinded-endpoint, comparative effectiveness study of goal-directed critical care based upon monitoring of brain tissue oxygen and intracranial pressure versus monitoring of intracranial pressure along in patients with severe traumatic brain injury. PI: Mainali/Wisler
Analyzing the long-term impact of epigenetic immunomodulation following sepsis PI: Wisler
Jonathan Wisler, MD, Lead Investigator
Adara McCarty, Clinical Research Coordinator
George Abboud II, Clinical Research Coordinator
Maya Daoud, Clinical Research Assistant
Regulatory, Business and Administrative Support provided by OSU’s Clinical Trials Management Organization (CTMO)