384 Biomedical Research Tower460 W. 12th Ave.
Columbus, OH 43210
614-688-9340
Daniel.Kinnamon@osumc.edu
Dr. Kinnamon’s scholarly interest lies in developing and applying statistical and bioinformatics approaches to understand the genetic basis of human disease. He currently provides statistical genetics, biostatistics, and informatics leadership for the Dilated Cardiomyopathy (DCM) Research Project (https://dcmproject.com) studies conducted by the DCM Consortium, a group led by Dr. Ray Hershberger at The Ohio State University that includes investigators at 25 leading academic cardiovascular programs across the US. In this role, he has been a co-investigator on the NHLBI- and NHGRI-funded DCM Precision Medicine Study and a multiple principal investigator on two NHLBI R01 awards to collect advanced echocardiographic and cardiac magnetic resonance imaging data on this cohort. His recent publications have appeared in journals including JAMA, Circulation, and Circulation: Genomic and Precision Medicine.
Dr. Kinnamon has also invested substantial effort in building informatics infrastructure to support genetics research in the Division of Human Genetics. One major product of his efforts is a platform that provides integrated management of clinical, sample, and genomic data within the scalable and cost-effective high-performance computing environment at the Ohio Supercomputer Center. He also established the Human Genetics Research Informatics Core team that manages the daily operation of this platform and provides specialized programming and analysis support to meet the unique needs of genomics researchers in the division.
Research Interests
- Statistical genetics
- Biostatistics
- Genetic epidemiology
- Bioinformatics
- Dilated cardiomyopathy
Education
PhD, Human Genetics and Genomics, University of Miami, 2013
MS, Statistics, Stanford University, 2003
BA, Economics and Latin American Studies, Stanford University, 2002
Selected Publications
Jordan E*, Kinnamon DD*, Haas GJ, Hofmeyer M, Kransdorf E, Ewald GA, Morris AA, Owens A, Lowes B, Stoller D, Tang WHW, Garg S, Trachtenberg BH, Shah P, Pamboukian SV, Sweitzer NK, Wheeler MT, Wilcox JE, Katz S, Pan S, Jimenez J, Fishbein DP, Smart F, Wang J, Gottlieb SS, Judge DP, Moore CK, Mead JO, Hurst N, Cao J, Huggins GS, Cowan J, Ni H, Rehm HL, Jarvik GP, Vatta M, Burke W, Hershberger RE; DCM Precision Medicine Study of the DCM Consortium. Genetic Architecture of Dilated Cardiomyopathy in Individuals of African and European Ancestry. JAMA. 2023 Aug 1;330(5):432-441. https://doi.org/10.1001/jama.2023.11970. PMID: 37526719.
* contributed equally as co–first authors
Kinnamon DD*, Jordan E*, Haas GJ, Hofmeyer M, Kransdorf E, Ewald GA, Morris AA, Owens A, Lowes B, Stoller D, Tang WHW, Garg S, Trachtenberg BH, Shah P, Pamboukian SV, Sweitzer NK, Wheeler MT, Wilcox JE, Katz S, Pan S, Jimenez J, Aaronson KD, Fishbein DP, Smart F, Wang J, Gottlieb SS, Judge DP, Moore CK, Mead JO, Huggins GS, Ni H, Burke W, Hershberger RE; DCM Precision Medicine Study of the DCM Consortium. Effectiveness of the Family Heart Talk Communication Tool in Improving Family Member Screening for Dilated Cardiomyopathy: Results of a Randomized Trial. Circulation. 2023 Apr 25;147(17):1281-1290. Epub 2023 Mar 20. https://doi.org/10.1161/CIRCULATIONAHA.122.062507. PMID: 36938756.
* contributed equally as co–first authors
Huggins GS*, Kinnamon DD*, Haas GJ, Jordan E, Hofmeyer M, Kransdorf E, Ewald GA, Morris AA, Owens A, Lowes B, Stoller D, Tang WHW, Garg S, Trachtenberg BH, Shah P, Pamboukian SV, Sweitzer NK, Wheeler MT, Wilcox JE, Katz S, Pan S, Jimenez J, Aaronson KD, Fishbein DP, Smart F, Wang J, Gottlieb SS, Judge DP, Moore CK, Mead JO, Ni H, Burke W, Hershberger RE; DCM Precision Medicine Study of the DCM Consortium. Prevalence and Cumulative Risk of Familial Idiopathic Dilated Cardiomyopathy. JAMA. 2022 Feb 1;327(5):454-463. https://doi.org/10.1001/jama.2021.24674. PMID: 35103767.
* contributed equally as co–first authors
Hershberger RE, Cowan J, Jordan E, Kinnamon DD. The Complex and Diverse Genetic Architecture of Dilated Cardiomyopathy. Circ Res. 2021 May 14;128(10):1514-1532. Epub 2021 May 13. https://doi.org/10.1161/CIRCRESAHA.121.318157. PMID: 33983834.
Morales A, Kinnamon DD, Jordan E, Platt J, Vatta M, Dorschner MO, Starkey CA, Mead JO, Ai T, Burke W, Gastier-Foster J, Jarvik GP, Rehm HL, Nickerson DA, Hershberger RE. Variant Interpretation for Dilated Cardiomyopathy: Refinement of the American College of Medical Genetics and Genomics/ClinGen Guidelines for the DCM Precision Medicine Study. Circ Genom Precis Med. 2020 Apr;13(2):e002480. Epub 2020 Mar 11. . https://doi.org/10.1161/CIRCGEN.119.002480. PMID: 32160020.
Kinnamon DD, Morales A, Bowen DJ, Burke W, Hershberger RE; DCM Consortium. Toward Genetics-Driven Early Intervention in Dilated Cardiomyopathy: Design and Implementation of the DCM Precision Medicine Study. Circ Cardiovasc Genet. 2017 Dec;10(6);e001826. https://doi.org/10.1161/CIRCGENETICS.117.001826. PMID: 29237686.
Kinnamon DD, Martin ER. Valid Monte Carlo permutation tests for genetic case-control studies with missing genotypes. Genet Epidemiol. 2014 May;38(4):325-44. Epub 2014 Apr 10. https://doi.org/10.1002/gepi.21805. PMID: 24723341.
Kinnamon DD, Hershberger RE, Martin ER. Reconsidering association testing methods using single-variant test statistics as alternatives to pooling tests for sequence data with rare variants. PLoS ONE. 2012;7(2):e30238. Epub 2012 Feb 17. https://doi.org/10.1371/journal.pone.0030238. PMID: 22363423.