Jay Zweier, MD

Professor, SBS-Physiology and Cell Biology
Professor, SBS-Biology, Chemistry and Pharmacology
Professor, Radiology

Biomedical Research Tower
460 W. 12th Ave.
Columbus, OH 43210

Education

MD: University of Maryland, George, 1980
BA: Brandeis University, 1976

Professional Activities

NHLBI PPG Review Committee, 2011 - present
Reviewer NRCC Scientific Conference Review Committee, 2010 - present
NIH Reviewers Reserve, 2010 - present
Present Ad Hoc BMIT Study Section, 2010 - present
Reviewer for the Veterans Admin. Cardiovascular Study Section, 2010 - present

Kuppusamy P, Chzhan M, Zweier JL. "Principles of Imaging." In Oxygen Transport to Tissue XXIV. Edited by edited by Dunn and Swartz. -. Norwell, MA: Kluwer Academic/Plenum Publishers, January 2003

Zweier JL, He G, Samouilov A, Kuppusamy P. "Cardiac Applications of In Vivo EPR Spectroscopy and Imaging." In Oxygen Transport to Tissue XXIV. Edited by edited by Dunn and Swartz. -. Norwell, MA: Kluwer Academic/Plenum Publishers, January 2003

Zweier JL, Villamena FA. "Chemistry of free radicals in biological systems." In Oxidative Stress and Cardiac Failure. Edited by edited by Kukin ML, Fuster V. -. New York: Futura Publishing, Armonk, January 2003

Xia Y, Zweier JL. "Superoxide anion release from inducible nitric oxide synthase." In Nitric Oxide and Inflammation. Edited by edited by Salvemini D, Billiar T, & Vodovotz Y. -. Switzerland: Birkhauser Verlag Basel, January 2001

deSouza H, Zweier JL. "Free radicals as mediators of inflammation in atherosclerosis." In Inflammatory and Infectious Basis of Atherosclerosis. Edited by edited by Jay L. Mehta. -. Switzerland: Birkhauser Verlag Basel, January 2001

Zweier JL. "Mechanism of Leukocyte Accumulation in Postischemic Tissues:Role of Oxygen Free Radicals." In The Neutrophils: New Outlook for the Old Cells. Edited by edited by D. Gabrilovich. -. London: Imperial College Press, January 1998

Zweier JL, Kuppusamy P. "Principles of Electron Paramagnetic Resonance Spectroscopy for Measurement of Free Radicals In Biological Tissues." In Nitric Oxide in Transplant Rejection and Anti-tumor Defense. Edited by edited by Lukiewicz & Zweier. -. MA: Kluwer Academic Publishers, January 1998

Zweier JL, Samouilov A, Kuppusamy P. "Independent Formation of Nitric Oxide In Tissues." In Nitric Oxide in Transplant Rejection and Anti-tumor Defense. Edited by edited by Lukiewicz & Zweier. -. Norwell, MA: Kluwer Academic Publishers, January 1998

Kuppusamy P, Zweier JL. "EPR Imaging of Free Radicals in Biological Systems." In Nitric Oxide in Transplant Rejection and Anti-tumor Defense. Edited by edited by Lukiewicz & Zweier. -. MA: Kluwer Academic Publishers, January 1998

Zweier JL, Kuppusamy P. "EPR Imaging of the Rat Heart." In Spatially Resolved Magnetic Resonance: Methods and Applications in Materials Science, Agriculture, and Biomedicine. Edited by edited by B Blumich, P Blumler, R Botto, E Fukushima. -. Weinheim: VCH, January 1998

Xu KY, Zweier JL, Becker LC. "Oxygen-free Radicals Directly Attack the ATP Binding Site of the Cardiac Na+,K+-ATPase." In Annals New York Academy of Sciences. -. New York: Annals New York Academy of Sciences, January 1997

Kuppusamy P, Zweier JL. "Study of Free Radical Generation in Isolated Cells and Whole Tissues Using Electron Paramagnetic Resonance Spectroscopy." In Cellular Membrane: A Key to Disease Processes. -. edited by Ohnishi/Ohnishi: Chapter 10, CRC Press, Inc, January 1992

Zweier JL. "The Role of Iron in Myocardial Reperfusion Injury." In Iron and Human Disease. -. edited by R.B. Lauffer: CRC Press, Inc, January 1991

Kensler T, Dolan P, Egner P, Lesko S, Swauger J, Zweier J, Akman S. "Free Radical Metabolism and DNA Damage by Organic Peroxide Tumor Promoters." In Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury. -. edited by S Nigam, KV Honn, LJ Marnett, TL Walden,Jr: Chapter 80, Proceedings of the 2nd International Conference, January 1991

Zweier JL, Kuppusamy P, Shandelya SML, Thompson-Gorman S, Weisman HF, Fearon DT, Weisfeldt ML. "Electron Paramagnetic Resonance Measurements of Free Radical Generation in Isolated Cells and Whole Tissues.." In Molecular Basis of Oxidative Damage by Leukocytes. Edited by edited by Jesaitis/Dratz. -. edited by Jesaitis/Dratz: CRC Press, Inc, January 1991

Weisfeldt ML, Zweier JL, Becker LC, Ambrosio G, Flaherty JT. "New Aspects of Drug Therapy: Free Radical Scavengers.." In Limitation of Infarct Size. 75-82. Springer Verlag: Schmutler H, Rutsch W, Doughtery FC, January 1989

Zweier JL, Flaherty JT. "The Role of Free Radicals in the Pathogenesis of Postischemic Reperfusion Injury, in Early Interventions.." In Acute Myocardial Infarction. -. edited by E. Rapaport: Kluwer Academic Publishers, January 1989

Taffe BG, Zweier JL, Kensler TW. "Tumor promotion by butylated hydroxytoluene hyperoxide. In: Pharmacological effects of lipids.." In Role of lipid in carcinogenesis and therapy.. 293-302. IL: American Oil Chemists Society, Champaign, January 1989

Weisfeldt ML, Zweier JL, Flaherty JT. "Oxygen-Derived Radicals and Myocardial Ischemic Injury.." In Heart Disease: Clinical Update (3). -. edited by Braunwald E: W.B. Saunders & Co, January 1988

Weisfeldt ML, Zweier JL, Ambrosio G, Becker LC, Flaherty JT. "Evidence that free radicals result in reperfusion injury in heart muscle.." In Oxygen Radicals in Biology and Medicine. Edited by edited by Simic ME, Taylor KA, Ward JF, Von Sonntag C. -. New York: Plenum, January 1988

Zweier, J L. "An electron paramagnetic resonance study of single site copper complexes of transferrin.." The Journal of biological chemistry. Vol. 253, no. 21. (January 1978.): 7616-21

Zweier, J L. "Electron paramagnetic resonance studies of the binding of copper to conalbumin. Probes of the structure and properties of the metal and anion binding sites.." The Journal of biological chemistry. Vol. 255, no. 7. (January 1980.): 2782-9

Atlas, S, A; Zweier, J, L; Nebert, D W. "Genetic differences in phenytoin pharmacokinetics. In vivo clearance and in vitro metabolism among inbred strains of mice.." Developmental pharmacology and therapeutics. Vol. 1, no. 5. (January 1980.): 281-304

Zweier, J, L; Wooten, J, B; Cohen, J S. "Studies of anion binding by transferrin using carbon-13 nuclear magnetic resonance spectroscopy.." Biochemistry. Vol. 20, no. 12. (January 1981.): 3505-10

Zweier, J, L; Peisach, J; Mims, W B. "Electron spin echo studies of the copper complexes of conalbumin.." The Journal of biological chemistry. Vol. 257, no. 17. (January 1982.): 10314-6

Zweier, J L. "Electron paramagnetic resonance measurement of the distance between the metal binding sites of transferrin.." The Journal of biological chemistry. Vol. 258, no. 22. (January 1983.): 13759-60

Zweier, J L. "Reduction of O2 by iron-adriamycin.." The Journal of biological chemistry. Vol. 259, no. 10. (January 1984.): 6056-8

Zweier, J L. "Iron-mediated formation of an oxidized adriamycin free radical.." Biochimica et biophysica acta. Vol. 839, no. 2. (January 1985.): 209-13

Gianni, L; Zweier, J, L; Levy, A; Myers, C E. "Characterization of the cycle of iron-mediated electron transfer from Adriamycin to molecular oxygen.." The Journal of biological chemistry. Vol. 260, no. 11. (January 1985.): 6820-6

Zweier, J, L; Gianni, L; Muindi, J; Myers, C E. "Differences in O2 reduction by the iron complexes of adriamycin and daunomycin: the importance of the sidechain hydroxyl group.." Biochimica et biophysica acta. Vol. 884, no. 2. (January 1986.): 326-36

Kusuoka, H; Weisfeldt, M, L; Zweier, J, L; Jacobus, W, E; Marban, E. "Mechanism of early contractile failure during hypoxia in intact ferret heart: evidence for modulation of maximal Ca2+-activated force by inorganic phosphate.." Circulation research. Vol. 59, no. 3. (January 1986.): 270-82

Hilton, B, D; Misra, R; Zweier, J L. "Magnetic resonance studies of fredericamycin A: evidence for O2-dependent free-radical formation.." Biochemistry. Vol. 25, no. 19. (January 1986.): 5533-9

Zweier, J, L; Rayburn, B, K; Flaherty, J, T; Weisfeldt, M L. "Recombinant superoxide dismutase reduces oxygen free radical concentrations in reperfused myocardium.." The Journal of clinical investigation. Vol. 80, no. 6. (January 1987.): 1728-34

Zweier, J, L; Jacobus, W E. "Substrate-induced alterations of high energy phosphate metabolism and contractile function in the perfused heart.." The Journal of biological chemistry. Vol. 262, no. 17. (January 1987.): 8015-21

Zweier, J, L; Flaherty, J, T; Weisfeldt, M L. "Direct measurement of free radical generation following reperfusion of ischemic myocardium.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 84, no. 5. (January 1987.): 1404-7

Ambrosio, G; Zweier, J, L; Jacobus, W, E; Weisfeldt, M, L; Flaherty, J T. "Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury.." Circulation. Vol. 76, no. 4. (January 1987.): 906-15

Zweier, J L. "Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.." The Journal of biological chemistry. Vol. 263, no. 3. (January 1988.): 1353-7

Zweier, J, L; Kuppusamy, P; Lutty, G A. "Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 85, no. 11. (January 1988.): 4046-50

Zweier, J, L; Kuppusamy, P. "Electron paramagnetic resonance measurements of free radicals in the intact beating heart: a technique for detection and characterization of free radicals in whole biological tissues.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 85, no. 15. (January 1988.): 5703-7

Kuppusamy, P; Zweier, J L. "Characterization of free radical generation by xanthine oxidase. Evidence for hydroxyl radical generation.." The Journal of biological chemistry. Vol. 264, no. 17. (January 1989.): 9880-4

Zweier, J, L; Kuppusamy, P; Williams, R; Rayburn, B, K; Smith, D; Weisfeldt, M, L; Flaherty, J T. "Measurement and characterization of postischemic free radical generation in the isolated perfused heart.." The Journal of biological chemistry. Vol. 264, no. 32. (January 1989.): 18890-5

Zweier, J, L; Duke, S, S; Kuppusamy, P; Sylvester, J, T; Gabrielson, E W. "Electron paramagnetic resonance evidence that cellular oxygen toxicity is caused by the generation of superoxide and hydroxyl free radicals.." FEBS letters. Vol. 252, no. 1-2. (January 1989.): 12-6

Taffe, B, G; Zweier, J, L; Pannell, L, K; Kensler, T W. "Generation of reactive intermediates from the tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin.." Carcinogenesis. Vol. 10, no. 7. (January 1989.): 1261-8

Thompson-Gorman, S, L; Zweier, J L. "Evaluation of the role of xanthine oxidase in myocardial reperfusion injury.." The Journal of biological chemistry. Vol. 265, no. 12. (January 1990.): 6656-63

Zweier, J, L; Jacobus, W, E; Korecky, B; Brandejs-Barry, Y. "Bioenergetic consequences of cardiac phosphocreatine depletion induced by creatine analogue feeding.." The Journal of biological chemistry. Vol. 266, no. 30. (January 1991.): 20296-304

Swauger, J, E; Dolan, P, M; Zweier, J, L; Kuppusamy, P; Kensler, T W. "Role of the benzoyloxyl radical in DNA damage mediated by benzoyl peroxide.." Chemical research in toxicology. Vol. 4, no. 2. (January 1991.): 223-8

Josephson, R, A; Silverman, H, S; Lakatta, E, G; Stern, M, D; Zweier, J L. "Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes.." The Journal of biological chemistry. Vol. 266, no. 4. (January 1991.): 2354-61

Williams, R, E; Zweier, J, L; Flaherty, J T. "Treatment with deferoxamine during ischemia improves functional and metabolic recovery and reduces reperfusion-induced oxygen radical generation in rabbit hearts.." Circulation. Vol. 83, no. 3. (January 1991.): 1006-14

Guyton, K, Z; Bhan, P; Kuppusamy, P; Zweier, J, L; Trush, M, A; Kensler, T W. "Free radical-derived quinone methide mediates skin tumor promotion by butylated hydroxytoluene hydroperoxide: expanded role for electrophiles in multistage carcinogenesis.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 88, no. 3. (January 1991.): 946-50

Zweier, J, L; Thompson-Gorman, S; Kuppusamy, P. "Measurement of oxygen concentrations in the intact beating heart using electron paramagnetic resonance spectroscopy: a technique for measuring oxygen concentrations in situ.." Journal of bioenergetics and biomembranes. Vol. 23, no. 6. (January 1991.): 855-71

Flaherty, J, T; Zweier, J L. "Role of oxygen radicals in myocardial reperfusion injury: experimental and clinical evidence.." Klinische Wochenschrift. Vol. 69, no. 21-23. (January 1991.): 1061-5

Corretti, M, C; Koretsune, Y; Kusuoka, H; Chacko, V, P; Zweier, J, L; Marban, E. "Glycolytic inhibition and calcium overload as consequences of exogenously generated free radicals in rabbit hearts.." The Journal of clinical investigation. Vol. 88, no. 3. (January 1991.): 1014-25

Ambrosio, G; Zweier, J, L; Flaherty, J T. "The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion.." Journal of molecular and cellular cardiology. Vol. 23, no. 12. (January 1991.): 1359-74

Kukreja, R, C; Kearns, A, A; Zweier, J, L; Kuppusamy, P; Hess, M L. "Singlet oxygen interaction with Ca(2+)-ATPase of cardiac sarcoplasmic reticulum.." Circulation research. Vol. 69, no. 4. (January 1991.): 1003-14

Ziegelstein, R, C; Zweier, J, L; Mellits, E, D; Younes, A; Lakatta, E, G; Stern, M, D; Silverman, H S. "Dimethylthiourea, an oxygen radical scavenger, protects isolated cardiac myocytes from hypoxic injury by inhibition of Na(+)-Ca2+ exchange and not by its antioxidant effects.." Circulation research. Vol. 70, no. 4. (January 1992.): 804-11

Grill, H, P; Zweier, J, L; Kuppusamy, P; Weisfeldt, M, L; Flaherty, J T. "Direct measurement of myocardial free radical generation in an in vivo model: effects of postischemic reperfusion and treatment with human recombinant superoxide dismutase.." Journal of the American College of Cardiology. Vol. 20, no. 7. (January 1992.): 1604-11

Povey, A, C; Wilson, V, L; Zweier, J, L; Kuppusamy, P; O'Neill, I, K; Harris, C C. "Detection by 32P-postlabelling of DNA adducts induced by free radicals and unsaturated aldehydes formed during the aerobic decomposition of fecapentaene-12.." Carcinogenesis. Vol. 13, no. 3. (January 1992.): 395-401

Gabrielson, E, W; Kuppusamy, P; Povey, A, C; Zweier, J, L; Harris, C C. "Measurement of neutrophil activation and epidermal cell toxicity by palytoxin and 12-O-tetradecanoylphorbol-13-acetate.." Carcinogenesis. Vol. 13, no. 9. (January 1992.): 1671-4

Shandelya, S, M; Kuppusamy, P; Herskowitz, A; Weisfeldt, M, L; Zweier, J L. "Soluble complement receptor type 1 inhibits the complement pathway and prevents contractile failure in the postischemic heart. Evidence that complement activation is required for neutrophil-mediated reperfusion injury.." Circulation. Vol. 88, no. 6. (January 1993.): 2812-26

Shandelya, S, M; Kuppusamy, P; Weisfeldt, M, L; Zweier, J L. "Evaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury. Evidence for plasma-mediated leukocyte activation.." Circulation. Vol. 87, no. 2. (January 1993.): 536-46

Sanders, S, P; Zweier, J, L; Kuppusamy, P; Harrison, S, J; Bassett, D, J; Gabrielson, E, W; Sylvester, J T. "Hyperoxic sheep pulmonary microvascular endothelial cells generate free radicals via mitochondrial electron transport.." The Journal of clinical investigation. Vol. 91, no. 1. (January 1993.): 46-52

Ambrosio, G; Zweier, J, L; Duilio, C; Kuppusamy, P; Santoro, G; Elia, P, P; Tritto, I; Cirillo, P; Condorelli, M; Chiariello, M. "Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow.." The Journal of biological chemistry. Vol. 268, no. 25. (January 1993.): 18532-41

Lefer, D, J; Shandelya, S, M; Serrano, C V Jr; Becker, L, C; Kuppusamy, P; Zweier, J L. "Cardioprotective actions of a monoclonal antibody against CD-18 in myocardial ischemia-reperfusion injury.." Circulation. Vol. 88, no. 4 Pt 1. (January 1993.): 1779-87

Sanders, S, P; Harrison, S, J; Kuppusamy, P; Sylvester, J, T; Zweier, J L. "A comparative study of EPR spin trapping and cytochrome c reduction techniques for the measurement of superoxide anions.." Free radical biology & medicine. Vol. 16, no. 6. (January 1994.): 753-61

Hano, O; Thompson-Gorman, S, L; Zweier, J, L; Lakatta, E G. "Coenzyme Q10 enhances cardiac functional and metabolic recovery and reduces Ca2+ overload during postischemic reperfusion.." The American journal of physiology. Vol. 266, no. 6 Pt 2. (January 1994.): H2174-81

Zweier, J, L; Chzhan, M; Ewert, U; Schneider, G; Kuppusamy, P. "Development of a highly sensitive probe for measuring oxygen in biological tissues.." Journal of magnetic resonance. Series B. Vol. 105, no. 1. (January 1994.): 52-7

Zweier, J, L; Kuppusamy, P; Thompson-Gorman, S; Klunk, D; Lutty, G A. "Measurement and characterization of free radical generation in reoxygenated human endothelial cells.." The American journal of physiology. Vol. 266, no. 3 Pt 1. (January 1994.): C700-8

Zweier, J, L; Kuppusamy, P. "In vivo EPR spectroscopy of free radicals in the heart.." Environmental health perspectives. Vol. 102 Suppl 10, (January 1994.): 45-51

Zweier, J, L; Broderick, R; Kuppusamy, P; Thompson-Gorman, S; Lutty, G A. "Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.." The Journal of biological chemistry. Vol. 269, no. 39. (January 1994.): 24156-62

Chen, K; Ng, C, E; Zweier, J, L; Kuppusamy, P; Glickson, J, D; Swartz, H M. "Measurement of the intracellular concentration of oxygen in a cell perfusion system.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 31, no. 6. (January 1994.): 668-72

Ziegelstein, R, C; Corda, S; Pili, R; Passaniti, A; Lefer, D; Zweier, J, L; Fraticelli, A; Capogrossi, M C. "Initial contact and subsequent adhesion of human neutrophils or monocytes to human aortic endothelial cells releases an endothelial intracellular calcium store.." Circulation. Vol. 90, no. 4. (January 1994.): 1899-907

Kuppusamy, P; Chzhan, M; Vij, K; Shteynbuk, M; Lefer, D, J; Giannella, E; Zweier, J L. "Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: a technique for imaging tissue metabolism and oxygenation.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 91, no. 8. (January 1994.): 3388-92

Xu, K, Y; Zweier, J, L; Becker, L C. "Functional coupling between glycolysis and sarcoplasmic reticulum Ca2+ transport.." Circulation research. Vol. 77, no. 1. (January 1995.): 88-97

Xia, Y; Zweier, J L. "Substrate control of free radical generation from xanthine oxidase in the postischemic heart.." The Journal of biological chemistry. Vol. 270, no. 32. (January 1995.): 18797-803

Sanders, S, P; Zweier, J, L; Harrison, S, J; Trush, M, A; Rembish, S, J; Liu, M C. "Spontaneous oxygen radical production at sites of antigen challenge in allergic subjects.." American journal of respiratory and critical care medicine. Vol. 151, no. 6. (January 1995.): 1725-33

Serrano Junior, C, V; Ramires, J, A; Cesar, L, A; Zweier, J, L; Rati, M; De Luz, P; Pileggi, F. "Prognostic significance of right ventricular dysfunction in patients with acute inferior myocardial infarction and right ventricular involvement.." Clinical cardiology. Vol. 18, no. 4. (January 1995.): 199-205

Chzhan, M; Kuppusamy, P; Zweier, J L. "Development of an electronically tunable L-band resonator for EPR spectroscopy and imaging of biological samples.." Journal of magnetic resonance. Series B. Vol. 108, no. 1. (January 1995.): 67-72

Zweier, J, L; Wang, P; Samouilov, A; Kuppusamy, P. "Enzyme-independent formation of nitric oxide in biological tissues.." Nature medicine. Vol. 1, no. 8. (January 1995.): 804-9

Zweier, J, L; Wang, P; Kuppusamy, P. "Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy.." The Journal of biological chemistry. Vol. 270, no. 1. (January 1995.): 304-7

Li, Y; Kuppusamy, P; Zweier, J, L; Trush, M A. "ESR evidence for the generation of reactive oxygen species from the copper-mediated oxidation of the benzene metabolite, hydroquinone: role in DNA damage.." Chemico-biological interactions. Vol. 94, no. 2. (January 1995.): 101-20

Kuppusamy, P; Wang, P; Zweier, J L. "Three-dimensional spatial EPR imaging of the rat heart.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 34, no. 1. (January 1995.): 99-105

Kuppusamy, P; Ohnishi, S, T; Numagami, Y; Ohnishi, T; Zweier, J L. "Three-dimensional imaging of nitric oxide production in the rat brain subjected to ischemia-hypoxia.." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. Vol. 15, no. 6. (January 1995.): 899-903

Kuppusamy, P; Chzhan, M; Zweier, J L. "Development and optimization of three-dimensional spatial EPR imaging for biological organs and tissues.." Journal of magnetic resonance. Series B. Vol. 106, no. 2. (January 1995.): 122-30

Kuppusamy, P; Chzhan, M; Samouilov, A; Wang, P; Zweier, J L. "Mapping the spin-density and lineshape distribution of free radicals using 4D spectral-spatial EPR imaging.." Journal of magnetic resonance. Series B. Vol. 107, no. 2. (January 1995.): 116-25

Zweier, J, L; Samouilov, A; Chzhan, M. "Measurement of nitric oxide with a solid-state-char EPR probe.." Journal of magnetic resonance. Series B. Vol. 109, no. 3. (January 1995.): 259-63

Xia, Y; Khatchikian, G; Zweier, J L. "Adenosine deaminase inhibition prevents free radical-mediated injury in the postischemic heart.." The Journal of biological chemistry. Vol. 271, no. 17. (January 1996.): 10096-102

Xia, Y; Dawson, V, L; Dawson, T, M; Snyder, S, H; Zweier, J L. "Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 93, no. 13. (January 1996.): 6770-4

Fraticelli, A; Serrano, C V Jr; Bochner, B, S; Capogrossi, M, C; Zweier, J L. "Hydrogen peroxide and superoxide modulate leukocyte adhesion molecule expression and leukocyte endothelial adhesion.." Biochimica et biophysica acta. Vol. 1310, no. 3. (January 1996.): 251-9

Crawford, L, E; Milliken, E, E; Irani, K; Zweier, J, L; Becker, L, C; Johnson, T, M; Eissa, N, T; Crystal, R, G; Finkel, T; Goldschmidt-Clermont, P J. "Superoxide-mediated actin response in post-hypoxic endothelial cells.." The Journal of biological chemistry. Vol. 271, no. 43. (January 1996.): 26863-7

Li, Y; Kuppusamy, P; Zweier, J, L; Trush, M A. "Role of Cu/Zn-superoxide dismutase in xenobiotic activation. I. Chemical reactions involved in the Cu/Zn-superoxide dismutase-accelerated oxidation of the benzene metabolite 1,4-hydroquinone.." Molecular pharmacology. Vol. 49, no. 3. (January 1996.): 404-11

Kuppusamy, P; Zweier, J L. "A forward-subtraction procedure for removing hyperfine artifacts in electron paramagnetic resonance imaging.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 35, no. 3. (January 1996.): 316-22

Kuppusamy, P; Wang, P; Samouilov, A; Zweier, J L. "Spatial mapping of nitric oxide generation in the ischemic heart using electron paramagnetic resonance imaging.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 36, no. 2. (January 1996.): 212-8

Serrano, C V Jr; Mikhail, E, A; Wang, P; Noble, B; Kuppusamy, P; Zweier, J L. "Superoxide and hydrogen peroxide induce CD18-mediated adhesion in the postischemic heart.." Biochimica et biophysica acta. Vol. 1316, no. 3. (January 1996.): 191-202

Primiano, T; Kensler, T, W; Kuppusamy, P; Zweier, J, L; Sutter, T R. "Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones.." Carcinogenesis. Vol. 17, no. 11. (January 1996.): 2291-6

Kuppusamy, P; Wang, P; Zweier, J, L; Krishna, M, C; Mitchell, J, B; Ma, L; Trimble, C, E; Hsia, C J. "Electron paramagnetic resonance imaging of rat heart with nitroxide and polynitroxyl-albumin.." Biochemistry. Vol. 35, no. 22. (January 1996.): 7051-7

Kuppusamy, P; Chzhan, M; Wang, P; Zweier, J L. "Three-dimensional gated EPR imaging of the beating heart: time-resolved measurements of free radical distribution during the cardiac contractile cycle.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 35, no. 3. (January 1996.): 323-8

Schauer, D, A; Desrosiers, M, F; Kuppusamy, P; Zweier, J L. "Radiation dosimetry of an accidental overexposure using EPR spectrometry and imaging of human bone.." Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. Vol. 47, no. 11-12. (January 1996.): 1345-50

Wang, P; Zweier, J L. "Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury.." The Journal of biological chemistry. Vol. 271, no. 46. (January 1996.): 29223-30

Serrano, C V Jr; Fraticelli, A; Paniccia, R; Teti, A; Noble, B; Corda, S; Faraggiana, T; Ziegelstein, R, C; Zweier, J, L; Capogrossi, M C. "pH dependence of neutrophil-endothelial cell adhesion and adhesion molecule expression.." The American journal of physiology. Vol. 271, no. 3 Pt 1. (January 1996.): C962-70

MacGowan, G, A; Burkhoff, D; Rogers, W, J; Salvador, D; Azhari, H; Hees, P, S; Zweier, J, L; Halperin, H, R; Siu, C, O; Lima, J, A; Weiss, J, L; Shapiro, E P. "Effects of afterload on regional left ventricular torsion.." Cardiovascular research. Vol. 31, no. 6. (January 1996.): 917-25

Serrano, C V Jr; Ramires, J, A; Venturinelli, M; Arie, S; D'Amico, E; Zweier, J, L; Pileggi, F; da Luz, P L. "Coronary angioplasty results in leukocyte and platelet activation with adhesion molecule expression. Evidence of inflammatory responses in coronary angioplasty.." Journal of the American College of Cardiology. Vol. 29, no. 6. (January 1997.): 1276-83

Irani, K; Xia, Y; Zweier, J, L; Sollott, S, J; Der, C, J; Fearon, E, R; Sundaresan, M; Finkel, T; Goldschmidt-Clermont, P J. "Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts.." Science. Vol. 275, no. 5306. (January 1997.): 1649-52

Roubaud, V; Sankarapandi, S; Kuppusamy, P; Tordo, P; Zweier, J L. "Quantitative measurement of superoxide generation using the spin trap 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide.." Analytical biochemistry. Vol. 247, no. 2. (January 1997.): 404-11

Polyak, K; Xia, Y; Zweier, J, L; Kinzler, K, W; Vogelstein, B. "A model for p53-induced apoptosis.." Nature. Vol. 389, no. 6648. (January 1997.): 300-5

Seacat, A, M; Kuppusamy, P; Zweier, J, L; Yager, J D. "ESR identification of free radicals formed from the oxidation of catechol estrogens by Cu2+.." Archives of biochemistry and biophysics. Vol. 347, no. 1. (January 1997.): 45-52

Xia, Y; Zweier, J L. "Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 94, no. 13. (January 1997.): 6954-8

Xia, Y; Zweier, J L. "Measurement of myeloperoxidase in leukocyte-containing tissues.." Analytical biochemistry. Vol. 245, no. 1. (January 1997.): 93-6

Xia, Y; Zweier, J L. "Direct measurement of nitric oxide generation from nitric oxide synthase.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 94, no. 23. (January 1997.): 12705-10

Giraldez, R, R; Panda, A; Xia, Y; Sanders, S, P; Zweier, J L. "Decreased nitric-oxide synthase activity causes impaired endothelium-dependent relaxation in the postischemic heart.." The Journal of biological chemistry. Vol. 272, no. 34. (January 1997.): 21420-6

Xu, K, Y; Zweier, J, L; Becker, L C. "Oxygen-free radicals directly attack the ATP binding site of the cardiac Na+,K(+)-ATPase.." Annals of the New York Academy of Sciences. Vol. 834, (January 1997.): 680-3

Xu, K, Y; Zweier, J, L; Becker, L C. "Hydroxyl radical inhibits sarcoplasmic reticulum Ca(2+)-ATPase function by direct attack on the ATP binding site.." Circulation research. Vol. 80, no. 1. (January 1997.): 76-81

Kuppusamy, P; Wang, P; Chzhan, M; Zweier, J L. "High resolution electron paramagnetic resonance imaging of biological samples with a single line paramagnetic label.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 37, no. 4. (January 1997.): 479-83

Samouilov, A; Kuppusamy, P; Zweier, J L. "Evaluation of the magnitude and rate of nitric oxide production from nitrite in biological systems.." Archives of biochemistry and biophysics. Vol. 357, no. 1. (January 1998.): 1-7

Hu, Q; Xia, Y; Corda, S; Zweier, J, L; Ziegelstein, R C. "Hydrogen peroxide decreases pHi in human aortic endothelial cells by inhibiting Na+/H+ exchange.." Circulation research. Vol. 83, no. 6. (January 1998.): 644-51

Hu, Q; Corda, S; Zweier, J, L; Capogrossi, M, C; Ziegelstein, R C. "Hydrogen peroxide induces intracellular calcium oscillations in human aortic endothelial cells.." Circulation. Vol. 97, no. 3. (January 1998.): 268-75

Xia, Y; Tsai, A, L; Berka, V; Zweier, J L. "Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process.." The Journal of biological chemistry. Vol. 273, no. 40. (January 1998.): 25804-8

Xia, Y; Roman, L, J; Masters, B, S; Zweier, J L. "Inducible nitric-oxide synthase generates superoxide from the reductase domain.." The Journal of biological chemistry. Vol. 273, no. 35. (January 1998.): 22635-9

Roubaud, V; Sankarapandi, S; Kuppusamy, P; Tordo, P; Zweier, J L. "Quantitative measurement of superoxide generation and oxygen consumption from leukocytes using electron paramagnetic resonance spectroscopy.." Analytical biochemistry. Vol. 257, no. 2. (January 1998.): 210-7

Giraldez, R, R; Zweier, J L. "An improved assay for measurement of nitric oxide synthase activity in biological tissues.." Analytical biochemistry. Vol. 261, no. 1. (January 1998.): 29-35

Ambrosio, G; Zweier, J, L; Becker, L C. "Apoptosis is prevented by administration of superoxide dismutase in dogs with reperfused myocardial infarction.." Basic research in cardiology. Vol. 93, no. 2. (January 1998.): 94-6

Zweier, J, L; Chzhan, M; Samouilov, A; Kuppusamy, P. "Electron paramagnetic resonance imaging of the rat heart.." Physics in medicine and biology. Vol. 43, no. 7. (January 1998.): 1823-35

Samouilov, A; Zweier, J L. "Development of chemiluminescence-based methods for specific quantitation of nitrosylated thiols.." Analytical biochemistry. Vol. 258, no. 2. (January 1998.): 322-30

Ha, H, C; Sirisoma, N, S; Kuppusamy, P; Zweier, J, L; Woster, P, M; Casero, R A Jr. "The natural polyamine spermine functions directly as a free radical scavenger.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 95, no. 19. (January 1998.): 11140-5

Li, Y; Zhu, H; Kuppusamy, P; Roubaud, V; Zweier, J, L; Trush, M A. "Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems.." The Journal of biological chemistry. Vol. 273, no. 4. (January 1998.): 2015-23

Kuppusamy, P; Wang, P; Shankar, R, A; Ma, L; Trimble, C, E; Hsia, C, J; Zweier, J L. "In vivo topical EPR spectroscopy and imaging of nitroxide free radicals and polynitroxyl-albumin.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 40, no. 6. (January 1998.): 806-11

Kuppusamy, P; Shankar, R, A; Zweier, J L. "In vivo measurement of arterial and venous oxygenation in the rat using 3D spectral-spatial electron paramagnetic resonance imaging.." Physics in medicine and biology. Vol. 43, no. 7. (January 1998.): 1837-44

Kuppusamy, P; Afeworki, M; Shankar, R, A; Coffin, D; Krishna, M, C; Hahn, S, M; Mitchell, J, B; Zweier, J L. "In vivo electron paramagnetic resonance imaging of tumor heterogeneity and oxygenation in a murine model.." Cancer research. Vol. 58, no. 7. (January 1998.): 1562-8

Sankarapandi, S; Zweier, J, L; Mukherjee, G; Quinn, M, T; Huso, D L. "Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase-dependent pathway.." Archives of biochemistry and biophysics. Vol. 353, no. 2. (January 1998.): 312-21

Wang, P; Chen, H; Qin, H; Sankarapandi, S; Becher, M, W; Wong, P, C; Zweier, J L. "Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 95, no. 8. (January 1998.): 4556-60

Zweier, J L. "Free radical generation in human endothelial cells exposed to anoxia and reoxygenation.." Transplantation proceedings. Vol. 30, no. 8. (January 1998.): 4228-32

Sankarapandi, S; Zweier, J L. "Evidence against the generation of free hydroxyl radicals from the interaction of copper,zinc-superoxide dismutase and hydrogen peroxide.." The Journal of biological chemistry. Vol. 274, no. 49. (January 1999.): 34576-83

Sankarapandi, S; Zweier, J L. "Bicarbonate is required for the peroxidase function of Cu, Zn-superoxide dismutase at physiological pH.." The Journal of biological chemistry. Vol. 274, no. 3. (January 1999.): 1226-32

Chzhan, M; Kuppusamy, P; Samouilov, A; He, G; Zweier, J L. "A tunable reentrant resonator with transverse orientation of electric field for in vivo EPR spectroscopy.." J Magn Reson. Vol. 137, no. 2. (January 1999.): 373-8

Salvemini, D; Wang, Z, Q; Zweier, J, L; Samouilov, A; Macarthur, H; Misko, T, P; Currie, M, G; Cuzzocrea, S; Sikorski, J, A; Riley, D P. "A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats.." Science. Vol. 286, no. 5438. (January 1999.): 304-6

He, G; Shankar, R, A; Chzhan, M; Samouilov, A; Kuppusamy, P; Zweier, J L. "Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 96, no. 8. (January 1999.): 4586-91

Lu, R; Wang, P; Wartofsky, L; Sutton, B, D; Zweier, J, L; Bahn, R, S; Garrity, J; Burman, K D. "Oxygen free radicals in interleukin-1beta-induced glycosaminoglycan production by retro-ocular fibroblasts from normal subjects and Graves' ophthalmopathy patients.." Thyroid : official journal of the American Thyroid Association. Vol. 9, no. 3. (January 1999.): 297-303

Wei, G; Dawson, V, L; Zweier, J L. "Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia.." Biochimica et biophysica acta. Vol. 1455, no. 1. (January 1999.): 23-34

Zweier, J, L; Samouilov, A; Kuppusamy, P. "Non-enzymatic nitric oxide synthesis in biological systems.." Biochimica et biophysica acta. Vol. 1411, no. 2-3. (January 1999.): 250-62

Xia, Y; Cardounel, A, J; Vanin, A, F; Zweier, J L. "Electron paramagnetic resonance spectroscopy with N-methyl-D-glucamine dithiocarbamate iron complexes distinguishes nitric oxide and nitroxyl anion in a redox-dependent manner: applications in identifying nitrogen monoxide products from nitric." Free radical biology & medicine. Vol. 29, no. 8. (January 2000.): 793-7

Li, H; Xu, K, Y; Zhou, L; Kalai, T; Zweier, J, L; Hideg, K; Kuppusamy, P. "A pyrroline derivative of mexiletine offers marked protection against ischemia/reperfusion-induced myocardial contractile dysfunction.." The Journal of pharmacology and experimental therapeutics. Vol. 295, no. 2. (January 2000.): 563-71

Lee, C; Miura, K; Liu, ; XZweier, J L. "Biphasic regulation of leukocyte superoxide generation by nitric oxide and peroxynitrite.." The Journal of biological chemistry. Vol. 275, no. 50. (January 2000.): 38965-72

Lee, C, I; Liu, ; XZweier, J L. "Regulation of xanthine oxidase by nitric oxide and peroxynitrite.." The Journal of biological chemistry. Vol. 275, no. 13. (January 2000.): 9369-76

Giraldez, R, R; Panda, A; Zweier, J L. "Endothelial dysfunction does not require loss of endothelial nitric oxide synthase.." American journal of physiology. Heart and circulatory physiology. Vol. 278, no. 6. (January 2000.): H2020-7

Hu, Q; Zheng, G; Zweier, J, L; Deshpande, S; Irani, K; Ziegelstein, R C. "NADPH oxidase activation increases the sensitivity of intracellular Ca2+ stores to inositol 1,4,5-trisphosphate in human endothelial cells.." The Journal of biological chemistry. Vol. 275, no. 21. (January 2000.): 15749-57.

Zorov, D, B; Filburn, C, R; Klotz, L, O; Zweier, J, L; Sollott, S J. "Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes.." The Journal of experimental medicine. Vol. 192, no. 7. (January 2000.): 1001-14

Vanin, A, F; Liu, ; XSamouilov, A; Stukan, R, A; Zweier, J L. "Redox properties of iron-dithiocarbamates and their nitrosyl derivatives: implications for their use as traps of nitric oxide in biological systems.." Biochimica et biophysica acta. Vol. 1474, no. 3. (January 2000.): 365-77

Pieper, A, A; Walles, T; Wei, G; Clements, E, E; Verma, A; Snyder, S, H; Zweier, J L. "Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption.." Mol Med. Vol. 6, no. 4. (January 2000.): 271-82

Velan, S, S; Spencer, R, G; Zweier, J, L; Kuppusamy, P. "Electron paramagnetic resonance oxygen mapping (EPROM): direct visualization of oxygen concentration in tissue.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 43, no. 6. (January 2000.): 804-9

Shankar, R, A; Hideg, K; Zweier, J, L; Kuppusamy, P. "Targeted antioxidant properties of N-[(tetramethyl-3-pyrroline-3-carboxamido)propyl]phthalimide and its nitroxide metabolite in preventing postischemic myocardial injury.." The Journal of pharmacology and experimental therapeutics. Vol. 292, no. 3. (January 2000.): 838-45

Sanders, S, P; Bassett, D, J; Harrison, S, J; Pearse, D; Zweier, J, L; Becker, P M. "Measurements of free radicals in isolated, ischemic lungs and lung mitochondria.." Lung. Vol. 178, no. 2. (January 2000.): 105-18

Zweier, J, L; Fertmann, J; Wei, G. "Nitric oxide and peroxynitrite in postischemic myocardium.." Antioxidants & redox signaling. Vol. 3, no. 1. (January 2001.): 11-22

Liu, ; XZweier, J L. "A real-time electrochemical technique for measurement of cellular hydrogen peroxide generation and consumption: evaluation in human polymorphonuclear leukocytes.." Free radical biology & medicine. Vol. 31, no. 7. (January 2001.): 894-901

Li, H; Samouilov, A; Liu, ; XZweier, J L. "Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues.." The Journal of biological chemistry. Vol. 276, no. 27. (January 2001.): 24482-9

He, G; Samouilov, A; Kuppusamy, P; Zweier, J L. "In vivo EPR imaging of the distribution and metabolism of nitroxide radicals in human skin.." J Magn Reson. Vol. 148, no. 1. (January 2001.): 155-64

He, G; Petryakov, S; Samouilov, A; Chzhan, M; Kuppusamy, P; Zweier, J L. "Development of a resonator with automatic tuning and coupling capability to minimize sample motion noise for in vivo EPR spectroscopy.." J Magn Reson. Vol. 149, no. 2. (January 2001.): 218-27

Petryakov, S; Chzhan, M; Samouilov, A; He, G; Kuppusamy, P; Zweier, J L. "A bridged loop-gap S-band surface resonator for topical EPR spectroscopy.." J Magn Reson. Vol. 151, no. 1. (January 2001.): 124-8

Paolocci, N; Biondi, R; Bettini, M; Lee, C, I; Berlowitz, C, O; Rossi, R; Xia, Y; Ambrosio, G; L'Abbate, A; Kass, D, A; Zweier, J L. "Oxygen radical-mediated reduction in basal and agonist-evoked NO release in isolated rat heart.." Journal of molecular and cellular cardiology. Vol. 33, no. 4. (January 2001.): 671-9

Gabrielson, K, L; Hogue, B, A; Bohr, V, A; Cardounel, A, J; Nakajima, W; Kofler, J; Zweier, J, L; Rodriguez, E, R; Martin, L, J; de Souza-Pinto, N, C; Bressler, J. "Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice.." American journal of pathology. Vol. 159, no. 4. (January 2001.): 1507-20

Kuppusamy, P; Shankar, R, A; Roubaud, V, M; Zweier, J L. "Whole body detection and imaging of nitric oxide generation in mice following cardiopulmonary arrest: detection of intrinsic nitrosoheme complexes.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 45, no. 4. (January 2001.): 700-7

Souza, H, P; Laurindo, F, R; Ziegelstein, R, C; Berlowitz, C, O; Zweier, J L. "Vascular NAD(P)H oxidase is distinct from the phagocytic enzyme and modulates vascular reactivity control.." American journal of physiology. Heart and circulatory physiology. Vol. 280, no. 2. (January 2001.): H658-67

Song, Y; Zweier, J, L; Xia, Y. "Heat-shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding.." The Biochemical journal. Vol. 355, no. Pt 2. (January 2001.): 357-60

Song, Y; Zweier, J, L; Xia, Y. "Determination of the enhancing action of HSP90 on neuronal nitric oxide synthase by EPR spectroscopy.." American journal of physiology. Cell physiology. Vol. 281, no. 6. (January 2001.): C1819-24

Duilio, C; Ambrosio, G; Kuppusamy, P; DiPaula, A; Becker, L, C; Zweier, J L. "Neutrophils are primary source of O2 radicals during reperfusion after prolonged myocardial ischemia.." American journal of physiology. Heart and circulatory physiology. Vol. 280, no. 6. (January 2001.): H2649-57

Biondi, R; Xia, Y; Rossi, R; Paolocci, N; Ambrosio, G; Zweier, J L. "Detection of hydroxyl radicals by D-phenylalanine hydroxylation: a specific assay for hydroxyl radical generation in biological systems.." Analytical biochemistry. Vol. 290, no. 1. (January 2001.): 138-45

Ellis, S, J; Velayutham, M; Velan, S, S; Petersen, E, F; Zweier, J, L; Kuppusamy, P; Spencer, R G. "EPR oxygen mapping (EPROM) of engineered cartilage grown in a hollow-fiber bioreactor.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 46, no. 4. (January 2001.): 819-26

Liu, Xiaoping; Samouilov, Alexandre; Lancaster, Jack R Jr; Zweier, Jay L. "Nitric oxide uptake by erythrocytes is primarily limited by extracellular diffusion not membrane resistance.." The Journal of biological chemistry. Vol. 277, no. 29. (January 2002.): 26194-9

Lurie, David, J; Li, Haihong; Petryakov, Sergey; Zweier, Jay L. "Development of a PEDRI free-radical imager using a 0.38 T clinical MRI system.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 47, no. 1. (January 2002.): 181-6

Lee, Masaichi-Chang-il; Shoji, Hirofumi; Komatsu, Tomoko; Yoshino, Fumihiko; Ohmori, Yoichi; Zweier, Jay L. "Inhibition of superoxide generation from fMLP-stimulated leukocytes by high concentrations of nitric oxide or peroxynitrite: characterization by electron spin resonance spectroscopy.." Redox report : communications in free radical research. Vol. 7, no. 5. (January 2002.): 271-5

Lam, Y Amy; Lawson, T Glen; Velayutham, Murugesan; Zweier, Jay, L; Pickart, Cecile M. "A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal.." Nature. Vol. 416, no. 6882. (January 2002.): 763-7

Janiszewski, Mariano; Souza, Heraldo, P; Liu, Xiaoping; Pedro, Marcelo, A; Zweier, Jay, L; Laurindo, Francisco R M. "Overestimation of NADH-driven vascular oxidase activity due to lucigenin artifacts.." Free radical biology & medicine. Vol. 32, no. 5. (January 2002.): 446-53

Cardounel, Arturo, J; Zweier, Jay L. "Endogenous methylarginines regulate neuronal nitric-oxide synthase and prevent excitotoxic injury.." The Journal of biological chemistry. Vol. 277, no. 37. (January 2002.): 33995-4002

He, Guanglong; Evalappan, Sathesh, P; Hirata, Hiroshi; Deng, Yuanmu; Petryakov, Sergey; Kuppusamy, Periannan; Zweier, Jay L. "Mapping of the B1 field distribution of a surface coil resonator using EPR imaging.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 48, no. 6. (January 2002.): 1057-62

Souza, Heraldo, P; Liu, Xiaoping; Samouilov, Alexandre; Kuppusamy, Periannan; Laurindo, Francisco R, M; Zweier, Jay L. "Quantitation of superoxide generation and substrate utilization by vascular NAD(P)H oxidase.." American journal of physiology. Heart and circulatory physiology. Vol. 282, no. 2. (January 2002.): H466-74

Li, Yunbo; Seacat, Andrew; Kuppusamy, Periannan; Zweier, Jay, L; Yager, James, D; Trush, Michael A. "Copper redox-dependent activation of 2-tert-butyl(1,4)hydroquinone: formation of reactive oxygen species and induction of oxidative DNA damage in isolated DNA and cultured rat hepatocytes.." Mutation research. Vol. 518, no. 2. (January 2002.): 123-33

Li, Haiquan; Ma, Li; Hsia, Carleton J, C; Zweier, Jay, L; Kuppusamy, Periannan. "Polynitroxyl-albumin (PNA) enhances myocardial infarction therapeutic effect of tempol in rat hearts subjected to regional ischemia-reperfusion.." Free radical biology & medicine. Vol. 32, no. 8. (January 2002.): 712-9

Kuppusamy, Periannan; Li, Haiquan; Ilangovan, Govindasamy; Cardounel, Arturo, J; Zweier, Jay, L; Yamada, Kenichi; Krishna, Murali, C; Mitchell, James B. "Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels.." Cancer research. Vol. 62, no. 1. (January 2002.): 307-12

Song, Yao; Cardounel, A, J; Zweier, Jay, L; Xia, Yong. "Inhibition of superoxide generation from neuronal nitric oxide synthase by heat shock protein 90: implications in NOS regulation.." Biochemistry. Vol. 41, no. 34. (January 2002.): 10616-22

Li, Haihong; Deng, Yuanmu; He, Guanglong; Kuppusamy, Periannan; Lurie, David, J; Zweier, Jay L. "Proton electron double resonance imaging of the in vivo distribution and clearance of a triaryl methyl radical in mice.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 48, no. 3. (January 2002.): 530-4

Samouilov, Alexandre; Zweier, Jay L. "Analytical implications of iron dithiocarbamates for measurement of nitric oxide.." Methods in enzymology. Vol. 352, (January 2002.): 506-22

Ilangovan, Govindasamy; Manivannan, Ayyakkannu; Li, Haiquan; Yanagi, Hisao; Zweier, Jay, L; Kuppusamy, Periannan. "A naphthalocyanine-based EPR probe for localized measurements of tissue oxygenation.." Free radical biology & medicine. Vol. 32, no. 2. (January 2002.): 139-47

Ilangovan, Govindasamy; Li, Haiquan; Zweier, Jay, L; Kuppusamy, Periannan. "In vivo measurement of tumor redox environment using EPR spectroscopy.." Molecular and cellular biochemistry. Vol. 234-235, no. 1-2. (January 2002.): 393-8

Ilangovan, Govindasamy; Li, Haiquan; Zweier, Jay, L; Krishna, Murali, C; Mitchell, James, B; Kuppusamy, Periannan. "In vivo measurement of regional oxygenation and imaging of redox status in RIF-1 murine tumor: effect of carbogen-breathing.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 48, no. 4. (January 2002.): 723-30

He, Guanglong; Samouilov, Alexandre; Kuppusamy, Periannan; Zweier, Jay L. "In vivo imaging of free radicals: applications from mouse to man.." Molecular and cellular biochemistry. Vol. 234-235, no. 1-2. (January 2002.): 359-67

He, Guanglong; Deng, Yuanmu; Li, Haihong; Kuppusamy, Periannan; Zweier, Jay L. "EPR/NMR co-imaging for anatomic registration of free-radical images.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 47, no. 3. (January 2002.): 571-8

Zweier, Jay, L; He, Guanglong; Samouilov, Alexandre; Kuppusamy, Periannan. "EPR spectroscopy and imaging of oxygen: applications to the gastrointestinal tract.." Advances in experimental medicine and biology. Vol. 530, (January 2003.): 123-31

Liebgott, Thibaut; Li, Haihong; Deng, Yuanmu; Zweier, Jay L. "Proton electron double resonance imaging (PEDRI) of the isolated beating rat heart.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 50, no. 2. (January 2003.): 391-9

Deng, Yuanmu; He, Guanglong; Kuppusamy, Periannan; Zweier, Jay L. "Deconvolution algorithm based on automatic cutoff frequency selection for EPR imaging.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 50, no. 2. (January 2003.): 444-8

Cardounel, Arturo, J; Dumitrescu, Christian; Zweier, Jay, L; Lockwood, Samuel F. "Direct superoxide anion scavenging by a disodium disuccinate astaxanthin derivative: Relative efficacy of individual stereoisomers versus the statistical mixture of stereoisomers by electron paramagnetic resonance imaging.." Biochemical and biophysical research communications. Vol. 307, no. 3. (January 2003.): 704-12

Parinandi, Narasimham, L; Kleinberg, Michael, A; Usatyuk, Peter, V; Cummings, Rhett, J; Pennathur, Arjun; Cardounel, Arturo, J; Zweier, Jay, L; Garcia, Joe G, N; Natarajan, Viswanathan. "Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells.." American journal of physiology. Lung cellular and molecular physiology. Vol. 284, no. 1. (January 2003.): L26-38

Velayutham, Murugesan; Li, Haiquan; Kuppusamy, Periannan; Zweier, Jay L. "Mapping ischemic risk region and necrosis in the isolated heart using EPR imaging.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 49, no. 6. (January 2003.): 1181-7

Li, Haitao; Samouilov, Alexandre; Liu, Xiaoping; Zweier, Jay L. "Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues.." Biochemistry. Vol. 42, no. 4. (January 2003.): 1150-9

Zeigler, Mandy, M; Doseff, Andrea, I; Galloway, Michelle, F; Opalek, Judy, M; Nowicki, Philip, T; Zweier, Jay, L; Sen, Chandan, K; Marsh, Clay B. "Presentation of nitric oxide regulates monocyte survival through effects on caspase-9 and caspase-3 activation.." The Journal of biological chemistry. Vol. 278, no. 15. (January 2003.): 12894-902

Souza, Heraldo, P; Cardounel, Arturo, J; Zweier, Jay L. "Mechanisms of free radical production in the vascular wall.." Coronary artery disease. Vol. 14, no. 2. (January 2003.): 101-7

Pandian, Ramasamy, P; Parinandi, Narasimham, L; Ilangovan, Govindasamy; Zweier, Jay, L; Kuppusamy, Periannan. "Novel particulate spin probe for targeted determination of oxygen in cells and tissues.." Free radical biology & medicine. Vol. 35, no. 9. (January 2003.): 1138-48

Pandian, Ramasamy, P; Kutala, Vijay Kumar; Parinandi, Narasimham, L; Zweier, Jay, L; Kuppusamy, Periannan. "Measurement of oxygen consumption in mouse aortic endothelial cells using a microparticulate oximetry probe.." Archives of biochemistry and biophysics. Vol. 420, no. 1. (January 2003.): 169-75

Muscoli, Carolina; Cuzzocrea, Salvatore; Riley, Dennis, P; Zweier, Jay, L; Thiemermann, Christoph; Wang, Zhi-Qiang; Salvemini, Daniela. "On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies.." British journal of pharmacology. Vol. 140, no. 3. (January 2003.): 445-60

Cai, Zheqing; Manalo, Dominador, J; Wei, Guo; Rodriguez, E Rene; Fox-Talbot, Karen; Lu, Huasheng; Zweier, Jay, L; Semenza, Gregg L. "Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury.." Circulation. Vol. 108, no. 1. (January 2003.): 79-85

Roy, Sashwati; Khanna, Savita; Wallace, William, A; Lappalainen, Jani; Rink, Cameron; Cardounel, Arturo, J; Zweier, Jay, L; Sen, Chandan K. "Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart.." The Journal of biological chemistry. Vol. 278, no. 47. (January 2003.): 47129-35

Rizzi, Cecile; Samouilov, Alexandre; Kutala, Vijay Kumar; Parinandi, Narasimham, L; Zweier, Jay, L; Kuppusamy, Periannan. "Application of a trityl-based radical probe for measuring superoxide.." Free radical biology & medicine. Vol. 35, no. 12. (January 2003.): 1608-18

Ilangovan, Govindasamy; Li, Haiquan; Zweier, Jay, L; Kuppusamy, Periannan. "Effect of carbogen-breathing on redox status of the RIF-1 tumor.." Advances in experimental medicine and biology. Vol. 510, (January 2003.): 13-7

Tiravanti, Edy; Samouilov, Alexandre; Zweier, Jay L. "Nitrosyl-heme complexes are formed in the ischemic heart: evidence of nitrite-derived nitric oxide formation, storage, and signaling in post-ischemic tissues.." The Journal of biological chemistry. Vol. 279, no. 12. (January 2004.): 11065-73

Li, Haitao; Samouilov, Alexandre; Liu, Xiaoping; Zweier, Jay L. "Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation.." The Journal of biological chemistry. Vol. 279, no. 17. (January 2004.): 16939-46

Dodd-o, Jeffrey, M; Welsh, Laura, E; Salazar, Jorge, D; Walinsky, Peter, L; Peck, Eric, A; Shake, Jay, G; Caparrelli, David, J; Ziegelstein, Roy, C; Zweier, Jay, L; Baumgartner, William, A; Pearse, David B. "Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury.." American journal of physiology. Heart and circulatory physiology. Vol. 287, no. 2. (January 2004.): H927-36

Chen, Yeong-Renn; Chen, Chwen-Lih; Liu, Xiaoping; Li, Haitao; Zweier, Jay, L; Mason, Ronald P. "Involvement of protein radical, protein aggregation, and effects on NO metabolism in the hypochlorite-mediated oxidation of mitochondrial cytochrome c.." Free radical biology & medicine. Vol. 37, no. 10. (January 2004.): 1591-603

Chen, Yeong-Renn; Chen, Chwen-Lih; Chen, Weiguo; Zweier, Jay, L; Augusto, Ohara; Radi, Rafael; Mason, Ronald P. "Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical.." The Journal of biological chemistry. Vol. 279, no. 17. (January 2004.): 18054-62

Liu, Xiaoping; Cheng, Crystal; Zorko, Nicholas; Cronin, Scott; Chen, Yeong-Renn; Zweier, Jay L. "Biphasic modulation of vascular nitric oxide catabolism by oxygen.." American journal of physiology. Heart and circulatory physiology. Vol. 287, no. 6. (January 2004.): H2421-6

Ilangovan, Govindasamy; Zweier, Jay, L; Kuppusamy, Periannan. "Mechanism of oxygen-induced EPR line broadening in lithium phthalocyanine microcrystals.." J Magn Reson. Vol. 170, no. 1. (January 2004.): 42-8

Crowther, Joy, E; Kutala, Vijay Kumar; Kuppusamy, Periannan; Ferguson, J Scott; Beharka, Alison, A; Zweier, Jay, L; McCormack, Francis, ; XSchlesinger, Larry S. "Pulmonary surfactant protein a inhibits macrophage reactive oxygen intermediate production in response to stimuli by reducing NADPH oxidase activity.." J Immunol. Vol. 172, no. 11. (January 2004.): 6866-74

Villamena, Frederick, A; Zweier, Jay L. "Detection of reactive oxygen and nitrogen species by EPR spin trapping.." Antioxidants & redox signaling. Vol. 6, no. 3. (January 2004.): 619-29

Villamena, Frederick, A; Rockenbauer, Antal; Gallucci, Judith; Velayutham, Murugesan; Hadad, Christopher, M; Zweier, Jay L. "Spin trapping by 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO): theoretical and experimental studies.." The Journal of organic chemistry. Vol. 69, no. 23. (January 2004.): 7994-8004

Villamena, Frederick, A; Hadad, Christopher, M; Zweier, Jay L. "Theoretical study of the spin trapping of hydroxyl radical by cyclic nitrones: a density functional theory approach.." Journal of the American Chemical Society. Vol. 126, no. 6. (January 2004.): 1816-29

Mikuni, Tomiko; He, Guanglong; Petryakov, Sergey; Fallouh, Mohanad, M; Deng, Yuanmu; Ishihara, Ryu; Kuppusamy, Periannan; Tatsuta, Masaharu; Zweier, Jay L. "In vivo detection of gastric cancer in rats by electron paramagnetic resonance imaging.." Cancer research. Vol. 64, no. 18. (January 2004.): 6495-502

Zhou, Yingbi; Dirksen, Wessel, P; Zweier, Jay, L; Periasamy, Muthu. "Endothelin-1-induced responses in isolated mouse vessels: the expression and function of receptor types.." American journal of physiology. Heart and circulatory physiology. Vol. 287, no. 2. (January 2004.): H573-8

Foss, Bente Jeanette; Sliwka, Hans-Richard; Partali, Vassilia; Cardounel, Arturo, J; Zweier, Jay, L; Lockwood, Samuel F. "Direct superoxide anion scavenging by a highly water-dispersible carotenoid phospholipid evaluated by electron paramagnetic resonance (EPR) spectroscopy.." Bioorganic & medicinal chemistry letters. Vol. 14, no. 11. (January 2004.): 2807-12

Ilangovan, Govindasamy; Osinbowale, Sola; Bratasz, Anna; Bonar, Mary; Cardounel, Arturo, J; Zweier, Jay, L; Kuppusamy, Periannan. "Heat shock regulates the respiration of cardiac H9c2 cells through upregulation of nitric oxide synthase.." American journal of physiology. Cell physiology. Vol. 287, no. 5. (January 2004.): C1472-81

Kutala, Vijay Kumar; Parinandi, Narasimham, L; Zweier, Jay, L; Kuppusamy, Periannan. "Reaction of superoxide with trityl radical: implications for the determination of superoxide by spectrophotometry.." Archives of biochemistry and biophysics. Vol. 424, no. 1. (January 2004.): 81-8

Kuppusamy, Periannan; Zweier, Jay L. "Cardiac applications of EPR imaging.." NMR in biomedicine. Vol. 17, no. 5. (January 2004.): 226-39

Deng, Yuanmu; He, Guanglong; Petryakov, Sergy; Kuppusamy, Periannan; Zweier, Jay L. "Fast EPR imaging at 300 MHz using spinning magnetic field gradients.." J Magn Reson. Vol. 168, no. 2. (January 2004.): 220-7

Samouilov, Alexandre; Roubaud, Valerie; Kuppusamy, Periannan; Zweier, Jay L. "Kinetic analysis-based quantitation of free radical generation in EPR spin trapping.." Analytical biochemistry. Vol. 334, no. 1. (January 2004.): 145-54

Jackson, Henry, L; Cardounel, Arturo, J; Zweier, Jay, L; Lockwood, Samuel F. "Synthesis, characterization, and direct aqueous superoxide anion scavenging of a highly water-dispersible astaxanthin-amino acid conjugate.." Bioorganic & medicinal chemistry letters. Vol. 14, no. 15. (January 2004.): 3985-91

Ilangovan, Govindasamy; Zweier, Jay, L; Kuppusamy, Periannan. "Microximetry: simultaneous determination of oxygen consumption and free radical production using electron paramagnetic resonance spectroscopy.." Methods in enzymology. Vol. 381, (January 2004.): 747-62

Ilangovan, Govindasamy; Liebgott, Thibaut; Kutala, Vijay Kumar; Petryakov, Sergey; Zweier, Jay, L; Kuppusamy, Periannan. "EPR oximetry in the beating heart: myocardial oxygen consumption rate as an index of postischemic recovery.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 51, no. 4. (January 2004.): 835-42

Ilangovan, Govindasamy; Bratasz, Anna; Li, Haiquan; Schmalbrock, Petra; Zweier, Jay, L; Kuppusamy, Periannan. "In vivo measurement and imaging of tumor oxygenation using coembedded paramagnetic particulates.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 52, no. 3. (January 2004.): 650-7

He, Guanglong; Kutala, Vijay Kumar; Kuppusamy, Periannan; Zweier, Jay L. "In vivo measurement and mapping of skin redox stress induced by ultraviolet light exposure.." Free radical biology & medicine. Vol. 36, no. 5. (January 2004.): 665-72

Zhu, Hong; Itoh, Ken; Yamamoto, Masayuki; Zweier, Jay, L; Li, Yunbo. "Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury.." FEBS letters. Vol. 579, no. 14. (January 2005.): 3029-36

Villamena, Frederick, A; Merle, John, K; Hadad, Christopher, M; Zweier, Jay L. "Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. The thermodynamics of decay and EPR spectral properties.." The journal of physical chemistry. A. Vol. 109, no. 27. (January 2005.): -

Villamena, Frederick, A; Hadad, Christopher, M; Zweier, Jay L. "Comparative DFT study of the spin trapping of methyl, mercapto, hydroperoxy, superoxide, and nitric oxide radicals by various substituted cyclic nitrones.." The journal of physical chemistry. A. Vol. 109, no. 8. (January 2005.): -

Velayutham, Murugesan; Villamena, Frederick, A; Navamal, Mettachit; Fishbein, James, C; Zweier, Jay L. "Glutathione-mediated formation of oxygen free radicals by the major metabolite of oltipraz.." Chemical research in toxicology. Vol. 18, no. 6. (January 2005.): 970-5

Chen, Yeong-Renn; Chen, Chwen-Lih; Zhang, Liwen; Green-Church, Kari, B; Zweier, Jay L. "Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formation.." The Journal of biological chemistry. Vol. 280, no. 45. (January 2005.): 37339-48

Li, Haitao; Cui, Hongmei; Liu, Xiaoping; Zweier, Jay L. "Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation.." The Journal of biological chemistry. Vol. 280, no. 17. (January 2005.): 16594-600

Deng, Yuanmu; Kuppusamy, Periannan; Zweier, Jay L. "Progressive EPR imaging with adaptive projection acquisition.." J Magn Reson. Vol. 174, no. 2. (January 2005.): 177-87

Zhou, Yingbi; Dirksen, Wessel, P; Chen, Yanfang; Morris, Mariana; Zweier, Jay, L; Periasamy, Muthu. "A major role for AT1b receptor in mouse mesenteric resistance vessels and its distribution in heart and neuroendocrine tissues.." Journal of molecular and cellular cardiology. Vol. 38, no. 4. (January 2005.): 693-6

Zhao, Xue; He, Guanglong; Chen, Yeong-Renn; Pandian, Ramasamy, P; Kuppusamy, Periannan; Zweier, Jay L. "Endothelium-derived nitric oxide regulates postischemic myocardial oxygenation and oxygen consumption by modulation of mitochondrial electron transport.." Circulation. Vol. 111, no. 22. (January 2005.): 2966-72

Chen, Yeong-Renn; Chen, Chwen-Lih; Liu, Xiaoping; He, Guanglong; Zweier, Jay L. "Involvement of phospholipid, biomembrane integrity, and NO peroxidase activity in the NO catabolism by cytochrome c oxidase.." Archives of biochemistry and biophysics. Vol. 439, no. 2. (January 2005.): 200-10

Cardounel, Arturo, J; Xia, Yong; Zweier, Jay L. "Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin.." The Journal of biological chemistry. Vol. 280, no. 9. (January 2005.): 7540-9

Henry, Jon, C; Bonar, Mary, M; Kearns, Patrick, N; Cui, Hongmei; Mutchler, Megan, M; Martin, Michael, V; Orsini, Anthony, R; Elford, Howard, L; Bush, Charles, A; Zweier, Jay, L; Cardounel, Arturo J. "Inhibition of ribonucleotide reductase reduces neointimal formation following balloon injury.." The Journal of pharmacology and experimental therapeutics. Vol. 314, no. 1. (January 2005.): 70-6

Zhou, Yingbi; Varadharaj, Saradhadevi; Zhao, Xue; Parinandi, Narasimham; Flavahan, Nicholas, A; Zweier, Jay L. "Acetylcholine causes endothelium-dependent contraction of mouse arteries.." American journal of physiology. Heart and circulatory physiology. Vol. 289, no. 3. (January 2005.): H1027-32

Tritto, Isabella; Wang, Penghai; Kuppusamy, Periannan; Giraldez, Roberto; Zweier, Jay, L; Ambrosio, Giuseppe. "The anti-anginal drug trimetazidine reduces neutrophil-mediated cardiac reperfusion injury.." Journal of cardiovascular pharmacology. Vol. 46, no. 1. (January 2005.): 89-98

Locigno, Edward, J; Zweier, Jay, L; Villamena, Frederick A. "Nitric oxide release from the unimolecular decomposition of the superoxide radical anion adduct of cyclic nitrones in aqueous medium.." Organic & biomolecular chemistry. Vol. 3, no. 17. (January 2005.): 3220-7

Liu, Xiaoping; Liu, Qihui; Gupta, Era; Zorko, Nicholas; Brownlee, Emma; Zweier, Jay L. "Quantitative measurements of NO reaction kinetics with a Clark-type electrode.." Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society. Vol. 13, no. 1. (January 2005.): 68-77

Serrano, Carlos V Jr; Rocha Giraldez, Roberto; de Lara Fernandes, Juliano; Nicolau, Jose Carlos; Zweier, Jay, L; Ramires, Jose Antonio F. "Platelet and leukocyte adhesion and activation in unstable angina and post-PTCA.." International journal of cardiology. Vol. 99, no. 3. (January 2005.): 423-8

Velayutham, Murugesan; Villamena, Frederick, A; Fishbein, James, C; Zweier, Jay L. "Cancer chemopreventive oltipraz generates superoxide anion radical.." Archives of biochemistry and biophysics. Vol. 435, no. 1. (January 2005.): 83-8

Varadharaj, Saradhadevi; Watkins, Tonya; Cardounel, Arturo, J; Garcia, Joe G, N; Zweier, Jay, L; Kuppusamy, Periannan; Natarajan, Viswanathan; Parinandi, Narasimham L. "Vitamin C-induced loss of redox-dependent viability in lung microvascular endothelial cells.." Antioxidants & redox signaling. Vol. 7, no. 1-2. (January 2005.): 287-300

Villamena, Frederick, A; Locigno, Edward, J; Rockenbauer, Antal; Hadad, Christopher, M; Zweier, Jay L. "Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 1. Carbon dioxide radical anion.." The journal of physical chemistry. A. Vol. 110, no. 49. (January 2006.): -

Petryakov, Sergey; Samouilov, Alexandre; Roytenberg, Michael; Li, Haihong; Zweier, Jay L. "Modified Alderman-Grant resonator with high-power stability for proton electron double resonance imaging.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 56, no. 3. (January 2006.): -

Chen, Yeong-Renn; Chen, Chwen-Lih; Yeh, Alexander; Liu, Xiaoping; Zweier, Jay L. "Direct and indirect roles of cytochrome b in the mediation of superoxide generation and NO catabolism by mitochondrial succinate-cytochrome c reductase.." The Journal of biological chemistry. Vol. 281, no. 19. (January 2006.): 13159-68

Xia, Shijing; Villamena, Frederick, A; Hadad, Christopher, M; Kuppusamy, Periannan; Li, Yunbo; Zhu, Hong; Zweier, Jay L. "Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicals.." The Journal of organic chemistry. Vol. 71, no. 19. (January 2006.): -

Venkatakrishnan, C, D; Tewari, Arun, K; Moldovan, Leni; Cardounel, Arturo, J; Zweier, Jay, L; Kuppusamy, Periannan; Ilangovan, Govindasamy. "Heat shock protects cardiac cells from doxorubicin-induced toxicity by activating p38 MAPK and phosphorylation of small heat shock protein 27.." American journal of physiology. Heart and circulatory physiology. Vol. 291, no. 6. (January 2006.): -

Pandian, Ramasamy, P; Dang, Vinh; Manoharan, Periakaruppan, T; Zweier, Jay, L; Kuppusamy, Periannan. "Effect of nitrogen dioxide on the EPR property of lithium octa-n-butoxy 2,3-naphthalocyanine (LiNc-BuO) microcrystals.." J Magn Reson. Vol. 181, no. 1. (January 2006.): 154-61

Pandian RP, Kim YI, Woodward PM, Zweier JL, Manoharan PT, Kuppusamy P.. "The open molecular framework of paramagnetic lithium octabutoxy-naphthalocyanine: implications for the detection of oxygen and nitric oxide using EPR spectroscopy.." Journals of Materials Chemistry. no. 16. (January 2006.): 1-11

Deng, Yuanmu; Pandian, Ramasamy, P; Ahmad, Rizwan; Kuppusamy, Periannan; Zweier, Jay L. "Application of magnetic field over-modulation for improved EPR linewidth measurements using probes with Lorentzian lineshape.." J Magn Reson. Vol. 181, no. 2. (January 2006.): 254-61

Cao, Zhuoxiao; Zhu, Hong; Zhang, Li; Zhao, Xue; Zweier, Jay, L; Li, Yunbo. "Antioxidants and phase 2 enzymes in cardiomyocytes: Chemical inducibility and chemoprotection against oxidant and simulated ischemia-reperfusion injury.." Exp Biol Med (Maywood). Vol. 231, no. 8. (January 2006.): 1353-64

Ahmad, Rizwan; Clymer, Bradley; Deng, Yuanmu; He, Guanglong; Vikram, Deepti; Kuppusamy, Periannan; Zweier, Jay L. "Optimization of data acquisition for EPR imaging.." J Magn Reson. Vol. 179, no. 2. (January 2006.): 263-72

Roy, Sashwati; Khanna, Savita; Kuhn, Donald, E; Rink, Cameron; Williams, Willis, T; Zweier, Jay, L; Sen, Chandan K. "Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix.." Physiological genomics. Vol. 25, no. 3. (January 2006.): -

Xia, Yong; Berlowitz, Carlos, O; Zweier, Jay L. "PIN inhibits nitric oxide and superoxide production from purified neuronal nitric oxide synthase.." Biochimica et biophysica acta. Vol. 1760, no. 9. (January 2006.): 1445-9

Nadolski, Geoff; Cardounel, Arturo, J; Zweier, Jay, L; Lockwood, Samuel F. "The synthesis and aqueous superoxide anion scavenging of water-dispersible lutein esters.." Bioorganic & medicinal chemistry letters. Vol. 16, no. 4. (January 2006.): 775-81

Zhou, Yingbi; Mitra, Srabani; Varadharaj, Saradhadevi; Parinandi, Narasimham; Zweier, Jay, L; Flavahan, Nicholas A. "Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice.." Circulation research. Vol. 98, no. 11. (January 2006.): 1439-45

Ahmad, Rizwan; Vikram, Deepti, S; Petryakov, Sergey; Deng, Yuanmu; Zweier, Jay, L; Kuppusamy, Periannan; Clymer, Bradley. "Automated on-the-fly detection and correction procedure for EPR imaging data acquisition.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 56, no. 3. (January 2006.): -

Ilangovan, Govindasamy; Venkatakrishnan, C, D; Bratasz, Anna; Osinbowale, Sola; Cardounel, Arturo, J; Zweier, Jay, L; Kuppusamy, Periannan. "Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells.." American journal of physiology. Cell physiology. Vol. 290, no. 2. (January 2006.): C313-24

Varadharaj, Saradhadevi; Steinhour, Emily; Hunter, Melissa, G; Watkins, Tonya; Baran, Christopher, P; Magalang, Ulysses; Kuppusamy, Periannan; Zweier, Jay, L; Marsh, Clay, B; Natarajan, Viswanathan; Parinandi, Narasimham L. "Vitamin C-induced activation of phospholipase D in lung microvascular endothelial cells: regulation by MAP kinases.." Cellular signalling. Vol. 18, no. 9. (January 2006.): -

Presley, Tennille; Kuppusamy, Periannan; Zweier, Jay, L; Ilangovan, Govindasamy. "Electron paramagnetic resonance oximetry as a quantitative method to measure cellular respiration: a consideration of oxygen diffusion interference.." Biophysical journal. Vol. 91, no. 12. (January 2006.): -

Li, Haitao; Liu, Xiaoping; Cui, Hongmei; Chen, Yeong-Renn; Cardounel, Arturo, J; Zweier, Jay L. "Characterization of the mechanism of cytochrome P450 reductase-cytochrome P450-mediated nitric oxide and nitrosothiol generation from organic nitrates.." The Journal of biological chemistry. Vol. 281, no. 18. (January 2006.): 12546-54

Li, Haihong; He, Guanglong; Deng, Yuanmu; Kuppusamy, Periannan; Zweier, Jay L. "In vivo proton electron double resonance imaging of the distribution and clearance of nitroxide radicals in mice.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 55, no. 3. (January 2006.): 669-75

Deng, Yuanmu; Shet, Keerthi; Li, Haihong; Kuppusamy, Periannan; Zweier, Jay L. "Real-time calculation and visualization of spectra in field-cycled dynamic nuclear polarization spectroscopy.." Computer methods and programs in biomedicine. Vol. 82, no. 1. (January 2006.): 67-72

Bratasz, Anna; Weir, Nathan, M; Parinandi, Narasimham, L; Zweier, Jay, L; Sridhar, Rajagopalan; Ignarro, Louis, J; Kuppusamy, Periannan. "Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 103, no. 10. (January 2006.): 3914-9

Biondi, Roberto; Ambrosio, Giuseppe; Liebgott, Tibaud; Cardounel, Arturo, J; Bettini, Marco; Tritto, Isabella; Zweier, Jay L. "Hydroxylation of D-phenylalanine as a novel approach to detect hydroxyl radicals: application to cardiac pathophysiology.." Cardiovascular research. Vol. 71, no. 2. (January 2006.): -

Zweier, Jay, L; Talukder, M A Hassan. "The role of oxidants and free radicals in reperfusion injury.." Cardiovascular research. Vol. 70, no. 2. (January 2006.): 181-90

Zhu, Hong; Zhang, Li; Xi, Xiaoqing; Zweier, Jay, L; Li, Yunbo. "4-Hydroxy-2-nonenal upregulates endogenous antioxidants and phase 2 enzymes in rat H9c2 myocardiac cells: protection against overt oxidative and electrophilic injury.." Free radical research. Vol. 40, no. 8. (January 2006.): -

Zhu, Hong; Zhang, Li; Itoh, Ken; Yamamoto, Masayuki; Ross, David; Trush, Michael, A; Zweier, Jay, L; Li, Yunbo. "Nrf2 controls bone marrow stromal cell susceptibility to oxidative and electrophilic stress.." Free radical biology & medicine. Vol. 41, no. 1. (January 2006.): 132-43

Zhao X, Chen RR, He G, Zhang A, Strauch AR, Druhan L, Zweier JL.. "Endothelial Nitric Oxide synthase (NOS3) Knockout Decreases NOS2 Induction Limiting Hyperoxygenation and Conferring Protection in the Postischemic Heart.." Am J Physiol Heart Circ Physiol. Vol. 3, no. 292. (January 2006.): H1541-H1550

Presley T, Kuppusamy P, Zweier JL.. "The role of heat shock protein 90 and endothelial nitric oxide synthase signaling in cardiovascular therapy.." Current Signal transduction Therapy. Vol. 3, no. 1. (January 2006.): 305-315

Zhu, Xuehai; Liu, Bin; Zhou, Shaotang; Chen, Yeong-Renn; Deng, Yuanmu; Zweier, Jay, L; He, Guanglong. "Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption.." American journal of physiology. Heart and circulatory physiology. Vol. 293, no. 3. (January 2007.): -

He, Guanglong; Dumitrescu, Cristian; Petryakov, Sergey; Deng, Yuanmu; Kesselring, Eric; Zweier, Jay L. "Transverse oriented electric field re-entrant resonator (TERR) with automatic tuning and coupling control for EPR spectroscopy and imaging of the beating heart.." Journal of magnetic resonance (San Diego, Calif. : 1997). Vol. 187, no. 1. (January 2007.): -

Forbes, SP; Pope, AJ; Druhan, L; Zweier, J; Cardounel, A. "Regulation of eNOS derived superoxide by endogenous methylarginines." CIRCULATION. Vol. 116, no. 16. (October 2007.): 293-294

Chen, YR; Chen, CL; Zweier, JL. "Nitric oxide generated by eNOS exerts cardioprotection by increasing the mitochondrial biogenesis and decreasing electron leakage for superoxide production by mitochondrial succinate cytochrome c reductase." CIRCULATION. Vol. 116, no. 16. (October 2007.): 183-183

Chen, J; Chen, CL; Palmer, B; Zweier, JL; Chen, YR. "Decreased mitochondrial biogenesis and increased pro-oxidant activity are associated with oxidative impairment of complex 11 in the postischemic heart." CIRCULATION. Vol. 116, no. 16. (October 2007.): 249-249

Chen, CA; Druhan, LJ; Chen, YR; Zweier, JL. "S-glutathiolation of endothelial nitric oxide synthase modulates its enzymatic activity and protects against oxidative damage." CIRCULATION. Vol. 116, no. 16. (October 2007.): 7-7

Turakhia, Samir; Venkatakrishnan, C, D; Dunsmore, Kathy; Wong, Hector; Kuppusamy, Periannan; Zweier, Jay, L; Ilangovan, Govindasamy. "Doxorubicin-induced cardiotoxicity: direct correlation of cardiac fibroblast and H9c2 cell survival and aconitase activity with heat shock protein 27.." American journal of physiology. Heart and circulatory physiology. Vol. 293, no. 5. (January 2007.): -

Petryakov, Sergey; Samouilov, Alexandre; Kesselring, Eric; Wasowicz, Tomasz; Caia, George, L; Zweier, Jay L. "Single loop multi-gap resonator for whole body EPR imaging of mice at 1.2 GHz.." Journal of magnetic resonance (San Diego, Calif. : 1997). Vol. 188, no. 1. (January 2007.): -

Dinkova-Kostova, A, T; Cheah, J; Samouilov, A; Zweier, J, L; Bozak, R, E; Hicks, R, J; Talalay, P. "Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants.." Medicinal chemistry (Sh?ariqah, United Arab Emirates). Vol. 3, no. 3. (January 2007.): -

Dhimitruka, Ilirian; Velayutham, Murugesan; Bobko, Andrey, A; Khramtsov, Valery, V; Villamena, Frederick, A; Hadad, Christopher, M; Zweier, Jay L. "Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging.." Bioorganic & medicinal chemistry letters. Vol. 17, no. 24. (January 2007.): -

Dhimitruka I, Velayutham M, Bobko AA, Khramtsov VV, villamena F, Hadad CM, Zweier JL.. "Large scale synthesis of a trityl spin-probe for use in biomedical EPR imaging.." Bioorg Med Chem Lett. Vol. 24, no. 17. (January 2007.): 6801-6805

Deng, Yuanmu; Petryakov, Sergy; He, Guanglong; Kesselring, Eric; Kuppusamy, Periannan; Zweier, Jay L. "Fast 3D spatial EPR imaging using spiral magnetic field gradient.." Journal of magnetic resonance (San Diego, Calif. : 1997). Vol. 185, no. 2. (January 2007.): -

Yangping, L; Villamena, FA; Sun, J; Xu, Y; Zweier, JL. "Assessment of various ester-derivatized tetrathiatriarylmethyl radicals as intracellular oxygen probes." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 43, (January 2007.): S18-S19

Yan, Qingtao; Liu, Qihui; Zweier, Jay, L; Liu, Xiaoping. "Potency of authentic nitric oxide in inducing aortic relaxation.." Pharmacological research : the official journal of the Italian Pharmacological Society. Vol. 55, no. 4. (January 2007.): -

Xu, Y; Villamena, FA; Liu, Y; Zweier, JL. "EPR studies of a new isopropoxy-carbonylated TPP+-nitrone." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 43, (January 2007.): S18-S18

Villamena, Frederick, A; Xia, Shijing; Merle, John, K; Lauricella, Robert; Tuccio, Beatrice; Hadad, Christopher, M; Zweier, Jay L. "Reactivity of superoxide radical anion with cyclic nitrones: role of intramolecular H-bond and electrostatic effects.." Journal of the American Chemical Society. Vol. 129, no. 26. (January 2007.): -

Villamena, Frederick, A; Merle, John, K; Hadad, Christopher, M; Zweier, Jay L. "Rate constants of hydroperoxyl radical addition to cyclic nitrones: a DFT study.." The journal of physical chemistry. A. Vol. 111, no. 39. (January 2007.): -

Villamena, Frederick, A; Locigno, Edward, J; Rockenbauer, Antal; Hadad, Christopher, M; Zweier, Jay L. "Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. Carbonate radical anion.." The journal of physical chemistry. A. Vol. 111, no. 2. (January 2007.): -

Vikram, Deepti, S; Zweier, Jay, L; Kuppusamy, Periannan. "Methods for noninvasive imaging of tissue hypoxia.." Antioxidants & redox signaling. Vol. 9, no. 10. (January 2007.): -

Velayutham, Murugesan; Muthukumaran, Rajendra, B; Sostaric, Joe, Z; McCraken, John; Fishbein, James, C; Zweier, Jay L. "Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention.." Free radical biology & medicine. Vol. 43, no. 7. (January 2007.): -

Samouilov, Alexandre; Caia, George, L; Kesselring, Eric; Petryakov, Sergey; Wasowicz, Tomasz; Zweier, Jay L. "Development of a hybrid EPR/NMR coimaging system.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 58, no. 1. (January 2007.): -

Samouilov, A; Woldman, Ya Yu; Zweier, J, L; Khramtsov, V V. "Magnetic resonance study of the transmembrane nitrite diffusion.." Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society. Vol. 16, no. 3. (January 2007.): -

Bobko, Andrey, A; Dhimitruka, Ilirian; Zweier, Jay, L; Khramtsov, Valery V. "Trityl radicals as persistent dual function pH and oxygen probes for in vivo electron paramagnetic resonance spectroscopy and imaging: concept and experiment.." Journal of the American Chemical Society. Vol. 129, no. 23. (January 2007.): -

Alzawahra, W; Liu, XP; Li, HT; Samouilov, A; Zweier, JL. "Nitrite functions as a vascular relaxing factor forming NO and activating guanylate cyclase (sGC): Role of sGG in nitrite-mediated NO formation." CIRCULATION. Vol. 116, no. 16. (October 2007.): 296-296

Lu, Dongning; Nadas, Janos; Zhang, Guisheng; Johnson, Wesley; Zweier, Jay, L; Cardounel, Arturo, J; Villamena, Frederick, A; Wang, Peng George. "4-Aryl-1,3,2-oxathiazolylium-5-olates as pH-controlled NO-donors: the next generation of S-nitrosothiols.." Journal of the American Chemical Society. Vol. 129, no. 17. (January 2007.): -

Kundu, Tapan Kumar; Hille, Russ; Velayutham, Murugesan; Zweier, Jay L. "Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues.." Archives of biochemistry and biophysics. Vol. 460, no. 1. (January 2007.): -

Moustafa-Bayoumi M, Alhaj MA, El-Sayed O, Wisel S, Chotani MA, Aboelnaga ZA, Hassona MDH, Morris M, Nuovo G, Zweier JL, Goldschmidt-Clermont P, Hassanain H.. "Vascular Hypertrophy and Hypertension Caused by Transgenic Overexpression of Profilin 1.." J Biol Chem. (January 2007.): -

Hassanain, Hamdy, H; Gregg, David; Marcelo, Maria Luisa; Zweier, Jay, L; Souza, Heraldo, P; Selvakumar, Balakrishnan; Ma, Qi; Moustafa-Bayoumi, Moustafa; Binkley, Phillip, F; Flavahan, Nicholas, A; Morris, Mariana; Dong, Chunming; Goldschmidt-Clermont, Pascal J. "Hypertension caused by transgenic overexpression of Rac1.." Antioxidants & redox signaling. Vol. 9, no. 1. (January 2007.): -

Chen, Yeong-Renn; Chen, Chwen-Lih; Pfeiffer, Douglas, R; Zweier, Jay L. "Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation.." The Journal of biological chemistry. Vol. 282, no. 45. (January 2007.): -

Dinkova-Kostova, AT; Cheah, J; Samouilov, A; Zweier, JL; Bozak, RE; Hicks, RJ; Talalay, P. "Phenolic Michael reaction acceptors: Combined direct and indirect antioxidant Defenses against electrophiles and oxidants." MEDICINAL CHEMISTRY. Vol. 3, no. 3. (January 2007.): 261-268

Talukder, M A Hassan; Kalyanasundaram, Anuradha; Zhao, Xue; Zuo, Li; Bhupathy, Poornima; Babu, Gopal, J; Cardounel, Arturo, J; Periasamy, Muthu; Zweier, Jay L. "Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction.." American journal of physiology. Heart and circulatory physiology. Vol. 293, no. 4. (January 2007.): -

Chen, Chwen-Lih; Zhang, Liwen; Yeh, Alexander; Chen, Chun-An; Green-Church, Kari, B; Zweier, Jay, L; Chen, Yeong-Renn. "Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase.." Biochemistry. Vol. 46, no. 19. (January 2007.): -

Ahmad, Rizwan; Deng, Yuanmu; Vikram, Deepti, S; Clymer, Bradley; Srinivasan, Parthasarathy; Zweier, Jay, L; Kuppusamy, Periannan. "Quasi Monte Carlo-based isotropic distribution of gradient directions for improved reconstruction quality of 3D EPR imaging.." Journal of magnetic resonance (San Diego, Calif. : 1997). Vol. 184, no. 2. (January 2007.): -

Ahmad R, Clymer B, Vikram DS, Deng Y, Hirata H, Zweier JL, Kuppusamy P.. "Enhanced Resolution for EPR Imaging by Two-Step Deblurring.." J Magn Reson. no. 184. (January 2007.): 246-257

Khan, Mahmood; Kutala, Vijay Kumar; Vikram, Deepti, S; Wisel, Sheik; Chacko, Simi, M; Kuppusamy, M Lakshmi; Mohan, Iyyapu, K; Zweier, Jay, L; Kwiatkowski, Pawel; Kuppusamy, Periannan. "Skeletal myoblasts transplanted in the ischemic myocardium enhance in situ oxygenation and recovery of contractile function.." American journal of physiology. Heart and circulatory physiology. Vol. 293, no. 4. (January 2007.): -

Bobko, Andrey, A; Kirilyuk, Igor, A; Grigor'ev, Igor, A; Zweier, Jay, L; Khramtsov, Valery V. "Reversible reduction of nitroxides to hydroxylamines: roles for ascorbate and glutathione.." Free radical biology & medicine. Vol. 42, no. 3. (January 2007.): -

Liu, Zhenguo; Jiang, Yuehua; Hao, Hong; Gupta, Kalpna; Xu, Jian; Chu, Ling; McFalls, Edward; Zweier, Jay; Verfaillie, Catherine; Bache, Robert J. "Endothelial nitric oxide synthase is dynamically expressed during bone marrow stem cell differentiation into endothelial cells.." American journal of physiology. Heart and circulatory physiology. Vol. 293, no. 3. (January 2007.): -

Liu, Xiaoping; Yan, Qingtao; Baskerville, Kim, L; Zweier, Jay L. "Estimation of nitric oxide concentration in blood for different rates of generation. Evidence that intravascular nitric oxide levels are too low to exert physiological effects.." The Journal of biological chemistry. Vol. 282, no. 12. (January 2007.): -

Han, Y; Tuccio, B; Lauricella, R; Rockenbauer, A; Zweier, JL; Villamena, FA. "Synthesis and spin trapping properties of a new spirolactonyl-nitrone." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 43, (January 2007.): S14-S14

Dumitrescu, Cristian; Biondi, Roberto; Xia, Yong; Cardounel, Arturo, J; Druhan, Lawrence, J; Ambrosio, Giuseppe; Zweier, Jay L. "Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 104, no. 38. (January 2007.): -

Ahmad, Rizwan; Vikram, Deepti, S; Clymer, Bradley; Potter, Lee, C; Deng, Yuanmu; Srinivasan, Parthasarathy; Zweier, Jay, L; Kuppusamy, Periannan. "Uniform distribution of projection data for improved reconstruction quality of 4D EPR imaging.." Journal of magnetic resonance (San Diego, Calif. : 1997). Vol. 187, no. 2. (January 2007.): -

Talukder, MAH; Nishijima, Y; Bonagura, JD; Kalyanasundaram, A; Periasamy, M; Shimokawa, H; Zweier, JL. "Short-term treatment with DITPA, a thyroid hormone analog, improves postischemic coronary flow and cardiac contractile function in hypertensive endothelial nitric oxide synthase knockout (eNOS-KO) mice." CIRCULATION. Vol. 116, no. 16. (October 2007.): 199-199

Sun, J; Druhan, LJ; Zweier, JL. "Superoxide promotes reversible uncoupling of inducible nitric oxide synthase, while peroxynitrite induces irreversible and complete enzyme inactivation." CIRCULATION. Vol. 116, no. 16. (October 2007.): 7-7

Liu, X; Srinivasan, P; Collard, E; Grajdeanu, P; Zweier, JL; Friedman, A. "Oxygen regulates the flux of nitric oxide diffusion across the vascular wall." CIRCULATION. Vol. 116, no. 16. (October 2007.): 27-27

Zhu, Xuehai; Zuo, Li; Cardounel, Arturo, J; Zweier, Jay, L; He, Guanglong. "Characterization of in vivo tissue redox status, oxygenation, and formation of reactive oxygen species in postischemic myocardium.." Antioxidants & redox signaling. Vol. 9, no. 4. (January 2007.): -

Zhao, Xue; Chen, Yeong-Renn; He, Guanglong; Zhang, Aiwen; Druhan, Lawrence, J; Strauch, Arthur, R; Zweier, Jay L. "Endothelial nitric oxide synthase (NOS3) knockout decreases NOS2 induction, limiting hyperoxygenation and conferring protection in the postischemic heart.." American journal of physiology. Heart and circulatory physiology. Vol. 292, no. 3. (January 2007.): -

Han, Zhaosheng; Chen, Yeong-Renn; Jones, Charles I 3rd; Meenakshisundaram, Guruguhan; Zweier, Jay, L; Alevriadou, B Rita. "Shear-induced reactive nitrogen species inhibit mitochondrial respiratory complex activities in cultured vascular endothelial cells.." American journal of physiology. Cell physiology. Vol. 292, no. 3. (January 2007.): -

Cardounel, Arturo, J; Cui, Hongmei; Samouilov, Alexandre; Johnson, Wesley; Kearns, Patrick; Tsai, Ah-Lim; Berka, Vladomir; Zweier, Jay L. "Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function.." The Journal of biological chemistry. Vol. 282, no. 2. (January 2007.): -

Sun J, Druhan LJ, Zweier JL. "Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase." Arch. Biochem. Biophys. Vol. 2, no. 471. (January 2008.): 126-133

Jones CI 3rd, Han Z, Presley T, Varadharaj S, Zweier JL, Ilangovan G, Alevriadou BR. "Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite." Am J Physiol Cell Physiol. no. 295(1). (January 2008.): C180-91

Han Y, Tuccio B, Lauricella R, Rockenbauer A, Zweier JL, Villamena FA. "Synthesis and spin-trapping properties of a new spirolactonyl nitrone.." Journal of Organic Chemistry. Vol. 7, no. 73. (January 2008.): 2533-2541

Alzawahra WF, Talukder MA, Liu X, Samouilov A, Zweier JL.. "Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall." Am J Physiol Heart Circ Physiol. no. 295(2). (January 2008.): H499-508

Wu, W; Kehn-Hall, K; Pedati, C; Zweier, L; Castro, I; Klase, Z; Dowd, CS; Dubrovsky, L; Bukrinsky, M; Kashanchi, F. "Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formation." VIROLOGY JOURNAL. Vol. 5, (March 2008.): -

Venkatakrishnan, CD; Dunsmore, K; Wong, H; Roy, S; Sen, CK; Wani, A; Zweier, JL; Ilangovan, G. "HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G(2)/M phase cell cycle arrest." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. Vol. 294, no. 4. (April 2008.): H1736-H1744

Liu Y, Villamena FA, Zweier JL. "Highly stable dendritic trityl radicals as oxygen and pH probe.." Chem Commun (Camb). no. 28;(36):. (September 2008.): 4336-8

Cisse, B; Caton, ML; Lehner, M; Maeda, T; Scheu, S; Locksley, R; Holmberg, D; Zweier, C; den Hollander, NS; Kant, SG; Holter, W; Rauch, A; Zhuang, YA; Reizis, B. "Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development." CELL. Vol. 135, no. 1. (October 2008.): 37-48

Chen, CL; Varadhara, S; Kaumaya, PP; Zweier, JL; Chen, YR. "Oxidative Modification with Protein Tyrosine Nitration Occurs following Deglutathiolation of the 70 kDa Flavoprotein of Mitochondrial Complex II Is Associated with Loss of Electron Transfer Activity In the Post-Ischemic Myocardium." CIRCULATION. Vol. 118, no. 18. (October 2008.): S273-S273

Chen, CL; Chen, JF; Rawale, S; Varadharaj, S; Kaumaya, PPT; Zweier, JL; Chen, YR. "Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial Complex II in the post-ischemic myocardium." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 283, no. 41. (October 2008.): 27991-28003

Chen, CA; Druhan, LJ; Wang, TY; Chen, YR; Zweier, JL. "S-glutathiolation Uncouples Endothelial Nitric Oxide (NO) Synthase, Switching Enzyme from NO to Superoxide Production." CIRCULATION. Vol. 118, no. 18. (October 2008.): S274-S274

Chen, CA; Druhan, LJ; Varadharaj, S; Chen, YR; Zweier, JL. "Phosphorylation and L-Arginine Increase Superoxide Generation from Endothelial Nitric Oxide Synthase (eNOS)." CIRCULATION. Vol. 118, no. 18. (October 2008.): S273-S273

Villamena, FA; Liu, YP; Zweier, JL. "Superoxide Radical Anion Adduct of 5,5-Dimethyl-1-pyrroline N-Oxide. 4. Conformational Effects on the EPR Hyperfine Splitting Constants." JOURNAL OF PHYSICAL CHEMISTRY A. Vol. 112, no. 49. (December 2008.): 12607-12615

Talukder MA, Yang F, Nishijima Y, Chen CA, Kalyanasundaram A, Periasamy M, Zweier JL. "Reduced SERCA2a converts sub-lethal myocardial injury to infarction and affects postischemic functional recovery." J Mol Cell Cardiol. (November 2008.): -

Xu Y, Liu B, Zweier JL, He G. "Formation of Hydrogen Peroxide and Reduction of Peroxynitrite via Dismutation of Superoxide at Reperfusion Enhances Myocardial Blood Flow and Oxygen Consumption in Postischemic Mouse Heart." J Pharmacol Exp Ther. (January 2008.): -

Sun, Qinghua; Yue, Peibin; Ying, Zhekang; Cardounel, Arturo, J; Brook, Robert, D; Devlin, Robert; Hwang, Jing-Shiang; Zweier, Jay, L; Chen, Lung Chi; Rajagopalan, Sanjay. "Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK.." Arteriosclerosis, thrombosis, and vascular biology. Vol. 28, no. 10. (January 2008.): 1760-6

Patt, B; Sun, J; Zweier, J; Cardounel, A; Schutzman, S; Khayat, R. "Endothelial dysfunction in obstructive sleep apnea is due to increased endogenous inhibitors of nitric oxide." SLEEP. Vol. 31, (January 2008.): A174-A174

Li H, Cui H, Kundu TK, Alzawahra W, Zweier JL. "Nitric Oxide production from nitrite occurs primarily in tissues not in the blood: Critical role of xanthine oxidase and aldehyde oxidase." J Biol Chem. no. 283(26). (January 2008.): 17855-63

Lee, MCI; Velayutham, M; Shoji, H; Yoshino, F; Hille, R; Zweier, JL. "Measurement and Characterization of Superoxide Generation From Xanthine Dehydrogenase: a Redox Regulated Pathway of Radical Generation in Ischemic Tissues." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 45, (January 2008.): S150-S151

Hirata, H; He, GL; Deng, YM; Salikhov, I; Petryakov, S; Zweier, JL. "A loop resonator for slice-selective in vivo EPR imaging in rats." JOURNAL OF MAGNETIC RESONANCE. Vol. 190, no. 1. (January 2008.): 124-134

Liu, Y; Villamena, FA; Sun, J; Xu, Y; Dhimitruka, I; Zweier, JL. "Synthesis and characterization of ester-derivatized tetrathiatriarylmethyl radicals as intracellular oxygen probes." JOURNAL OF ORGANIC CHEMISTRY. Vol. 73, no. 4. (February 2008.): 1490-1497

Huehne, K; Zweier, C; Raab, K; Odent, S; Bonnaure-Mallet, M; Sixou, JL; Landrieu, P; Goizet, C; Sarlangue, J; Baumann, M; Eggermann, T; Rauch, A; Ruppert, S; Stettner, GM; Rautenstrauss, B. "Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis." NEUROMUSCULAR DISORDERS. Vol. 18, no. 2. (February 2008.): 159-166

Burns, PM; Kearns, PN; Nishijima, Y; Vargas-Pinto, P; Ding, Y; Jekic, M; Lian, J; Lin, HY; Huang, K; Simonetti, OP; Zweier, JL. "Real-time magnetic resonance imaging (MRI) of the time course of myocardial injury and cell death in a canine model of regional ischemia and reperfusion." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Vol. 51, no. 10. (March 2008.): A186-A186

Li, HT; Cui, HM; Kundu, TK; Alzawahra, W; Zweier, JL. "Nitric oxide production from nitrite occurs primarily in tissues not in the blood - Critical role of xanthine oxidase and aldehyde oxidase." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 283, no. 26. (June 2008.): 17855-17863

Kohr, MJ; Wang, H; Wheeler, DG; Velayutham, M; Zweier, JL; Ziolo, MT. "Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile state." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 45, no. 1. (July 2008.): 73-80

Jones, CI; Han, ZS; Presley, T; Varadharaj, S; Zweier, JL; Ilangovan, G; Alevriadou, BR. "Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite." AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. Vol. 295, no. 1. (July 2008.): C180-C191

Souza HP, Frediani D, Cobra AL, Moretti AI, Jurado MC, Fernandes TR, Cardounel AJ, Zweier JL, Tostes RC. "Angiotension II modulates CD40 expression in vascular smooth muscle cells.." Clin Sci (Lond).. (September 2008.): -

Holland, R; Velayutham, M; Hawkins, A; Eggler, AL; Zweier, JL; Fabris, D; Mesecar, AD; Kensler, TW; Fishbein, JC. "Examination of Reactive Oxygen Species as General Signaling Agents of Dithiolethiones and the Biochemical Repercussions of Their Action." CHEMICAL RESEARCH IN TOXICOLOGY. Vol. 21, no. 12. (December 2008.): 2436-2436

Kundu, TK; Velayutham, M; Hille, R; Zweier, JL. "NADH Oxidase Activity of Rat Liver Aldehyde Oxidase: Evaluation of Its Role in the Generation of Reactive Oxygen Species." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 45, (January 2008.): S19-S19

Kohr MJ, Wang H, Wheeler DG, Velayutham M, Zweier JL, Ziolo MT.. "Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile state." Free Radic Biol Med. no. 45(1). (January 2008.): 73-80

Kohr, MJ; Wang, H; Wheeler, DG; Velayutham, M; Zweier, JL; Ziolo, MT. "Targeting of phospholamban by peroxynitrite decreases beta-adrenergic stimulation in cardiomyocytes." CARDIOVASCULAR RESEARCH. Vol. 77, no. 2. (January 2008.): 353-361

Dhimitruka I, Bobko AA, Hadad CM, Zweier JL, Khramtsov VV. "Synthesis and characterization of amino derivatives of persistent trityl radicals as dual function pH and oxygen paramagnetic probes." J Am Chem Soc. no. 130(32):. (January 2008.): 10780-7

Chen CL, Chen J, Rawale S, Varadharaj S, Kaumaya PP, Zweier JL, Chen YR. "Protein tyrosine nitration of flavin subunit is associated with oxidative modification of mitochondrial complex II in the post-ischemic myocardium." J Biol Chem. (January 2008.): -

Chen CA, Druhan LJ, Varadharaj S, Chen YR, Zweier JL. "Phosphorylation of endothelial nitric oxide synthase (eNOS) regulates superoxide generation from the enzyme." J Biol Chem. (January 2008.): -

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Moldovan, NI; Anghelina, MI; Butt, OI; Wang, TS; Zweier, JL. "Role of oxygen and ROS in bone marrow derived progenitor cells accumulation in infarcted hearts: Implications for ventricular aneurysm formation." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Vol. 51, no. 10. (March 2008.): A190-A190

Moldovan, L; Moldovan, NI; Sun, J; Bergdall, V; Biswas, S; Sen, CK; Zweier, JL. "Critical role of arginase in nitric oxide metabolism in preclinical swine wound healing." WOUND REPAIR AND REGENERATION. Vol. 16, no. 2. (March 2008.): A51-A51

Ojha, N; Roy, S; Radtke, J; Simonetti, O; Gnyawali, S; Zweier, JL; Kuppusamy, P; Sen, CK. "Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. Vol. 294, no. 6. (June 2008.): H2435-H2443

Dhimitruka, I; Bobko, AA; Hadad, CM; Zweier, JL; Khramtsov, VV. "Synthesis and characterization of amino derivatives of persistent trityl radicals as dual function pH and oxygen paramagnetic probes." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. Vol. 130, no. 32. (August 2008.): 10780-10787

Varadharaj, S; Druhan, LJ; Chen, CA; Wang, TY; Wani, MA; Zweier, JL. "Intracellular Protein Trafficking In The Vascular Endothelium Is Regulated By Golgi Resident Nitric Oxide Sythase." CIRCULATION. Vol. 118, no. 18. (October 2008.): S274-S274

Sun, QH; Yue, PB; Ying, ZK; Cardounel, AJ; Brook, RD; Devlin, R; Hwang, JS; Zweier, JL; Chen, LC; Rajagopalan, S. "Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK." ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. Vol. 28, no. 10. (October 2008.): 1760-1766

Tejero, JS; Biswas, A; Wang, ZQ; Page, RC; Haque, MM; Hemann, C; Zweier, JL; Misra, S; Stuehr, DJ. "Stabilization and Characterization of a Heme-Oxy Reaction Intermediate in Inducible Nitric-oxide Synthase." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 283, no. 48. (November 2008.): 33498-33507

Tejero J, Biswas A, Wang ZQ, Page RC, Haque MM, Hemann C, Zweier JL, Misra S, Stuehr DJ. "Stabilization and Characterization of a Heme-Oxy Reaction Intermediate in Inducible Nitric-oxide Synthase.." J Biol Chem. no. 283(48):. (November 2008.): 33498-507

Presley, T; Vedam, K; Velayutham, M; Zweier, JL; Ilangovan, G. "Activation of Hsp90-eNOS and increased NO generation attenuate respiration of hypoxia-treated endothelial cells." AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. Vol. 295, no. 5. (November 2008.): C1281-C1291

Presley T, Vedam K, Velayutham M, Zweier JL, Ilangovan G. "Activation of Hsp90-eNOS and increased NO generation attenuate respiration of hypoxia-treated endothelial cells.." Am J Physiol Cell Physiol. no. 295(5):. (November 2008.): C1281-

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Raman, SV; Winner, MW; Tran, T; Velayutham, M; Simonetti, OP; Baker, PB; Olesik, J; McCarthy, B; Ferketich, AK; Zweier, JL. "In Vivo Atherosclerotic Plaque Characterization Using Magnetic Susceptibility Distinguishes Symptom-Producing Plaques." JACC-CARDIOVASCULAR IMAGING. Vol. 1, no. 1. (January 2008.): 49-57

Raman SV, Winner MW, Tran T, Velayutham M, Simonetti OP, Baker PB, Olesik J, McCarthy B, Ferketich AK, Zweier JL.. "In Vivo Atherosclerotic Plaque Characterization Using Magnetic Susceptibility Distinguishes Symptom-Producing Plaques.." JACC: Cardiovascular Imaging. (January 2008.): -

Talukder MAH, Kalyanasundaram A, Zuo L, Velayutham M, Nishijima Y, Periasamy M, Zweier JL. "Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice." American Journal of Physiology – Heart and Circulatory Physiology. Vol. 3, no. 294. (January 2008.): H1426-H1434

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Druhan LJ, Forbes SP, Pope AJ, Chen CA, Zweier JL, Cardounel AJ. "Regulation of eNOS-derived superoxide by endogenous methylarginines." Biochemistry. no. 47(27). (January 2008.): 7256-63

Talukder, MAH; Kalyanasundaram, A; Zuo, L; Velayutham, M; Nishijima, Y; Periasamy, M; Zweier, JL. "Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. Vol. 294, no. 3. (March 2008.): H1426-H1434

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Xu, Y; Liu, B; Zweier, JL; He, GL. "Formation of Hydrogen Peroxide and Reduction of Peroxynitrite via Dismutation of Superoxide at Reperfusion Enhances Myocardial Blood Flow and Oxygen Consumption in Postischemic Mouse Heart." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. Vol. 327, no. 2. (November 2008.): 402-410

Ojha N, Roy S, Radtke J, Simonetti O, Gnyawali S, Zweier JL, Kuppusamy P, Sen CK. "Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury." Am J Physiol Heart Circ Physiol. no. 294(6). (January 2008.): H2435-43

Ojha N, Roy S, He G, Biswas S, Velayutham M, Khanna S, Kuppusamy P, Zweier JL, Sen CK. "Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing.." Free Radical Biology and Medicine. Vol. 4, no. 44. (January 2008.): 682-691

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Venkatakrishnan CD, Dunsmore K, Wong H, Roy S, Sen CK, Wani A, Zweier JL, Ilangovan G. "HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G(2)/M phase cell cycle arrest.." American Journal of Physiology â€“ Heart and Circulatory Physiology. Vol. 4, no. 294. (January 2008.): H1736-H1744

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Liu Y, Villamena F, Sun J, Xu Y, Dhimitruka I, Zweier J.. "Synthesis and Characterization of Ester-Derivatized Tetrathiatriarylmethyl Radicals as Intracellular Oxygen Probes.." Journal of Organic Chemistry. (January 2008.): -

Talukder, MAH; Zuo, L; Kalyanasundaram, A; Murugesan, V; Periasamy, M; Zweier, JL. "Is sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) inhibition detrimental or beneficial for postischemic myocardial function and injury? Evidence from SERCA2a-deficient mice." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Vol. 51, no. 10. (March 2008.): A184-A184

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Han, Y; Tuccio, B; Lauricella, R; Rockenbauer, A; Zweier, JL; Villamena, FA. "Synthesis and spin-trapping properties of a new spirolactonyl nitrone." JOURNAL OF ORGANIC CHEMISTRY. Vol. 73, no. 7. (April 2008.): 2533-2541

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Chu, L; Jiang, YH; Hao, H; Xia, Y; Xu, J; Liu, ZH; Verfaillie, CM; Zweier, JL; Liu, ZG. "Nitric oxide enhances Oct-4 expression in bone marrow stem cells and promotes endothelial differentiation." EUROPEAN JOURNAL OF PHARMACOLOGY. Vol. 591, no. 1-3. (September 2008.): 59-65

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Villamena FA, Liu Y, Zweier JL. "Superoxide Radical Anion Adduct of 5,5-Dimethyl-1-pyrroline N-Oxide. 4. Conformational Effects on the EPR Hyperfine Splitting Constants.." J Phys Chem A. (November 2008.): -

Liu Z, Lei M, Jiang Y, Hao H, Chu L, Xu J, Luo M, Verfaillie CM, Zweier JL, Liu Z.. "High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signaling.." J Cell Mol Med. (September 2008.): -

Kohr MJ, Wang H, Wheeler DG, Velayutham M, Zweier JL, Ziolo MT. "Targeting of phospholamban by peroxynitrite decreases beta-adrenergic stimulation in cardiomyocytes." Cardiovascular Research. Vol. 2, no. 77. (January 2008.): 353-361

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Liu, XP; Srinivasant, P; Collard, E; Grajdeanu, P; Zweier, JL; Friedmant, A. "Nitric oxide diffusion rate is reduced in the aortic wall." BIOPHYSICAL JOURNAL. Vol. 94, no. 5. (March 2008.): 1880-1889

Alzawahra, WF; Talukder, MAH; Liu, XP; Samouilov, A; Zweier, JL. "Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. Vol. 295, no. 2. (August 2008.): H499-H508

Li, HT; Kundu, TK; Zweier, JL. "Characterization of the Magnitude and Mechanism of Aldehyde Oxidase-mediated Nitric Oxide Production." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 47, (January 2009.): S189-S189

Talukder, MAH; Yang, F; Nishijima, Y; Chen, CA; Kalyanasundaram, A; Periasamy, M; Zweier, JL. "Reduced SERCA2a converts sub-lethal myocardial injury to infarction and affects postischemic functional recovery." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. Vol. 46, no. 2. (February 2009.): 285-287

Crestanello, JA; Lee, DS; Steinbaugh, GE; Pfeiffer, DR; Zweier, JL. "Ischemic Preconditioning Selectively Protects Subsarcolemmal Mitochondrial Respiration Against Ischemic Injury." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Vol. 53, no. 10. (March 2009.): A307-A307

Soorappan, RN; Block, K; Varadharaj, S; Davidson, CJ; Jones, DP; Zweier, JL; Benjamin, IJ. "Evidence Against ROS-Induced Macromolecular Damage as a Causal Mechanism for hR120GCryAB Cardiomyopathy in Mice." CIRCULATION RESEARCH. Vol. 105, no. 7. (September 2009.): E21-E21

Chen, JF; Chen, CL; Chen, CA; Kaumaya, PP; Zweier, JL; Chen, YR. "Peptide-based Antibodies Against Glutathione-binding Domains Suppress Superoxide Production Mediated by Mitochondrial Complex I." CIRCULATION. Vol. 120, no. 18. (November 2009.): S1020-S1020

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Talukder, MAH; Zweier, JL; Periasamy, M. "Targeting calcium transport in ischaemic heart disease." CARDIOVASCULAR RESEARCH. Vol. 84, no. 3. (December 2009.): 345-352

Liu, YP; Villamena, FA; Rockenbauer, A; Zweier, JL. "Development of Trityl-nitroxide Biradicals: Unique Probes for Simultaneous Measurement of Redox Status and Oxygenation." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 47, (January 2009.): S189-S189

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Caia, G; Sun, ZQ; Yang, FC; Petryakov, S; Velayutham, M; Samouilov, A; Zweier, JL. "EPR/NMR Co-imaging of In Vivo Redox Status in Mice." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 47, (January 2009.): S55-S55

Yang, FC; Talukder, MAH; Zweier, JL. "Ischemic Preconditioning Robustly Reduces In Vivo Myocardial Infarction in Both Male and Female Mice With Short or Long Ischemic Periods and This Protection Is Lost in the Absence of Endothelial Nitric Oxide Synthase." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Vol. 53, no. 10. (March 2009.): A308-A308

Wang, TS; Wang, TY; Sun, J; Chen, CA; Yang, FC; Talukder, MAH; Zweier, JL. "In Vivo Myocardial Ischemia Reperfusion (I/R) Impairs Nitric Oxide Synthase (NOS) Activity: Potent Cardioprotection With BH4 Treatment." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Vol. 53, no. 10. (March 2009.): A312-A313

Talukder, MAH; Johnson, W; Varadharaj, S; Lian, JR; Kearns, P; Druhan, L; Liu, XP; Zweier, J. "Cigarette Smoke Exposure Results in Hypertension, Endothelial Dysfunction, Cardiac Hypertrophy, and Leukocyte-Specific Reactive Oxygen Species (ROS) Generation in Mice." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Vol. 53, no. 10. (March 2009.): A400-A400

Liu, YP; Villamena, FA; Sun, J; Wang, TY; Zweier, JL. "Esterified trityl radicals as intracellular oxygen probes." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 46, no. 7. (April 2009.): 876-883

Zweier, JL. "Mechanisms of nitrite reduction to nitric oxide in the vessel wall." NITRIC OXIDE-BIOLOGY AND CHEMISTRY. Vol. 20, (June 2009.): S21-S21

Liu, ZG; Chu, L; Hao, H; Luo, M; Liu, ZH; Huang, Y; Chen, ZY; Verfaillie, CM; Zweier, JL. "Ox-LDL Modifies the Behavior of Bone Marrow Stem Cells and Impairs Their Endothelial Differentiation via Inhibition of Akt Phosphorylation." ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. Vol. 29, no. 7. (July 2009.): E38-E38

Soorappan, RN; Varadharaj, S; Khanderao, GD; Davidson, CJ; Zweier, JL; Benjamin, IJ. "Oxidative Stress and Activation of Nrf2 Precedes the Pathogenic Transition of Reductive Stress-Induced Cardiomyopathy in Mice." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 47, (January 2009.): S65-S65

Chu, L; Hao, H; Liu, ZH; Xu, J; Luo, M; Huang, Y; Chen, ZY; Verfaillie, CM; Zweier, JL; Liu, ZG. "Ox-LDL Modifies the Behavior of Bone Marrow Stem Cells and Impairs Their Endothelial Differentiation via Inhibition of Akt Activation." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Vol. 53, no. 10. (March 2009.): A199-A199

Zhao, X; Zhang, JY; Mei, X; Liao, DN; Hu, JQ; Li, L; Liu, ZG; Zweier, JL. "Pulmonary vein electric shunting for therapy of atrial fibrillation." MEDICAL HYPOTHESES. Vol. 72, no. 4. (April 2009.): 474-475

Liu, ZH; Lei, MX; Jiang, YH; Hao, H; Chu, L; Xu, J; Luo, M; Verfaillie, CM; Zweier, JL; Liu, ZG. "High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signalling." JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol. 13, no. 9B. (September 2009.): 3427-3436

Chan, SY; Zhang, YY; Hemann, C; Mahoney, CE; Zweier, JL; Loscalzo, J. "MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2." CELL METABOLISM. Vol. 10, no. 4. (October 2009.): 273-284

Yang, FC; Talukder, MAH; Zweier, JL. "Are There Gender Differences in Cardioprotection? Influence of Aging and Endothelial Nitric Oxide Synthase (eNOS)." CIRCULATION. Vol. 120, no. 18. (November 2009.): S737-S737

Woldman, YY; Sun, J; Zweier, JL; Khramtsov, VV. "Direct chemiluminescence detection of nitric oxide in aqueous solutions using the natural nitric oxide target soluble guanylyl cyclase." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 47, no. 10. (November 2009.): 1339-1345

Talukder, MAH; Yang, FC; Wang, TS; Mammen, PP; Zweier, JL. "Role of Myoglobin in the Postischemic Heart." CIRCULATION. Vol. 120, no. 18. (November 2009.): S846-S846

Lundberg, JO; Gladwin, MT; Ahluwalia, A; Benjamin, N; Bryan, NS; Butler, A; Cabrales, P; Fago, A; Feelisch, M; Ford, PC; Freeman, BA; Frenneaux, M; Friedman, J; Kelm, M; Kevil, CG; Kim-Shapiro, DB; Kozlov, AV; Lancaster, JR; Lefer, DJ; McColl, K; McCurry, K; Patel, RP; Petersson, J; Rassaf, T; Reutov, VP; Richter-Addo, GB; Schechter, A; Shiva, S; Tsuchiya, K; van Faassen, EE; Webb, AJ; Zuckerbraun, BS; Zweier, JL; Weitzberg, E. "Nitrate and nitrite in biology, nutrition and therapeutics." NATURE CHEMICAL BIOLOGY. Vol. 5, no. 12. (December 2009.): 865-869

Li, HT; Kundu, TK; Zweier, JL. "Characterization of the Magnitude and Mechanism of Aldehyde Oxidase-mediated Nitric Oxide Production from Nitrite." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 284, no. 49. (December 2009.): 33850-33858

Zuo, L; Chen, YR; Reyes, LA; Lee, HL; Chen, CL; Villamena, FA; Zweier, JL. "The Radical Trap 5,5-Dimethyl-1-Pyrroline N-Oxide Exerts Dose-Dependent Protection against Myocardial Ischemia-Reperfusion Injury through Preservation of Mitochondrial Electron Transport." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. Vol. 329, no. 2. (May 2009.): 515-523

van Faassen, EE; Babrami, S; Feelisch, M; Hogg, N; Kelm, M; Kim-Shapiro, DB; Kozlov, AV; Li, HT; Lundberg, JO; Mason, R; Nohl, H; Rassaf, T; Samouilov, A; Slama-Schwok, A; Shiva, S; Vanin, AF; Weitzberg, E; Zweier, J; Gladwin, MT. "Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology." MEDICINAL RESEARCH REVIEWS. Vol. 29, no. 5. (September 2009.): 683-741

Petryakov, S; Samouilov, A; Chzhan-Roytenberg, M; Kesselring, E; Sun, ZQ; Zweier, JL. "Segmented surface coil resonator for in vivo EPR applications at 1.1 GHz." JOURNAL OF MAGNETIC RESONANCE. Vol. 198, no. 1. (May 2009.): 8-14

Liu, B; Tewari, AK; Zhang, LW; Green-Church, KB; Zweier, JL; Chen, YR; He, GL. "Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: Mitochondria as the major target." BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. Vol. 1794, no. 3. (March 2009.): 476-485

Velayutham, M; Villamena, FA; Fishbein, JC; Zweier, JL. "Generation of Singlet Oxygen by Cancer Chemopreventive Oltipraz on Illumination with Visible Light: Role of Melatonin." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 47, (January 2009.): S177-S177

Varadharaj, S; Druhan, LJ; Jackson, A; Soorappan, R; Zweier, JL. "Discrete Activation of the two Subcellular Nitric Oxide Synthase Pools Differentially Regulates Exocytosis in the Vascular Endothelium." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 47, (January 2009.): S67-S67

Racoma, I; Wang, A; Zweier, JL; Villamena, FA. "Effects of Natural and Synthetic Antioxidants on Uncoupled Endothelial Nitric Oxide Synthase Function." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 47, (January 2009.): S150-S150

Steinbaugh, GE; Lee, DS; Pfeiffer, DR; Zweier, JL; Crestanello, JA. "Ischemic Preconditioning Protects Mitochondrial Respiratory Function in Complex I and Complex II." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Vol. 53, no. 10. (March 2009.): A309-A309

Souza, HP; Frediani, D; Cobra, AL; Moretti, AI; Jurado, MC; Fernandes, TR; Cardounel, AJ; Zweier, JL; Tostes, RC. "Angiotensin II modulates CD40 expression in vascular smooth muscle cells." CLINICAL SCIENCE. Vol. 116, no. 5-6. (March 2009.): 423-431

Han, ZS; Varadharaj, S; Giedt, RJ; Zweier, JL; Szeto, HH; Alevriadou, BR. "Mitochondria-Derived Reactive Oxygen Species Mediate Heme Oxygenase-1 Expression in Sheared Endothelial Cells." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. Vol. 329, no. 1. (April 2009.): 94-101

Ilagan, RP; Tejero, J; Aulak, KS; Ray, SS; Hemann, C; Wang, ZQ; Gangoda, M; Zweier, JL; Stuehr, DJ. "Regulation of FMN Subdomain Interactions and Function in Neuronal Nitric Oxide Synthase." BIOCHEMISTRY. Vol. 48, no. 18. (May 2009.): 3864-3876

Holland, R; Navamal, M; Velayutham, M; Zweier, JL; Kensler, TW; Fishbein, JC. "Hydrogen Peroxide Is a Second Messenger in Phase 2 Enzyme Induction by Cancer Chemopreventive Dithiolethiones." CHEMICAL RESEARCH IN TOXICOLOGY. Vol. 22, no. 8. (August 2009.): 1427-1434

Han, YB; Liu, YP; Rockenbauer, A; Zweier, JL; Durand, G; Villamena, FA. "Lipophilic beta-Cyclodextrin Cyclic-Nitrone Conjugate: Synthesis and Spin Trapping Studies." JOURNAL OF ORGANIC CHEMISTRY. Vol. 74, no. 15. (August 2009.): 5369-5380

Crestanello, JA; Lee, DS; Steinbaugh, G; Pfeiffer, D; Zweier, J. "Superoxide radical production by mitochondrial respiratory complexes I and III is decreased by ischemic preconditioning." JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS. Vol. 209, no. 3. (September 2009.): S33-S33

Chen, CA; Druhan, LJ; Varadharaj, S; Wang, TY; Chen, YR; Zweier, JL. "Superoxide Generation from Endothelial Nitric Oxide Synthase Is Regulated by Posttranslational Modification and L-Arginine Binding." CIRCULATION RESEARCH. Vol. 105, no. 7. (September 2009.): E41-E41.

Bobko, AA; Dhimitruka, I; Eubank, TD; Marsh, CB; Zweier, JL; Khramtsov, VV. "Trityl-based EPR probe with enhanced sensitivity to oxygen." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 47, no. 5. (September 2009.): 654-658

Reyes, LA; Dumitrescu, C; Druhan, L; Zweier, JL. "Depletion of the Endothelial Nitric Oxide Synthase (eNOS) Substrate NADPH Triggers Endothelial Dysfunction in the Post-Ischemic Heart: Role of Glucose 6 Phosphate Dehydrogenase (G6PD)." CIRCULATION. Vol. 120, no. 18. (November 2009.): S1012-S1012

Presley, T; Vedam, K; Liu, XP; Zweier, JL; Ilangovan, G. "Activation of Hsp90/NOS and increased NO generation does not impair mitochondrial respiratory chain by competitive binding at cytochrome C Oxidase in low oxygen concentrations." CELL STRESS & CHAPERONES. Vol. 14, no. 6. (November 2009.): 611-627

Samouilov, A; Bobko, A; Colantuano, G; Zweier, JL. "Accelerated Autoxidation of Myoglobin During the Onset of Ischemia." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 49, (January 2010.): S29-S29

Talukder, MAH; Yang, FC; Shimokawa, H; Zweier, JL. "eNOS is required for acute in vivo ischemic preconditioning of the heart: effects of ischemic duration and sex." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. Vol. 299, no. 2. (August 2010.): H437-H445

Kim, SU; Liu, Y; Nash, KM; Zweier, JL; Rockenbauer, A; Villamena, FA. "Fast Reactivity of a Cyclic Nitrone-Calix[4]pyrrole Conjugate with Superoxide Radical Anion: Theoretical and Experimental Studies." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. Vol. 132, no. 48. (December 2010.): 17157-17173

Chen, CA; Wang, TY; Varadharaj, S; Reyes, LA; Hemann, C; Talukder, MAH; Chen, YR; Druhan, LJ; Zweier, JL. "S-glutathionylation uncouples eNOS and regulates its cellular and vascular function." NATURE. Vol. 7327, no. 468. (December 2010.): 1115-1118

Velayutham, M; Hemann, C; Zweier, JL. "Cytochrome c as a Source of Superoxide Radical: Role of H2O2 and NADH." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 49, (January 2010.): S216-S216

Liu, YP; Villamena, FA; Rockenbauer, A; Zweier, JL. "Trityl-nitroxide biradicals as unique molecular probes for the simultaneous measurement of redox status and oxygenation." CHEMICAL COMMUNICATIONS. Vol. 46, no. 4. (January 2010.): 628-630

Liu, YP; Song, YG; Villamena, FA; Zweier, JL. "Development of Trityl-conjugated Disulfide Biradical for the Measurement of Thiol Concentration and Oxygenation." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 49, (January 2010.): S212-S212

Li, HT; Cui, HM; Wang, TY; Zweier, JL. "Endogenous Methyl-arginine in Regulation of Nitric Oxide Generation from Inducible Nitric Oxide synthase." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 49, (January 2010.): S116-S117

Zweier, JL; Li, HT; Samouilov, A; Liu, XP. "Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall." NITRIC OXIDE-BIOLOGY AND CHEMISTRY. Vol. 22, no. 2. (February 2010.): 83-90

Petryakov, S; Samouilov, A; Kesselring, E; Caia, GL; Sun, ZQ; Zweier, JL. "Dual frequency resonator for 1.2 GHz EPR/16.2 MHz NMR co-imaging." JOURNAL OF MAGNETIC RESONANCE. Vol. 205, no. 1. (July 2010.): 1-8

Ahmad, R; Caia, G; Potter, LC; Petryakov, S; Kuppusamy, P; Zweier, JL. "In vivo multisite oximetry using EPR-NMR coimaging." JOURNAL OF MAGNETIC RESONANCE. Vol. 207, no. 1. (November 2010.): 69-77

Chen, JF; Chen, CL; Rawale, S; Chen, CA; Zweier, JL; Kaumaya, PTP; Chen, YR. "Peptide-based Antibodies against Glutathione-binding Domains Suppress Superoxide Production Mediated by Mitochondrial Complex I." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 285, no. 5. (January 2010.): 3168-3180

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Sun, J; Druhan, LJ; Zweier, JL. "Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production." ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. Vol. 494, no. 2. (February 2010.): 130-137

Chen, WG; Druhan, LJ; Chen, CA; Hemann, C; Chen, YR; Berka, V; Tsai, AL; Zweier, JL. "Peroxynitrite Induces Destruction of the Tetrahydrobiopterin and Heme in Endothelial Nitric Oxide Synthase: Transition from Reversible to Irreversible Enzyme Inhibition." BIOCHEMISTRY. Vol. 49, no. 14. (April 2010.): 3129-3137

Liu, YP; Villamena, FA; Song, YG; Sun, JA; Rockenbauer, A; Zweier, JL. "Synthesis of N-14- and N-15-labeled Trityl-nitroxide Bradicals with Strong Spin-Spin Interaction and Improved Sensitivity to Redox Status and Oxygen." JOURNAL OF ORGANIC CHEMISTRY. Vol. 75, no. 22. (November 2010.): 7796-7802

Vedam, K; Nishijima, Y; Druhan, LJ; Khan, M; Moldovan, NI; Zweier, JL; Ilangovan, G. "Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. Vol. 298, no. 6. (June 2010.): H1832-H1841

Dhimitruka, I; Grigorieva, O; Zweier, JL; Khramtsov, VV. "Synthesis, structure, and EPR characterization of deuterated derivatives of Finland trityl radical." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. Vol. 20, no. 13. (July 2010.): 3946-3949

Shet, K; Caia, GL; Kesselring, E; Samouilov, A; Petryakov, S; Lurie, DJ; Zweier, JL. "A novel variable field system for field-cycled dynamic nuclear polarization spectroscopy." JOURNAL OF MAGNETIC RESONANCE. Vol. 205, no. 2. (August 2010.): 202-208

Khramtsov, VV; Caia, GL; Shet, K; Kesselring, E; Petryakov, S; Zweier, JL; Samouilov, A. "Variable Field Proton-Electron Double-Resonance Imaging: Application to pH mapping of aqueous samples." JOURNAL OF MAGNETIC RESONANCE. Vol. 202, no. 2. (February 2010.): 267-273

Kundu, TK; Velayutham, M; Zweier, JL. "Generation of Reactive Oxygen Species by Aldehyde Oxidase through the Oxidation of NADH." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 49, (January 2010.): S96-S96

Liu, XP; Srinivasan, P; Collard, E; Grajdeanu, P; Lok, K; Boyle, SE; Friedman, A; Zweier, JL. "Oxygen regulates the effective diffusion distance of nitric oxide in the aortic wall." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 48, no. 4. (February 2010.): 554-559

Liu, XP; El-Sherbiny, GA; Collard, E; Huang, X; Follmer, D; El-Mandy, M; Zweier, JL. "Application of carbon fiber composite minielectrodes for measurement of kinetic constants of nitric oxide decay in solution." NITRIC OXIDE-BIOLOGY AND CHEMISTRY. Vol. 23, no. 4. (December 2010.): 311-318

Lee, DS; Steinbaugh, GE; Quarrie, R; Yang, FC; Talukder, MAH; Zweier, JL; Crestanello, JA. "Ischemic Postconditioning Does Not Provide Cardioprotection from Long-Term Ischemic Injury in Isolated Male or Female Rat Hearts." JOURNAL OF SURGICAL RESEARCH. Vol. 164, no. 2. (December 2010.): 175-181

Nishijima Y, Sridhar A, Bonilla I, Velayutham M, Khan M, Terentyeva R, Li C, Kuppusamy P, Elton TS, Terentyev D, Györke S, Zweier JL, Cardounel AJ, Carnes CA.. "Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology." Cardiovasc Res. (January 2011.): -

Muir WW, Ilangovan G, Zweier JL, Moon-Massat PF, Rentko VT. "Vital Organ Tissue Oxygenation after Serial Normovolemic Exchange Transfusion with HBOC-201 in Anesthetized Swine." Shock.. (January 2011.): -

Talukder, MAH; Johnson, WM; Varadharaj, S; Lian, JR; Kearns, PN; El-Mahdy, MA; Liu, XP; Zweier, JL. "Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. Vol. 300, no. 1. (January 2011.): H388-H396

Rajasekaran, NS; Varadharaj, S; Khanderao, GD; Davidson, CJ; Kannan, S; Firpo, MA; Zweier, JL; Benjamin, IJ. "Sustained Activation of Nuclear Erythroid 2-Related Factor 2/Antioxidant Response Element Signaling Promotes Reductive Stress in the Human Mutant Protein Aggregation Cardiomyopathy in Mice." ANTIOXIDANTS & REDOX SIGNALING. Vol. 14, no. 6. (March 2011.): 957-971

Zweier JL, Chen CA, Druhan LJ. "S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling.." Antioxid Redox Signal. Vol. 10, no. 14(. (May 2011.): 1769-75

Tewari AK, Popova-Butler A, El-Mahdy MA, Zweier JL. "Identification of differentially expressed proteins in blood plasma of control and cigarette smoke-exposed mice by 2-D DIGE/MS.." Proteomics. Vol. 10, no. 11. (May 2011.): 2051-62

Nishijima Y, Sridhar A, Zweier JL, Cardounel AJ, Carnes CA.. "Reply: Is NOS uncoupling the missing link between atrial fibrillation and chronic non-ischemic cardiomyopathy?." Cardiovasc Res.. (June 2011.): -

Druhan L, Karuppiah K, Chen CA, Smith T, Zweier JL, Sessa WC, Cardounel AJ.. "Suppression of eNOS-Derived Superoxide by Caveolin-1: A Biopterin-Dependent Mechanism.." Am J Physiol Heart Circ Physiol.. (July 2011.): -

Chu, L; Hao, H; Luo, M; Huang, Y; Chen, ZY; Lu, TW; Zhao, X; Verfaillie, CM; Zweier, JL; Liu, ZG. "Ox-LDL modifies the behaviour of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phosphorylation." JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol. 15, no. 2. (February 2011.): 423-432

Zweier, JL; Talukder, MAH. "Targeting Dimethylarginine Dimethylaminohydrolases in Pulmonary Arterial Hypertension A New Approach to Improve Vascular Dysfunction?." CIRCULATION. Vol. 123, no. 11. (March 2011.): 1156-1158

Chen CA, Lin CH, Druhan LJ, Wang TY, Chen YR, Zweier JL.. "Superoxide induces eNOS protein Thiyl radical formation: a novel mechanism regulating eNOS function and coupling.." J Biol Chem.. (June 2011.): -

Velayutham M, Hemann C, Zweier JL.. "Removal of H(2)O(2) and generation of superoxide radical: Role of cytochrome c and NADH.." Free Radic Biol Med.. Vol. (1), no. 51. (July 2011.): 160-170

Mital R, Zhang W, Cai M, Huttinger ZM, Goodman LA, Wheeler DG, Ziolo MT, Dwyer K, d'Apice A, Zweier JL, He G, Cowan P, Gumina RJ. "Antioxidant Network Expression Abrogates Oxidative Post-Translational Modifications in Mice." Am J Physiol Heart Circ Physiol. (January 2011.): -

Talukder, MAH; Yang, FC; Nishijima, Y; Chen, CA; Xie, L; Mahamud, SD; Kalyanasundaram, A; Bonagura, JD; Periasamy, M; Zweier, JL. "Detrimental effects of thyroid hormone analog DITPA in the mouse heart: increased mortality with in vivo acute myocardial ischemia-reperfusion." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. Vol. 300, no. 2. (February 2011.): H702-H711

Efimova, OV; Sun, ZQ; Petryakov, S; Kesselring, E; Caia, GL; Johnson, D; Zweier, JL; Khramtsov, VV; Samouilov, A. "Variable radio frequency proton-electron double-resonance imaging: Application to pH mapping of aqueous samples." JOURNAL OF MAGNETIC RESONANCE. Vol. 209, no. 2. (April 2011.): 227-232

Olga Effimova, Alexandre Samouilov, Jay Zweier. "Standard-based method for proton–electron double resonance imaging of oxygen." JOURNAL OF MAGNETIC RESONANCE. no. In Press. (January 2011.): -

Chen J, Chen CL, Alevriadou BR, Zweier JL, Chen YR. "Excess NO predisposes mitochondrial succinate-cytochrome c reductase to produce hydroxyl radical." Biochim Biophys Acta. Vol. 1807, no. 5. (January 2011.): 491-502

Joddar, B; Reen, RK; Firstenberg, MS; Varadharaj, S; McCord, JM; Zweier, JL; Gooch, KJ. "Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 50, no. 6. (March 2011.): 700-709

Liu Y, Song Y, Rockenbauer A, Sun J, Hemann C, Villamena FA, Zweier JL. "Synthesis of trityl radical-conjugated disulfide biradicals for the measurement of thiol concentration.." J Org Chem. (January 2011.): -

Quarrie, R; Cramer, BM; Lee, DS; Steinbaugh, GE; Erdahl, W; Pfeiffer, DR; Zweier, JL; Crestanello, JA. "Ischemic Preconditioning Decreases Mitochondrial Proton Leak and Reactive Oxygen Species Production in the Postischemic Heart." JOURNAL OF SURGICAL RESEARCH. Vol. 165, no. 1. (January 2011.): 5-14

Efimova OV, Sun Z, Petryakov S, Kesselring E, Caia GL, Johnson D, Zweier JL, Khramtsov VV, Samouilov A. "Variable radio frequency proton-electron double-resonance imaging: Application to pH mapping of aqueous samples." J Magn Reson. Vol. 2, no. 209. (January 2011.): 227-32

November 2012

Obal D, Dai S, Keith R, Dimova N, Kingery J, Zheng T, Zweier JL, Velayutham M, Prabhu D, Conklin D, Bolli R, Rokosh G.."Overexpression of cardiomyocyte specific extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusion."

April 2011

Zweier JL, Yang F, Yang C, Varadharaj S , Chen , Talukder H."Postconditioning protects the heart against in vivo Ischemia referfusion injury with reduced infarction and decreased superoxide generation: comaprison with early ischemic preconditioning in rats." . : 66

March 2011

Sun Z, Petryakov S, Caia G, Samouilov S, Zweier JL."Volume Localization using Adiabatic Inversion Pulses in FAIR Imaging"

Tamer M. Abdelghany, Mohamed M. El-Mahdy, and Jay L. Zweier."Chronic Cigarette Smoke Exposure Impairs Vascular Endothelial Function With Reactive Oxygen Species Formation and Alterations in NO Synthase"

Z. Chen, D. Johnson, G. Caia, Z. Sun, S. Petryakov, A. Samouilov, and J. Zweier.."EPR Acquisition with Adaptive Heterogeneous Clocking (AHC)."

November 2010

Samouilov A, Bobko A, Colantuano G , Zweier JL."Accelerated Autoxidation of Myoglobin During the Onset of Ischemia." . : S29

Varadharaj S, Druhan L, Chen C, Wang T, Rajasekaran S, Zweier JL."Reoxygenation- Induced activation of golgi resident eNOS regulates exocytosis in the vascular endothelium: The role if cytosolic Phosphatases."

Varadharaj S, Druhan L, Chen C, Wang T, Rajasekaran S, Zweier JL."Reoxygenation- Induced activation of golgi resident eNOS regulates exocytosis in the vascular endothelium: The role if cytosolic Phosphatases."

Velayutham M, Hemann C, Zweier JL.."Cytochrome c as a Source of Superoxide Radical: Role of H2O2 and NADH." . : S216

Xiaoping L, Huang X, Follmer D, Lui K, Hemann C, Druhan L, Zweier JL."Cytoglobin effectively regulates the oxygen dependent consumption of Nitric Oxide in the vascular wall"

Xie L, Talukder H, Sun J, Wang T, Zweier J."In vivo myocardial ischemic reperfusion alters endothelial nitric oxide synthase (eNOS) function secondary to endogenous tetrahydrobiopterin (BH4) depletion."

Chen C, Druhan L, Wang T, Zweier JL."Superoxide induces eNOS protein Thiyl Radical formation: A novel mechanism regulating eNOS function and coupling."

Druhan L, Liu X, Zweier JL."Tetrahydrobiopterin enhances hydrogen peroxide production by the nitric oxide synthase while suppressing superoxide generation: Implications for Cardiovascular Disease"
Kundu TK, Velayutham M, Zweier JL."Generation of Reactive Oxygen Species by Aldehyde Oxidase through the Oxidation of NADH" . : S96

Lee HL, Chen CL, Yeh S, Zweier JL, Chen YR."Impairment and down regulation of the flavin subcomplex is associated with the injury of complex I in the mitochondria of ischemic heart."

Li HT , Cui HM, Wang TY , Zweier JL.."Endogenous Methyl-arginine in Regulation of Nitric Oxide Generation from Inducible Nitric Oxide synthase." . : S116

Liu YP , Song YG, Villamena FA , Zweier JL .."Development of Trityl-conjugated Disulfide Biradical for the Measurement of Thiol Concentration and Oxygenation." . : S212

Nishijima Y, Sridhar A, Bonilla I, Velayutham M, Vargas P, Zweier JL, Gyorke S, Cardounel A, Carnes C."Tetrahydrobiopterin (NOS factor) treatment improves atrial electrophysiology in the chronic heart failure."

March 2010

Changjun Yang, M.A. Hassan Talukder, Chun-An Chen, and Jay L. Zweier."Akt- and PKA-mediated endothelial nitric oxide synthase activation triggers early ischemic preconditioning in isolated rat hearts"

Daniel Lee, Ricardo Quarrie, Jay L Zweier, and Juan A Crestanello."Effect of Hyponatremia in Isolated Rat Hearts"

Jay Zweier, Fuchun Yang, Changjun Yang, Saradhadevi Varadharaj, and M.A. Hassan Talukde."Ischemic Postconditioning (IPostC) Protects the Heart against in vivo Ischemia/Reperfusion (I/R) Injury with Effective Akt and ERK1/2 Activation and Decreased Superoxide Generation"

Levy Austin Reyes, Cristian Dumitrescu, Tse-Yao Wang, Lawrence Druhan, and Jay Louis Zweier."Ischemia-Reperfusion Injury Targets Endothelial Specific NADPH, Resulting in Endothelial Dysfunction in the Isolated Heart"

M.A. Hassan Talukder, Fuchun Yang, Changjun Yang, Chun-An Chen, and Jay Zweier."Role of Endothelial Nitric Oxide Synthase (eNOS) in in vivo Cardioprotection Mediated by Ischemic Preconditioning (IPC) and Ischemic Postconditioning (IPostC) in Mice and Rats"

January 2010

Li HT , Cui HM, Wang TY , Zweier JL."Endogenous Methyl-arginine in Regulation of Nitric Oxide Generation from Inducible Nitric Oxide synthase" . : S116

Liu YP , Song YG, Villamena FA , Zweier JL."Development of Trityl-conjugated Disulfide Biradical for the Measurement of Thiol Concentration and Oxygenation." . : S212

Velayutham M, Hemann C, Zweier JL.."Cytochrome c as a Source of Superoxide Radical: Role of H2O2 and NADH." . : S216

Kundu TK, Velayutham M, Zweier JL.."Generation of Reactive Oxygen Species by Aldehyde Oxidase through the Oxidation of NADH." . : S96

Samouilov A, Bobko A, Colantuano G , Zweier JL."Accelerated Autoxidation of Myoglobin During the Onset of Ischemia." . : S29

January 2009

Varadharaj S, Druhan LJ, Jackson A, Soorappan R, Zweier JL."Discrete Activation of the two Subcellular Nitric Oxide Synthase Pools Differentially Regulates Exocytosis in the Vascular Endothelium." . : S67

Velayutham M, Villamena FA , Fishbein JC , Zweier JL."Generation of Singlet Oxygen by Cancer Chemopreventive Oltipraz on Illumination with Visible Light: Role of Melatonin." . : S177

Wang TS, Wang TY, Sun J, Chen CA, Yang FC, Talukder MAH, Zweier JL."In Vivo Myocardial Ischemia Reperfusion (I/R) Impairs Nitric Oxide Synthase (NOS) Activity: Potent Cardioprotection With BH4 Treatment." . : A312

Li HT, Kundu TK, Zweier JL."Characterization of the Magnitude and Mechanism of Aldehyde Oxidase-mediated Nitric Oxide Production" . : S189

Liu YP, Villamena FA , Rockenbauer A, Zweier JL."Development of Trityl-nitroxide Biradicals: Unique Probes for Simultaneous Measurement of Redox Status and Oxygenation" . : S189

Liu ZG, Chu L, Hao H, Luo M, Liu ZH, Huang Y, Chen ZY, Verfaillie CM, Zweier JL."Ox-LDL Modifies the Behavior of Bone Marrow Stem Cells and Impairs Their Endothelial Differentiation via Inhibition of Akt Phosphorylation." . : E38

Reyes LA, Dumitrescu C, Druhan L, Zweier JL.."Depletion of the endothelial nitric oxide synthase (eNOS) substrate NADPH triggers endothelial dysfunction in the postischemic heart: Role of glucose-6-posphate dehydrogenase (G6PD)."

Caia G, Sun ZQ, Yang FC, Petryakov S, Velayutham M, Samouilov A, Zweier JL."EPR/NMR Co-imaging of In Vivo Redox Status in Mice." . : S55

Chan SY, Zhang Y, Hemann C, Zweier JL, Loscalzo J.."MicroRNA-210 controls metabolic adaptation during hypoxia in pulmonary vascular endothelium"

Chen CA, Druhan LJ, Varadharaj S, Wang TY, Chen YR, Zweier JL."Superoxide Generation from Endothelial Nitric Oxide Synthase Is Regulated by Posttranslational Modification and L-Arginine Binding." . : E41

Chen CA, Druhan LJ, Wang TS, Chen YR, Zweier JL."Oxidative stress uncouples eNOS in a BH4-independent manner via the formation of protein thiol radicals"

Chen CA, Wang TS, Varadharaj S, Reyes LA, Talukder MAH, Chen YR, Druhan LJ, Zweier JL."S-glutathiolation uncouples endothelial nitric oxide synthase. A novel mechanism of redox signaling and vascular regulation."

Chen J, Chen CL, Chen CA, Kaumaya PP, Zweier JL."Peptide-based antibodies against glutathione binding domains suppress superoxide production mediated by mitochondrial complex I."

Crestanello JA, Lee DS, Steinbaugh GE, Pfeiffer DR, Zweier JL."Ischemic Preconditioning Selectively Protects Subsarcolemmal Mitochondrial Respiration Against Ischemic Injury." . : A307

Racoma I, Wang A, Zweier JL, Villamena FA."Effects of Natural and Synthetic Antioxidants on Uncoupled Endothelial Nitric Oxide Synthase Function." . : S150

Yang F, Talukder MAH, Zweier JL."Are there gender differences in cardioprotection? Influence on Aging and endothelial nitric oxide synthase (eNOS)."

Yang FC, Talukder MAH, Zweier JL."Ischemic Preconditioning Robustly Reduces In Vivo Myocardial Infarction in Both Male and Female Mice With Short or Long Ischemic Periods and This Protection Is Lost in the Absence of Endothelial Nitric Oxide Synthase." . : A308

Zweier JL.."Mechanisms of nitrite reduction to nitric oxide in the vessel wall." . : S2

Soorappan RN, Block K, Varadharaj S, Davidson CJ, Jones DP, Zweier JL, Benjamin IJ.."Evidence Against ROS-Induced Macromolecular Damage as a Causal Mechanism for hR120GCryAB Cardiomyopathy in Mice" . : E21

Soorappan RN, Varadharaj S, Khanderao GD, Davidson CJ, Zweier JL, Benjamin IJ.."Oxidative Stress and Activation of Nrf2 Precedes the Pathogenic Transition of Reductive Stress-Induced Cardiomyopathy in Mice." . : S65

Steinbaugh GE, Lee DS, Pfeiffer DR, Zweier JL, Crestanello JA."Ischemic Preconditioning Protects Mitochondrial Respiratory Function in Complex I and Complex II." . : A309

Talukder MAH, Johnson W, Varadharaj S, Lian JR, Kearns P, Druhan L, Liu XP, Zweier JL.."Cigarette Smoke Exposure Results in Hypertension, Endothelial Dysfunction, Cardiac Hypertrophy, and Leukocyte-Specific Reactive Oxygen Species (ROS) Generation in Mice."

Talukder MAH, Yang F, Wang T, Mammen PP, Zweier JL.."Role of Myoglobin in the postischemic heart."

Chu L, Hao H, Liu ZH, Xu J, Luo M, Huang Y, Chen ZY, Verfaillie CM, Zweier JL, Liu ZG.."Ox-LDL Modifies the Behavior of Bone Marrow Stem Cells and Impairs Their Endothelial Differentiation via Inhibition of Akt Activation." . : A199

Kundu TK, Velayutham M, Hille R, Zweier JL."Role of Aldehyde Oxidase in the Generation of Reactive Oxygen Species in Biological Tissues." . : S127

January 2008

Burns PM, Kearns PN, Nishijima Y, Vargas-Pinto P, Ding Y, Jekic M, Lian J, Lin HY), Huang K, Simonetti OP, Zweier JL."Real-time magnetic resonance imaging (MRI) of the time course of myocardial injury and cell death in a canine model of regional ischemia and reperfusion"

Chen CA, Druhan LJ, Vardharaj S, Chen YR, Zweier JL."Phosphorylation and L-Arginine increase superoxide generation from endothelial nitric oxide synthase (eNOS)."

Chen CA, Druhan LJ, Wang TS, Chen YR, Zweier JL."S- glutathiolation uncouples endothelial nitric oxide (NO) synthase, switching enzyme from NO to superoxide production."

Chen CL, Vardharaj S, Kaumaya P, Zweier JL, Chen YR."Oxidative modification with the protein tyrosine nitration occurs following deglutatiolation of the 70KDa flavoprotein of mitochondrial complex II is associated with loss of electron transfer activity in the post-ischemic myocardium."

Moldovan L, Moldovan NI, Sun J, Bergdall V, Biswas S, Sen CK, Zweier JL."Critical role of arginase in nitric oxide metabolism in preclinical swine wound healing" . : A51

Moldovan NI, Anghelina MI, Butt OI, Wang TS, Zweier JL."Role of oxygen and ROS in bone marrow derived progenitor cells accumulation in infarcted hearts: Implications for ventricular aneurysm formation" . : A190

Vardharaj S, Druhan LJ, Chen CA, Wang TS, Wani MA, Zweier JL."Intracellular protein trafficking in the vascular endothelium is regulated by golgi resident nitric oside synthase."

Deng Y, Petryakov S, He G, Kesselring P, Kuppusamy P, Zweier JL."Fast 3D EPR Imaging using spiral Magnetic field gradient"

Kundu TK, Velayutham M, Hille R, Zweier JL."NADH Oxidase Activity ofLiver Aldehyde Oxidase: Evaluation of Its Role in the Generation of Reactive Oxygen Species." . : S19

Lee MCI, Velayutham M, Shoji H, Yoshino F, Hille R, Zweier JL.."Measurement and Characterization of Superoxide Generation From Xanthine Dehydrogenase: a Redox Regulated Pathway of Radical Generation in Ischemic Tissues." . : S150

Roy S, Ojha N, He GL, Biswas S, Velayutham M, Khanna S, Kuppusamy P, Zweier JL, Sen CK."Rac2 in redox regulated wound healin"

Shet K, He G, Zweier JL."Functional Imaging using nitroxides- a feasibility study ar 11.7T"

Shet K, Petryakov S, Zweier JL."Surface coil for EPR irradiation to reduce SAR in fixed-field PEDRI"

Sun Z, Petryakov S, Alzawahra W, Zweier JL."adiabatic pulses for T1-weighted contrast enhancement at 0.38T"

Sun Z, Zweier JL."Selective adiabatic refocusing pulse pair for 3D RARE"

Sun Z, Zweier JL."Selective adiabatic refocusing pulse train for nonlinear phase dispersion and flip angle error compensation"

January 2007

Forbes SP, Pope AJ, Druhan L, Zweier JL, Cardounel A."Regulation of eNOS derived superoxide by endogenous methylarginines" . : 293

Han Y, Tuccio B, Lauricella R, Rockenbauer A, Zweier JL, Villamena FA."Synthesis and spin trapping properties of a new spirolactonyl-nitrone" . : S14

He GL, Zhu XH, Liu B, Zhou ST, Chen YR, Zweier JL."Ischemic preconditioning, mitoKATP channel and in vivo myocardial oxygen consumption" . : A866

Pandian RP, Parinandi NL, Ilangovan G, Zweier JL, Kuppusamy P."Novel particulate spin probe for targeted determination of oxygen in cells and tissues"

Petryakov S, Samouilov A, Kesselring E, Wasowicz T, Cala GL, Zweier JL."Single loop multi-gap resonator for whole body EPR imaging of mice at 1.2 GHz" . : 68

Presley T, Venkatakrishnan CD, Velayutham M, Kuppusamy P, Zweier JL, Ilangovan G."Exposure to extreme hypoxia attenuates endothelial cellular respiration. A potential role of Hsp90-eNOS association" . : 339A

Li HT, Cui HM, Zweier JL."Role of flavo-enzymes in glyceryl trinitrate biotransformation" . : A623

Liu B, Tewari A, Zhang L, Chen YR, Zweier JL, He G."Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: Mitochondria as a major target" . : S112

Liu B, Zhou S, Chen YR, Hu K, Zweier JL, He G."Diazoxide increases superoxide generation in mitochondria by suppressing succinate dehydrogenase: A spin trapping EPR study" . : S154

Liu X, Srinivasan P, Collard E, Grajdeanu P, Zweier JL, Friedman A."Oxygen regulates the flux of nitric oxide diffusion across the vascular wall" . : 27

Liu XP, Yan QT), Liu QH, Zweier JL."Estimation of the steady-state NO concentration in blood" . : A523

Sun J, Druhan LJ, Zweier JL."Superoxide promotes reversible uncoupling of inducible nitric oxide synthase, while peroxynitrite induces irreversible and complete enzyme inactivation" . : 7 January 2007 Sun H, Druhan LJ, Zweier JL."Monomerization of inducible nitric oxide synthase blocks superoxide as well as nitric oxide production from the enzyme" . : A1146

Talukder MAH, Chen CA, Kalyanasundaram A , Bhupathy P, Babu GJ, Periasamy M, Zweier JL."Glutathiolation and nitration of sarcoplasmic reticulum Ca2+ - ATPase (SERCA) in hearts overexpressing SERCA1a-pump" . : A535

Talukder MAH, Kalyanasundaram A, Zhao X, Bhupathy P, Babu GJ, Cardounel AJ, Periasamy M, Zweier JL."Cardiac overexpression of sarcoplasmic reticulum Ca2+-ATPase with resistance to oxidative and acidotic stress protects against ex vivo and in vivo postischemic myocardial injury" . : 221A

Talukder MAH, Nishijima Y, Bonagura JD, Kalyanasundaram A, Periasamy M, Shimokawa H, Zweier JL."Short-term treatment with DITPA, a thyroid hormone analog, improves postischemic coronary flow and cardiac contractile function in hypertensive endothelial nitric oxide synthase knockout (eNOS-KO) mice" . : 199

Talukder MAH, Nishijima Y, Bonagura JD, Shimokawa H, Zweier JL."Differential effects of short-term thyroid hormone analog DITPA on postischemic cardiac contractile function of wild-type (WT) and endothelial nitric oxide synthase knockout (eNOS-KO) mice" . : A1378

Khramtsov VV, Bobko AA, Dhimitruka I, Zweier JL."Persistent triarylmethyl radicals as dual function pH and oxygen probes" . : S178

Kundu TK, Velayutham M, Hille R, Zweier JL."Evaluation of the role of aldehyde oxidase as an important source of reactive oxygen species in biological tissues" . : S37

Samouilav A, Zuo L, Colantuano G, Zweier JL."Superoxide production during onset of myocardial ischemia: Role of myoglobin" . : S40

Samouilov A, Caia GL, Kesselring E, Petryakov S, Wasowicz T, Zweier JL."Development of a hybrid EPR/NMR coimaging system" . : 156

Yangping L, Villamena FA, Sun J, Xu Y, Zweier JL."Assessment of various ester-derivatized tetrathiatriarylmethyl radicals as intracellular oxygen probes" . : S18

Butt OI, Carruth RW, Kuppusamy P, Zweier JL, Moldovan NI."Evidence for paracrine stimulation of neovascularization by bone marrow-derived progenitor cells: Assessment by in vivo EPR oximetry" . : E55

Carden TB, Druhan LJ, Chen CA, Zweier JL."Acidosis, as occurs during myocardial ischemia, inhibits nitric oxide synthesis but increases superoxide production from nitric oxide synthase" . : A624

Chen CA, Chen YR), Zweier JL."Phoshorylation of human endothelial nitric oxide synthase modulates nitric oxide and superoxide generation from the enzyme" . : A524

Chen CA, Chen YR, Zweier JL."Phosphorylation of human endothelial nitric oxide synthase modulates nitric oxide and superoxide generation from the enzyme" . : A624

Chen CA, Chen YR, Zweier JL."Superoxide generated from endothelial nitric oxide synthase (eNOS) modulates eNOS function through oxidative modification with protein radical formation" . : A623

Chen CA, Druhan LJ, Chen YR, Zweier JL."S-glutathiolation of endothelial nitric oxide synthase modulates its enzymatic activity and protects against oxidative damage" . : 7

Chen J, Chen CL, Palmer B, Zweier JL, Chen YR."Decreased mitochondrial biogenesis and increased pro-oxidant activity are associated with oxidative impairment of complex 11 in the postischemic heart" . : 249

Chen YR, Chen CL, Zweier JL."Nitric oxide generated by eNOS exerts cardioprotection by increasing the mitochondrial biogenesis and decreasing electron leakage for superoxide production by mitochondrial succinate cytochrome c reductase" . : 183

Chu L, Jiang YH, Hao H, Verfaillie C, Zweier JL, Liu ZG."Exogenous nitric oxide increases the expression of Oct-4 and may modify bone marrow stem cell differentiation into endothelial cells in vitro" . : A1427

Moldovan NI, Butt O, Alzawhra W, Khan M, Kuppusamy P, Zweier JL."Composition of bone marrow-derived progenitor cells in the cellular infiltrate of infareted hearts: Role of local oxygen tension" . : A228

Moldovan NI, Butt OI (Butt, Omer I.), Blaser BW, Moldovan L, He GL, Zweier JL."Spontaneously recruited bone marrow progenitor cells are cardiogenic and vasculogenic in chronically ischemic myocardium: Role of hypoxia and oxidants in their spatial distribution" . : E55

Vedam K, Nishijima Y, Khan M, Kuppusamy P, Zweier JL, Ilangovan G."Increased expression of heat shock protein 25 in doxorubicin-treated failing hearts" . : E60

Velayutham M, Muthukumaran RB, Sostaric JZ, McCraken J, Zweier JL."Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: A novel pathway for cancer chemoprevention" . : 1076

Vikram DS, Zweier JL, Kuppusamy P."Methods for noninvasive imaging of tissue hypoxia" . : 1745

Xu J, Liu XF, Gupta K, Jiang YH, Hao H, Verfaillie C, Zweier JL, Liu ZG."Phosphorylated Akt is critical to the differentiation of bone marrow stem cells into endothelial cells" . : 385A

Xu J, Liu XF, Gupta K, Jiang YH, Hao H, Verfaillie C, Zweier JL, Liu ZG."Phosphorylated Akt is critical to the differentiation of bone marrow stem cells into endothelial cells" . : 385A

Xu J, Liu XF, Gupta K, Jiang YH, Hao H, Verfaillie C, Zweier JL, Liu ZG."STAT-3 and p42/44 MAPK are dynamically phosphorylated during bone marrow stem cell differentiation into endothelial cells" . : A1427

Alzawahra W, Liu XP, Li HT, Samouilov A, Zweier JL."Nitrite functions as a vascular relaxing factor forming NO and activating guanylate cyclase (sGC): Role of sGG in nitrite-mediated NO formation" . : 296 January 2007 Xu Y, Villamena FA, Liu Y, Zweier JL."EPR studies of a new isopropoxy-carbonylated TPP+-nitrone" . : S18

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