Sweet_Kevin_460x460Professor, Clinical Internal Medicine
Division of Human Genetics

Comprehensive Cancer Center
2012 Kenny Road
Columbus, OH 43221


I am a professor in the Division of Human Genetics in the Department of Internal Medicine at The Ohio State University. I have more than 25 years of experience as a practicing genetic counselor and researcher, and contributed numerous clinical, translational, discovery, review and guideline publications to the cancer genetics, genetic counseling service delivery and precision medicine field. I was Principal Investigator on an R21 award, funded by the National Human Genome Research Institute (NHGRI), that focused on development of a novel genetic counseling patient preference (GCPP) intervention within the post-genetic test results delivery process. As PI I have also completed a randomized controlled trial (RCT) for patients receiving post-genetic test counseling for polygenic risk and complex disease test results through a patient portal. I have participated in numerous multi-institutional projects and RCTs to include quantitative research (national/international studies) and qualitative research. I have worked collaboratively with investigators across disciplines, including genetics/genomics, health behavior, health communications and public health.

My early work focused on the development of online family history risk tools and algorithms to identify individuals at elevated risk for breast cancer and other cancers, and appropriate referral for genetic counseling and testing. These algorithms were incorporated in the development of JamesLink® — one of the original automated family cancer history triage tools, resulted in a number of publications and contributions to the development of clinical guidelines. Subsequently, a web-integrated interactive family history platform with cancer and coronary heart disease algorithms (Family HealthLink®) was developed and deployed. Implementation research with Family HealthLink® in Ohio State patient care settings found a significant percentage of patients at high/familial risk require more intensive screening, and also referral for genetic counseling and genetic testing. Family HealthLink® is available as a general public resource on the NHGRI website and the U.S. Department of Health and Human Services.

The growing availability and accessibility of information technologies (IT) and innovative health communication approaches will make the practice of genetic counseling more inclusive and efficient. My research focus since 2009 has been on articulating, developing and evaluating alternative models of genetic counseling that capitalize on new technologies and actively accommodate a more patient-driven focus for precision medicine. In our funded NHGRI R21 study, qualitative research on patient participants and on community participants (Ohio State Wexner Medical Center-Coriell Personalized Medicine Collaborative) led to the development of a novel genetic counseling patient preference (GCPP) framework. The GCPP honors patient preferences to leverage patient-centered IT (e.g., electronic health record portals, mobile applications and Direct to Consumer services) to increase access to genetic testing and the provision of post-genetic test counseling. We included practicing genetic counselors in the design process with expertise that spanned academia, industry and DTC commercial services, as well as investigators proficient in health communications and health behavior research, for potential application in any large-scale genomic sequencing effort and for use in varied clinical practice settings.

Since 2000, I have participated in numerous collaborative national/international research projects, including multicenter studies on hereditary breast cancer (e.g., Hereditary Breast Cancer Clinical Study Group). Research on serrated polyposis and unexplained forms of polyposis allowed for collaborative work to further define disease spectrum and underlying etiology of these rare conditions.

I am committed to translating genetic, genomic and pharmacogenomic knowledge into the practice of precision medicine. I am dedicated to the continued education of the general public and peers through collaborative research, active involvement in special interest groups and academic medicine programs.

Complete list of Published Work in My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/kevin.sweet.1/bibliography/public/


  • Licensed genetic counselor: Ohio Board of Medical Examiners, 2013 - present

Genetic Counseling Service Delivery

  • Clinical cancer genetics
  • Family history tools and risk assessment

Clinical Interests

Mr. Sweet’s clinical duties include providing comprehensive cancer genetic consultations to individuals and families with a history of cancer. Cancer genetic consultation requires documentation of cancers in the family, risk assessment, screening recommendations and incorporation of genetic testing as necessary. To schedule an appointment, call 614-293-6694 or toll free at 1-888-329-1654. 


MS: Human genetics, Sarah Lawrence College, 1994
BS: Microbiology, University of Wisconsin, 1988