Associate Professor of Internal Medicine, Courtesy Faculty member in the Department of Microbial Infection and Immunity473 W. 12th Ave.
Room 507
Columbus, OH 43210
614-685-0212
Kymberly.Gowdy@osumc.edu
Follow on Twitter: @GowdyKymberly
Biography
Dr. Gowdy is an Associate Professor at The Ohio State University (OSU) where she leads a research program in the Department of Internal Medicine focused on how air pollutants can influence chronic lung diseases, both infectious and inflammatory. Her research has resulted in more than 50 research publications with that include her trainees and various extramural and intramural grants. Dr. Gowdy is an ad-hoc reviewer for multiple study sections (American Thoracic Society, American Heart Association) and is a standing member of SIEE standing NIH study section. She also is active in journal peer reviews including her role as Associate Editor for Toxicological Sciences and an Editorial Board member for Journal of Immunology, American Journal of Physiology-Lung Cellular and Molecular Physiology, Life Sciences, and Frontiers in Immunology. In addition to her research career, Dr. Gowdy is passionate about mentoring, career development, and teaching the next generation of toxicologists. She started the Eastern North Carolina Chapter of Graduate Women in Science in 2016, a chapter that now has more than 100 members. She has mentored numerous research faculty, postdoctoral fellows, graduate students, and undergraduates. She also currently contributes to the biomedical and toxicology curriculum at OSU for graduate and public health students. Lastly, she is currently the Vice President of the Society of Toxicology Inhalation and Respiratory Specialty Section.
Research Interests
Our lungs are constantly being challenged by environmental exposures (air pollutants, particulate matter, noxious gases, allergens, viruses, bacteria, etc). The central focus of our research is to explore and identify novel mechanisms of how environmental exposures can lead to lung and/or cardiovascular disease pathogenesis. We also have a great interest to understand how environmental exposures can alter the pulmonary immune response, making the lung more susceptible to infection. Of particular interest is determining the role of scavenger receptors in preventing infectious and inflammatory lung diseases. Our research, is currently funded by the National Institutes of Health, and we collaborate with multiple investigators at Ohio State University, Nationwide Children’s Hospital, Duke University, National Institutes of Environmental Health Sciences (NIEHS), University of North Carolina, and Vanderbilt University to collectively understand the health risks associated with environmental exposures. Our research provides fundamental information from basic and translational models of lung disease. More information on our research program can be found here: http://www.gowdyenvironmentallunglab.com/
Current Research
- Uncovering molecular mechanisms by which air pollution increases susceptibility to pulmonary infections.
- Understanding the influence of lipid mediators on the pulmonary inflammatory response following air pollution exposure
- Evaluating how dietary fatty acids mitigate/influence environmental lung diseases.
Active Funding
1R01ES031378-01
Title: Dietary DHA mitigates ozone induced pulmonary inflammation
Principal Investigator: Kymberly Gowdy, PhD
1R01ES028829-01A1
Title: Novel role for CD163 in ozone induced alterations of pulmonary immunity
Principal Investigator: Kymberly Gowdy, PhD
Education
Postdoctoral Fellowship, Laboratory of Respiratory Biology, NIEHS/NIH, Research Triangle Park, NC
Postdoctoral Research, Duke University Medical Center, Durham, NC
PhD: North Carolina State University, Raleigh, NC
MS: North Carolina State University, Raleigh, NC
BS: Virginia Polytechnic Institute, Blacksburg, VA
Honors
- Young Investigator Award, Inhalation and Respiratory Specialty Section, Society of Toxicology, 2017
- Outstanding Young Investigator Award, Immunotoxicology Specialty Section, Society of Toxicology, 2016
- Career Development Award, Center for Human Health and the Environment, 2015 & 2018
- Walter A. Rosenblith New Investigator Award, Health Effects Institute, 2015
Publications
Scavenger Receptor BI Attenuates IL-17A-Dependent Neutrophilic Inflammation in Asthma. Reece SW, Varikuti S, Kilburg-Basnyat B, Dunigan-Russell K, Hodge MX, Luo B, Madenspacher JH, Thomas SY, Tokarz DA, Tighe RM, Cook DN, Fessler MB, Gowdy KM. Am J Respir Cell Mol Biol. 2021 Jun;64(6):698-708. doi: 10.1165/rcmb.2020-0007OC.PMID: 33647226
Sex Differences in Pulmonary Eicosanoids and Specialized Pro-Resolving Mediators in Response to Ozone Exposure. Yaeger MJ, Reece SW, Kilburg-Basnyat B, Hodge MX, Pal A, Dunigan-Russell K, Luo B, You DJ, Bonner JC, Spangenburg EE, Tokarz D, Hannan J, Armstrong M, Manke J, Reisdorph N, Tighe RM, Shaikh SR, Gowdy KM.Toxicol Sci. 2021 Aug 30;183(1):170-183. doi: 10.1093/toxsci/kfab081.PMID: 34175951
Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses. Birukova A, Cyphert-Daly J, Cumming RI, Yu YR, Gowdy KM, Que LG, Tighe RM.Toxicol Sci. 2019 Jun 1;169(2):499-510. doi: 10.1093/toxsci/kfz056.PMID: 30825310
Specialized Pro-Resolving Lipid Mediators Regulate Ozone-Induced Pulmonary and Systemic Inflammation. Kilburg-Basnyat B, Reece SW, Crouch MJ, Luo B, Boone AD, Yaeger M, Hodge M, Psaltis C, Hannan JL, Manke J, Armstrong ML, Reisdorph N, Tighe RM, Shaikh SR, Gowdy KM.Toxicol Sci. 2018 Jun 1;163(2):466-477. doi: 10.1093/toxsci/kfy040.PMID: 29471542
Assistant Professor, Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University
Relevant Publications
Hussain S, Johnson CG, Scriuba J, Meng X, Stober VP, Liu C, Cyphert-Daly JM, Bulek K, Qian W, Solis A, Sakamachi Y, Trempus CS, Aloor JJ, Gowdy KM, Foster WM, Hollingsworth JW, Tighe RM, Li Xiaoxia, Fessler MB, Garantziotis S. TLR5 Participates in the TLR4 Receptor Complex and Promotes MyD88-dependent Signaling in Environmental Lung Injury. Elife. 2020 Jan 28 [Epub ahead of print].
Lin WC*, Gowdy KM*, Madenspacher JH, Zemans RL, Yamamoto K, Lyons-Cohen M, Nakano H, Janardhan K, Williams CJ, Cook DN, Mizgerd JP, Fessler MB. Epithelial Membrane Protein 2 Governs Transepithelial Migration of Neutrophils Into the Airspace. J Clin Invest. 2020 Jan 2; 130(1) 157-170. * Both authors contributed equally.
McDaniel DK, Ringel-Scaia VM, Morrison HA, Coutermarsh-Ott S, Council-Troce M, Angle JW, Perry JB, Davis G, Leng W, Minarchick V, Yang Y, Chen B, Reece SW, Brown DA, Cecere TE, Brown JM, Gowdy KM, Hochella MF, Allen IC. Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function. Front Immunol. 2019 Nov 28; 10:2714.
Hodge MX, Reece SW, Madenspacher JH, Gowdy KM. In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure. J Vis Exp. 2019 Oct 22; 152.
Martin CL, Jima D, Sharp GC, McCullough LE, Park SS, Gowdy KM, Skaar D, Cowley M, Maguire RL, Fuemmeler B, Collier D, Relton CL, Murphy SK, Hoyo C. Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study. Epigenetics. 2019 April; 14(4): 325-340.
McGee Hargrove M, Snow SJ, Luebke RW, Wood CE, Krug JD, Krantz QT, King C, Copeland CB, McCullough SD, Gowdy KM, Kodavanti UP, Gilmour MI, Gavett SH. Effects of Simulated Smog Atmospheres in Rodent Models of Metabolic and Immunologic Dysfunction. Environ Sci Technol. 2018 Mar 6;52(5):3062-3070.
Tighe RM, Birukova A, Yeager MJ, Reece SW, Gowdy KM. Euthanasia and Lavage Mediated Effects on Bronchoalveolar Measures of Lung Injury and Inflammation. Am J Respir Cell Mol Biol. 2018 Aug;59(2):257-266.
Kilburg-Basnyat B, Reece SW, Crouch MJ, Luo B, Boone AD, Yaeger M, Hodge M, Psaltis C, Hannan JL, Manke J, Armstrong ML, Reisdorph N, Tighe RM, Shaikh SR, Gowdy KM. Specialized proresolving lipid mediators regulate ozone-induced pulmonary and systemic inflammation. Toxicol Sci. 2018 Jun 1;163(2):466-477.
McGee Hargrove M, Snow SJ, Luebke RW, Wood CE, Krug JD, Krantz QT, King C, Copeland CB, McCullough SD, Gowdy KM, Kodavanti UP, Gilmour MI, Gavett SH. Effects of Simulated Smog Atmospheres in Rodent Models of Metabolic and Immunologic Dysfunction. Environ Sci Technol. 2018 Mar 6;52(5):3062-3070.
Snow SJ, Cheng WY, Henriquez A, Hodge M, Bass V, Nelson GM, Carswell G, Richards JE, Schladweiler MC, Ledbetter AD, Chorley B, Gowdy KM, Tong H, Kodavanti UP. Ozone-Induced Vascular Contractility and Pulmonary Injury are Differentially Impacted by Diets Enriched with Coconut Oil, Fish Oil, and Olive Oil. Toxicol Sci. 2018 May 1;163(1):57-69.
Henderson MW, Madenspacher JH, Whitehead GS, Thomas SY, Aloor JJ, Gowdy KM, Fessler MB. Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice. Environ Health Perspect. 2017 2017 Sep 28;125(9):097024.
Speen AM, Kim HH, Bauer RN, Meyer M, Gowdy KM, Fessler MB, Duncan KE, Liu W, Porter NA, Jaspers I. Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS. J Biol Chem. 2016 Nov 25;291(48):25192-25206.
Gowdy KM, Madenspacher JH, Azzam KM, Aloor JJ, Fessler MB. Key role for Scavenger Receptor B-I in the integrative physiology of host defense during bacterial pneumonia. Mucosal Immunology. 2015 May;8(3):559-71.