Laszlo Farkas
Associate Professor
Internal Medicine
Academic information
- Department: Internal Medicine
Research interests
- Pathobiology of pulmonary vascular diseases
- Class I and class III pulmonary hypertension
About
Biography
My research interest is the pathobiology of pulmonary vascular diseases, particular class I and class III pulmonary hypertension. During the COVID-19 pandemic, we have also started to explore lung tissue and lung vascular remodeling, as well as endothelial dysfunction due to SARS-CoV-2 infection. The focus in my lab is on innate immunity signaling, inflammation, endosomal trafficking and degradation, and endothelial progenitor cell biology. The goal of the translational research program is to develop novel therapies for pulmonary vascular disease based on new targets that we identify in our work.
One particular emphasis is on dysregulated recognition of ribonucleic acids and Toll-like receptor 3 signaling in the pulmonary endothelium, as well as the role of primitive endothelial cell clones in the pulmonary vasculature and in pulmonary hypertension. In addition, we are interested in vascular regeneration in the lung tissue. A further goal is to understand how endosomal trafficking and degradation are necessary to maintain pulmonary vascular health.
Credentials
Education
- Postdoctoral
- Virginia Commonwealth University, McMaster University/Firestone Institute for Respiratory Health, Richmond, VA, United States
- Residency
- University Hospital, University of Regensburg, Regensburg, Germany
- MD
- University of Regensburg, Regensburg, Germany
Research
Research interests
- Pathobiology of pulmonary vascular diseases
- Class I and class III pulmonary hypertension
Active funding
- R01HL139881 - Endothelial Toll-like Receptor 3 in the Pathogenesis and Therapy of Pulmonary Arterial Hypertension.