Narasimham Parinandi
Associate Professor
Internal Medicine
Academic information
- Department: Internal Medicine
Research interests
- Biochemistry & Toxicology
- Lipidomics of Phospholipases and Bioactive Lipids
- Lipid Signaling in Regulation of Secretory Phenomena
- Heavy Metal and Lipid Bilayer Interactions
- Oxidized Lipidome
- Translational Lipidomics of Chronic Diseases
- Analytical Biochemistry
- Methods of Teaching and Mentoring Research.
About
Biography
I am an Associate Professor in Department of Internal Medicine, The Ohio State University College of Medicine. I received my B.Sc. (Hons) in botany with chemistry, zoology, English and M.Sc. in Botany with Environmental Biology in Berhampur University, India in 1975-77. From 1977-80, I was a research fellow in Environmental Sciences at the Andhra University, India. I earned my Ph.D. (1986) at the University of Toledo, Toledo, OH in Biology & Toxicology under the tutelage of Prof. Woon H. Jyung, an established zinc metabolism expert and aging biologist. During my graduate training at Toledo, I was exposed to the field of lipids by Prof. Max Funk, an expert lipoxygenase enzymologist from the lineage of Prof. Ned Porter. I did my post-doctoral fellowship (1986-90) at the Hormel Institute, University of Minnesota, the premier lipid institute in USA where I was trained with Prof. Harald Schmid, a celebrity in the area of ether lipids and a pioneer in anandamide chemistry. At the Hormel Institute of the University of Minnesota, I was associated with Prof. Ralph T. Holman (Member of the National Academy of Sciences and Pioneer in Fatty Acid and Lipoxygenase Biochemistry who also coined the name “Omega-3 Fatty Acid”) and conducted studies on omega-3 fatty acid dynamics in humans. I was also a research scientist/junior faculty at the Johns Hopkins University School of Medicine (1998-2002) under the mentorship of Prof. V. Natarajan, renowned lipid signaling expert and Prof. Joe G.N. (Skip) Garcia, a celebrated lung vascular biologist.
I have published nearly 125 peer-reviewed original scientific papers, reviews, and book chapters and edited books on Free Radicals and Antioxidant Protocols with Prof. William Pryor, (legendary Free Radical and Lipid Peroxidation Scientist), Mitochondria in Lung Health and Disease with Prof. Natarajan (a lipid signaling celebrity), and on “Measuring Oxidants and Oxidative Stress” with Prof. Lawrence Berliner (a celebrity in the area of Oxygen and Oxidative Stress). I have given more than 50 invited scientific lectures at the national level in the US and international institutions and conferences. I have also conducted and chaired several scientific conferences and symposia in the areas of oxidative stress and lipidology.
I have teaching and mentoring experience of more than 30 years and mentored over 75 students, technicians, fellows, and junior faculty in my laboratory. I served as an editor of the Chemical Abstracts of the American Chemical Society. I have been a reviewer of over 70 peer-reviewed journals in the area of biochemistry, molecular biology, cell biology and Lipidomics. I have been on the editorial board of the Molecular Biology Reports (Springer), Frontiers in Pharmacology (Associate Editor), Vessel Plus (Associate Editor), Cell Biophysics and Biochemistry (Associate Editor), and The Protein Journal. I have also the Editor of the “Oxidative Stress” Series of Springer-Nature. I have also received extramural funding from the National Institutes of Health (NIH), Department of Defense (DOD), American Thoracic Society (ATS), and International Academy of Oral Medicine and Toxicology (IAOMT) as a principal investigator (PI) and co-investigator (Co-I). I also serve as a reviewer of grant proposals of the NIH, AHA, DOD, US Universities, Government of Israel, Government of Austria, and Government of South Africa. I have received awards including the Gold Medal for securing the highest GPA in the M.S. class of 1975-77 of the Berhampur University, India, the Outstanding Teaching Assistant Award of the Biology Department of the University of Toledo in 1986, Distinguished Mentor Award of the Davis Heart & Lung Research Institute of the Ohio State University Wexner Medical Center in 2008, and the Distinguished Undergraduate Mentor Award of the Ohio State Undergraduate Research Program in 2009.
Credentials
Education
- Residency
- Johns Hopkins University, Baltimore, MD, United States
- Post Doctoral
- University of Minnesota, Minneapolis, MN, United States
- PhD
- University of Toledo, Toledo, OH, United States
- Post Graduate
- University of Andhra, Andhra Pradesh, India
- MSc
- University of Berhampur, Berhampur, India
- BSc
- University of Berhampur, Berhampur, India
Research
Research interests
- Biochemistry & Toxicology
- Lipidomics of Phospholipases and Bioactive Lipids
- Lipid Signaling in Regulation of Secretory Phenomena
- Heavy Metal and Lipid Bilayer Interactions
- Oxidized Lipidome
- Translational Lipidomics of Chronic Diseases
- Analytical Biochemistry
- Methods of Teaching and Mentoring Research.
Additional Research Interests
Oxidant Lipid Signaling; Vascular Biology; Phospholipases A2 and D; Analytical Lipidomics; Oxidative Stress; Bioinorganic Chemistry
Current Research:
Phospholipase A2 and D regulation in Lung Vascular Endothelium and Epithelium; Membrane Lipid Dynamics; Oxidative Lipidomics of Eicosanoids and Oxidized PUFA; Redox Antioxidant Biochemistry in Lung Damage; Heavy Metal Toxicology
Active Funding
- R01: 64000015; (PI: Jodi McDaniel); Role: Co-I (Parinandi: 10% FTE)
NIH/National Institute on Aging
09/30/2018 - 03/31/2024
Total amount awarded: $ 3,331,920.00
Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older Adults.
This project investigates the role of omega-3 fatty acids in healing of wounds in human subjects. - R01: 1 R01 AI154553-01 (PI: Amal Amer); Role: Co-I (Parinandi: 5% effort)
NIH/MPI
Award period: from 12/01/2020 to 11/30/2025
Total amount awarded: $ 3,030,911.00
The Inflammasome and host-Legionella interaction.
The goal of this project and my role is to investigate the cytoskeletal rearrangement and the ECIS behavior of the macrophages under Legionella infection.
Honors and Awards
- 2009 Distinguished Undergraduate Research Mentor, The Oho State University Denman Undergraduate Research Forum, Columbus, OH
- 2008 Distinguished Mentor Award, Davis Heart & Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH
- 2012 U.S. Environmental Protection Agency (EPA) 2012 Honorable Mention in Scientific & Technological Achievement Award Competition for Research Publication, “Vascular and Cardiac Impairments in Rats Inhaling Ozone and Diesel Exhaust Particles” in Environmental Health Perspectives.
- 1998 Recognition by the American Chemical Society (ACS), Columbus Chapter, Columbus, OH
- 1997 Recognition by the Chemical Abstracts Service for launching SciFinder, Columbus, OH
- 1986 Outstanding Teaching Assistant Award, Department of Biology, University of Toledo, OH
- 1977 University Gold Medal for scoring highest GPA in the M.S. program, University of Berhampur, India
- 1975-77 National Merit Scholarship, Govt. of India, University of Berhampur, India
Books
Books:
Kutala, V. K.; Parinandi, N. L.; Khan, M.; Iyyapu, K. M.; Kuppusamy, P.. Spirulina - A Blue-Green Alga with Novel Therapeutic Actions. Houston, TX: Stadium Press, LLC, January 2007
Chapters in books:
Steinhour E, Ciapala V, Butler S, Mazerik JN, Cruff JP, Kuppusamy P, Magalang U, Parthasarathy S, Marsh CB, Sen CK, Parinandi NL. "Redox-active antioxidant mudulation of lipid signaling in vascular endothelial cells: Vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase." In Free Radicals and Antioxidant Protocols 2nd ED - Methods in Mol Biol Sseries. Edited by Rao M. Uppu, Subrananyam N. Murthy and William A. Pryor. -. Totowa, NJ: Humana Press, January 2007
Kutala VK, Iyyapu KM, Khan M, Parinandi NL, Kuppusamy PK. "Drug-induced nephrotoxicity protection by Spirulina." In Spirulina in Human Nutrition and Health. Edited by Gershwin E and Belay A. 151-172. Boca Raton, FL: CRC Press, Taylor & Francis Group, January 2007
Kutual VK, Parinandi NL, Khan M, Iyyapu KM, Kuppusamy P. "Spirulina - A Blue-green Alga with Novel Therapeutic Actions." In Recent Progress in Medicinal Plants. Edited by J.N. Govil. Volume 22-. Houston, TX: Stadium Press LLC, January 2007
Butler S, Mazerik JN, Weis BK, Marsh CB, Schmid HHO, Parinandi NL. "Lipoxygenase-catalyzed phospholipid peroxidation: Preparation, purification and characterization of phosphatidylinositol peroxides." In Free Radicals and Antioxidant Protocols 2nd Edition - Methods in Mol Biol Sseries. -. Totowa, NJ: Humana Press, January 2007
Edited books:
"Free Radicals and Antioxidant Protocols (Methods in Molecular Biology)." Edited by Uppu, R.; Pror, W.; Murthy, S. N.; Parinani, N. L.. Totowa, NJ: Humana Press, January 2010
Editorial Activities
2007:
1990:
- Bulletin (Chemical Record) American Chemical Society, Columbus Chapter
1989:
- Bulletin (Chemical Record) American Chemical Society, Columbus Chapter
Presentations
"Catecholamines as Model Systems to Study Metal-induced Free Radical Oxidations." Presented at Analytical Chemistry & Industrial Processing Workshop Symposium, July 1985
"Antioxidants for Vanadium-induced Lipid Peroxidation in the Rat Brain in vitro." Presented at Sigma XI Annual Graduate Symposium, March 1985
"Trace Metal-induced Lipid Peroxidation in Rat Brain and Mechanisms." Presented at The Hormel Institute, University of Minnesota, February 1986
"Vanadium-induced Lipid Peroxidation in the Rat Brain." Presented at The Ohio Academy of Sciences Annual Conference, June 1986
"Lipid Peroxidation - Fact or Fiction." Presented at University of Minnesota, Hormel Institute Seminar Series, July 1987
"Free Radicals - Biology, Biochemistry and Toxicity." Presented at Andhra University, Department of Environmental Sciences Educational Lectures, June 1988
"Biochemican and Molecular basis of Circadian Rhythms." Presented at Hormel Institute Seminar Series, University of Minnesota, June 1988
"Diabetic Heart and Kidney exhibit Increased Resistance to Oxidative Stress." Presented at American Diabetes Association, Minneapolis Chapter, August 1989
"Lipid Peroxidation in Sciatic Nerve during Ischemia and Reperfusion." Presented at The Mayo Clinic, Peripheral Neuropathy Division, July 1989
"Mechanisms of Vanadium-induced Free Radical-mediated Lipid Peroxidation in Rat Brain." Presented at Annual Conference on Trace Substances in Environmental Health, July 1990
"Oxidative Stress and Lipid Peroxidation in Myocardium." Presented at IUPUC Medical Center, Division of Pulmonary and Critical Care Medicine, June 1990
"Involvement of Src Kinase in Oxidant-mediated Activation of Phospholipase D in Vascular Endothelial Cells." Presented at Johns Hopkins University, Combined Research Seminar Series, February 1999
"Signal Transduction and Kinases." Presented at Chemical Abstracts Service, American Chemical Society, July 2000
"NAD[P]H Oxidase-mediated Generation of Reactive Oxygen Species during Hyperoxia in Vascular Endothelial Cells." Presented at Johns Hopkins University, School of Public Health, October 2001
"Particulate Matter Respiratory Toxicity - Present State." Presented at Johns Hopkins University, Lung Seminar Series, February 2001
"Role of Phospholipase D in Urban Particulate Matter-induced Interleukin-8 Secretion by Bronchial Epithelial Cells." Presented at Maryland Thoracic Society, March 2001
"Phospholipase and Protein Kinase Network in Pulmonary Endothelial Cell Oxidant Signaling." Presented at OSU Division of Pulmonary and Critical Care Pulmonary Research Conference, August 2002
"Oxidant Activation of Phospholipase D in Vascular Endothelium and Respiratory Tract Epithelium." Presented at OSU College of Pharmacy, June 2002
"Electron Paramagnetic Resonance Spectroscopic Analysis of Lipid Peroxidation." Presented at American Oil Chemists' Society Annual Meeting, May 2003
"Signaling mechanisms of agricultural dust-induced inflammatory cytokine release by respiratory tract epithelial cells." Presented at University of Nebraska, Division of Pulmonary and Critical Care Medicine, November 2004
"Redox-active antioxidant-mediated Lipid Signaling." Presented at Medical College of Virginia, Department of Cardiology, April 2006
"Lipidomics of phospholipase cross-talk in vascular endothelium." Presented at OSU College of Ecology, Department of Nutrition, November 2006
"Agricultural Particulate matter-induced inflammatory cytokine secretion regulation by A2 in lung epithelial cells." Presented at Society of Free Radical Biology and Medicine Annual Conference, November 2006
"Nitric oxide-mediated lipid signaling in the vascular endothelium and the barrier dysfunction." Presented at University of Toledo, Department of Biological Sciences, April 2007
"Phospholipase D, a Redox-Sensitive Lipid Signalase in Lung Endothelial Cells, Regulates Vascular Permeability and Vasculotoxicity.." Presented at Harvard Medical School, Brigham and Women's Hospital, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, July 2009
"Metals, Oxidative Stress, Antioxidants and Vascular Endothelium." Presented at CTI Science, Inc., Lexington, KY, October 2009
"Lipid Oxygenases Regulate Phospholipase D activation Under Redox Modulation in Endothelial Cells." Dayton, OH, October 2009
"Mercury-induced Vasculotoxicity and Impairment of Angiogenesis." Presented at Silver Jubilee Celebrations of The International Academy of Oral Medicine & Toxicology (IAOMT, USA), Las Vegas, NV, September 2009
"Mercury-induced Lipid Signaling - A membrane Basis for Mercury Toxicity." Presented at International Academy of Oral Medicine & Toxicology, London, UK, February 2010
"How to Evolve as a Successful Scientist." Presented at Society for Free Radical Research, Annual Conference, Hyderabad, IN|IND, January 2010
"Adipose Tissue Protects Against Hyperoxic Lung Damage." Presented at Society for Free Radical Research, Annual Conference, Hyderabad, IN|IND, January 2010
"Novel Sulfhydryl Protective Compound for Leaky Gut Syndrome." Presented at Autism One/Generation Rescue, Annual Conference, Chicago, IL, May 2010