Narasimham Parinandi, PhD

Associate Professor
Research & Teaching

5180-Graves Hall & 5139-Optometry Clinic, OSU Wexner Medical Center
5130-Graves Hall, OSU Wexner Medical Center
narasimham.parinandi@osumc.edu; Parinandi.3@osu.edu
(614) 292-8577 Narasimham.Parinandi@osumc.edu

PubMed Articles Google Scholar ResearchGate

Teaching, Mentoring, and Research Interests

Teaching & Mentoring: Teaches wide variety of topics in Life Sciences and Biochemistry and Environmental Sciences. Passionate and committed to mentor undergraduate and graduate students on independent projects in fundamental research in Biological Sciences and Biochemistry.

Research: Biochemistry & Toxicology; Lipidomics of Phospholipases and Bioactive Lipids; Lipid Signaling in Regulation of Secretory Phenomena; Heavy Metal and Lipid Bilayer Interactions; Oxidized Lipidome; Translational Lipidomics of Chronic Diseases; Analytical Biochemistry; Methods of Teaching and Mentoring Research.

Research Interests

Oxidant Lipid Signaling; Vascular Biology; Phospholipases A2 and D; Analytical Lipidomics; Oxidative Stress; Bioinorganic Chemistry

Current Research:
Phospholipase A2 and D regulation in Lung Vascular Endothelium and Epithelium; Membrane Lipid Dynamics; Oxidative Lipidomics of Eicosanoids and Oxidized PUFA; Redox Antioxidant Biochemistry in Lung Damage; Heavy Metal Toxicology

Active Funding

R01: 64000015; (PI: Jodi McDaniel); Role: Co-I (Parinandi: 10% FTE)
NIH/National Institute on Aging
09/30/2018 - 03/31/2024
Total amount awarded: $ 3,331,920.00
Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older Adults.
This project investigates the role of omega-3 fatty acids in healing of wounds in human subjects.
R01: 1 R01 AI154553-01 (PI: Amal Amer); Role: Co-I (Parinandi: 5% effort)
NIH/MPI
Award period: from 12/01/2020 to 11/30/2025
Total amount awarded: $ 3,030,911.00
The Inflammasome and host-Legionella interaction.
The goal of this project and my role is to investigate the cytoskeletal rearrangement and the ECIS behavior of the macrophages under Legionella infection.

Education and Training

University of Berhampur, India B.Sc.(Hons) 1971-75 Chem/Botany/Zoology/English Literature
University of Berhampur, India M.Sc. 1975-77 Botany – Environ. Biol.
University of Andhra, India Post-Grad 1977-80 Environmental Sciences
University of Toledo, Toledo, OH Ph.D. 1980-86 Biology - Toxicology
University of Minnesota, Hormel Institute, MN Post-Doc 1986-90 Lipid Biochemistry
Johns Hopkins University, Baltimore, MD Res Assoc1998-02 Oxidant Lipid Signaling

Honors and Awards

2009 Distinguished Undergraduate Research Mentor, The Oho State University Denman Undergraduate Research Forum, Columbus, OH
2008 Distinguished Mentor Award, Davis Heart & Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH
2012 U.S. Environmental Protection Agency (EPA) 2012 Honorable Mention in Scientific & Technological Achievement Award Competition for Research Publication, “Vascular and Cardiac Impairments in Rats Inhaling Ozone and Diesel Exhaust Particles” in Environmental Health Perspectives.
1998 Recognition by the American Chemical Society (ACS), Columbus Chapter, Columbus, OH
1997 Recognition by the Chemical Abstracts Service for launching SciFinder, Columbus, OH
1986 Outstanding Teaching Assistant Award, Department of Biology, University of Toledo, OH
1977 University Gold Medal for scoring highest GPA in the M.S. program, University of Berhampur, India
1975-77 National Merit Scholarship, Govt. of India, University of Berhampur, India

Select Publications

(list of high impact pubs out of 130)

Parinandi, N.L. and Schmid, H.H.O. (1988). Effects of long-chain N-acylethanolamines on lipid peroxidation in cardiac mitochondria. FEBS Lett.237(1-2):49-52.
Parinandi, N.L., Weis, B.K., and Schmid, H.H.O. (1988). Assay of cardiolipin peroxidation by high-performance liquid chromatography. Chem. Phys. Lipids 49(3):215-220.
Parinandi, N.L., Weis, B.K., Natarajan, V., and Schmid, H.H.O. (1990). Peroxidative modification of phospholipids in myocardial membranes. Arch. Biochem. Biophys.280(1):45-52.
Parinandi, N.L., Thompson, Ed.W., and Schmid, H.H.O. (1990). Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. Biochem. Biophys. Acta1047(1):63-69.
Parinandi, N.L., Zwizinski, C.W., and Schmid, H.H.O. (1991). Free radical-induced alterations of myocardial membrane proteins. Arch. Biochem. Biophys.289(1):118-123.
Natarajan, V., Mohiuddin, M., Roehm, B., Parinandi, N.L., Schmid, H.H.O., Kiss, Z., and Garcia, J.G.N. (1993). Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide. J. Biol. Chem.268(2):930-937.
Parinandi, N.L., Scribner, W.M., Vepa, S., Shi, S., and Natarajan, V. (1999). Phospholipase D activation in endothelial cells is redox sensitive. Antioxidants & Redox Signaling1(2):193-210.
Shi, S., Garcia, J.G.N., Roy, S., Parinandi, N.L., and Natarajan, V. (2000). Involvement of c-Src in diperoxovanadate-induced endothelial barrier dysfunction. Am. J. Physiol. Lung Cell Mol. Physiol. 279:L441-L451.(Editorial Focus Paper).
Parinandi, N.L., Roy, S., Cummings, R., Morris, A.J., Garcia, J.G.N., and Natarajan, V. (2001). Role of Src kinase in diperoxovanadate-mediated activation of phospholipase D in endothelial cells. Arch. Biochem. Biophys. 396(2), 231-243.
Cummings, R., Parinandi, N.L., Zaiman, A., Wang, L., Garcia, J.G.N., and Natarajan, V. (2001): Phospholipase D activation by sphingosine-1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells. J. Biol. Chem.16;277(33):30227-35, 2002.
Varadharaj S, Watkins T, Cardounel AJ, Joe G.N. Garcia, Zweier JL, Kuppusamy, P., Natarajan V, Parinandi NL. (2005). Vitamin C-induced loss of redox-dependent viability in lung microvascular endothelial cells. Antioxidants Redox Signal. 7(1-2):287-300.
Varadharaj, S., Sakthivel, R., Vedamoorthyrao, S.,Parinandi, N.L. (2005). Alterations in band 3 protein and anion exchange in red blood cells of renal failure patients. J. Mol. Cell. Biochem.2005 May; 273(1-2):11-24.
Varadharaj S, Steinhour E, Hunter M, Watkins T, Baran C, Magalang U, Kuppusamy P, Marsh C, Zweier JL, Natarajan V, Parinandi NL. (2006) Vitamin C-induced activation of phospholipase D in lung endothelial cells: Regulation by MAP kinases. Cell Signaling. 2006 18(9):1396-407.
Bratasz A, Weir NM, Parinandi NL, Zweier JL, Sridhar R, Ignarro LJ, Kuppusamy P. (2006) Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin. Proc Natl Acad Sci U S A. 2006, 7;103(10):3914-9.(With Nobel Laureate, Dr. Ignarro).
Usatyuk PV, Parinandi NL, Natarajan V. (2006) Redox regulation of 4-HNE-mediated endothelial barrier dysfunction by focal adhesion, adherens and tight junction proteins. J Biol Chem. 2006 Nov 17;281(46):35554-66.
Parinandi NL, Sharma A, Eubank TD, Kaufman BF, Kutala VK, Marsh CB, Ignarro LJ, Kuppusamy P. (2007). Nitroaspirin, NCX-4016, is antiangiogenic through induction of loss of redox-dependent viability and cytoskeletal reorganization in endothelial cells. Antioxid Redox Signal. 2007 Nov;9(11):1837-49. (With Nobel Laureate, Dr. Ignarro).
Hagele TJ, Mazerik JN, Gregory A, Kaufman BF, Magalang U, Kuppusamy M, Marsh CB, Kuppusamy P, Parinandi NL. (2007). Mercury activates vascular endothelial cell phospholipase D through thiols and oxidative stress. Int. J. Toxicol.2007 Jan-Feb;26(1):57-69.
Usatyuk PV, Romer L, He D, Parinandi NL, Kleinberg ME, Zhan S, Jacobson JR, Dudek S, Garcia JGN, Natarajan V. (2007). Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin. J Biol Chem. 2007 Aug 10;282(32):23284-95.
Mazerik JN, Mikkilineni H, Kuppusamy VA, Steinhour E, Peltz A, Marsh CB, Kuppusamy P, Parinandi NL. (2007). Mercury activates phospholipase A2 and induces formation of arachidonic acid metabolites in vascular endothelial cells. Toxicol. Mech. Methods. 2007, 17: 541-557.
Mazerik JN, Hagele T, Sherwani S, Ciapala V, Butler S, Kuppusamy ML, Hunter M, Kuppusamy P, Marsh CB, Parinandi NL. (2007). Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells. Int J Toxicol. 2007 Nov-Dec;26(6):553-69.
Steinhour E, Sherwani S, Mazerik JN, Ciapala V, Butler S, Cruff JP, Magalang U, Parthasarathy S, Sen CK, Marsh CB, Kuppusamy P, Parinandi NL. (2008). Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: Vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase. Mol Cell Biochem. 2008 Aug;315(1-2):97-112.
Sathishkumar K, Gao X, Raghavamenon AC, Parinandi NL, Pryor WA, Uppu RM. (2009). Cholesterol secoaldehyde induces apoptosis in H9c2 cardiomyoblasts through reactive oxygen species involving mitochondrial and death receptor pathways. Free Radic Biol Med. 2009 Sep 1;47(5):548-58.
Peltz A, Sherwani SI, Kotha SR, Mazerik JN, O'Connor Butler ES, Kuppusamy ML, Hagele T, Magalang UJ, Kuppusamy P, Marsh CB, Parinandi NL. (2009). Calcium and calmodulin regulate mercury-induced phospholipase D activation in vascular endothelial cells. Int J Toxicol. 2009 May-Jun;28(3):190-206.
Sliman SM, Eubank TD, Kotha SR, Kuppusamy ML, Sherwani SI, Butler ES, Kuppusamy P, Roy S, Marsh CB, Stern DM, Parinandi NL. (2009). Hyperglycemic oxoaldehyde, glyoxal, causes barrier dysfunction, cytoskeletal alterations, and inhibition of angiogenesis in vascular endothelial cells: aminoguanidine protection. Mol Cell Biochem. 2010 Jan;333(1-2):9-26.
Patel RB, Kotha SR, Sherwani SI, Sliman SM, Gurney TO, Loar B, O’Connor Butler S, Morris AJ, Marsh CB, Parinandi NL. (2011). Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase D and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cells. Int J Toxicol. 2011 Feb;30(1):69-90.
Kodavanti UP, Thomas R, Ledbetter AD, Schladweiler MC, Shannahan JH, Wallenborn JG, Lund AK, Campen MJ, Butler EO, Gottipolu RR, Nyska A, Richards JE, Andrews D, Jaskot RH, McKee J, Kotha SR, Patel RB, Parinandi NL. (2011). Vascular and cardiac impairments in rats inhaling ozone and diesel exhaust particles. Environ Health Perspect. 2011 Mar;119(3):312-8.
Crouser ED, Parinandi N. (2011). Mitochondrial mechanisms are at the 'heart' of novel ischemia-reperfusion therapies. Crit Care Med. 2011 Mar;39(3):593-5.
Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL. (2011). Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. Int J Toxicol. 2011 Dec;30(6):619-38.
Patel RB, Kotha SR, Sauers LA, Malireddy S, Gurney TO, Gupta NN, Elton TS, Magalang UJ, Marsh CB, Haley BE, Parinandi NL. (2012). Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N'-bis-2-mercaptoethyl isophthalamide. Toxicol Mech Methods. 2012 Jun;22(5):383-96.
Parinandi NL, Magalang UJ. (2013). Avatars of adipose tissue: the saga of transformation of white fat, the villain into brown fat, the protector. Focus on "Inflammation induced by RAW macrophages suppresses the UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes". Am J Physiol Cell Physiol. 2013 Apr 15;304(8):C715-6.
Sherwani SI, Pabon S, Patel RB, Muzzammil MS, Hagele T, Kotha SR, Magalang UJ, Maddipati KR and Parinandi NL. (2013). Eicosanoid signaling of methylmercury-induced phospholipase D activation in vascular endothelial cells: Bioactive lipid-mediated cytotoxicity of methylmercury. Cell Biochem Biophys. 2013 Nov;67(2):317-29.
Kotha SR, Piper MG, Patel RB, Sliman S, Malireddy S, Baran CP, Nana-Sinkam SP, Wewers MD, Romberger D, Marsh CB, Parinandi NL. (2013). Phospholipase A2 activation by poultry particulate matter is mediated through extracellular signal-regulated kinase in lung epithelial cells: Regulation of interleukin-8 release. Cell Biochem Biophys. 2013 Nov;67(2):415-29.
Sliman SM, Patel RB, Cruff JP, Kotha SR, Newland CA, Schrader CA, Sherwani SI, Gurney TO, Magalang UJ, Parinandi NL. (2013). Adiponectin protects against hyperoxic lung injury and vascular leak. Cell Biochem Biophys. 2013 Nov;67(2):399-414.
Huang LS, Mathew B, Li H, Zhao Y, Ma SF, Noth I, Reddy SP, Harijith A, Usatyuk PV, Berdyshev EV, Kaminski N, Zhou T, Zhang W, Zhang Y, Rehman J, Kotha SR, Gurney TO, Parinandi NL, Lussier YA, Garcia JG, Natarajan V. (2014). The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis. Am J Respir Crit Care Med. 2014 Jun 1;189(11):1402-15.
Parinandi NL, Maulik N, Thirunavukkarasu M, McFadden D. Antioxidants in longevity and medicine. Oxidative Medicine and Cellular Longevity, 2015.
Heisler DB, Kudryashova E, Grinevich DO, Suarez C, Winkelman JD, Birukov KG, Kotha SR, Parinandi NL, Vavylonis D, Kovar DR, Kudryashov DS. ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization. Science. 2015 Jul 31;349(6247):535-9.
Das A, Ghatak S, Sinha M, Chaffee S, Ahmed NS, Parinandi NL, Wohleb ES, Sheridan JF, Sen CK, Roy S. Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes. J Immunol. 2016 Jun 15;196(12):5089-100.
McDaniel JC, Szalacha L, Sales M, Roy S, Chafee S, Parinandi N. EPA + DHA supplementation reduces PMN activation in microenvironment of chronic venous leg ulcers: A randomized, double-blind, controlled study. Wound Repair Regen. 2017 Aug;25(4):680-690.
Oghumu S, Varikuti S, Saljoughian N, Terrazas C, Huntsman AC, Parinandi NL, Fuchs JR, Kinghorn AD, Satoskar AR. Pentalinonsterol, a Constituent of Pentalinon andrieuxii, Possesses Potent Immunomodulatory Activity and Primes T Cell Immune Responses. J Nat Prod. 2017 Sep 22;80(9):2515-2523.
Kulkarni A, Kuppusamy P, Parinandi NL. (2007). Oxygen: The lead actor in the pathophysiological drama: Enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy. Antioxid Redox Signal. 2007 Oct;9(10):1717-30.
Malireddy S, Kotha SR, Secor JD, Gurney TO, Abbott JL, Maulik G, Maddipati KR, Parinandi NL. (2012). Phytochemical antioxidants modulate mammalian cellular epigenome: implications in health and disease. Antioxid Redox Signal. 2012 Jul 15;17(2):327-39.
Elton TS, Selemon H, Elton SM, Parinandi NL. (2013). Regulation of the MIR155 host gene in physiological and pathological processes. Gene. 2013 Dec 10;532(1):1-12.
Kodali ST, Kauffman P, Kotha SR, Yenigalla A, Veeraraghavan R, Pannu SR, Hund TJ, Satoskar AR, McDaniel JC, Maddipati RK, Parinandi NL. Oxidative Lipidomics: Analysis of Oxidized Lipids and Lipid Peroxidation in Biological Systems with Relevance to Health and Disease. 2020 Aug 9. In: Berliner LJ, Parinandi NL, editors. Measuring Oxidants and Oxidative Stress in Biological Systems: Springer; 2020. Chapter 5. PMID: 33411442.
Oliver PJ, Arutla S, Yenigalla A, Hund TJ, Parinandi NL. Lipid Nutrition in Asthma. Cell Biochem Biophys. 2021 Sep;79(3):669-694.
Fu P, Ramchandran R, Sudhadevi T, Kumar PPK, Krishnan Y, Liu Y, Zhao Y, Parinandi NL, Harijith A, Sadoshima J, Natarajan V. NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium. Antioxidants (Basel). 2021 Mar 17;10(3):477.
Nirujogi TS, Kotha SR, Chung S, Reader BF, Yenigalla A, Zhang L, Shapiro JP, Wisler J, Christman JW, Maddipati K, Parinandi NL, Karpurapu M. Lipidomic Profiling of Bronchoalveolar Lavage Fluid Extracellular Vesicles Indicates Their Involvement in Lipopolysaccharide-Induced Acute Lung Injury. J Innate Immun. 2022;14(5):555-568.
Parinandi N, Gerasimovskaya E, Verin A. Editorial: Molecular mechanisms of lung endothelial permeability. Front Physiol. 2022 Jul 22;13:976873. doi: 10.3389/fphys.2022.976873.

View CV (PDF)

Biography

Narasimham L. Parinandi (pAri) is an Associate Professor in Department of Internal Medicine, The Ohio State University College of Medicine. Parinandi received his B.Sc. (Hons) in botany with chemistry, zoology, English and M.Sc. in Botany with Environmental Biology in Berhampur University, India in 1975-77. From 1977-80, he was a research fellow in Environmental Sciences at the Andhra University, India. He earned his Ph.D. (1986) at the University of Toledo, Toledo, OH in Biology & Toxicology under the tutelage of Prof. Woon H. Jyung, an established zinc metabolism expert and aging biologist. During his graduate training at Toledo, he was exposed to the field of lipids by Prof. Max Funk, an expert lipoxygenase enzymologist from the lineage of Prof. Ned Porter. He did his post-doctoral fellowship (1986-90) at the Hormel Institute, University of Minnesota, the premier lipid institute in USA where he was trained with Prof. Harald Schmid, a celebrity in the area of ether lipids and a pioneer in anandamide chemistry. At the Hormel Institute of the University of Minnesota, Parinandi was associated with Prof. Ralph T. Holman (Member of the National Academy of Sciences and Pioneer in Fatty Acid and Lipoxygenase Biochemistry who also coined the name “Omega-3 Fatty Acid”) and conducted studies on omega-3 fatty acid dynamics in humans. He was also a research scientist/junior faculty at the Johns Hopkins University School of Medicine (1998-2002) under the mentorship of Prof. V. Natarajan, renowned lipid signaling expert and Prof. Joe G.N. (Skip) Garcia, a celebrated lung vascular biologist. Parinandi has published nearly 125 peer-reviewed original scientific papers, reviews, and book chapters and edited books on Free Radicals and Antioxidant Protocols with Prof. William Pryor, (legendary Free Radical and Lipid Peroxidation Scientist), Mitochondria in Lung Health and Disease with Prof. Natarajan (a lipid signaling celebrity), and on “Measuring Oxidants and Oxidative Stress” with Prof. Lawrence Berliner (a celebrity in the area of Oxygen and Oxidative Stress). Parinandi has given more than 50 invited scientific lectures at the national level in the US and international institutions and conferences. He has also conducted and chaired several scientific conferences and symposia in the areas of oxidative stress and lipidology. He has teaching and mentoring experience of more than 30 years and mentored over 75 students, technicians, fellows, and junior faculty in his laboratory. He served as an editor of the Chemical Abstracts of the American Chemical Society. He has been a reviewer of over 70 peer-reviewed journals in the area of biochemistry, molecular biology, cell biology and Lipidomics. Parinandi has been on the editorial board of the Molecular Biology Reports (Springer), Frontiers in Pharmacology (Associate Editor), Vessel Plus (Associate Editor), Cell Biophysics and Biochemistry (Associate Editor), and The Protein Journal. He is also the Editor of the “Oxidative Stress” Series of Springer-Nature. He has also received extramural funding from the National Institutes of Health (NIH), Department of Defense (DOD), American Thoracic Society (ATS), and International Academy of Oral Medicine and Toxicology (IAOMT) as a principal investigator (PI) and co-investigator (Co-I). Parinandi also serves as a reviewer of grant proposals of the NIH, AHA, DOD, US Universities, Government of Israel, Government of Austria, and Government of South Africa. Parinandi has received awards including the Gold Medal for securing the highest GPA in the M.S. class of 1975-77 of the Berhampur University, India, the Outstanding Teaching Assistant Award of the Biology Department of the University of Toledo in 1986, Distinguished Mentor Award of the Davis Heart & Lung Research Institute of the Ohio State University Wexner Medical Center in 2008, and the Distinguished Undergraduate Mentor Award of the Ohio State Undergraduate Research Program in 2009.
Books

Books:

Kutala, V. K.; Parinandi, N. L.; Khan, M.; Iyyapu, K. M.; Kuppusamy, P.. Spirulina - A Blue-Green Alga with Novel Therapeutic Actions. Houston, TX: Stadium Press, LLC, January 2007

Chapters in books:

Steinhour E, Ciapala V, Butler S, Mazerik JN, Cruff JP, Kuppusamy P, Magalang U, Parthasarathy S, Marsh CB, Sen CK, Parinandi NL. "Redox-active antioxidant mudulation of lipid signaling in vascular endothelial cells: Vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase." In Free Radicals and Antioxidant Protocols 2nd ED - Methods in Mol Biol Sseries. Edited by Rao M. Uppu, Subrananyam N. Murthy and William A. Pryor. -. Totowa, NJ: Humana Press, January 2007

Kutala VK, Iyyapu KM, Khan M, Parinandi NL, Kuppusamy PK. "Drug-induced nephrotoxicity protection by Spirulina." In Spirulina in Human Nutrition and Health. Edited by Gershwin E and Belay A. 151-172. Boca Raton, FL: CRC Press, Taylor & Francis Group, January 2007

Kutual VK, Parinandi NL, Khan M, Iyyapu KM, Kuppusamy P. "Spirulina - A Blue-green Alga with Novel Therapeutic Actions." In Recent Progress in Medicinal Plants. Edited by J.N. Govil. Volume 22-. Houston, TX: Stadium Press LLC, January 2007

Butler S, Mazerik JN, Weis BK, Marsh CB, Schmid HHO, Parinandi NL. "Lipoxygenase-catalyzed phospholipid peroxidation: Preparation, purification and characterization of phosphatidylinositol peroxides." In Free Radicals and Antioxidant Protocols 2nd Edition - Methods in Mol Biol Sseries. -. Totowa, NJ: Humana Press, January 2007

Edited books:

"Free Radicals and Antioxidant Protocols (Methods in Molecular Biology)." Edited by Uppu, R.; Pror, W.; Murthy, S. N.; Parinani, N. L.. Totowa, NJ: Humana Press, January 2010
Editorial Activities
2007:
- Lipids
- American Journal of Respiratory Cell and Molecular Biology,
- American Journal of Physiology Cell Biology,
- Journal of Lipid Research,
- Chemistry and Physics of Lipids,
- Progress of Lipid Research,
- Antioxidants and Redox Signaling,
1990:
- Bulletin (Chemical Record) American Chemical Society, Columbus Chapter
1989:
- Bulletin (Chemical Record) American Chemical Society, Columbus Chapter
Journal Articles

Parinandi NL, Raju PA. "Plant insectides." Science Reporter. Vol. 17(2), (January 1980.): 110-111

Parinandi NL, Raju PA. "crassulacean plants in aird environment." Science Reporter. (January 1981.): 540-542

Parinandi, N, L; Weis, B, K; Schmid, H H. "Assay of cardiolipin peroxidation by high-performance liquid chromatography.." Chemistry and physics of lipids. Vol. 49, no. 3. (January 1988.): 215-20

Parinandi, N, L; Schmid, H H. "Effects of long-chain N-acylethanolamines on lipid peroxidation in cardiac mitochondria.." FEBS letters. Vol. 237, no. 1-2. (January 1988.): 49-52

Parinandi, N, L; Weis, B, K; Natarajan, V; Schmid, H H. "Peroxidative modification of phospholipids in myocardial membranes.." Archives of biochemistry and biophysics. Vol. 280, no. 1. (January 1990.): 45-52

Parinandi, N, L; Thompson, E, W; Schmid, H H. "Diabetic heart and kidney exhibit increased resistance to lipid peroxidation.." Biochimica et biophysica acta. Vol. 1047, no. 1. (January 1990.): 63-9

Parinandi, N, L; Zwizinski, C, W; Schmid, H H. "Free radical-induced alterations of myocardial membrane proteins.." Archives of biochemistry and biophysics. Vol. 289, no. 1. (January 1991.): 118-23

Natarajan, V; Taher, M, M; Roehm, B; Parinandi, N, L; Schmid, H, H; Kiss, Z; Garcia, J G. "Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.." The Journal of biological chemistry. Vol. 268, no. 2. (January 1993.): 930-7

Parinandi, N, L; Scribner, W, M; Vepa, S; Shi, S; Natarajan, V. "Phospholipase D activation in endothelial cells is redox sensitive." Antioxidants & redox signaling. Vol. 1, no. 2. (January 1999.): 193-210

Vepa, S; Scribner, W, M; Parinandi, N, L; English, D; Garcia, J, G; Natarajan, V. "Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cells.." The American journal of physiology. Vol. 277, no. 1 Pt 1. (January 1999.): L150-8

Shi, S; Garcia, J, G; Roy, S; Parinandi, N, L; Natarajan, V. "Involvement of c-Src in diperoxovanadate-induced endothelial cell barrier dysfunction.." American journal of physiology. Lung cellular and molecular physiology. Vol. 279, no. 3. (January 2000.): L441-51

Natarajan, V; Scribner, W, M; Morris, A, J; Roy, S; Vepa, S; Yang, J; Wadgaonkar, R; Reddy, S, P; Garcia, J, G; Parinandi, N L. "Role of p38 MAP kinase in diperoxovanadate-induced phospholipase D activation in endothelial cells.." American journal of physiology. Lung cellular and molecular physiology. Vol. 281, no. 2. (January 2001.): L435-49

Parinandi, N, L; Roy, S; Shi, S; Cummings, R, J; Morris, A, J; Garcia, J, G; Natarajan, V. "Role of Src kinase in diperoxovanadate-mediated activation of phospholipase D in endothelial cells.." Archives of biochemistry and biophysics. Vol. 396, no. 2. (January 2001.): 231-43

Cummings, Rhett; Parinandi, Narasimham; Wang, Lixin; Usatyuk, Peter; Natarajan, Viswanathan. "Phospholipase D/phosphatidic acid signal transduction: role and physiological significance in lung.." Molecular and cellular biochemistry. Vol. 234-235, no. 1-2. (January 2002.): -

Cummings, Rhett, J; Parinandi, Narasimham, L; Zaiman, Ari; Wang, Lixin; Usatyuk, Peter, V; Garcia, Joe G, N; Natarajan, Viswanathan. "Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells." The Journal of biological chemistry. Vol. 277, no. 33. (January 2002.): 30227-35

Roy, Shukla; Parinandi, Narasimham; Zeigelstein, Roy; Hu, Qinghua; Pei, Yong; Travers, Jeffrey, B; Natarajan, Viswanathan. "Hyperoxia alters phorbol ester-induced phospholipase D activation in bovine lung microvascular endothelial cells.." Antioxidants & redox signaling. Vol. 5, no. 2. (January 2003.): 217-28

Usatyuk, Peter, V; Vepa, Suryanarayana; Watkins, Tonya; He, Donghong; Parinandi, Narasimham, L; Natarajan, Viswanathan. "Redox regulation of reactive oxygen species-induced p38 MAP kinase activation and barrier dysfunction in lung microvascular endothelial cells.." Antioxidants & redox signaling. Vol. 5, no. 6. (January 2003.): 723-30

Parinandi, Narasimham, L; Kleinberg, Michael, A; Usatyuk, Peter, V; Cummings, Rhett, J; Pennathur, Arjun; Cardounel, Arturo, J; Zweier, Jay, L; Garcia, Joe G, N; Natarajan, Viswanathan. "Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells.." American journal of physiology. Lung cellular and molecular physiology. Vol. 284, no. 1. (January 2003.): L26-38

Pandian, Ramasamy, P; Parinandi, Narasimham, L; Ilangovan, Govindasamy; Zweier, Jay, L; Kuppusamy, Periannan. "Novel particulate spin probe for targeted determination of oxygen in cells and tissues.." Free radical biology & medicine. Vol. 35, no. 9. (January 2003.): 1138-48

Pandian, Ramasamy, P; Kutala, Vijay Kumar; Parinandi, Narasimham, L; Zweier, Jay, L; Kuppusamy, Periannan. "Measurement of oxygen consumption in mouse aortic endothelial cells using a microparticulate oximetry probe.." Archives of biochemistry and biophysics. Vol. 420, no. 1. (January 2003.): 169-75

Byrnes, Colman, K; Bahadursingh, Anil; Akhter, Nabeel; Parinandi, Narasimham, L; Natarajan, Viswanathan; Montgomery, Elizabeth; Tihan, Tarik; Duncan, Mark, D; Nass, Petra, H; Harmon, John W. "Duodenal reflux produces hyperproliferative epithelial esophagitis--a possible precursor to esophageal adenocarcinoma in the rat.." Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. Vol. 7, no. 2. (January 2003.): 172-80

Rizzi, Cecile; Samouilov, Alexandre; Kutala, Vijay Kumar; Parinandi, Narasimham, L; Zweier, Jay, L; Kuppusamy, Periannan. "Application of a trityl-based radical probe for measuring superoxide.." Free radical biology & medicine. Vol. 35, no. 12. (January 2003.): 1608-18

Kutala, Vijay Kumar; Parinandi, Narasimham, L; Zweier, Jay, L; Kuppusamy, Periannan. "Reaction of superoxide with trityl radical: implications for the determination of superoxide by spectrophotometry.." Archives of biochemistry and biophysics. Vol. 424, no. 1. (January 2004.): 81-8

Kutala, Vijay Kumar; Parinandi, Narasimham, L; Pandian, Ramasamy, P; Kuppusamy, Periannan. "Simultaneous measurement of oxygenation in intracellular and extracellular compartments of lung microvascular endothelial cells.." Antioxidants & redox signaling. Vol. 6, no. 3. (January 2004.): 597-603

Varadharaj S, Watkins T, Cardounel AJ, Joe GN Garcia, Zweier JL, Kuppusamy P, Natarajan V, Parinandi NL. "Vitamin C-induced loss of redox-dependent viability in lung microvascular endothelial cells." Antioxidants Redox Signal. Vol. 7(1-2), (January 2005.): 287-300

Khanna S, roy s, Slivka A, Craft TKS, Chaki S, Rink C. "Molecular basis of vitamin E action. Potent neuroprotective properties of a-tocotrienol in cultured neurons and against stroke." Stroke. Vol. 36(10), (January 2005.): 2258-64

Chowdhury, Ashis, K; Watkins, Tonya; Parinandi, Narasimham, L; Saatian, Bahman; Kleinberg, Michael, E; Usatyuk, Peter, V; Natarajan, Viswanathan. "Src-mediated tyrosine phosphorylation of p47phox in hyperoxia-induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cells.." The Journal of biological chemistry. Vol. 280, no. 21. (January 2005.): 20700-11

Zhou Y; Varadharaj S; Zhao X; Parinandi N; Flavahan NA; Zweier JL. "Acetylcholine causes endothelium-dependent contraction of mouse arteries.." American Journal Of Physiology. Heart And Circulatory Physiology. Vol. 289, no. 3. (September 2005.): H1027-

Pandian, Ramasamy, P; Kutala, Vijay Kumar; Liaugminas, Alex; Parinandi, Narasimham, L; Kuppusamy, Periannan. "Lipopolysaccharide-induced alterations in oxygen consumption and radical generation in endothelial cells.." Molecular and cellular biochemistry. Vol. 278, no. 1-2. (January 2005.): 119-27

Khanna, Savita; Roy, Sashwati; Slivka, Andrew; Craft, Tara K, S; Chaki, Soma; Rink, Cameron; Notestine, Margaret, A; DeVries, A Courtney; Parinandi, Narasimham, L; Sen, Chandan K. "Neuroprotective properties of the natural vitamin E alpha-tocotrienol.." Stroke; a journal of cerebral circulation. Vol. 36, no. 10. (January 2005.): 2258-64

Zhou, Yingbi; Varadharaj, Saradhadevi; Zhao, Xue; Parinandi, Narasimham; Flavahan, Nicholas, A; Zweier, Jay L. "Acetylcholine causes endothelium-dependent contraction of mouse arteries.." American journal of physiology. Heart and circulatory physiology. Vol. 289, no. 3. (January 2005.): H1027-32

Martin, Sergio, F; Chatterjee, Subroto; Parinandi, Narasimham; Alevriadou, B Rita. "Rac1 inhibition protects against hypoxia/reoxygenation-induced lipid peroxidation in human vascular endothelial cells.." Vascular pharmacology. Vol. 43, no. 3. (January 2005.): 148-56

Saradhadevi, Varadharaj; Sakthivel, Ramasamy; Vedamoorthy, Srikanth; Selvam, Ramasamy; Parinandi, Narasimham. "Alterations in band 3 protein and anion exchange in red blood cells of renal failure patients.." Molecular and cellular biochemistry. Vol. 273, no. 1-2. (January 2005.): 11-24

Parinandi NL, Deli E, Raj RK, ramasarma T, Holman RT, Bibus D. "High co3 nutritive status indicated by essential fatty acid projiles in Keralites of India." Lipids - Submitted. (January 2005.): -

Varadharaj, Saradhadevi; Watkins, Tonya; Cardounel, Arturo, J; Garcia, Joe G, N; Zweier, Jay, L; Kuppusamy, Periannan; Natarajan, Viswanathan; Parinandi, Narasimham L. "Vitamin C-induced loss of redox-dependent viability in lung microvascular endothelial cells.." Antioxidants & redox signaling. Vol. 7, no. 1-2. (January 2005.): 287-300

Martin SF; Chatterjee S; Parinandi N; Alevriadou BR. "Rac1 inhibition protects against hypoxia/reoxygenation-induced lipid peroxidation in human vascular endothelial cells.." Vascular Pharmacology. Vol. 43, no. 3. (September 2005.): 148-

Zhou Y; Mitra S; Varadharaj S; Parinandi N; Zweier JL; Flavahan NA. "Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice.." Circulation Research. Vol. 98, no. 11. (June 2006.): 1439-

Usatyuk, Peter, V; Parinandi, Narasimham, L; Natarajan, Viswanathan. "Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins.." The Journal of biological chemistry. Vol. 281, no. 46. (January 2006.): 35554-66

Magalang, Ulysses, J; Rajappan, Ramya; Hunter, Melissa, G; Kutala, Vijay, K; Kuppusamy, Periannan; Wewers, Mark, D; Marsh, Clay, B; Parinandi, Narasimham L. "Adiponectin inhibits superoxide generation by human neutrophils.." Antioxidants & redox signaling. Vol. 8, no. 11-12. (January 2006.): 2179-86

Khan, Mahmood; Varadharaj, Saradhadevi; Shobha, Jagdish, C; Naidu, Madireddi, U; Parinandi, Narasimham, L; Kutala, Vijay Kumar; Kuppusamy, Periannan. "C-phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult rat cardiomyocytes.." Journal of cardiovascular pharmacology. Vol. 47, no. 1. (January 2006.): 9-20

Varadharaj, Saradhadevi; Steinhour, Emily; Hunter, Melissa, G; Watkins, Tonya; Baran, Christopher, P; Magalang, Ulysses; Kuppusamy, Periannan; Zweier, Jay, L; Marsh, Clay, B; Natarajan, Viswanathan; Parinandi, Narasimham L. "Vitamin C-induced activation of phospholipase D in lung microvascular endothelial cells: regulation by MAP kinases.." Cellular signalling. Vol. 18, no. 9. (January 2006.): -

Parinandi, Narasimham, L; Sen, Chandan, K; Kuppusamy, Periannan. "Joint International Conference on EPR Spectroscopy and wound healing.." Antioxidants & redox signaling. Vol. 8, no. 7-8. (January 2006.): 1385-7

Khanna, Savita; Roy, Sashwati; Parinandi, Narasimham, L; Maurer, Mariah; Sen, Chandan K. "Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol.." Journal of neurochemistry. Vol. 98, no. 5. (January 2006.): 1474-86

Khan, Mahmood; Varadharaj, Saradhadevi; Ganesan, Latha, P; Shobha, Jagdish, C; Naidu, Madireddi, U; Parinandi, Narasimham, L; Tridandapani, Susheela; Kutala, Vijay Kumar; Kuppusamy, Periannan. "C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling.." American journal of physiology. Heart and circulatory physiology. Vol. 290, no. 5. (January 2006.): H2136-45

Zhou, Yingbi; Mitra, Srabani; Varadharaj, Saradhadevi; Parinandi, Narasimham; Zweier, Jay, L; Flavahan, Nicholas A. "Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice.." Circulation research. Vol. 98, no. 11. (January 2006.): 1439-45

Bratasz, Anna; Weir, Nathan, M; Parinandi, Narasimham, L; Zweier, Jay, L; Sridhar, Rajagopalan; Ignarro, Louis, J; Kuppusamy, Periannan. "Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 103, no. 10. (January 2006.): 3914-9

Mazerik JN, Mikkilineni H, Kuppusamy VA, Steinhour E, Peltz A, Marsh CB, Kuppusamy P, Parinandi NL. "Mercury activates phospholipase A2 and induces formation of arachidonic acid metabolites in vascular endothelial cells - IN REVIEW." Toxicol. Mech. Methods. (January 2006.): -

Parinandi, Narasimham, L; Sharma, Ashish; Eubank, Timothy, D; Kaufman, Bruce, F; Kutala, Vijay Kumar; Marsh, Clay, B; Ignarro, Louis, J; Kuppusamy, Periannan. "Nitroaspirin (NCX-4016), an NO donor, is antiangiogenic through induction of loss of redox-dependent viability and cytoskeletal reorganization in endothelial cells.." Antioxidants & redox signaling. Vol. 9, no. 11. (January 2007.): -

Parinandi NL, Sharma A, Eubank TD, Kaufman BF, Kutala VK, Marsh CB, Ignarro LJ, Kuppusamy P. "Nitroaspirin, NCX-4016, is antiangiogenic through induction of loss of redox-dependent viability and cytoskeletal reorganization in endothilial cells." Free Radic. Biol. Med. - IN REVIEW. (January 2007.): -

Kulkarni, Aditi, C; Kuppusamy, Periannan; Parinandi, Narasimham. "Oxygen, the lead actor in the pathophysiologic drama: enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy.." Antioxidants & redox signaling. Vol. 9, no. 10. (January 2007.): -

Kulkarni, A.; Kuppusamy, P.; Parinandi, N. L.. Antioxid Redox Signal. Vol. 9, no. 10. (January 2007.): 1717-1730

Kulkarni A, Kuppusamy P, Parinandi, NL. "The lead actor in the pathophysiological drama: Enactment of the trinity of normoxia, hypoxia and hyperoxia in disease and therapy." Antioxid Redox Signal. (January 2007.): -

Hagele TJ, Mazerik JN, Gregory A, Kaufman BF, Magalang U, Kuppusamy M, Marsh CB, Kuppusamy P, Parinandi NL. "Mercury activates vascular endothelia cell phospholipase D through thiols and oxidative stress." Radic. Biol. Med.. (January 2007.): -

Usatyuk, Peter, V; Romer, Lewis, H; He, Donghong; Parinandi, Narasimham, L; Kleinberg, Michael, E; Zhan, Steve; Jacobson, Jeffrey, R; Dudek, Steven, M; Pendyala, Srikanth; Garcia, Joe G, N; Natarajan, Viswanathan. "Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin.." The Journal of biological chemistry. Vol. 282, no. 32. (January 2007.): -

Usatyuk PV, Romer L, He D, Prinandi NL, Kleinberg ME, Zhan S, Jacobson JR, Dudek S, Garcia JGN, Natarajan V. "Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin." Biol. Chem. - IN REVIEW. (January 2007.): -

Pope, Arthur, J; Druhan, Lawrence; Guzman, Jorge, E; Forbes, Scott, P; Murugesan, Velayutham; Lu, Deqin; Xia, Yong; Chicoine, Louis, G; Parinandi, Narasimham, L; Cardounel, Arturo J. "Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation.." American journal of physiology. Cell physiology. Vol. 293, no. 5. (January 2007.): -

Mazerik, Jessica, N; Hagele, Thomas; Sherwani, Shariq; Ciapala, Valorie; Butler, Susan; Kuppusamy, M Lakshmi; Hunter, Melissa; Kuppusamy, Periannan; Marsh, Clay, B; Parinandi, Narasimham L. "Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells.." International journal of toxicology. Vol. 26, no. 6. (January 2007.): -

Kulkarni AC; Kuppusamy P; Parinandi N. "Oxygen, the lead actor in the pathophysiologic drama: enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy.." Antioxidants & Redox Signaling. Vol. 9, no. 10. (October 2007.): 1717-

Hagele, Thomas, J; Mazerik, Jessica, N; Gregory, Anita; Kaufman, Bruce; Magalang, Ulysses; Kuppusamy, M Lakshmi; Marsh, Clay, B; Kuppusamy, Periannan; Parinandi, Narasimham L. "Mercury activates vascular endothelial cell phospholipase D through thiols and oxidative stress.." International journal of toxicology. Vol. 26, no. 1. (January 2007.): -

Kutala VK, Parinandi NL, Khan M, Iyyapu KM, Kuppusamy P. "Spirulina - A Blue-green Alga with Novel Therapeutic Actions." Recent Progress in Medicinal Plants. Vol. 22, (January 2008.): -

Steinhour E, Sherwani SI, Mazerik JN, Ciapala V, O'Connor Butler E, Cruff JP, Magalang U, Parthasarathy S, Sen CK, Marsh CB, Kuppusamy P, Parinandi NL. "Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase." Mol Cell Biochem.. Vol. 315, no. 1-2. (January 2008.): 97-112

Forbes SP, Druhan LJ, Guzman JE, Parinandi NL, Zhang L, Green-Church KB, Cardounel AJ.. "Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in NO regulation.." Biochemistry. Vol. 47, no. 6. (January 2008.): 1819-1826

Forbes SP; Druhan LJ; Guzman JE; Parinandi N; Zhang L; Green-Church KB; Cardounel AJ. "Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in no regulation.." Biochemistry. Vol. 47, no. 6. (February 2008.): 1819-

Kutala VK, Parinandi NL, Khan M, Iyyapu KM, Kuppusamy P. "Drug-induced nephrotoxicity protection by Spirulina.." Spirulina in Human Nutrition. (January 2008.): 153-176

Oliver SR; Wright VP; Parinandi N; Clanton TL. "Thermal tolerance of contractile function in oxidative skeletal muscle: no protection by antioxidants and reduced tolerance with eicosanoid enzyme inhibition.." American Journal Of Physiology. Regulatory, Integrative And Comparative Physiology. Vol. 295, no. 5. (November 2008.): R1695-

Oliver SR, Wright VP, Parinandi N, Clanton TL. "Thermal tolerance of contractile function in oxidative skeletal muscle: no protection by antioxidants and reduced tolerance with eicosanoid enzyme inhibition." Am J Physiol Regul Integr Comp Physiol.. Vol. 295, no. 5. (November 2008.): R1695-705

Khan M, Iyyapu KM, Kutala V, Kotha S, Parinandi NL, Hamlin RL, Kuppusamy P. "Sulfaphenazole protects heart against ischemia-reperfusion injury and cardiac dysfunction by overexpression of iNOS leading to enhancement of nitric-oxide bioavailability and tissue oxygenation." Antioxid Redox Signal.. (October 2008.): -

Magalang UJ, Cruff JP, Rajappan R, Hunter MG, Patel T, Marsh CB, Raman SV, Parinandi NL. "Intermittent Hypoxia Suppresses Adiponectin Secretion by Adipocytes." Exp Clin Endocrinol Diabetes.. (June 2008.): -

Sathishkumar K; Gao X; Raghavamenon AC; Parinandi N; Pryor WA; Uppu RM. "Cholesterol secoaldehyde induces apoptosis in H9c2 cardiomyoblasts through reactive oxygen species involving mitochondrial and death receptor pathways.." Free Radical Biology & Medicine. Vol. 47, no. 5. (September 2009.): 548-

Magalang UJ; Richards K; McCarthy B; Fathala A; Khan M; Parinandi N; Raman SV. "Continuous positive airway pressure therapy reduces right ventricular volume in patients with obstructive sleep apnea: a cardiovascular magnetic resonance study.." Journal Of Clinical Sleep Medicine: JCSM: Official Publication Of The American Academy Of Sleep Medicine. Vol. 5, no. 2. (April 2009.): 110-

Magalang UJ; Cruff JP; Rajappan R; Hunter MG; Patel T; Marsh CB; Raman SV; Parinandi NL. "Intermittent hypoxia suppresses adiponectin secretion by adipocytes.." Experimental And Clinical Endocrinology & Diabetes: Official Journal, German Society Of Endocrinology [And] German Diabetes Association. Vol. 117, no. 3. (March 2009.): 129-

O'Connor Butler ES; Mazerik JN; Cruff JP; Sherwani SI; Weis BK; Marsh CB; Raghavamenon AC; Uppu RM; Schmid HH; Parinandi NL. "Lipoxygenase-catalyzed phospholipid peroxidation: preparation, purification, and characterization of phosphatidylinositol peroxides.." Methods In Molecular Biology (Clifton, N.J.). Vol. 610, (January 2010.): 387-

Sathishkumar K; Raghavamenon AC; Ganeshkumar K; Telaprolu R; Parinandi NL; Uppu RM. "Simultaneous analysis of expression of multiple redox-sensitive and apoptotic genes in hypothalamic neurons exposed to cholesterol secoaldehyde.." Methods In Molecular Biology (Clifton, N.J.). Vol. 610, (January 2010.): 263-

Kline MA; O'Connor Butler ES; Hinzey A; Sliman S; Kotha SR; Marsh CB; Uppu RM; Parinandi NL. "A simple method for effective and safe removal of membrane cholesterol from lipid rafts in vascular endothelial cells: implications in oxidant-mediated lipid signaling.." Methods In Molecular Biology (Clifton, N.J.). Vol. 610, (January 2010.): 201-

Sliman SM; Eubank TD; Kotha SR; Kuppusamy ML; Sherwani SI; Butler ES; Kuppusamy P; Roy S; Marsh CB; Stern DM; Parinandi NL. "Hyperglycemic oxoaldehyde, glyoxal, causes barrier dysfunction, cytoskeletal alterations, and inhibition of angiogenesis in vascular endothelial cells: aminoguanidine protection.." Molecular And Cellular Biochemistry. Vol. 333, no. 1-2. (January 2010.): 9-

Khanna S; Parinandi NL; Kotha SR; Roy S; Rink C; Bibus D; Sen CK. "Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection.." Journal Of Neurochemistry. Vol. 112, no. 5. (March 2010.): 1249-
Presentations

"Catecholamines as Model Systems to Study Metal-induced Free Radical Oxidations." Presented at Analytical Chemistry & Industrial Processing Workshop Symposium, July 1985

"Antioxidants for Vanadium-induced Lipid Peroxidation in the Rat Brain in vitro." Presented at Sigma XI Annual Graduate Symposium, March 1985

"Trace Metal-induced Lipid Peroxidation in Rat Brain and Mechanisms." Presented at The Hormel Institute, University of Minnesota, February 1986

"Vanadium-induced Lipid Peroxidation in the Rat Brain." Presented at The Ohio Academy of Sciences Annual Conference, June 1986

"Lipid Peroxidation - Fact or Fiction." Presented at University of Minnesota, Hormel Institute Seminar Series, July 1987

"Free Radicals - Biology, Biochemistry and Toxicity." Presented at Andhra University, Department of Environmental Sciences Educational Lectures, June 1988

"Biochemican and Molecular basis of Circadian Rhythms." Presented at Hormel Institute Seminar Series, University of Minnesota, June 1988

"Diabetic Heart and Kidney exhibit Increased Resistance to Oxidative Stress." Presented at American Diabetes Association, Minneapolis Chapter, August 1989

"Lipid Peroxidation in Sciatic Nerve during Ischemia and Reperfusion." Presented at The Mayo Clinic, Peripheral Neuropathy Division, July 1989

"Mechanisms of Vanadium-induced Free Radical-mediated Lipid Peroxidation in Rat Brain." Presented at Annual Conference on Trace Substances in Environmental Health, July 1990

"Oxidative Stress and Lipid Peroxidation in Myocardium." Presented at IUPUC Medical Center, Division of Pulmonary and Critical Care Medicine, June 1990

"Involvement of Src Kinase in Oxidant-mediated Activation of Phospholipase D in Vascular Endothelial Cells." Presented at Johns Hopkins University, Combined Research Seminar Series, February 1999

"Signal Transduction and Kinases." Presented at Chemical Abstracts Service, American Chemical Society, July 2000

"NAD[P]H Oxidase-mediated Generation of Reactive Oxygen Species during Hyperoxia in Vascular Endothelial Cells." Presented at Johns Hopkins University, School of Public Health, October 2001

"Particulate Matter Respiratory Toxicity - Present State." Presented at Johns Hopkins University, Lung Seminar Series, February 2001

"Role of Phospholipase D in Urban Particulate Matter-induced Interleukin-8 Secretion by Bronchial Epithelial Cells." Presented at Maryland Thoracic Society, March 2001

"Phospholipase and Protein Kinase Network in Pulmonary Endothelial Cell Oxidant Signaling." Presented at OSU Division of Pulmonary and Critical Care Pulmonary Research Conference, August 2002

"Oxidant Activation of Phospholipase D in Vascular Endothelium and Respiratory Tract Epithelium." Presented at OSU College of Pharmacy, June 2002

"Electron Paramagnetic Resonance Spectroscopic Analysis of Lipid Peroxidation." Presented at American Oil Chemists' Society Annual Meeting, May 2003

"Signaling mechanisms of agricultural dust-induced inflammatory cytokine release by respiratory tract epithelial cells." Presented at University of Nebraska, Division of Pulmonary and Critical Care Medicine, November 2004

"Redox-active antioxidant-mediated Lipid Signaling." Presented at Medical College of Virginia, Department of Cardiology, April 2006

"Lipidomics of phospholipase cross-talk in vascular endothelium." Presented at OSU College of Ecology, Department of Nutrition, November 2006

"Agricultural Particulate matter-induced inflammatory cytokine secretion regulation by A2 in lung epithelial cells." Presented at Society of Free Radical Biology and Medicine Annual Conference, November 2006

"Nitric oxide-mediated lipid signaling in the vascular endothelium and the barrier dysfunction." Presented at University of Toledo, Department of Biological Sciences, April 2007

"Phospholipase D, a Redox-Sensitive Lipid Signalase in Lung Endothelial Cells, Regulates Vascular Permeability and Vasculotoxicity.." Presented at Harvard Medical School, Brigham and Women's Hospital, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, July 2009

"Metals, Oxidative Stress, Antioxidants and Vascular Endothelium." Presented at CTI Science, Inc., Lexington, KY, October 2009

"Lipid Oxygenases Regulate Phospholipase D activation Under Redox Modulation in Endothelial Cells." Dayton, OH, October 2009

"Mercury-induced Vasculotoxicity and Impairment of Angiogenesis." Presented at Silver Jubilee Celebrations of The International Academy of Oral Medicine & Toxicology (IAOMT, USA), Las Vegas, NV, September 2009

"Mercury-induced Lipid Signaling - A membrane Basis for Mercury Toxicity." Presented at International Academy of Oral Medicine & Toxicology, London, UK, February 2010

"How to Evolve as a Successful Scientist." Presented at Society for Free Radical Research, Annual Conference, Hyderabad, IN|IND, January 2010

"Adipose Tissue Protects Against Hyperoxic Lung Damage." Presented at Society for Free Radical Research, Annual Conference, Hyderabad, IN|IND, January 2010

"Novel Sulfhydryl Protective Compound for Leaky Gut Syndrome." Presented at Autism One/Generation Rescue, Annual Conference, Chicago, IL, May 2010

Associate Professor, Division of Pulmonary, Critical Care and Sleep Medicine

Associate Professor
Research & Teaching

Teaching, Mentoring, and Research Interests

Research Interests

Active Funding

Education and Training

Honors and Awards

Select Publications

Biography

Books

Editorial Activities

Journal Articles

Presentations

Helpful Links

Narasimham Parinandi, PhD

Associate Professor, Division of Pulmonary, Critical Care and Sleep Medicine

Associate Professor Research & Teaching

Teaching, Mentoring, and Research Interests

Research Interests

Active Funding

Education and Training

Honors and Awards

Select Publications

Biography

Books

Editorial Activities

Journal Articles

Presentations

Helpful Links

Associate Professor
Research & Teaching