Ohio Research Scholar
Professor Brüschweiler's research is highly cross-disciplinary in the area of biophysical chemistry as well as analytical chemistry. It focuses on the understanding of the role of dynamics and thermodynamics of proteins properties for their function and on the analysis of complex biological mixtures in the context of metabolomics. The main research tools are high-field nuclear magnetic resonance (NMR) and high-performance computation, which includes the development of new and improved techniques. Biological systems studied in the lab include the proteins p53/MDM2, sodium-calcium exchanger NCX, Cu2+-ATPase, ubiquitin, and the enzymes arginine kinase and glucokinase. Metabolic studies are conducted on drosophila, E. coli, yeast, and cancer cell lines in combination with isotope labeling, such as carbon-13.
Dr. Brüschweiler is accepting new graduate students for the Fall that have interest in studying (1) protein dynamics, interactions, and function by state-of-the-art NMR spectroscopy, (2) protein dynamics and function by computational methods (molecular dynamics simulations) in combination with experimental data, (3) complex mixture analysis and metabolomics by NMR, computation, and other methods, and/or (4) development of new NMR methods (pulse sequences, sparse sampling, covariance spectroscopy). Graduate students from any of the chemistry (physical, bio, analytical) and chemical physics programs are encouraged to request a meeting to discuss possible projects.
Education and Training
PhD, Physical Chemistry - ETH Zurich, Switzerland
Post-Doctoral - Scripps Research Institute
Office: 224 CBEC Building, Room 382
151 West Woodruff Ave.
Lab: Room 370