Huebner Kay

Professor Emerita, Department of Cancer Biology and Genetics

Research Interests

Cancer, DNA Damage, Carcinoma, Breast Cancer, Carcinoma, Renal Cell, Loss of Heterozygosity, Leukemia, Lung Cancer

The major focus of the laboratory was to thoroughly investigate and define the biological functions of the tumor suppressor proteins, Fhit and Wwox, encoded by the chromosome fragile sites FRA3B and FRA16D, two of the most frequently inactivated tumor suppressors in a broad spectrum of human cancers. The biological functions of the two proteins are studied using the full panoply of molecular genetic techniques in in vitro and in vivo models. Tumor suppressor related changes defined in tissue culture or mouse models are quickly examined also in human tissues from anonymous human cancers in order to confirm the laboratory findings in actual human cancers of breast, pancreas and other cancers, with the ultimate goal of identifying prognostically useful protein markers and possible therapeutic targets for specific cancers.

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Education and Training

PhD, Microbiology, University of Pennsylvania, 1974
Postdoctoral Training, Molecular Genetics, The Wistar Institute Cancer Center, Philadelphia, PA


916 Biomedical Research Tower
460 W 12th Avenue
Columbus, OH 43210
Lab Phone: 614-292-3716