Associate Director, Infectious Diseases Institute
540A Biological Sciences Building
484 W. 12th Ave, Columbus OH 43210
Membership: Infectious Diseases Institute
Dr. Rappleye's laboratory studies the mechanisms that underlie the virulence of fungal pathogens. The majority of our efforts are directed at understanding Histoplasma capsulatum, the causative agent of histoplasmosis. We are using molecular approaches to discover the factors that facilitate Histoplasma pathogenesis and are determining their role using in vitro and animal infection models. In addition we are screening chemical libraries and using forward genetics to identify potential drugs and drug targets that could be exploited to improve outcomes for fungal disease.
540 Biological Sciences Building
484 W 12th Ave, Columbus OH 43210