Chair, Department of Microbial Infection and Immunity
Novartis Pharmaceuticals Corporation Chair for Clinical Research, Microbial Infection and Immunity

776A Biomedical Research Tower (BRT)
460 W 12th Ave, Columbus OH 43210

Membership:  OSU Comprehensive Cancer Center - JamesInfectious Diseases InstitutePelotonia Institute for Immuno-Oncology

Research Interests

Current projects in the Oltz Lab aim to determine the roles of transcription, chromatin states and architectural proteins in orchestrating developmental programs of the lymphoid cells that compose our innate and adaptive immune systems. Our goal is to identify the key factors and pathways that endow each cell type with its signature functions, then leveraging the information to engineer better cellular therapeutics for cancer and chronic inflammatory diseases. In addition, we apply our approaches to understand epigenetic mechanisms that sculpt the diverse repertoire antigen receptors required for B and T lymphocytes to recognize a veritable universe of pathogens and, the same time, allow these cells to respond rapidly to DNA damage during the assembly of B and T cell receptors. Finally, our laboratory has initiated studies to profile immune responses mounted against SARS-CoV-2, as part of our Serological Sciences Center of Excellence, called STOP-COVID, and the national SeroNet community.

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770 Biomedical Research Tower (BRT)
460 W 12th Ave, Columbus OH 43210


Grace Brown, Undergraduate Student, brown.8980@osu.edu
Rachel Brown, Graduate Student, rachel.brown5@osumc.edu
Sophie Hopkins, Graduate Student, hopkins.1006@osu.edu
Matthew McCullen, Research Assistant, matthew.mccullen@osumc.edu
Ella Murphy, Undergraduate Student, murphy.2243@osu.edu
John Patton, Clinical Fellow, john.patton@osumc.edu
Ankita Saini, Post Doctoral Scholar, ankita.saini@osumc.edu
Ann Serna, Research Associate 2, vanida.serna@osumc.edu