Chair, Department of Microbial Infection and Immunity
Novartis Pharmaceuticals Corporation Chair for Clinical Research, Microbial Infection and Immunity
776A Biomedical Research Tower (BRT)
460 W 12th Ave, Columbus OH 43210
Eugene.Oltz@osumc.edu
614-293-7570
Membership: OSU Comprehensive Cancer Center - James, Infectious Diseases Institute, Pelotonia Institute for Immuno-Oncology
Research Interests
Current projects in the Oltz Lab aim to determine the roles of transcription, chromatin states and architectural proteins in orchestrating developmental programs of the lymphoid cells that compose our innate and adaptive immune systems. Our goal is to identify the key factors and pathways that endow each cell type with its signature functions, then leveraging the information to engineer better cellular therapeutics for cancer and chronic inflammatory diseases. In addition, we apply our approaches to understand epigenetic mechanisms that sculpt the diverse repertoire antigen receptors required for B and T lymphocytes to recognize a veritable universe of pathogens and, the same time, allow these cells to respond rapidly to DNA damage during the assembly of B and T cell receptors. Finally, our laboratory has initiated studies to profile immune responses mounted against SARS-CoV-2, as part of our Serological Sciences Center of Excellence, called STOP-COVID, and the national SeroNet community.
Laboratory
770 Biomedical Research Tower (BRT)
460 W 12th Ave, Columbus OH 43210
614-685-0192
Personnel
Rachel Brown, Graduate Student, rachel.brown5@osumc.edu
Christopher Gebhardt, Graduate Student, christopher.gebhardt@osumc.edu
Matthew McCullen, Research Assistant, matthew.mccullen@osumc.edu
Clement Oyeniran, Research Scientist, clement.oyeniran@osumc.edu
Ankita Saini, Post Doctoral Scholar, ankita.saini@osumc.edu
Ann Serna, Research Associate 2, vanida.serna@osumc.edu