Professor, Microbial Infection and Immunity

786 Biomedical Research Tower
460 W 12th Ave, Columbus OH 43210

Membership:  Infectious Diseases Institute

Research Interests

Dr. Seveau's laboratory focuses on molecular mechanisms underlying host-pathogen interactions using Listeria monocytogenes as a model facultative intracellular pathogen. Specific projects currently are to: (1) establish how L. monocytogenes infects mammalian cells and tissues, (2) determine the molecular basis and outcomes of host-cell signaling in response to listeriolysin O, the major virulence factor of L. monocytogenes and a member of the cholesterol-dependent cytolysin (CDC) toxins, and (3) elucidate the mechanisms underlying the anti-toxin and immune-modulatory activities of antimicrobial peptides that belong to the defensin family.

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770 Biomedical Research Tower
460 W 12th Ave, Columbus OH 43210


Maddie Chamberlain, Undergraduate Student,
Ludmila Diaz-Starokozheva, Graduate Student,
Madalyn Fields, Graduate Student,
Marilynn Ng, Research Technician,
Isabella Prislusky, Graduate Student,
Miguel Ramirez, Undergraduate Student,
Sindhu Sharma, Undergraduate Student,