Associate Professor, Molecular Medicine and Therapeutics
Pelotonia Research Center
2255 Kenny Rd.
Columbus, OH 43210
Martin.Benej@osumc.edu
The mission of Benej Lab is to study the role of tumor microenvironment, especially tumor hypoxia, in modulating the response to conventional anti-cancer treatment strategies. The metabolic cross-talk between tumor, stromal and immune cells undergoing oxygen and metabolite stress has a major role in facilitating treatment resistance by dictating the gene expression and chromatin modification patterns. We are developing pharmacological and genetic strategies to modulate tumor oxygenation levels in mouse models to discover novel synergistic therapies to address anti-cancer treatment resistance.