Associate Professor, Molecular Medicine and Therapeutics
Dorothy M. Davis Heart and Lung Research Institute
Pelotonia Research Center
2255 Kenny Rd.
Columbus, OH 43210
Michael.Tranter@osumc.edu
The Tranter Lab research is focused on understanding the molecular mechanisms of post-transcriptional gene regulation that drive cardiometabolic diseases and has been continuously funded by the NIH and American Heart Association. The Tranter Lab has shown a functional role for the RNA binding protein HuR in the pathophysiology of cardiac remodeling through its actions in both myocytes and fibroblasts. Additionally, our work has made contributions to the field of adipose tissue biology and our understanding of how disruptions in adipose tissue homeostasis impact cardiac physiology. Current ongoing projects in the lab apply multi-disciplinary mechanism-focused translational systems physiology approaches using both mouse and human tissues in the setting of (1) pathological left ventricular cardiac hypertrophy and fibrosis leading to heart failure, (2) calcium-mediated thermogenic metabolism in brown adipocytes, and (3) adipose tissue-mediated endocrine effects on cardiac physiology.