Gu_Bin_720x720612 Biomedical Research Tower
460 W 12th Avenue
Columbus, OH 43210
Phone: (614) 685-0586

The Gu Lab

Research Focus

Epilepsies are a highly heritable yet clinically heterogeneous group of neurological disorders. Seizures are commonly drug-resistant, comorbid with autistic and psychiatric conditions and increase the risk of death, also known as SUDEP (Sudden Unexpected Death in Epilepsy). SUDEP is the leading cause of death in epileptic individuals and second only to stroke in the number of life years lost. My overarching goal is to understand the genetic and pathophysiologic basis of epilepsy, SUDEP, and related neurological disorders. This information will allow me to further explore molecular control of brain synchronization, identify biomarkers, and finally develop therapeutics for epilepsy and SUDEP.

Research Approaches

My lab tackles these challenges using combination of interdisciplinary approaches including systems genetics (e.g. Collaborative Cross mice), molecular biology, pharmacology, electrophysiology, optogenetics, and behavioral assays.

Education and Training

PhD: Pharmacology, Duke University
Postdoctoral Training: The University of North Carolina, Chapel Hill

PubMed articles  GoogleScholar articles