McTigue_Dana_460x460_AdditionalProfessor and Vice Chair of Research, Department of Neuroscience and the Center for Brain and Spinal Cord Repair
Faculty Affiliate, Chronic Brain Injury

694 Biomedical Research Tower
460 W. 12th Ave.
dana.mctigue@osumc.edu

Research Focus

My laboratory uses rodent preclinical models of spinal cord injury (SCI) to examine the endogenous reparative response within the spinal cord, and systemic and metabolic problems that occur as a result of the injury. Specifically, we study the response of oligodendrocyte progenitor cells (NG2+ cells) to SCI, including intracellular and extracellular factors that influence their behavior and their ability to form new remyelinating oligodendrocytes.

Our systemic studies revealed marked and chronic liver pathology occurs after SCI that is consistent with the development of fatty liver disease and metabolic syndrome, a feature that is common in the SCI population and likely contributes to their reduced lifespan. We are examining mechanisms that drive chronic post-injury liver inflammation and testing translatable approaches to reduce liver pathology and improve overall liver and metabolic health after SCI.

Approaches

We use clinically-relevant models of SCI in rodents and use multiple behavioral assays to examine recovery of functions. We also use histological techniques including confocal and light-sheet microscopy, molecular techniques and are beginning to perform -omics projects.

Education and Training

PhD: Ohio State University, Department of Physiology, 1995
Post-doc: Ohio State University, Dr. Bradford Stokes’ lab
Research Scientist: Ohio State University

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