KokikoCochran_Olga_460x460Assistant Professor, Department of Neuroscience
Faculty, Chronic Brain Injury

Institute for Behavioral Medicine Research Building
460 Medical Center Drive
Columbus, OH  43210

Research Focus

Inflammation following traumatic brain injury (TBI) is a dynamic response of both the central and peripheral nervous systems, which is influenced by age, sex, injury location and severity. Because inflammation occurs after all brain injuries, I considers it an integral component of recovery. TBI is not an isolated event, and data indicate that pre- and post-injury immune challenges influence the response to TBI and chronic recovery. Additionally, evidence suggests that the brain’s stress response to an immune challenge is compromised following TBI. As a result, subsequent life stressors that further challenge the immune system alter long-tern recovery from TBI. We predict that post-injury sleep disruption is a significant and understudied stressor that largely influences outcome through inflammatory pathways. 

Approaches

  • experimental TBI; fluid percussion injury
  • behavioral testing; motor, cognitive, and sensory 
  • immunohistochemistry
  • western blot
  • ELISA
  • qPCR
  • flow cytometry

Education and Training

BA, Psychology, Mount Union College, Alliance, OH
MS, Experimental Psychology, East Carolina University, Greenville, NC
PhD, Biopsychology, Virginia Commonwealth University, Richmond, VA
Post-doc, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH

Kokiko-Cochran Lab  PubMed articles