I am interested in investigating the role of the ubiquitin-proteasome system in the pathogenesis of acute lung injury. My laboratory research focuses on the molecular regulation of innate immunity, lung endothelial inflammation and barrier integrity.
The Skp1-Cul1-F-box protein (SCF) ligase complex is one of the largest amongst the ubiquitin E3 ligase families. The F-box protein connects the ligase complex and specific substrates through its F-box domain and substrate binding motif, respectively. We have shown that SCFFBXL19 targets ST2L, the CREB binding protein (CBP), and members of the Rho family of GTPases for their ubiquitination and proteasomal degradation. Our current project is to investigate the molecular regulation of FBXL19 in acute lung injury.
Endothelial cell (EC) barrier disruption and inflammation are pathological hallmarks for inflammatory diseases, such as acute lung injury and sepsis. Our current project is to investigate the role of the de-ubiquitinating enzyme, USP40, in the regulation of lung microvascular inflammation and barrier function.View my PubMed
Education and TrainingPhD, Gifu University School of Medicine, Japan
Post Doctoral, University of Chicago, Chicago, Illinois