Heart failure and malignant cardiac arrhythmias remain the major causes of mortality in postindustrial world. The Terentyev laboratory is focused on investigating the mechanisms that regulate calcium (Ca2+) dynamics in healthy and diseased hearts, and how changes in Ca2+ homeostasis lead to cardiac arrhythmia and sudden cardiac death. The laboratory accumulated broad expertise in monitoring Ca2+ dynamics in various subcellular compartments and analyses of the molecular, biochemical, and electrophysiological parameters of cardiomyocytes in a number of models of acquired and inherited cardiac disease including diabetic cardiomyopathy, heart failure, aging, infarct, Long QT Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia. The group has longstanding interests in the role of phosphorylation-dephosphorylation signaling cascades, microRNAs, reactive oxygen species, mitochondria and Ca2+-dependent K+ channels in aberrant myocyte function in cardiac disease and aging. The research program is supported by the American Heart Association and NIH.
Education and Training
PhD, Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences
Postdoctoral, Texas Tech University
Hometown: St. Petersburg, Russia