Ai_Xun_460x460Professor of Physiology

Director of OSUMC Human Biorepository

Graves Hall
333 W. 10th Ave
Columbus, OH 43210
ai.87@osu.edu

614-366-0127

 Research Interests

  • Calcium signaling in electrophysiological pathogenesis
  • Cardiac arrhythmias (atrial fibrillation, ventricular arrhythmias)
  • Heart failure
  • Ischemic Stroke
  • Stress-evoked thrombogenesis
  • Aging and/or alcohol-evoked abnormal emotional behaviors and impaired cognitive function

The Ai lab focus on understanding the mechanisms of cardiac arrhythmia including atrial fibrillation and ventricular arrhythmias in stressed hearts (e.g. heart failure, aging, alcohol abuse, obesity) and developing effective novel therapeutic approaches to treat and prevent arrhythmias. Another focus of the Ai lab is understanding stress induced calcium mishandling in synaptic physiology and behavioral defects and cognitive impairments.

Our laboratory has established several state-of-the-art electrophysiological techniques including dual channel optical mapping and confocal Ca imaging and in vivo arrhythmia induction in intact hearts and isolated myocytes from humans and animal models. In addition, some updated molecular biochemical techniques such as flow cytometry, and enzyme activity assays, qPCR, immunoblotting, immunostaining, ChIP assay, gene cloning have also been well-established in the lab.

Education and Training

Postdoctoral Training: Johns Hopkins University
Postdoctoral Training: University of Illinois at Chicago