Yutong Zhao, MD, PhD

Professor
Yutong.Zhao@osumc.edu
614-685-0360

Research Interests

My laboratory primary research focuses on the role of protein ubiquitination and ISGylation in regulation of lung homeostasis and diseases. Our goal is to develop new therapeutic targets for treating lung injury, pulmonary fibrosis, pulmonary arterial hypertension, and sepsis. Research projects encompass these general areas:

1. To understand the role of ubiquitin E3 ligases and de-ubiquitination enzymes in the regulation of lung epithelial inflammation and remodeling through modulating transmembrane receptor stabillity including Toll/IL-1 receptors (TIRs), GPCRs, and tyrosine kinase receptors.

2. To investigate the role of ubiquitin E3 ligases and de-ubiquitination enzymes in TGF-β and BMP signaling in pulmonary fibrosis and pulmonary arterial hypertension.

3. To investigate the role of ubiquitin E3 ligases and de-ubiquitination enzymes in the regulation of lung microvascular inflammation, barrier integrity, and angiogenesis.

4. To investigate the role of bio-active phospholipids and their receptors in the pathogenesis of sepsis, lung injury, and pulmonary fibrosis.

View my PubMed

Education and Training

PhD, Gifu University School of Medicine, Japan
Post Doctoral, Johns Hopkins University School of Medicine