Yutong Zhao, PhD
Professor
Physiology and Cell Biology
Academic contact
Academic information
- Department: Physiology and Cell Biology
Research interests
- Ubiquitin E3 Ligases
- De-Ubiquitination Enzymes
- Lung Injury
- Pulmonary Fibrosis
- Pulmonary Arterial Hypertension
- Sepsis
About
Biography
My laboratory primary research focuses on the role of protein ubiquitination and ISGylation in regulation of lung homeostasis and diseases. Our goal is to develop new therapeutic targets for treating lung injury, pulmonary fibrosis, pulmonary arterial hypertension, and sepsis. Research projects encompass these general areas:
- To understand the role of ubiquitin E3 ligases and de-ubiquitination enzymes in the regulation of lung epithelial inflammation and remodeling through modulating transmembrane receptor stabillity including Toll/IL-1 receptors (TIRs), GPCRs, and tyrosine kinase receptors.
- To investigate the role of ubiquitin E3 ligases and de-ubiquitination enzymes in TGF-β and BMP signaling in pulmonary fibrosis and pulmonary arterial hypertension.
- To investigate the role of ubiquitin E3 ligases and de-ubiquitination enzymes in the regulation of lung microvascular inflammation, barrier integrity, and angiogenesis.
- To investigate the role of bio-active phospholipids and their receptors in the pathogenesis of sepsis, lung injury, and pulmonary fibrosis.
Credentials
Education
- Post Doctoral
- Johns Hopkins University School of Medicine, Baltimore, MD, United States
- PhD
- Gifu University School of Japan, Gifu, Japan
Research
Research interests
- Ubiquitin E3 Ligases
- De-Ubiquitination Enzymes
- Lung Injury
- Pulmonary Fibrosis
- Pulmonary Arterial Hypertension
- Sepsis