Jesse Kwiek, PhD

Present activities:

• AIDS Research and Human Retroviruses
• Retrovirology
• American Journal of Tropical Medicine and Hygiene
• AIDS
• Scientific Reports

Graves P.R., Kwiek J.J. (co-first author), Fadden P., Ray, R., Hardeman, K., Coley, A. M., Foley, M., Haystead, T. A.. "Discovery of Novel Targets of Quinoline Drugs in the Human Purine Binding Proteome.." Molecular Pharmacology. Vol. 62, (January 2002.): 1364-1372

Gioeli D., Ficarro S.B., Kwiek, J.J., Aaronson, D., Hancock, M., Catling, A.D., White, F.M., Christian, R.E., Settlage, R.E., Shabanowitz, J., Hunt, D.F., Weber, M.J. "Androgen Receptor Phosphorylation. Regulation and Identification of the Phosphorylation Sites.." J Biol Chem. Vol. 277, (January 2002.): 29304-29314

Graves PR, Kwiek JJ, Fadden P, Ray R, Hardeman K, Coley AM, Foley M, Haystead TAJ. "Discovery of novel targets of quinoline drugs in the human purine binding proteome." Molecular Pharmacology. Vol. 62, no. 6. (December 2002.): 1364-1372

Gioeli D, Ficarro SB, Kwiek JJ, Aaronson D, Hancock M, Catling AD, White FM, Christian RE, Settlage RE, Shabanowitz J, Hunt, DF, Weber MJ. "Androgen receptor phosphorylation - Regulation and identification of the phosphorylation sites.." Journal of Biological Chemistry. Vol. 277, no. 32. (August 2002.): 29304-29314

Abrams, E.T., Milner, D.A. Jr., Kwiek, J.J., Mwapasa, V., Kamwendo, D.D., Zeng, D., Tadesse, E., Lema, V.M., Molyneux, M.E., Rogerson, S.J., Meshnick, S.R.. "Risk Factors and Mechanisms of Preterm Delivery in Malawi." American Journal of Reproductive Immunology. Vol. 52, no. 2. (January 2004.): 174-183

Abrams, ET; Milner, DA; Kwiek, J; Mwapasa, V; Kamwendo, DD; Zeng, D; Tadesse, E; Lema, VM; Molyneux, ME; Rogerson, SJ; Meshnick, SR. "Risk factors and mechanisms of preterm delivery in Malawi." AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. Vol. 52, no. 2. (August 2004.): 174-183

Abrams ET, Milner DA, Kwiek JJ, Mwapasa V, Kamwendo DD, Zeng D, Tadesse E, Lema VM, Molyneux ME, Rogerson SJ, Meshnick SR. "Risk factors and mechanisms of preterm delivery in Malawi." American Journal of Reproductive Immunology. Vol. 52, no. 2. (August 2004.): 174-183

Kwiek, J.J., Haystead, T.A., Rudolf, J.. "The Kinetic Mechanism of Quinone-Oxidoreductase 2 and its Inhibition by the Anti-Malarial Quinolines.." Biochemistry. Vol. 43, no. 15. (January 2004.): 4538-4547

Kwiek JJ, Haystead TAJ, Rudolph J. "Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines." Biochemistry. Vol. 43, no. 15. (April 2004.): 4538-4547

Abrams, E.,T.,Kwiek, J.J., Mwapasa,V., Kamwendo, D.D., Tadesse, E., Lema, V.M., Molyneux, M.E., Rogerson, S.J., Meshnick, S.R.. "Malaria During Pregnancy and Fetal Hematological Status in Blantyre, Malawi.." Malaria Journal. Vol. 4, no. 1. (January 2005.): 39

Yeramian, P., Meshnick, S.R., Krudsood, S., Chalermrut, K., Silachamroon, U., Allen, J., Brun, R., Kwiek, J.J., Tidwell, R. Looareesuwan, S.. "Efficacy of DB289 in Thai Patients with Plasmodium vivax and Acute Uncomplicated Plasmodium falciparum Infections.." Journal of Infectious Disease. Vol. 192, no. 2. (January 2005.): 319-22

Yeramian P, Meshnick SR, Krudsood S, Chalermrut K, Silachamroon U, Tangpukdee N, Allen J, Brun R, Kwiek JJ, Tidwell R, Looareesuwan S. "Efficacy of DB289 in Thai patients with Plasmodium vivax or acute, uncomplicated Plasmodium falciparum infections." Journal of Infectious Diseases. Vol. 192, no. 2. (July 2005.): 319-322

Ngrenngarmlert, W.,Kwiek, J.J. (co-first author), Kamwendo, D.D., Ritola, K., Swanstrom, R., Wongsrichanalai, C., Ittarat, W., Miller, R.S., and Meshnick, S.R.. "Measuring Allelic Heterogeneity in Plasmodium falciparum by Heteroduplex Tracking Assay.." American Journal of Tropical Medicine and Hygiene. Vol. 72, (January 2005.): 694-701

Ngrenngarmlert W, Kwiek JJ, Kamwendo DD, Ritola K, Swanstrom R, Wongsrichanalai C, Miller RS, Ittarat W, Meshnick SR. "Measuring allelic heterogeneity in Plasmodium falciparum by a heteroduplex tracking assay." American Journal of Tropical Medicine and Hygiene. Vol. 72, no. 6. (June 2005.): 694-701

Abrams ET, Kwiek JJ, Mwapasa V, Kamwendo DD, Tadesse E, Lema VM, Molyneux ME, Rogerson SJ, Meshnick SR. "Malaria during pregnancy and foetal haematological status in Blantyre, Malawi." Malaria Journal. Vol. 4, (August 2005.): 39

Malhotra, I., Mungai, P., Muchiri, E., Kwiek, J.J., Meshnick, S.R., King, C.L.. "Congenital P. falciparum Malaria Acquired Antenatally in Kenya.." Journal of Infectious Diseases. Vol. 194, no. 2. (January 2006.): 176-183

Kwiek JJ, Mwapasa V, Milner DA, Alker AP, Miller WC, Tadesse E, Molyneux ME, Rogerson SJ, Meshnick SR. "Maternal-fetal microtransfusions and HIV-1 mother-to-child transmission in Malawi." PLoS Medicine. Vol. 3, no. 1. (January 2006.): 70-75

Mwapasa, V., Rogerson, S.J., Kwiek, J.J., Molyneux, M.E., Kamwendo, D.D., Tadesse, E., Chaluluka, E., Wilson, P.E., Meshnick, S.R.. "Is Maternal Syphilis Infection a Risk Factor for HIV Mother-to-Child Transmission?." AIDS. Vol. 20, (January 2006.): 1869-1877

Kwiek, J.J., Mwapasa V., Milner, D., Alker, A., Miller, W., Ou, C.Y., Tadesse, E., Molyneux, M.E., Rogerson, S.J., Meshnick, S.R.. "Maternal-fetal Microtransfusions and HIV-1 Mother-to-Child Transmission in Malawi.." PLoS-Medicine. Vol. 3, no. 1. (January 2006.): e10

Malhotra I, Mungai P, Muchiri E, Kwiek JJ, Meshnick SR, King CL. "Congenital P. falciparum Malaria Acquired Antenatally in Kenya." Journal of Infectious Diseases. Vol. 194, no. 2. (July 2006.): 176-183

Mwapasa V, Rogerson SJ, Kwiek JJ, Wilson PE, Milner D, Molyneux ME, Kamwendo DD, Tadesse E, Chaluluka E, Meshnick SR. "Maternal syphilis infection is associated with increased risk of mother-to-child transmission of HIV in Malawi." AIDS. Vol. 20, no. 14. (September 2006.): 1869-1877

Juliano, J.,Kwiek, J.J., Mwapasa, V., Meshnick, S.R.. "Development of a Multiple-Site Specific Heteroduplex Tracking Assay that can Detect Low Prevalence pfcrt K76T Mutations.." Emerging Infectious Diseases. Vol. 13, no. 6. (January 2007.): 872-877

Kalilani,Linda; Mofolo,Innocent; Chaponda,Marjorie; Rogerson,Stephen,J; Alker,Alisa,P; Kwiek,Jesse,J; Meshnick,Steven,R. "A Randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women." PLOS CLINICAL TRIALS. Vol. 2, no. 11. (November 2007.): e1166

Kwiek, J.J., Alker, A.P., Kalilani, L., Wenink, E.C., Chaponda, M., E., Meshnick, S. R.. "Estimating True Antimalarial Efficacy by Heteroduplex Tracking Assay in Patients with Complex Plasmodium falciparum Infections.." Antimicrobial Agents and Chemotherapy. Vol. 51, no. 2. (January 2007.): 521-527

Kalilani L., Mofolo I., Chaponda M., Rogerson S.J., Alker A.P., Kwiek, J.J. Meshnick, S.R.. "A Randomized Controlled Pilot Trial of Azithromycin or Artesunate Added to Sulfadoxine-Pyrimethamine as Treatment for Malaria in Pregnant Women.." PLoS ONE. Vol. 2: e1166 doi:10.1371/journal.pone.0001166, no. 11. (January 2007.)

Juliano,Jonathan,J; Kwiek,Jesse,J; Cappell,Kathryn; Mwapasa,Victor; Meshnick,Steven,R. "Minority-variant pfcrt K76T mutations and chloroquine resistance, Malawi.." Emerging infectious diseases. Vol. 13, no. 6. (June 2007.): 872-877

Kalilani L, Mofolo I, Chaponda M, Rogerson SJ, Alker AP, Kwiek JJ, Meshnick SR. "A Randomized Controlled Pilot Trial of Azithromycin or Artesunate Added to Sulfadoxine-Pyrimethamine as Treatment for Malaria in Pregnant Women." PLoS One. Vol. 2, no. 11. (November 2007.): e1166

Kalilani,Linda; Mofolo,Innocent; Chaponda,Marjorie; Rogerson,Stephen,J; Alker,Alisa,P; Kwiek,Jesse,J; Meshnick,Steven,R. "A Randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women." PLOS CLINICAL TRIALS. Vol. 2, no. 11. (November 2007.): e1166

Kwiek JJ, Alker AP, Wenink EC, Chaponda M, Kalilani LV, Meshnick SR. "Estimating true antimalarial efficacy by heteroduplex tracking assay in patients with complex Plasmodium falciparum infections." Antimicrobial Agents and Chemotherapy. Vol. 51, no. 2. (February 2007.): 521-527

Juliano JJ, Kwiek JJ, Cappell K, Mwapasa V, Meshnick SR. "Minority-variant pfcrt K76T mutations and chloroquine resistance, Malawi." Emerging Infectious Diseases. Vol. 13, no. 6. (June 2007.): 873-877

Kwiek, J.J., Mwapasa, V., Muula, A.S., Misiri, H., Alker, A.P., Molyneux, M.E., Rogerson, S.J., Meshnick, S.R.. "HIV and Syphilis Infections Among Pregnant Women in Blantyre, Malawi.." Malawi Medical Journal. Vol. 3, (January 2008.): 80-85

Kwiek, J.J., Russell, E.S., Dang, K.K., Burch, C.L., Meshnick, S.R., Mwapasa, V., Swanstrom, R.. "The Molecular Epidemiology of HIV-1 Envelope Diversity During HIV-1 Subtype C Vertical Transmission in Malawian Mother-Infant Pairs." AIDS. Vol. 22, (July 2008.): 863-871

Kwiek, J.J. Russell, E.S., Dang, K.K., Burch, C.L., Meshnick, S. R, Mwapasa, V., Swanstrom, R.. "Molecular Epidemiology of HIV-1 Envelope Diversity During HIV-1 Subtype C Vertical Transmission in Malawian Mother-Infant Pairs.." AIDS. Vol. 22, (January 2008.): 863-871

Meshnick SR, Kwiek JJ, Juliano JJ. "Complexity of infection and drug resistance in human P-falciparum infections.." International Journal for Parasitology. Vol. 38, (January 2008.): S25-S25

Kwiek, J.J., Arney, L.A., Pederson, B., Hararwa, V., Mwapasa, V., and Meshnick, S.R.. "Detection of Placental Microtransfusions during HIV-1 Mother-to-Child Transmission." Journal of Infectious Diseases. Vol. 197, no. 10. (January 2008.): 1378-1381

Kwiek JJ, Arney LA, Pederson B, Hararwa V, Mwapasa V, Meshnick SR. "Detection of Placental Microtransfusions during HIV-1 Mother-to-Child Transmission." Journal of Infectious Diseases. Vol. 197, no. 10. (May 2008.): 1378-1381

Kwiek JJ, Mwapasa V, Muula AS, Misiri H, Alker AP, Molyneux ME, Rogerson SJ, Meshnick SR. "HIV and Syphilis Infections Among Pregnant Women in Blantyre, Malawi." Malawi Medical Journal. Vol. 20, no. 3. (July 2008.): 80-85

Gay CL; Mwapasa V; Murdoch DM; Kwiek JJ; Fiscus SA; Meshnick SR; Cohen MS. "Acute HIV infection among pregnant women in Malawi.." Diagnostic Microbiology And Infectious Disease. Vol. 66, no. 4. (April 2010.): 356

Mwapasa V; Cachafeiro A; Makuta Y; Beckstead DJ; Pennell ML; Chilima B; Mwagomba B; Fiscus SA; Kwiek JJ. "Using a simplified human immunodeficiency virus type 1 p24 antigen assay to diagnose pediatric HIV-infection in Malawi.." Journal Of Clinical Virology: The Official Publication Of The Pan American Society For Clinical Virology. Vol. 49, no. 4. (December 2010.): 299

Mwapasa V, Cachafeiro A, Makuta Y, Beckstead DJ, Pennell ML, Chilima B, Mwagomba B, Fiscus SA, Kwiek JJ. "Using a simplified human immunodeficiency virus type 1 p24 antigen assay to diagnose pediatric HIV-infection in Malawi." Journal of Clinical Virology. Vol. 49, no. 4. (December 2010.): 299-302

Mwapasa, V., Cachafeiro, A., Makhuta, Y., Beckstead, D.J., Pennell, M.L., Chilima, B., Mwagomba, B., Fiscus, S.A., Kwiek, J.J.. "Using a Simplified Human Immunodeficiency Virus Type I p24 Antigen Assay to Diagnose Pediatric HIV-Infections in Malawi." Journal of Clinical Virolgoy. (September 2010.)

Gay, C.L., Mwapasa, V., Murdoch, D.M., Kwiek, J.J., Fiscus, S.A., Meshnick, S.R., Cohen, M.S.. "Acute HIV Infection among Pregnant Women in Malawi.." Diagnostic Microbiology and Infectious Disease. Vol. 66, no. 4. (January 2010.): 356-360

Gay CL, Mwapasa V, Murdoch DM, Kwiek JJ, Fiscus SA, Meshnick SR, Cohen MS. "Acute HIV infection among pregnant women in Malawi." Diagnostic Microbiology and Infectious Disease. Vol. 66, no. 4. (April 2010.): 356-360

Kumar SB, Handelman SK, Voronkin I, Mwapasa V, Janies D, Rogerson SJ, Meshnick SR, Kwiek JJ. "Different regions of HIV-1 subtype C env are associated with placental localization and in utero mother-to-child transmission.." Journal of Virology. Vol. 85, no. 14. (July 2011.): 7142-7152

22. Kumar, S.B., Rice, C., E., Milner, D.A. Jr., Ramirez, N.C., Ackerman, W.E. IV, Mwapasa, V. l Norris Turner. A., Kwiek, J.J.. "Elevated Cytokine and Chemokine Levels in the Placenta Are Associated With in utero HIV-1 Mother-To-Child Transmission.." AIDS. (January 2012.)

Kumar SB, Rice CE, Milner DA, Ramirez NC, Ackerman WE, Mwapasa V, Turner AN, Kwiek JJ. "Elevated cytokine and chemokine levels in the placenta are associated with in-utero HIV-1 mother-to-child transmission." AIDS. Vol. 26, no. 6. (March 2012.): 685-694

Keim SA, Hogan JS, McNamara KA, Gudimetla V, Dillon CE, Kwiek JJ, Geraghty SR. "Microbial Contamination of Human Milk Purchased Via the Internet.." Pediatrics. Vol. 132, no. 5. (November 2013.): PMID: 24144714

Walton JR, Frey HA, Vandre DD, Kwiek JJ, Ishikawa T, Takizawa T, Robinson JM, Ackerman WE. "Expression of flotillins in the human placenta: potential implications for placental transcytosis." Histochemistry and Cell Biology. Vol. 139, no. 3. (March 2013.): 487-500

Ackerman WE, Kwiek JJ. "Role of the placenta in adverse perinatal outcomes among HIV-1 seropositive women.." Journal of Nippon Medical School. Vol. 80, no. 2. (April 2013.): 90-94

Mates JM, Kumar SB, Bazan J, Voronkin I, Handelman SK, Janies DJ, Kwiek JJ. "Genotypic and phenotypic heterogeneity in the U3R region of HIV-1 subtype C.." AIDS Research and Human Retroviruses. Vol. epub ahead of print, (August 2013.): PMID:23826737

Geraghty SR, McNamara KA, Dillon CE, Hogan JS, Kwiek JJ, Keim SA. "Buying Human Milk Via the Internet: Just a Click Away.." Breastfeeding Medicine. Vol. epub ahead of print, (August 2013.): PMID:23971685

Norris Turner A, Tabbah S, Mwapasa V, Rogerson SJ, Meshnick SR, Ackerman WE, Kwiek JJ. "Severity of maternal HIV-1 disease is associated with adverse birth outcomes in Malawian women: a cohort study.." Journal of Acquired Immune Deficiency Syndrome. Vol. epub ahead of print, (July 2013.): PMID:23846560

Fouda GG, Mahlokozera T, Salazar-Gonzalez JF, Salazar MG, Learn G, Kumar SB, Dennison SM, Russell E, Rizzolo K, Jaeger F, Cai, F, Vandergrift NA, Gao F, Hahn B, Shaw GM, Ochsenbauer C, Swanstrom R, Meshnick SR, Mwapasa V, Kalilani L, Fiscus S, Montefiori D, Haynes B, Kwiek JJ, Alam SM, Permar SR. "Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants." Retrovirology. Vol. 10, (January 2013.): 3

Norris Turner, A., Tabbah, S., Mwapasa, V., Rogerson, S.J., Meshnick, S.R., Ackerman, W.E. IV, Kwiek, J.J.. "Severity of maternal HIV-1 disease is associated with adverse birth outcomes in Malawian women: a cohort study." JAIDS

Geraghty, SR; McNamara, KA; Dillon, CE; Hogan, JS; Kwiek, JJ; Keim, SA. "Buying Human Milk Via the Internet: Just a Click Away." Breastfeeding Medicine

July 2013: 

• Turner AN, Tabbah S, Mwapasa V, Rogerson SJ, Meshnick SR, Ackerman W, Kwiek JJ."Severity of maternal HIV-1 disease is associated with adverse birth outcomes in Malawian women, #2013-A-1316-STI" Vienna

August 2012: 

• Mefford ME, Hayes AM, Kwiek JJ, Boris-Lawrie K."Striking a balance: miRNA-Mediated Silencing in HIV-1 infection" Palm Springs

August 2011:

• Kumar SB, Rice CE, Milner DA Jr., Ramirez N, Ackerman WE IV, Mwapasa V, Norris Turner A, and Kwiek JJ."Elevated Cytokine and Chemokine Levels in the Placenta Are Associate with in utero HIV-1 Mother-To-Child Transmission" Durham

July 2011: 

• Handelman S, Verducci JS, Kwiek JJ, Kumar SB, and Janies DA."PhyloPTE: Genotype/Phenotype Association with Reference to Phylogeny" Vienna, Austria

June 2011: 

• Handelman S, Verducci JS, Kwiek JJ, Kumar SB, and Janies DA."GENPHEN: Genotype/Phenotype Association with Reference to Phylogeny" Kraków, Poland

May 2011: 

• Mates J, Kumar SB, Bazan J, Mwapasa V, Kwiek JJ."Diversity of HIV-1 subtype C U3R influences mother-to-child transmission, Abst #153" Cold Spring Harbor, NY

• Kumar SB, Kwiek JJ."Different Regions of HIV-1 subtype C env are associated with placental localization and in utero mother-to-child transmission, Abst #3" Cold Spring Harbor, NY

• Handelman SK, Kumar S, Mates JM, Meshnick SR, Mwapasa V, Janies D, and Kwiek JJ."In utero mother to child transmission of HIV-1 Subtype C associated with specific changes in env and with placental localization" Athens, OH

March 2011: 

• Handelman S, Verducci JS, Kwiek JJ, Kumar SB, Janies DA."GENPHEN: Genotype/Phenotype Association with Reference to Phylogeny" Vancouver

September 2010:

• Kumar SB, Handelman SK, Voronkin I, Mwapasa V, Janies D, Rogerson SJ, Meshnick SR, and Kwiek JJ."Specific changes in HIV-1 subtype C ENV are associated with placental localization and in utero mother-to-child transmission" Durham

June 2010:

• Kumar S, Handelman SK, Mwapasa V, Janies D, Kwiek JJ."Perturbations in HIV-1 quasispecies dynamics during in utero mother to child transmission." Boston

January 2008: 

• Meshnick, S; Kwiek, J; Juliano, J."Complexity of infection and drug resistance in human P-falciparum infections." Chapel Hill. : S25

November 2006: 

• Kwiek, J; Alker, AP; Wenink, EC; Kalilani, LV; Meshnick, S."Use of the quantitative MSP-1 heteroduplex tracking assay to distinguish Plasmodium falciparum reinfection from failure" Chapel Hill. : 190

• Juliano, JJ; Kwiek, J; Mwapasa, V; Meshnick, S."Minority variant pfcrt K76T mutations in Malawi suggest lurking chloroquine resistance" Chapel Hill. : 4

December 2005: 

• Purfield, A; Kwiek, J; Tidwell, RR; Meshnick, SR."Determining drug partners for the novel antimalarial compound, DB75" Chapel Hill. : 268

March 2004: 

• Kwiek, J; Abrams, ET; Milner, D; Mwapasa, V; Meshnick, SR."Balancing the immunological demands of pregnancy and infection." Chapel Hill. : 211

January 2004: 

• Kwiek, J; Abrams, ET; Milner, D; Mwapasa, V; Meshnick, SR."Balancing the immunological demands of pregnancy and infection." Chapel Hill. : 13

"Molecular mechanism of vertical HIV transmission." Presented at The Burnet Institute, Laboratory Meeting, Melbourne, AU|AUS. (July 2007)

"Molecular tools to assess antimalarial treatment failure.." Presented at Walter and Eliza Hall Institute, Laboratory Meeting, Melbourne, AU|AUS. (July 2007)

"Pertubations in HIV-1 quasispecies dynamics during in utero mother to child transmission." Presented at DARPA/Department of Defense, Prophecy Teaming Day, Boston, MA. (June 2010)

"When is the best time for a science professional to start a family?." Presented at OSU Integrated Biomedical Science Graduate Program, . (January 2010)

"HIV/AIDS in sub-Saharan Africa." Presented at OSU African Youth League, (January 2010)

"Careers in Research." Presented at OSU Biomedical Sciences, (January 2010)

"The HIV pandemic." Presented at OSU Honors Day, Recruitment Session, (January 2010)

"Host proteins required for HIV-1 replication." Presented at Duke University, Department of Pharmacology and Cancer Biology, Haystead Research Group, (August 2011)

"Mechanisms of HIV-1c Mother-to-Child Transmission." Presented at Ethiopian Society of Tropical and Infectious Disease, Addis Ababa, Ethiopia, (December 2012)

"The Global Health Summit on HIV/AIDS." Presented at OSU Global Health Initiative, (January 2012)

"Personal Perspectives on Global Health Research." Presented at OSU Buckeyes Without Borders, (January 2012)

"HIV evolution." Presented at OSU Microbiology Club, (January 2012)

"HIV-1 evolution and vertical HIV transmission." Presented at University of Toledo, Department of Medical Microbiology and Immunology, Toledo. (May 2012)

"Vertical HIV transmission." Presented at The Research Institute at Nationwide Children's Hospital, Bench to Outcomes Seminar Series (BOSS), Columbus. (June 2012)

"Molecular Mechanism of vertical HIV transmission." Presented at Case Western Reserve University, World Health Interest Group and The Infectious Diseases & HIV Medicine Host Defense Joint Seminar Series, (August 2012)

"HIV-associated adverse birth outcomes." Presented at OSU Center for Women's Health - Women's Health Initiative, Research Collaboration Seminar, (January 2013)

"HIV-associated Low Birth Weight." Presented at Case Western Reserve Center for AIDS Research Conference, Cleveland, Ohio. (August 2013)

Kulkarni, M., Hughes, P., Matous, J., Haystead, T., Kwiek, J.J.. Identification of HSP-90 inhibitors that block HIV replication. January 0

Alwarah, Y, Ratcliff, A, Kulkarni, M., Hughes, P., Matous, J., Haystead, T., Kwiek, J.J.. Inhibitors of Fatty Acid Biosynthesis efficiently block HIV-replication. January 0

Handelman, S.K., Aaronson, J.M., Kwiek, J.J., Verducci, J.S., Janies, D.. Phylogeny with Path to Event for Viruses (PhyloPTE/V): Robust efficient association detection for qualitative traits on phylogenies. June 2013

• Brylan May received an NIH-diversity supplement award (R01AI084110-03S1)
• Vishnu Gudimetla earned a middle author, peer-reviewed publication
• Rachael Billock was awarded an OSU SOLAR award in 2012
• Emily Chen was awarded an undergraduate research scholarship award in 2010

My first graduate student, Surender Kumar, published two first and two middle author peer-reviewed manuscripts. He received the OSU PHPID graduate student fellowship. He was selected to give an oral presentation at the Cold Spring Harbor Retrovirus Conference and had two poster presentations at the Conference of Retroviruses and Opportunistic Infections. These are both international meetings. He did a postdoctoral fellowship at the National Institute of Health studying HIV immunology.

My second graduate student, Jessica Mates, has just published a first author manuscript and currently has one first author and one middle author publication in preparation. She presented her research as a poster at the Cold Spring Harbor Retrovirus Conference. She received first place for her poster at the OSU CMIB Research Retreat in 2013.

• Since I joined OSU in 2007, I have mentored two high school students, twelve undergraduate students, two graduate students, three medical students (each supported with an internal OSU fellowship [Roessler Fellowships]), two post doctoral fellows (both with PhDs in virology) and two medical fellows. I have also served on the undergraduate honors thesis committee for six OSU students and on the PhD advisory committee for 13 graduate students.

2013-present:

• Allison Slaughter, The Ohio State University, Pharmaceutics and Pharmaceutical Chemistry

2012-present:

• Megan Mefford, The Ohio State University

2011-present:

• Jorge Salazar, The Ohio State University

2009-present:

• Jessy Mates, The Ohio State University, Department of Microbiology

2013:

• Sammy Tabbah, The Ohio State University - Graduated 0, OB/GYN fellow
• John Skendelas, The Ohio State University - Graduated 2013, honors thesis in microbiology
• Robert Easterling, The Ohio State University - Graduated 2013, honors thesis in microbiology
• Anna Askari, The Ohio State University - Graduated 2013, honors thesis in public health
• Matthew Plumb, The Ohio State University - Graduated 0, Molecular, Cellular and Developmental Biology (MCDB)
• Nathan Titkemeier, The Ohio State University - Graduated 0, Biomedical Sciences Graduate Program

2012-2013:

• Christina Durchholz, The Ohio State University - Graduated 0, medical student

2011-2013:

• Zackary Bittinger, The Ohio State University

2010-2013:

• Vishnu Gudimetla, The Ohio State University - Graduated 0, 2010 - 2013

2012:

• Annette Ratcliff, The Ohio State University - Graduated 0
• Nathan Dissinger, The Ohio State University - Graduated 0, Integrated Biomedical Science Graduate Program (IBGP)
• Jacob Al-Saleem, The Ohio State University - Graduated 0, Molecular, Cellular and Developmental Biology (MCDB)
• Brylan May, Case Western Reserve University
• Rachel Kominsky, The Ohio State University - Graduated 2012, honors thesis in microbiology

2011-2012:

• Claire Meeks, The Ohio State University

2010-2012:

• Surender Kumar, The Ohio State University - Graduated

2011:

• Rachael Billock, The Ohio State University - Graduated 2011
• Nina Kvaratskhelia, Hilliard Davidson High School,
• Emily Chen, The Ohio State University - Graduated 2011, honors thesis in microbiology,
• Brylan May, Thomas Worthington High School - Graduated 0
• Joanna Daigle, The Ohio State University
• Nadine Bowden, The Ohio State University - Graduated 2011, Department of Veterinary Medicine

2010-2011:

• Vikram Shankar, The Ohio State University, Maximus scholar

2010:

• Daniel Richardson, The Ohio State University - Graduated 0, medical student, Roessler fellow

I currently teach an average of 27 lectures per year, including one half of the OSU undergraduate immunology class (Micro 5122), and several lectures to OSU graduate students on retrovirus biology. I am course director for biomedical sciences class 4810H: Select Topics in Microbiology and Immunology and co-course director for Microbiology 5122: Immunology. I have completely redone the 4810H syllabus, which now includes a service learning component. The students' service learning projects are being conducted in both Columbus and Malawi.

Turner, A.N., Maierhofer, C., Funderburg, N.T., Snyder, B., Small, K., Clark, J., Bazan, J.A., Kwiek, N.C.,Kwiek, J.J. “High levels of self-reported prescription opioid use by HIV-positive individuals.” AIDS Care, June 2016. Dec;28(12):1559-1565. PMID: 27320493

Alwarawrah, Y., Hughes, P., Loiselle, D., Carlson, D.A., Darr, D.B., Jordan, J.L., Xiong, J., Hunter, L.M., Dubois, L.G., Thompson, J.W., Kulkarni, M.M, Ratcliff, A.N, Kwiek, J.J.†, Haystead, T.A.† “Fasnall, a selective FASN inhibitor shows potent anti-tumor activity in the MMTV Neu model of HER2+ breast cancer.” † = Co-corresponding authors. Cell Chemical Biology, May 2016; 23:678-688. PMID: 27265747
35. Keim, S.A., McNamara, K.A., Kwiek, J.J., Geraghty, S. R. “Drugs of abuse in human milk purchased via the Internet” Breastfeeding Medicine, 2015, Breastfeed Med. 2015 Nov; 10(9):416-8. PMID: 26460596

Geraghty, S.R., McNamara, K.A., Kwiek, J.J., Rogers, L, Klebanoff, M.A., Augustine, M., Keim, S.A. “Tobacco metabolites and caffeine in human milk purchased via the Internet.” Breastfeeding Medicine, 2015, Breastfeed Med. 2015 Nov; 10(9):419-24. PMID: 26394021

Mates, J.M.; de Silva, S, Lustberg, M, Van Deusen, K, Baiocchi, R.A. Wu, L. (co-senior author), Kwiek, J.J.(co-senior author). “A Novel Histone Deacetylase Inhibitor, AR-42, 1 Reactivates HIV-1 from Chronically and Latently Infected CD4+ T-Cells. Retrovirology (Auckl). 2015; 7:1-5. Epub 2015 Oct 15. PMID: 26855567

Keim, S.A., Kulkarni, M., Billock, R.M., Hogan, J.S., McNamara, K.A., Dillon, C.E., Geraghty, S. R., Kwiek, J.J. “Cow’s Milk Contamination of Human Milk Purchased Via the Internet.” Pediatrics, 2015, May135(5):e1157-62. PMID: 25847797

Mates, J.M., Kumar, S.B., Bazan, J., Voronkin, I., Handelman, S.K., Janies, D.J., Kwiek, J.J. “Genotypic and phenotypic heterogeneity in the U3R region of HIV-1 subtype C.” AIDS Research and Human Retroviruses,2014 Jan.;30(1):102-12. PMID: 23826737

Norris Turner, A., Tabbah, S., Mwapasa, V., Rogerson, S.J., Meshnick, S.R., Ackerman, W.E. IV, Kwiek, J.J.Severity of maternal HIV-1 disease is associated with adverse birth outcomes in Malawian women: a cohort study. JAIDS, 2013, Dec; 64(4):392-9. PMID: 23846560

Keim, S.A., Hogan, J.S., McNamara, K.A., Gudimetla, V, Dillon, C.E., Kwiek, J.J., Geraghty, S.R. “Microbial Contamination of Human Milk Purchased Via the Internet.” Pediatrics, 2013 Nov; 132(5):e1227-35. PMID: 24144714

Geraghty, S.R., McNamara, K.A., Dillon, C.E., Hogan, J.S., Kwiek, J.J., Keim, S.A. “Buying Human Milk Via the Internet: Just a Click Away.” Breastfeeding Medicine, 2013 Dec.; 8(6):474-8. PMID: 23971685

Ackerman, WE 4th, Kwiek, J.J. "Role of the placenta in adverse perinatal outcomes among HIV-1 seropositive women." J Nippon Med Sch, 2013 80: 90-94. (Review) PMID: 23657060

Fouda, G.G., Mahlokozera, T., Salazar-Gonzalez, J., Salazar, M., Learn, G., Barotra, S., Sekaran, M., Russell, E.S., Rizzolo, K., Jaeger, F., Cai, F., Gao, F., Hahn, B., Swanstrom, R.I., Meshnick, S.R., Mwapasa, V., Kalilani, L., Fiscus, S.A., Montefiori, D., Haynes, B., Kwiek, J.J., Alam, M., Permar, S.M. “Postnatally-transmitted HIV-1 Envelope variants are efficient at dendritic cell trans-infection and are sensitive to neutralization by autologous and broadly-neutralizing antibodies.” Retrovirology, 2013 Jan; 10(3). PMID: 23305422

Kumar, S.B., Rice, C., E., Milner, D.A. Jr., Ramirez, N.C., Ackerman, W.E. IV, Mwapasa, V. l Norris Turner. A., Kwiek, J.J. “Elevated Cytokine and Chemokine Levels in the Placenta Are Associated With in utero HIV-1 Mother-To-Child Transmission.” AIDS, 2012 Mar; 26(6):685-94. PMID: 22301415

Russell ES, Kwiek J.J., Keys J, Barton K, Montefiori, D., Mwapasa V, Meshnick S, and Swanstrom R. “The Genetic Bottleneck in Vertical Transmission of Subtype C HIV-1 Is Not Driven by Selection of Especially Neutralization Resistant Virus from the Maternal Viral Population.” J Virol. 2011 Aug;85(16):8253-62. PMID: 21593171

Kumar, S.B, Handelman, S.K., Voronkin, I., Mwapasa, V., Janies, D., Rogerson, S.J., Meshnick, S.R., andKwiek, J.J. “Different Regions of HIV-1 Subtype C env are Associated with Placental Localization and In Utero Mother-to-Child Transmission.” J Virol. 2011 Jul;85(14):7142-52. PMID: 21543508

Garnsey, M.R., Matous, J.A., Kwiek, J.J., Coltart, D.M. “Asymmetric Total Synthesis of (+)- and (–)-Clusianone and (+)- and (–)- Clusianone Methyl Enol Ether via ACC Alkylation and Evaluation of their Anti- HIV Activity.” Bioorganic & Medicinal Chemistry Letters, 2011, 21(8):2406-9. PMID: 21414776

Mwapasa, V., Cachafeiro, A., Makhuta, Y., Beckstead, D.J., Pennell, M.L., Chilima, B., Mwagomba, B., Fiscus, S.A., Kwiek, J.J. “Using a Simplified Human Immunodeficiency Virus Type I p24 Antigen Assay to Diagnose Pediatric HIV-Infections in Malawi.” Journal of Clinical Virology, 2010, 49, 299-302. PMID: 20855231

Gay, C.L., Mwapasa, V., Murdoch, D.M., Kwiek, J.J., Fiscus, S.A., Meshnick, S.R., Cohen, M.S. “Acute HIV Infection among Pregnant Women in Malawi.” Diagnostic Microbiology and Infectious Disease, 2010,66(4):356-60. PMID: 20226326

Kwiek, J.J., Mwapasa, V., Mule, A.S., Misiri, H., Alker, A.P., Molyneux, M.E., Rogerson, S.J., Meshnick, S.R.HIV and Syphilis Infections Among Pregnant Women in Blantyre, Malawi. Malawi Medical Journal, 2008, 3: 80-85. PMID: 19537404

Kwiek, J.J., Arney, L.A., Pederson, B., Hararwa, V., Mwapasa, V., and Meshnick, S.R. “Detection of Placental Microtransfusions during HIV-1 Mother-to-Child Transmission. Journal of Infectious Diseases 2008,197(10):1378-81. PMID:18444794

Kwiek, J.J., Russell, E.S., Dang, K.K., Burch, C.L., Meshnick, S. R, Mwapasa, V., Swanstrom, R. The Molecular Epidemiology of HIV-1 Envelope Diversity During HIV-1 Subtype C Vertical Transmission in Malawian Mother-Infant Pairs. AIDS 2008, 22:863-71. PMID: 18427205

Kwiek, J.J., Alker, A.P. (co-first author), Kalilani, L., Wenink, E.C., Chaponda, M., E., Meshnick, S. R. Estimating True Antimalarial Efficacy by Heteroduplex Tracking Assay in Patients with Complex Plasmodium falciparum Infections. Antimicrobial Agents and Chemotherapy 2007, 51(2):521-7. PMID: 17116685

Mwapasa, V., Rogerson, S.J., Kwiek, J.J., Molyneux, M.E., Kamwendo, D.D., Tadesse, E., Chaluluka, E., Wilson, P.E., Meshnick, S.R. Is Maternal Syphilis Infection a Risk Factor for HIV Mother-to-Child Transmission? AIDS 2006, 20:1869-77. PMID: 16954728

Kwiek J.J., Mwapasa V., Milner, D., Alker, A., Miller, W., Ou, C.Y., Tadesse, E., Molyneux, M.E., Rogerson, S.J., Meshnick, S.R. Maternal-fetal Microtransfusions and HIV-1 Mother-to-Child Transmission in Malawi.PLoS-Medicine 2006, 3(1):e10. PMID: 16287342

Kwiek J.J., Haystead, T.A., Rudolf, J. The Kinetic Mechanism of Quinone-Oxidoreductase 2 and its Inhibition by the Anti-Malarial Quinolines. Biochemistry 2004, 43 (15): 4538-4547. PMID: 15078100

Graves P.R., Kwiek J.J. (co-first author), Fadden P., Ray, R., Hardeman, K., Coley, A. M., Foley, M., Haystead, T. A. Discovery of Novel Targets of Quinoline Drugs in the Human Purine Binding Proteome.Molecular Pharmacology 2002, 62:1364-1372. PMID: 12435804

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