Past and current areas of methods research by our biostatisticians:

  • Adaptive clinical trial design
  • Sample size re-estimation for laboratory experiments
  • Causal inference using propensity score methods
  • Moderated t-statistics for small sample size gene expression arrays
  • Mice-human correlations based on gene expression data
  • Missing data sensitivity analysis
  • Bias with propensity scores used as a regression covariate
  • Sample size re-estimation for clinical trials
  • Robust mixed model hypothesis testing
  • Microarray/microRNA normalization and filtering methods

Selected Publications

2017 - 2019:

  • Zhao, J., et al. (2019). "Predicting outcomes of chronic kidney disease from EMR data based on Random Forest Regression." Math Biosci 310: 24-30.
  • Yu L, Fernandez S, Brock G. Power analysis for RNA-Seq differential expression studies. BMC Bioinformatics. 2017 May 3;18(1):234. doi: 10.1186/s12859-017-1648-2. PubMed PMID: 28468606; PubMed Central PMCID: PMC5415728.
  • Garbett NC, Brock GN, Chaires JB, Mekmaysy CS, DeLeeuw L, Sivils KL, Harley JB, Rovin BH, Kulasekera KB, Jarjour WN. (2017) “Characterization and classification of lupus patients based on plasma thermograms,” PLoS One, 12(11):e0186398. PMID: 29149219.
  • Kendrick SK, Zheng Q, Garbett NC, Brock GN. (2017) “Application and interpretation of functional data analysis techniques to differential scanning calorimetry data from lupus patients,” PLoS One, 12(11):e0186232. PMID: 29121669.
  • Alver SK, Lorenz DJ, Washburn K, Marvin MR, Brock GN (2017). “Comparison of two equivalent MELD scores for hepatocellular carcinoma patients in the liver transplant allocation system” Transplant International, 30(11):1098-1109. PMID: 28403575
  • Shah JS, Rai SN, DeFilippis AP, Hill BG, Bhatnagar A, Brock GN (2017). “Distribution based nearest neighbor imputation for truncated high dimensional data with applications to pre-clinical and clinical metabolomics studies.” BMC Bioinformatics, 18(1):114. PMCID: PMC5319174

2014 - 2016:

  • Alver SK, Lorenz DJ, Marvin MR, Brock GN (2016). “Projected outcomes of six-month delay in exception points vs. an equivalent MELD score for HCC liver transplant candidates.” Liver Transplantation, 22(10):1343-55. PMID:27343202
  • Egger ME, Myers JA, Arnold FW, Pass LA, Ramirez JA, and Brock GN (2016). “Cost effectiveness of adherence to IDSA/ATS guidelines in elderly patients hospitalized for Community-Aquired Pneumonia”, BMC Medical Informatics and Decision Making, 16(1):34. PMID: 26976388
  • Garbett NC, Brock GN (2016). “Differential scanning calorimetry as a complementary diagnostic tool for the evaluation of biological samples.” Biochim Biophys Acta. 1860(5):981-9. PMID: 26459005
  • Wei L, Jarjoura D. Options and Considerations for Adaptive Laboratory Experiments. Stat Biosci. 2015 Oct 1;7(2):348-366. Epub 2014 Nov 25. PubMed PMID: 26539252; PubMed Central PMCID: PMC4628833.
  • Marvin MR, Ferguson N, Cannon RM, Jones C, Brock GN (2015). “MELDEQ: An alternative MELD score for patients with hepatocellular carcinoma”, Liver Transplantation. 21(5):612-22.
  • Yang D, Parrish RS, and Brock GN (2014). “Empirical evaluation of consistency and accuracy of methods to detect differentially expressed genes based on microarray data”, Computers in Biology and Medicine 46:1-10.

2010 – 2013:

  • Hade EM, Lu B. Bias associated with using the estimated propensity score as a regression covariate. Stat Med. 2014 Jan 15;33(1):74-87. doi: 10.1002/sim.5884. Epub 2013 Jun 21. PubMed PMID: 23787715
  • Rhoda D, Murray DM, Andridge RR, Pennell ML, Hade EM. Multiple Baseline Designs and Group-Randomized Trials. American Journal of Public Health. 2011 Nov; 101(11):2164-9. doi: 10.2105/AJPH.2011.300264. Epub 2011 Sep 22. Review. Erratum in: Am J Public Health. 2014 Mar;104(3):e12. PMID:21940928
  • Pennell M, Hade EM, Murray DM, Rhoda D. Cutoff Designs for Community-Based Intervention Studies. Statistics in Medicine. 2011; 30: 1865-1882. PMID: 21500240
  • Yu L, Gulati P, Fernandez S, Pennell M, Kirschner L, Jarjoura D. Fully moderated T-statistic for small sample size gene expression arrays. Stat Appl Genet Mol Biol. 2011 Sep 15;10(1). pii: /j/sagmb.2011.10.issue-1/1544-6115.1701/1544-6115.1701.xml. doi: 10.2202/1544-6115.1701. PMID: 23089813;
  • Hade EM, Jarjoura D, Wei L. Sample size re-estimation in a breast cancer trial. Clinical Trials. 2010; 7: 219-226. PMID:20392786
  • Hade EM, Murray DM, Pennell M, Rhoda D, Paskett E. et al. Intraclass Correlation Estimates for Cancer Screening Outcomes: Estimates and Applications in the Design of Group Randomized Cancer Screening Studies. J Natl Cancer Inst Monogr. 2010; 40: 97-103. PMID:20386058
  • Murray DM, Pennell M, Rhoda D, Hade EM, Paskett E. Designing Studies that Would Address the Multilayered Nature of Health Care. J Natl Cancer Inst Monogr. 2010; 40: 90-96. PMID:20386057