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Dissertation Defense Archives

Spring 2018

Samantha Ohmer

Megan20Duggan.jpgAdvisor: Christopher Walker








Kelly Regan-Fendt

Zachary Hing

Megan20Duggan.jpgAdvisors: John Byrd & Rosa Lapalombella

 

 

 

 

 

 

Autumn 2017

Summer 2017

Spring 2017

  Linan Wang

Advisor: Mike Freitas


Vivek Chowdhary

David Clever

Megan20Duggan.jpgAdvisor: Larry Schlesinger

 

 
T Cell-Intrinsic Oxygen Sensing Regulates Pulmonary Immunity

Megan Duggan

Megan20Duggan.jpgAdvisor: William E. Carson III

 

 

Priscilla Do

Advisor: John Byrd

 

 

Stephen Bergin

Advisor: Michael Caligiuri

 

 

Tatevik Broutian

Advisor: Maura L. Gillison

 

 

Andrew Stiff

Advisor: William E. Carson III

 

Autumn 2016

Nicholas Chesarino

Chesarino_Nicholas.jpgAdvisor: Jacob Yount

 

Sara Koenig

Advisor: Vidu Garg

 

Tierra Ware

 
Advisors: Joanna Groden & Clay Marsh

"Epigenetic and Pten regulation of Longevity Pathways as it Relates to Idiopathic Pulmonary Fibrosis and Organismal Aging"

         

Emily McWilliams

EmilyMcwilliamsPic.jpg Advisors: John Byrd & Natarajan Muthusamy

"Restoring Innate NK-cell Immunity with Antibody Therapeutics in CLL B-Cell Malignancy"

         

Jeremy Baeten

 JeremyBaeten.jpgAdvisor: Brenda Lilly

"The Roles of the Notch2 and Notch3 Receptors in Vascular Smooth Muscle Cells"

         

Cynthia Canan

Alaina Martinez


 

William Hankey

  

Hankey-William.jpgAdvisor: Joanna Groden 
Chromatin-associated APC tumor suppressor protein antagonizes canonical WNT repression of the MALL gene

        

Katherine Hartmann

KateHartmannPortraitresize(1).jpg 
Advisor: Sadee Wolfgang

 

 

 

 

 

 

Summer 2016


 

Cecelia Miller

  miller.jpg

     Advisor: John Byrd
"Discovery and Functional Interrogation of Biomarkers Related to Therapeutic Response in Chronic Lymphocytic Leukemia "
                                  

Porsha Smith

                                Advisor: Robert Baiocchi 

 

Spring 2016

David Clever

Megan20Duggan.jpgAdvisor: Larry Schlesinger

 

 
T Cell-Intrinsic Oxygen Sensing Regulates Pulmonary Immunity

Amanda Campbell

AmandaHarperportraitresize.jpgAdvisor: William E Carson

 

 

 

 

 

 

Daphne Guinn

DaphneGuinnphoto.jpg 

 
Advisor: John Byrd

 

 

 

 

 

 

 

 

 

Ashley Jackson

Advisor: Kirk Mchugh

 

 

Michael Makara

download.jpeg

Advisor: Peter Mohler

 
"Molecular physiology of ankyrin-G in the heart: Critical regulator of excitability and cellular architecture" 

 

 

Elizabeth McMichael

McMichael_Elizabeth.jpgAdvisor: William Carson

 

 

 

 

 

 

 

 

 

 

Komal Rambani

Advisor: Gustavo Leone

 
"A genome wide screen in C. elegans identifies cell non-autonomous suppressors of oncogenic Ras mediated over-proliferation"

 

 

 

 

Steven Scoville

scoville.jpg

Advisor: Michael Caligiuri

 

 

Michael Trimarchi

Advisor: Joanna Groden

 

 

 

 

 

 

Parker Woods

ParkerWoodspic.jpgAdvisor: Ian Davis

 

 

 

 

 

 

 

 

 

 

 

Autumn 2015

Kyle Caution

Kyle-Caution.jpg   
Advisor: Amal Amer 

 

Jacqueline Corry


 

 

 

 

 

 

 

 

Sara Johnson

Mary Severin

mary severin.jpg
Advisor: Amy Lovett-Racke

 

 

 

 

 

 

 

Catherine Waters

CatherineWatersphoto.jpg

Advisor: Kay Huebner

 

 

Summer 2015

Advisor: W. James Waldman

 

 

Carolyn Paisie

 
Advisor: Kay Huebner

 

 

 


 

 

 

 
 

Spring 2015

Advisor: Ramesh Ganju

 

 
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Advisor: Wolfgang Sadee

 
helongzhaopic.jpgAdvisor: Ramesh Ganju

 

 

 

Autumn 2014 

Nathan Dissinger

Dissinger-Nathan.jpgAdvisor: Patrick Green 

 

 

 

 

 

 

 

 

 

 


 

Adam Rauckhorst 

Adam RauckhorstAdvisor: Douglas Pfeiffer 

 

 

Estevan A. Santana 

Santana-Estevan.jpgAdvisor: Dr. Robert S. Munson 

 

 

 

Elizabeth Stofko-Barrie 

Beth-Stofko.jpgAdvisor: Dr. Wolfgang Sadee

 

 

 

Summer 2014 

Spring 2014

Julie Ann Dougherty

Julie-Dougherty-2.jpgAdvisor: Dr. Daniel R. Schoenberg

 

 

 

Nima Milani-Nejad 

Nimamilani.jpgAdvisor: Dr. Paul M.L. Janssen 

 

 

Benjamin R. Nixon 

Nixon-Benjamin.jpgAdvisor: Dr. Brandon J. Biesiadecki

 

 

James Perry

Advisor: Dr. Arnab Chakravarti 

 

 

 

 

Autumn 2013

Chelsea Bolyard

chelseabolyard.jpgAdvisor: Dr. Balveen Kaur

 

 

 

Heather Costello

Heather-Costello.jpgAdvisor: Dr. Mark Peeples

"The N500 Glycan of the Respiratory Syncytial Virus F Protein is Required for Fusion, but not for Stabilization or Triggering of the Protein"


 

Devyn Gillette

PhotoNotAvailable.jpgAdvisor: Dr. Susheela Tridandpani

 
 

 

Sean Harshman

Harshman-Sean.jpgAdvisor: Dr. Michael A. Freitas

"Characterization of Histone H1 and Extracellular Vesicles by Mass Spectrometry"


 

Kelly Johnson 

kelly-nye.jpgAdvisor: Dr. Traci Wilgus 

 

 

 

Suman Kanji 

Kanji Suman.pngAdvisors: Dr. Sujit Basu and Dr. Hiranmoy Das

 

 

Joanna Marshall

Joanna-Marshall.jpgAdvisor: Dr. John S. Gunn

 

 

 

Joseph Ostler

josephostler.jpgAdvisor: Dr. Muthu Periasamy 

 

 

Caroline Padro

Caroline-Padro.jpgAdvisor: Dr. Virginia M. Sanders

 

 

Christopher Penton 

chrispenton.jpgAdvisor: Dr. Federica Montanaro

 

 

Brenda Reader

BrendaReaderresized.jpgAdvisor: Dr. John F. Sheridan

 

 

Dawn Walker

Dawn-Walker-2.jpgAdvisor: Dr. Mark E. Drew

 

 

William Willis

Advisor: Dr. Art Strauch 

 
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Summer 2013

Edward Briercheck

Advisor: Dr. Michael Caliguiri

"Elucidation of the Mechanism by which Phosphatase and Tensin Homologue Deleted on Chromosome Ten (PTEN) Regulates Natural Killer Cell Function"


 

Joshua Oakes

Advisor: Dr. Danilo Perrotti


 

Ira Racoma

Advisor: Dr. Altaf Wani

“Targeting Glioblastoma Survival Signaling: A Novel Mechanism of Action of Thymoquinone”


 


 


 

Nicholas Zorko

Advisor: Dr. Michael Caliguiri

“The role of the mixed lineage leukemia partial tandem duplication in acute myeloid leukemogenesis”


 

Spring 2013

Erin Burns

Erin BurnsAdvisor: Dr. Tatiana Oberyzyn

"Men and Women are Not Just From Different Planets: The Role of Sex-Based Differences in the Prevention of Non-Melamona Skin Cancer"


 

Erin Frey

Erin FreyAdvisor: Dr. Candice Askwith

"Acid-Sensing Ion Channels: Targets for Neuropeptide Modulation and Neuronal Damage"


 

Alena Cristina Jaime-Ramirez

Alena Cristina Jaime-RamirezAdvisor: Dr. Bill Carson

"The NK Cell-mediated Anti-tumor Effects of a Folate-conjugated Immunoglobulin are Enhanced by Cytokines”


 

Samantha McCarty

Reeva AggarwalAdvisor: Dr. Matthew D. Ringel

"A Novel Braf Signaling Cascade through p-21 Activated Kinases Regulates Thyroid Cancer Cell Motility"


 


 

Pierpaolo Peruzzi

Pierpaolo PeruzziAdvisor: Dr. E. Antonio Chiocca & Dr. Balveen Kaur

"MiR-128 Controls the Activity of Polycomb Repressor Complexes 1 and 2 in Neural Stem Cells: Implications of its Loss in Gliomagensis"


 


 

Joshua C. Saldivar

Reeva AggarwalAdvisor: Dr. Kay Huebner

"The Origin of Genome Instability in Cancer: Role of the Fragile Site Gene Product Fhit"


 


 

Autumn 2012

Reeva Aggarwal

Reeva AggarwalAdvisor: Dr. Hiranmoy Das

"Mechanisms of Human CD34+ Stem Cell-Mediated Regulation of Osteoporosis in a Preclinical Model."


 

Houda Alachkar

Reeva AggarwalAdvisor: Dr. Guido Marcucci

“SPARC Contributes to Leukemia Growth and Aggressive Disease in Acute Myeloid Leukemia (AML)”


 

Rodney D. Britt Jr.

Rodney BrittAdvisor: Dr. Lynette Rogers

"The Role of Cyclooxygenase-2 in Newborn Hyperoxic Lung Injury."


 


 


 


 

April Renee Sandy Gocha

April Renee Sandy GochaAdvisor: Dr. Joanna Groden

"Mechanisms of alternative telomere elongation in human cancer cells ."


 


 

Jill Green

Jill GreenAdvisor: Dr. Kirk Mykytyn

"Characterization of Neuronal Primary Cilia in Cellular Homeostasis and Disease."


 


 

Sean Little

Sean LittleAdvisor: Dr. Jonathan P. Davis

"The Role of Troponin C in the Heart."


 


 

Chris Lucas

Chris LucasAdvisor: Dr. Virginia M. Sanders

"Prohibitins and the Cytoplasmic Domain of CD86 Cooperate to Mediate CD86 Signaling in B Lymphocytes."


 


 

Ananth Narayanan

Ananth NarayananAdvisor: Dr. Petra Schmalbrock

"Pharmacological Modulation of Functional Connectivity in Neuropsychological Disorders."


 


 

Steve Roof

Reeva AggarwalAdvisor: Dr. Mark T. Ziolo

“Neuronal Nitric Oxide Synthase Signaling Contributes to the Beneficial Cardiac Effects of Exercise”


 


 

Nikki Seagraves

                                       Advisor: Kim McBride

Jessica Suboticki

                                       Advisor: Paul Janssen 

Summer 2012

Joshua Cyktor

Joshua CyktorAdvisor: Dr. Joanne Turner

"Immune Correlates of Resistance and Susceptibility to Tuberculosis."


 


 


 


 

Xun Lan

Xun LanAdvisor: Dr. Victor Jin

"Uncover Transcription Factor Networks by Integrating One Dimensional 'Omics and Three Dimensional Chromatin Structure."


 


 

Richard Price

Richard PriceAdvisor: Dr. E. Antonio Chiocca

"The Role of Cytomegalovirus in Glioblastoma and Rhabdomyosarcoma."


 


 


 


 


 

Spring 2012

Adam Bevan

Adam BevanAdvisor: Dr. Brian K. Kaspar

"AAV-based approaches for modeling and treating spinal muscular atrophy."


 


 

Patrick Grierson

Patrick GriersonAdvisor: Dr. Joanna Groden

"The BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription."


 

Kaylan Haizlip

Advisor:Dr. Paul Janssen

“Manipulations and Alterations of the Force-Frequency Response in Isolated Cardiac Muscle”


 

Alison Lyon

Alison LyonAdvisor: Dr. Christine E. Beattie

"Generation and Analysis of Motor Neuron Disease Models in Zebrafish."


 


 

Carolyn Marion

Carolyn MarionAdvisor: Dr. Samantha King

"Modification and Utilization of Carbohydrates by Streptococcus pneumoniae."


 

Susan McClory

Susan McCloryAdvisor: Dr. Michael Caligiuri

"Extrathymic T cell development in the human tonsil."


 

Sarwish Rafiq

Sarwish RafiqAdvisor: Dr. John C. Byrd

"Evaluation of Antibody-based Therapeutics for B cell Malignancies."


 


 

Levy Reyes

Levy Austin ReyesAdvisor: Dr. Jay L. Zweier

"New Mechanisms for Endothelial Nitric Oxide Synthase Dysfunction in the Isolated Rat Heart."


 


 

Kenny Roman

Kenny RomanAdvisor: Dr. Robert Stephens

"GLT-1 Over-Expression Attenuates Bladder and Colonic Nociception By Either Pharmacological or Gene Therapy Approach"


 


 

Neha Singhal

Neha SinghalAdvisor: Dr. Paul T. Martin

"Distinct roles of synaptic GalNAc transferases, Galgt1 and Galgt2, in muscle biology."


 

Sarah Stevens

Sarah StevensAdvisor: Dr. Loren E. Wold

"Calcium and Cancer: Implications for Cardiovascular Function and Disease."


 

Fatemeh Talebian

Fatemeh TalebianAdvisor: Xue-Feng Bai

CD200-CD200R Interaction in Tumor Immunity

Winter 2012

Rebecca Allen

Rebecca AllenAdvisor: Dr. John Sheridan

"Macrophage microbicidal activity is enhanced by stressor-exposure."


 


 

Bryan Anthony

Bryan AnthonyAdvisor: Dr. Gregg Hadley

"The Role of CD103 Expression in Promoting Intestinal Graft Versus Host Disease."


 


 


 


 

Kristen Smith

Kristen SmithAdvisor: Dr. Caroline Whitacre

"MicroRNAs in multiple sclerosis: a study of the effects on T cell trafficking and effector function."


 


 


 


 

Autumn 2011

Huizi Chen

Huizi ChenAdvisor: Gustavo Leone, PhD

"Atypical E2Fs link mammalian endocycle control to cancer."


 

Gina Mavrikis Cox

Gina CoxAdvisor: Dr. Caroline C. Whitacre

"Macrophage migration inhibitory factor: a study of the effects on the central nervous system microenvironment autoimmune encephalomyelitis."


 


 

Dennis Horvath

Dennis HorvathAdvisor: Dr. Sheryl Justice

"The Impact of Phagocyte-UPEC Interactions Upon Pathogenesis of Urinary Tract Infections."


 

Summer 2011

Besma Abbaoui

Besma AbbaouismallerAdvisor: Dr. Steven Clinton

“Broccoli Isothiocyanates as Chemopreventive Agents and Epigenetic Modulators of Bladder Cancer”

Dustin Donnelly

Dustin DonnellyAdvisor: Dr. Denis Guttridge

“Tailoring the heterogeneous macrophage response to spinal cord injury towards neuroprotection"


 

Sara Fischer

Sara FischerAdvisor: Dr. Clay Marsh

“Electrospun Nanofiber Scaffolds as a Model of the Lung Microenvironment in Pulmonary Fibrosis”


 

Bethany Mundy

Bethany MundyAdvisor: Dr. William Carson

“Myeloid-Derived Suppressor Cells in Tumor Immunology”


 

Alan Smith

Alan SmithAdvisor: Dr. Amy Lovett-Racke

“IL-23 Receptor Expression and Effects of Signaling on T Cell Encephalitogenicity”


 

Georgia Triantafillou

Georgia TriantafillouAdvisor: Dr. John Byrd

"CD74 Targeted Nanoparticles as Dexamethasone Delivery System for B lymphoid Malignancies"

Jessica Williams

Jessica WilliamsAdvisor: Dr. Caroline Whitacre

“Pregnancy-associated Effects on Immune Modulation and Neuroprotection in a Model of Multiple Sclerosis: Role of T Cells and Serum Exosomes”


 

Dan Xu

Dan XuAdvisor: Dr. Christopher Walker

“Cellular Immunity in Adeno-Associated Virus Mediated Gene Therapy”


 

Spring 2011.

Jordan Jensen

Jordan JensenAdvisor: Dr. Jeffrey Kuret, PhD

"Development of Tau-Selective Imaging Agents for Improved Diagnosis of Alzheimer’s Disease and Other Tauopathies"


 

Olga Malykhina

Olga MalykhinaAdvisor: Dr. Mark Peeples, PhD

Christopher J. Traynham

Christopher TraynhamAdvisor: Mark T. Ziolo, PhD

"Effects of Neuronal Nitric Oxide Synthase Signaling on Myocyte Contractile Function"


 

Winter 2011

Shante Williams

Advisors: Sean Lawler & Antonio Chiocca

"The Role of Glycogen Synthase Kinase3 Inhibitors in Brain Tumor Migration and Invasion"


 

Autumn 2010

Stephanie Cush

Advisor: Emilio Flano

"Generation and Function of CD8 T Cell Memory to γ-Herpesviral Infection"


 

Chad Groer

Advisors: Laura Bohn and Wolfgang Sadee

"Agonist-Selective Regulation of the Mu Opioid Receptor by βarrestins"


 

Mark Hanke

Advisor: John Sheridan

"Sympathetic Nervous System Mediated Alterations in the Immunological and Behavioral Effects of Social Defeat"


 

Sarah May Herman

Advisor: John Byrd

"Manipulation of Kinase Signaling in Chronic Lymphocytic Leukemia: The effect on Disease state"


 


 


 


 


 

Anna Kwilas

Advisor: Mark Peeples

"Respiratory Syncytial Virus Based Vectors for the Treatment of Cystic Fibrosis"

Robert Moyer

Advisor: Wolfgang Sadee

"Exploration of Functional Genetic Variants in Candidate Genes for Psychiatric Disorders"


 


 

Amber Nagy

Advisor: James Waldman

"Characterization and Interaction of Nanoparticles in Biological Systems"


 

Susan Richards

Advisor: John Gunn

"PhoPQ- and PmrAB-mediated LPS Modification and Cationic Antimicrobial Peptide Resistance in Salmonella enterica Serovars Typhimurium and Typhi"


 

Summer 2010

Sasha Beyer

Advisor: Sissy Jhiang

"Modulation of Cell Surface Sodium Iodide Symporter Expression and Activity in Breast Cancer"


 


 


 


 

Jordan Gladman

Advisor: Dawn Chandler

"Understanding RNA Splicing to Fight Spinal Muscular Atrophy"


 


 

Spring 2010

Jessica L. Buescher

Advisor: Christopher Phiel

"Structure-Function Analysis of GSK-3 Isoforms"


 


 


 

Melinda C.C. Dunn

Advisor: James Waldman

"Inhibition of Respiratory Syncytial Virus in Vitro and In Vivo by the Experimental Immunosuppressive Agent Leflunomide"


 


 


 


 


 

Amanda M. Haidet

Advisor: Brian Kaspar

"Gene Therapy for Neuromuscular Disorders"


 


 

Sanjida Saklayen

Advisor: Howard Gu

"Effects of Propranolol on Cognition and Eye Contact in Autism Spectrum Disorders (ASD)"


 

Winter 2010

Victoria Best

Advisor: Christopher Walker

"Ongoing Cellular Responses to Transgene Products Encoded by Recombinant Adeno-Associated Virus (RAAV)"


 

Troy Cline

Advisor: Joan Durbin

"Innate Immune Mechanisms of Controlling Respiratory Virus Infection"


 

Jason M. Dahlman

Advisor: Dennis Guttridge

"Investigating the Molecular Mechanisms Involved in Skeletal Muscle Development: NF-kB and Skeletal Myogenesis"


 


 

Amy Dworkin

Advisor: Amanda Toland

"Environmental and Genetic Contributions of Susceptibility to Cutaneous Squamous Cell Carcinoma"


 

Ene Raig Fairchild

Advisor: William Carson

"Differential Expression of MicroRNAs in Melanoma"


 

Sohee Kim

Advisor: Jeff Kuret

"Computational modeling in Alzheimer's disease"


 

Kathryn J. Kitzmiller

Advisor: C. Yung Yu

"Variation of Complement Factor H and Mannan Binding Lectin in Systemic and Vascular Immune-Mediated Diseases"


 

Benjamin A.T. Rodriguez

Advisor: Tim Huang

"Estrogen represses target genes through epigenetic modification of proximal and distal elements"


 

Chris Woldford

Advisor: Tsonwin Hai

"The Roles of ATF3, an Adaptive Response gene, in Cancer Development and Metastasis"


 

Autumn 2009

Corey Clay

                                       Advisor: Larry Schlesinger

Chalonda Handy

                                       Advisor: Brian Kaspar 

Anuradha Kalyanasundaram

                                       Advisor: Muthu Periasamy

Holly Moose

                                       Advisor: Heithem El-Hodiri

Krithika Selvarajan

Advisor: Sampath Parthasarathy

"Adherent and Non Adherent Macrophages in Cell Survival and Death"


 


 

Inimary Toby

Advisor: Leif Nelin

"Activation of Epidermal Growth Factor Receptor and Stimulation of Arginase in Pulmonary Hypertension"


 

Summer 2009

Anna Eiring

                                       Advisor: Danilo Perrotti

Christopher I. Karanfilov

Advisor: Alan Litsky

"Ion Implantation of Ultra High Molecular Weight Polyethylene"

Preeyal Kotadiya

                                       Advisor: Beth Lee

Jessica Suboticki

                                       Advisor: Paul Janssen 

Jennifer J. Stanke

Advisor: Andy Fischer

"Beyond Neuronal Replacement: Embryonic Retinal Cells Protect Mature Retinal Neurons"


 


 


 

Jessica Suboticki

                                       Advisor: Paul Janssen 

Spring 2009

Brian L. Bell

Advisor: John Gunn

"Regulation of Virulence Gene Transcripts by the Francisella Orphan Response Regulator PmrA"


 

Amanda Michelle Beltramini

Advisor: Vijay Pancholi

"Eukaryotic-like serine/threonine kinase signaling in Staphylococcus aureus"


 

Edward Chang

Advisor: Jeff Kuret

"Role of Tau Protein in Neurodegenerative Disorders"


 

Robert Crawford

Advisor: John Gunn

"Chronic Carriage of Salmonella: Biofilms and Gallstones"


 


 

Jennifer M. Curry

Advisor: Clay Marsh

"Microenvironment Effects on Angiogenesis"


 

Nitisha Hiranandan

Advisor: Paul Janssen

"Imapact of Reperfusion Injury on Heart"


 

Aaron Kithcart

Advisor: Caroline Whitacre

"Macrophage Migration Inhibitory Factor: A Key Mediator of Inflammatory Disease"


 

Mark J. Kohr

Advisor: Mark Ziolo

"Modulation of Cardiac Contraction by Reactive Nitrogen Species"


 


 

Jaclyn Walisa McAlees

Advisor: Virginia Sanders

"Allergic asthma and the regulation of IgE production by B lymphocytes"


 


 

Erin K. Rottinghaus

Advisor: Joanne Turner

"Pulmonary Innate Immune Mechanisms in Old Mice"


 


 

Winter 2009

Kristin M. Ackerman

Advisor: Robert Boyd

"Zebrafish Neuronal Nicotinic Acetylcholine Receptors:Cloning, Expression, and Functional Analysis"


 

F Jason Duncan

Advisor: Tatiana Oberyszyn

"THE EFFECTS OF BLACK RASPBERRY EXTRACT ON UVB-INDUCED INFLAMMATION AND CARCINOGENESIS"


 

Kristen M. Raehal M.A.

Advisor: Laura Bohn

"Opioid-Induced Side Effects in Beta-Arrestin2 and G Protein Coupled Receptor Kinase Knockout Mice"


 


 


 

Yee Wu

                                       Advisor: Chack Yung

Autumn 2008

James M. Pauff

AAEAAQAAAAAAAAltAAAAJDY0ODdlZmVkLWI2NzAtNDNlMC1hODc0LThmYmIyZDJiMTk1NA.jpg

Advisor: Virginia Sanders

"Structure-Function Studies of Xanthine Oxidoreductase"


 


 

Brian C. Wulff

Advisor: Tatiana Oberyszyn

"Effects of Therapeutic Immunosuppressants on UVB Induced Inflammation and Skin Carcinogenesis in a Murine Model"


 


 

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