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Microbial Pathogenesis

​Contact John Gunn, PhD, and Jacob Yount, PhD
Faculty Liaisons

 

Overview​

Microbial pathogens include bacteria, viruses, fungi, and parasites and together account for a significant percentage of acute and chronic human diseases. In addition to understanding the mechanisms by which various pathogens cause human disease, research in microbial pathogenesis also addresses mechanisms of antimicrobial resistance and the development of new antimicrobial agents and vaccines. Answering fundamental questions regarding host-microbe interactions requires an interdisciplinary approach, including microbiology, genomics, informatics, molecular and cellular biology, biochemistry, immunology, and epidemiology. The core curriculum will provide the major foundation for graduate students in microbial pathogenesis, while the specialized courses, seminars, and journal clubs will allow students to gain a more in-depth understanding of microbes and innate and specific immune defenses that are critical to a complete understanding of the interplay between host and microbe. The Center for Microbial Interface Biology augments even further the opportunities for graduate education in microbial pathogenesis.

Recommended Curriculum

All students requesting the transcript designation Microbial Pathogenesis and participating in a non-Virology-focused laboratory will be required to register for BSGP 7240. Those in a Virology-focused laboratory will be required to register for MVIMG 7741. Including these required courses, students must register in relevant classes to reach a total of 10 credit hours beyond the core BSGP curriculum. 5 of these credits should be in didactic elective courses and 5 credits should be in Journal Club/discussion courses.


Didactic Elective Courses:
  • BSGP 7240 Molecular Pathogenesis (3 credits). In-depth presentation and discussion of the molecular and cellular mechanisms of pathogenesis, emphasizing current research in the field. Cross-listed as Micro 7724.  
  • MICRBIO 7020 Physiology meets Pathogenesis (2 credits)  The physiological basis for growth and virulence of microbes in the host.
  • MICRBIO 7010 Cellular and Molecular Immunology (3 credits) Cellular and molecular mechanisms of immune response, cell recognition and communication, molecular biology of cell recognition structures, cytokines, and effector mechanisms. Cross-listed as MVIMG 7010.
  • MVIMG 7741 Molecular Biology and Pathogenesis of Viruses (5 credits) An integrated study of the molecular mechanisms of virus replication and host-virus relationships that control virus pathogenesis or use as a therapeutic agent. Cross listed as MolGen 7540 and in VetBios.
Journal Club and/or Discussion Electives
  • BSGP 7950 Host-Pathogen Interactions: Research Seminar (1 credit) Students and outside speakers will give research presentations on microbial-host interactions.
  • BSGP 7400 Selected Topics in Microbial Pathogenesis (2 credits) Student led discussion of specific aspects of current and classic literature.
  • BSGP 8510 Advanced Seminar in Integrated Biomedical Science (1 credit) Interdisciplinary biomedical topics will be reviewed in depth with student participation in analyzing literature, and faculty and outside experts presenting their own original research. Available when relevant to microbial pathogenesis.
  • MVIMG 8142 Current Topics Immunology (1 credit) Journal club format course discussing immunology from a historical perspective, identifying critical discoveries that provide an understanding of how the immune system functions and how these findings influence our research methods and concepts today. Cross-listed as Micro 8142 and VetBioS 8142. 
  • BSGP 7910 Current Research in Human Viral Diseases (1 credit) Faculty, students and postdoctoral trainees will give critical interpretations of research and journal readings on human viral diseases.
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